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Research Paper Association between FNDC5 Deficiency and Compromised Mitochondrial Integrity and Biogenesis in Kidney Disease Chien-Wei Huang, Chia-Jung Li, Junne-Ming Sung, Yau-Sheng Tsai, Jin-Shuen Chen Int. J. Med. Sci. 2026; 23(10): 3281-3295. doi:10.7150/ijms.130226 Full text PDF


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Research Paper Habitual tea consumption is associated with a low prevalence of gastroesophageal reflux disease in a Taiwanese population study Cheng-Ming Kuo, Jiun-Hung Geng, Wen-Hung Hsu, Neng-Shen Chu, Szu-Chia Chen Int. J. Med. Sci. 2026; 23(10): 3271-3280. doi:10.7150/ijms.139922 Full text PDF


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Research Paper Cytomegalovirus Infection Is Associated with Increased Disease Activity and Worse Long-Term Course in Ulcerative Colitis Richard Vollenberg, Benedikt Blömer, Clara Zippel, Markus Strauss, Eva Lorentzen, Jonel Trebicka, Phil-Robin Tepasse Int. J. Med. Sci. 2026; 23(10): 3262-3270. doi:10.7150/ijms.139439 Full text PDF


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Association between FNDC5 Deficiency and Compromised Mitochondrial Integrity and Biogenesis in Kidney Disease

Background: Mitochondrial dysfunction is a hallmark of acute and chronic kidney diseases. This study investigates the expression landscape and potential association of FNDC5 with renal injury. Methods: We integrated human scRNA-seq, mouse spatial transcriptomics (ischemia-reperfusion injury model), in vitro high-glucose (HG) models in proximal tubule cells and podocytes, and a constitutive Fndc5 knockout mouse model. Candidate transcription factor ...


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