International Journal of Medical Sciences

Research Paper
miR-23b mediates TNF-α-Inhibited Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Targeting Runx2
Xuefei Sun, Mingwei Li, Jinghao Ban, Zhidan Li
Int. J. Med. Sci. 2021; 18(16): 3674-3683. doi:10.7150/ijms.64312
[Abstract] [Full text] [PDF]

Research Paper
Self-emulsified annatto tocotrienol improves bone histomorphometric parameters in a rat model of oestrogen deficiency through suppression of skeletal sclerostin level and RANKL/OPG ratio
Nur-Vaizura Mohamad, Soelaiman Ima-Nirwana, Kok-Yong Chin
Int. J. Med. Sci. 2021; 18(16): 3665-3673. doi:10.7150/ijms.64045
[Abstract] [Full text] [PDF]

Research Paper
Elimination of Ox-LDL through the liver inhibits advanced atherosclerotic plaque progression
Zhiwen Wang, Xiaopeng Guo, Qing Zhang, Gaohui Du, Zhuanglin Zeng, Chuansheng Zheng, Yumiao Wei
Int. J. Med. Sci. 2021; 18(16): 3652-3664. doi:10.7150/ijms.63065
[Abstract] [Full text] [PDF]

Review
The Peripheral Immune System and Traumatic Brain Injury: Insight into the role of T-helper cells
Wangxiao Bao, Yajun Lin, Zuobing Chen
Int. J. Med. Sci. 2021; 18(16): 3644-3651. doi:10.7150/ijms.46834
[Abstract] [Full text] [PDF]

Research Paper
Integrated Analysis of Expression and Prognostic Values of Acyl-CoA Dehydrogenase short-chain in Colorectal Cancer
Qi Wu, Tao Yan, Yijiao Chen, Jiang Chang, Yudong Jiang, Dexiang Zhu, Ye Wei
Int. J. Med. Sci. 2021; 18(16): 3631-3643. doi:10.7150/ijms.63953
[Abstract] [Full text] [PDF]

Research Paper
Radiomics based on fluoro-deoxyglucose positron emission tomography predicts liver fibrosis in biopsy-proven MAFLD: a pilot study
Zhong-Wei Chen, Kun Tang, You-Fan Zhao, Yang-Zong Chen, Liang-Jie Tang, Gang Li, Ou-Yang Huang, Xiao-Dong Wang, Giovanni Targher, Christopher D. Byrne, Xiang-Wu Zheng, Ming-Hua Zheng
Int. J. Med. Sci. 2021; 18(16): 3624-3630. doi:10.7150/ijms.64458
[Abstract] [Full text] [PDF]

Research Paper
Role of “Stiff Rim” sign obtained by shear wave elastography in diagnosis and guiding therapy of breast cancer
Yan-jun Xu, Hui-ling Gong, Bin Hu, Bing Hu
Int. J. Med. Sci. 2021; 18(15): 3615-3623. doi:10.7150/ijms.64243
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
The Impact of Motor Disability and the Level of Fatigue on Adherence to Therapeutic Recommendations in Patients with Multiple Sclerosis Treated with Immunomodulation
Robert Ślusarz, Joanna Olkiewicz, Robert Bonek, Karolina Filipska, Monika Biercewicz, Adam Wiśniewski
Int. J. Med. Sci. 2021; 18(15): 3609-3614. doi:10.7150/ijms.61964
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Predictive performance of eLIFT for liver inflammation and fibrosis in chronic liver diseases
Zongguo Yang, Xin Ma, Xinlan Zhou, Dan Huang, Yanbing Wang, Xiufen Li, Wei Lu, Zhanqing Zhang, Rongrong Ding
Int. J. Med. Sci. 2021; 18(15): 3599-3608. doi:10.7150/ijms.62386
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
PRMT4 promotes hepatocellular carcinoma progression by activating AKT/mTOR signaling and indicates poor prognosis
Peng Du, Kaifeng Luo, Guoyong Li, Jisheng Zhu, Qi Xiao, Yong Li, Xingjian Zhang
Int. J. Med. Sci. 2021; 18(15): 3588-3598. doi:10.7150/ijms.62467
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Plasma levels of amino acids and derivatives in retinopathy of prematurity
Yedi Zhou, Yu Xu, Xiang Zhang, Qian Huang, Wei Tan, Yonghui Yang, Xiaori He, Shigeo Yoshida, Peiquan Zhao, Yun Li
Int. J. Med. Sci. 2021; 18(15): 3581-3587. doi:10.7150/ijms.63603
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Polypharmacy Is Associated With Amiodarone-Induced Hypothyroidism
Satoshi Yokoyama, Yuki Tanaka, Kouichi Hosomi, Mitsutaka Takada
Int. J. Med. Sci. 2021; 18(15): 3574-3580. doi:10.7150/ijms.61412
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Risk of Pneumonia is associated with Antipsychotic Drug Use among older patients with Parkinson's Disease: A Case-control Study
Kuang-Hua Huang, Wei-Yin Kuo, Yu-Hsiang Kuan, Yu-Chia Chang, Tung-Han Tsai, Chien-Ying Lee
Int. J. Med. Sci. 2021; 18(15): 3565-3573. doi:10.7150/ijms.63246
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Roles of the miR-139-5p/CCT5 axis in hepatocellular carcinoma: a bioinformatic analysis
Jingjing Xu, Yuan Zhang, Cheng Liu, Ping Yan, Zongguo Yang
Int. J. Med. Sci. 2021; 18(15): 3556-3564. doi:10.7150/ijms.57504
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Thymopentin treatment of murine premature ovarian failure via attenuation of immune cell activity and promotion of the BMP4/Smad9 signalling pathway
Xueqin Zhu, Jianjun Liu, Hao Pan, Zixiang Geng, William Huang, Te Liu, Bimeng Zhang
Int. J. Med. Sci. 2021; 18(15): 3544-3555. doi:10.7150/ijms.61975
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Possible mechanisms of cholesterol elevation aggravating COVID-19
Yan Tang, Longtai Hu, Yi Liu, Bangyi Zhou, Xiaohuan Qin, Jujian Ye, Maoze Shen, Zhijian Wu, Peidong Zhang
Int. J. Med. Sci. 2021; 18(15): 3533-3543. doi:10.7150/ijms.62021
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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Journal of Genomics recent articles:

Research Paper
Identification of a novel pathogenic variant in PALB2 and BARD1 genes by a multigene sequencing panel in triple negative breast cancer in Morocco
Abdelilah Laraqui, Mathias Cavaillé, Nancy Uhrhammer, Oubaida ElBiad, Yannick Bidet, Hicham El Rhaffouli, Hicham El Anaz, Driss Moussaoui Rahali, Jaouad Kouach, Khaled Guelzim, Bouabid Badaoui, Abderrahman AlBouzidi, Mohammed Oukabli, Rachid Tanz, Yasser Sbitti, Mohammed Ichou, Khaled Ennibi, Yassine Sekhsokh, Yves-Jean Bignon
J. Genomics 2021; 9: 43-54. doi:10.7150/jgen.61713
[Abstract] [Full text] [PDF]

Research Paper
Genetic Diversity of Clinical Bordetella Pertussis ST2 Strains in comparison with Vaccine Reference Strains of India
Naresh Chand Sharma, Shalini Anandan, Naveen Kumar Devanga Ragupathi, Dhiviya Prabaa Muthuirulandi Sethuvel, Karthick Vasudevan, Dhirendra Kumar, Sushil Kumar Gupta, Lucky Sangal, Balaji Veeraraghavan
J. Genomics 2021; 9: 38-42. doi:10.7150/jgen.58823
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Analysis of Genome Sequences of Coagulase-Negative Staphylococci Isolates from South Africa and Nigeria Highlighted Environmentally Driven Heterogeneity
Tawanda Elias Maguvu, Adegboyega Oyedele Oladipo, Cornelius Carlos Bezuidenhout
J. Genomics 2021; 9: 26-37. doi:10.7150/jgen.53019
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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Computed tomography (CT) of the chest is one of the main diagnositic tools for coronavirus disease 2019 (COVID-19) infection. To document the chest CT findings in patients with confirmed COVID-19 and their association with the clinical severity, we searched related literatures through PubMed, MEDLINE, Embase, Web of Science (inception to May 4, 2020) and reviewed reference lists of previous systematic reviews. A total of 31 case reports (3768 patients) on CT findings of COVID-19 were included. The most common comorbid conditions were hypertension (18.4%) and diabetes mellitus (8.3%). The most common....