◂ Last issue Next issue ▸ Archive Cover PDF
Volume 22 (15); 2025
Research Papers
Proteogenomic Analysis on RNA m6A Modification-Associated Genes Identifies a Distinct Subgroup with High IGF2BPs Expression Across Cancer Types Yebin Ryu, Eunhyong Chang, Hayoon Park, Sung-Yup Cho, Joon-Yong An
Int. J. Med. Sci. 2025; 22(15): 3815-3827. doi:10.7150/ijms.115609
Full text
PDF
PubMed
PMC
Targeting LC3B/MCL-1 expression by Protodioscin induces autophagy and apoptosis in human glioblastoma cells in vitro and in vivo Ching-Ting Tai, Yi-Hsien Hsieh, Hsiang-Lin Lee, Pei-Ni Chen, Hui-Ling Chiou, Tsai-Yun Wu, Chia-Liang Lin, Yi-Chen Lin, Chien-Min Chen
Int. J. Med. Sci. 2025; 22(15): 3828-3838. doi:10.7150/ijms.116656
Full text
PDF
PubMed
PMC
PRDX3 Promotes Lymph Node Metastasis in Cervical Cancer by Activating NF-κB Signaling Pathway and Anoikis Resistance Weijia Wen, Jiaying Li, Li Yuan, Yan Liao, Caixia Shao, Dingze Xu, Hongye Jiang, Yuandong Liao, Pan Liu, Chunyu Zhang, Shuzhong Yao, Wei Wang
Int. J. Med. Sci. 2025; 22(15): 3839-3853. doi:10.7150/ijms.118912
Full text
PDF
PubMed
PMC
The natural compound n-butylidenephthalide suppresses type II ovarian cancer cell growth by inducing ferroptosis Shinn-Zong Lin, Chih-Yang Huang, Yueh-Min Lin, Rathinasamy Baskaran, Yu-Jung Lin, Wei-Wen Kuo, Dah-Ching Ding
Int. J. Med. Sci. 2025; 22(15): 3854-3867. doi:10.7150/ijms.114086
Full text
PDF
PubMed
PMC
Punching Above Its Weight: A Head-to-Head Comparison of Deepseek-R1 and OpenAI-o1 on Pancreatic Adenocarcinoma-Related Questions Cheng-Peng Li, Yuan Chu, Wei-Wei Jia, Priska Hakenberg, Flavius Șandra-Petrescu, Christoph Reißfelder, Cui Yang
Int. J. Med. Sci. 2025; 22(15): 3868-3877. doi:10.7150/ijms.118887
Full text
PDF
PubMed
PMC
ABCC6 Transporter Contributed to Cisplatin Resistance on Bladder Cancer Kuang‑Yu Chou, An-Chen Chang, Thomas I‑Sheng Hwang, Te‑Fu Tsai, Chao‑Yen Ho, Hsiu-Wen Liu, David Achudhan, Chih-Hsin Tang, Yen-You Lin
Int. J. Med. Sci. 2025; 22(15): 3895-3905. doi:10.7150/ijms.115487
Full text
PDF
PubMed
PMC
Decoding Endoplasmic Reticulum Stress on Chondrocyte Driving Osteoarthritis Development through Integrating Single-Cell and Transcriptomic Profiling Zhao Zhang, Debin Cheng, Jingyi Dang, Xiaohe Wang, Hongbin Fan, Dong Liu
Int. J. Med. Sci. 2025; 22(15): 3906-3923. doi:10.7150/ijms.119573
Full text
PDF
PubMed
PMC
Deep Learning Based on Automated Breast Volume Scanner Images for the Diagnosis of Breast Lesions: A Multicenter Diagnostic Study Hui Liu, Ying Zhang, Bin Tan, Yi-Fei Yin, Li-Xia Yan, Li-Hua Xiang, Dan-Dan Shan, Yun-Yao Zhang, Shi-Si Ding, Guang Xu, Bo-Yang Zhou, Yi-Lei Shi, Xiao-Xiang Zhu, Jing-Liang Hu, Li-Ping Sun, Hui-Xiong Xu, Yi-Feng Zhang
Int. J. Med. Sci. 2025; 22(15): 3924-3937. doi:10.7150/ijms.118430
Full text
PDF
PubMed
PMC
Drug Interaction of Dasatinib with Thymoquinone: A Pharmacokinetic Study in Rats Ajaz Ahmad, Mohammad Raish, Khalid M. Alkharfy, Yousef A Bin Jardan, Abdul Ahad, Mohd Abul Kalam, Muzaffer Iqbal, Ibrahim A. Abdelrahman, Naushad Ali, Ali Akhtar, Fahad I Al-Jenoobi
Int. J. Med. Sci. 2025; 22(15): 3939-3945. doi:10.7150/ijms.109707
Full text
PDF
PubMed
PMC
Potential impact of omentin-1 genetic variants with the clinical features and progression of buccal mucosa cancer Ya-Hsin Wu, Chiao-Wen Lin, Hsiao-Chi Tsai, Chun-Wen Su, Ming-Yu Lien, Shun-Fa Yang, Chih-Hsin Tang
Int. J. Med. Sci. 2025; 22(15): 3958-3964. doi:10.7150/ijms.117708
Full text
PDF
PubMed
PMC
Multidimensional Factors Related to Engagement in Child-to-Parent Violence among Adolescents with Attention-Deficit/Hyperactivity Disorder Wen-Jiun Chou, Ray C. Hsiao, Peng-Wei Wang, Cheng-Fang Yen
Int. J. Med. Sci. 2025; 22(15): 3965-3973. doi:10.7150/ijms.116091
Full text
PDF
PubMed
PMC
Association of Fine Particulate Matter (PM2.5) and Wet-Bulb Globe Temperature (WBGT) with Osteoporosis Incidence: A Nationwide Prospective Cohort Study En-Che Chang, Fu-Wen Liang, Jiun-Chi Huang, Hao-Han Chang, Shu-Pin Huang, Szu-Chia Chen, Chih-Da Wu, Ya-Chin Huang, Jiun-Hung Geng
Int. J. Med. Sci. 2025; 22(15): 3974-3984. doi:10.7150/ijms.115460
Full text
PDF
PubMed
PMC
Environmental Lead Exposure Predicts Lower Bone Mineral Density in a Large Taiwanese Population-Based Study Po-Yin Shen, Fu-Wen Liang, Cheng-Chang Lu, Shu-Pin Huang, Szu-Chia Chen, Jiun-Hung Geng
Int. J. Med. Sci. 2025; 22(15): 3985-3993. doi:10.7150/ijms.117042
Full text
PDF
PubMed
PMC
Cerebrospinal fluid profile in coronavirus disease 2019, a prospective case series study Huiying Lin, Xiaoli Zhang, Hangfeng Li, Shuangfang Fang, Huapin Huang, Nan Liu, Houwei Du
Int. J. Med. Sci. 2025; 22(15): 3994-4002. doi:10.7150/ijms.111747
Full text
PDF
PubMed
PMC
Circulating miRNAs are Down-regulated in Asthmatic Patients; Case-control Study Christian A. Trejo-Jasso, Héctor Isaac Rocha-González, Eduardo Montes-Martínez, Manuel Castillejos-López, Arnoldo Aquino-Galvez, Dora Patricia Rosete-Olvera, Jose S. Lopez-Gonzalez, Mario Perez-Medina, Martha Patricia Sierra-Vargas, Angeles Carlos-Reyes, Misael O. García-Martin, Jazmín García-Machorro, Angel Camarena, Victor Ruiz
Int. J. Med. Sci. 2025; 22(15): 4003-4012. doi:10.7150/ijms.111022
Full text
PDF
PubMed
PMC
Inhibition of autophagy enhances the sensitivity of ciclopirox olamine in human chronic myelogenous leukemia K562 cells Hongyu Zhou, Hongyan Chen, Kaitao Luo, Lingmei Kong, Yan Li
Int. J. Med. Sci. 2025; 22(15): 4013-4025. doi:10.7150/ijms.114452
Full text
PDF
PubMed
PMC
Clinical Efficacy of Topical Ziyun Ointment in Improving Skin Hydration and Reducing Transepidermal Water Loss in Psoriasis Yu-Ping Hsiao, Wen-Li Ou, Chun-Te Lu, Jiunn-Liang Ko, Chih-Ting Hsu, Sheau-Chung Tang
Int. J. Med. Sci. 2025; 22(15): 4026-4035. doi:10.7150/ijms.118035
Full text
PDF
PubMed
PMC
Plasma Proteome Profiling Identifies Biomarkers and Potential Drug Targets for Non-Small Cell Lung Cancer Minghui Zhao, Xiaoke Di, Yucui Zhao
Int. J. Med. Sci. 2025; 22(15): 4036-4048. doi:10.7150/ijms.107109
Full text
PDF
PubMed
PMC
Tetrahydrocurcumin Protects Microglial Cells Against Pseudomonas aeruginosa Lipopolysaccharide-Induced Reactive Oxygen Species Production and Cathepsin B to Activate NLRP3 Inflammasome-Mediated Pyroptosis Via the HO-1 and p38/JNK Pathway Hui-Wen Lin, Tzu-Chun Chen, Inga Wang, Jui-Hsuan Yeh, Shang-Chun Tsou, Lee Sun, Shih-Chi Chung, Chen-Ju Chuang, Yuan-Yen Chang
Int. J. Med. Sci. 2025; 22(15): 4049-4062. doi:10.7150/ijms.118252
Full text
PDF
PubMed
PMC
Exploring the relationship between exercise and diabetes risk in a prediabetes population Chih-Wei Chiang, Oswald Ndi Nfor, Wen-Yu Lu, Chien-Ning Huang, Yung-Po Liaw
Int. J. Med. Sci. 2025; 22(15): 4077-4084. doi:10.7150/ijms.116287
Full text
PDF
PubMed
PMC
CHAF1B: the hidden culprit behind sorafenib resistance in hepatocellular carcinoma Wenfeng Zhuo, Jiali Zhao, Zhouying Zheng, Shanglin Cai, Guifang Zeng, En Lin, Zirui Bai, Bo Wang, Yingbin Jia, Peiping Li, Jian Li
Int. J. Med. Sci. 2025; 22(15): 4085-4101. doi:10.7150/ijms.118471
Full text
PDF
PubMed
PMC
Targeting ORMDL2 in glioblastoma through integrated landscape of high-throughput sequencing and pharmacogenomic analysis Fitria Sari Wulandari, Chih-Yang Wang, Sachin Kumar, Ngoc Phung Ly, Juan Lorell Ngadio, Dahlak Daniel Solomon, Do Thi Minh Xuan, Gabriela Natasha Sutandi, Hung-Yun Lin, Hui-Ru Lin, Yung-Kuo Lee, Hao-Chien Yang, Ming-Cheng Tsai, Ching-Chung Ko
Int. J. Med. Sci. 2025; 22(15): 4102-4118. doi:10.7150/ijms.116954
Full text
PDF
PubMed
PMC
Study on Predictive Models for Differential Diagnosis of Diabetic Kidney Disease and Non-Diabetic Kidney Disease Based on Clinical and Biochemical Indicators Pinning Feng, Xianlian Deng, Wenjia Gan, Yijiang Song, Yuyan Yang, Ruijie Zhang, Jin Li, Wenbin Lin
Int. J. Med. Sci. 2025; 22(15): 4119-4130. doi:10.7150/ijms.115709
Full text
PDF
PubMed
PMC
Real-World Safety of Anti-EGFR Antibodies: 20-Year Pharmacovigilance of Cetuximab and Panitumumab Liang-Yan Jin, Guo-Quan Chen, Jun Xie, Ping Chen, Hua-Yu Sun, Hong-Liang Zheng, Liu-Cheng Li, Kai-Li Mao
Int. J. Med. Sci. 2025; 22(15): 4131-4144. doi:10.7150/ijms.122194
Full text
PDF
PubMed
PMC
Effects of a Taekwondo-Specific High-Intensity Interval Training Protocol on the Biomarkers of Cardiovascular and Biochemical Recovery in Collegiate Athletes Po-Teng Huang, Chih-Han Wu, Po-Fang Huang, Ming-Chin Tsai, Kuei-Ling Chang, Kun-He Lin, Hsing-Chieh Huang, Shu-Cheng Lin
Int. J. Med. Sci. 2025; 22(15): 4145-4151. doi:10.7150/ijms.115788
Full text
PDF
PubMed
PMC
Impact of Adiposity on Cardiopulmonary Fitness in Children and Adolescents with Ventricular Septal Defects: a CPET-Based Comparative Study I-Hsiu Liou, Guan-Bo Chen, Shu-Fen Sun, Ruei-Sian Ding, Wan-Yun Huang, Sheng-Hui Tuan
Int. J. Med. Sci. 2025; 22(15): 4152-4160. doi:10.7150/ijms.121548
Full text
PDF
PubMed
PMC
Reviews
Association between Disorders of Lipid Metabolism and Oculopathy: An Overview Yuanting Yang, Ruixue Zhang, Miao Zhang, Zhaohui Yang, Zhongyu Ma, Yinqiao Zhang, Mengke Wu, Dadong Guo, Hongsheng Bi
Int. J. Med. Sci. 2025; 22(15): 3878-3894. doi:10.7150/ijms.116512
Full text
PDF
PubMed
PMC
The Application of Epicardium in Heart Failure Treatment: Opportunities and Challenges Chenlei Zhou, Yaping Xu, Zhikun Guo
Int. J. Med. Sci. 2025; 22(15): 3946-3957. doi:10.7150/ijms.118408
Full text
PDF
PubMed
PMC
The Role of Calcium Signaling in Sensorineural Hearing Loss Yun Hu, Juanjuan Li, Li Tian, Peng Zhang, Xianhai Zeng
Int. J. Med. Sci. 2025; 22(15): 4063-4076. doi:10.7150/ijms.119492
Full text
PDF
PubMed
PMC
Erratum
CEMIP as a potential biomarker and therapeutic target for breast cancer patients: Erratum Jinqi Xue, Xudong Zhu, Xinbo Qiao, Yulun Wang, Jiawen Bu, Xiaoying Zhang, Qingtian Ma, Lu Liang, Lisha Sun, Caigang Liu
Int. J. Med. Sci. 2025; 22(15): 3938. doi:10.7150/ijms.114765
Full text
PDF
PubMed
PMC
Global reach, higher impact