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Research Paper C1q CIC in Lupus Nephritis: An Analysis of 883 Patients Huang-Chen Chang, Yen-Ching Wu, Jun-Peng Chen, Wen-Nan Huang, Yi-Hsing Chen, Yi-Ming Chen Int. J. Med. Sci. 2026; 23(8): 2578-2586. doi:10.7150/ijms.125522 Full text PDF


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Review Advances in Artificial Intelligence for Wrist Joint Injury Diagnosis Hong Li, Xilin Liu Int. J. Med. Sci. 2026; 23(8): 2548-2567. doi:10.7150/ijms.134301 Full text PDF


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Research Paper Interplay of Atrial Arrhythmia and Chronic Heart Failure: A Population-Based Analysis of Hospital Outcomes in Germany Anastasia Janina Hobbach, Jannik Feld, Jürgen Reinhard Sindermann, Wolfgang Albrecht Linke, Holger Reinecke Int. J. Med. Sci. 2026; 23(8): 2540-2547. doi:10.7150/ijms.131856 Full text PDF


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Research Paper Targeting the Extracellular Signal-Regulated Kinase 5-Cellular Jun-Vimentin Axis to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Patients with Triple-Negative Breast Cancer Chia-Chi Chen, Shu-Jyuan Chang, Cheng-Loong Liang, Hieu D. H. Nguyen, Chi-Wen Luo, Yi-Zi Chen, Yu-Tzu Yang, Mei-Chiang Hsu, Sin-Hua Moi, Chao-Ming Hung, Mei-Ren Pan Int. J. Med. Sci. 2026; 23(8): 2524-2539. doi:10.7150/ijms.131682 Full text PDF


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Research Paper Exploratory Immunophenotyping of Programmed cell death-1 (PD-1) Expression and Regulatory T-Cell (Treg) Profiles in Systemic Lupus Erythematosus and Healthy Controls: A Cohort Study with Illustrative Clinical Cases Po-Jen Hsiao, Jeng-Wei Lu, Yi-Jung Ho, Shan-Wen Lui, Ting-Yu Hsieh, Wun-Long Jheng, Anna Blyzniuk, Feng-Cheng Liu Int. J. Med. Sci. 2026; 23(8): 2511-2523. doi:10.7150/ijms.131673 Full text PDF

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Targeting the Extracellular Signal-Regulated Kinase 5-Cellular Jun-Vimentin Axis to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Patients with Triple-Negative Breast Cancer

Breast cancer is the second most common cancer worldwide and remains the leading cause of cancer-related deaths among women. Triple-negative breast cancer (TNBC) represents approximately 15-20% of all breast cancer cases and is characterized by an aggressive clinical course and a high risk of metastasis. Extracellular signal-regulated kinase 5 (ERK5) is a critical biomarker that promotes tumor progression through mechanisms involving cell proliferation, ...


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