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Research Paper Lutein Attenuates Synovial Hyperplasia, Cartilage Loss, and Bone Erosion by Suppressing Inflammatory Pathways in Rheumatoid Arthritis Chi-Jen Chang, Tsung-Ming Chang, Ying-Sui Sun, Ji-Fan Lin, Skye Hsin-Hsien Yeh, Ju-Fang Liu Int. J. Med. Sci. 2026; 23(7): 2486-2498. doi:10.7150/ijms.135369 Full text PDF

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Review Overcoming Biological Barriers: A Comprehensive Review of Advanced Melatonin Delivery Systems for Therapeutic Applications Zhenyu Yang, Yiduo Chen, Shaoying Li, Xiaoyue Lei, Xincheng Wu, Yuan Wang, Shuli Deng Int. J. Med. Sci. 2026; 23(7): 2462-2485. doi:10.7150/ijms.134841 Full text PDF

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Research Paper Prognostic Role of Gut Microbiota and Clinical Parameters in Predicting Survival in Advanced Cholangiocarcinoma Patients Receiving Chemotherapy Thanika Ketpueak, Chanon Kunasol, Kanokphong Suparan, Nakarin Inmutto, Sunhawit Junrungsee, Nattayaporn Apaijai, Sasiwan Kerdphoo, Chanisa Thonusin, Chaiyut Charoentum, Thatthan Suksombooncharoen, Sarawut Kongkarnka, Sirinart Kumfu, Lakkhana Sadaow, Wanchai Maleewong, Siriporn C. Chattipakorn, Nipon Chattipakorn Int. J. Med. Sci. 2026; 23(7): 2448-2461. doi:10.7150/ijms.131376 Full text PDF

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Review The interplay between type 2 diabetes mellitus and sepsis: a scoping review Sarah Sharul Sham, Sok Kuan Wong, Kok-Yong Chin, Nur Liyana Mohammed Yusof, Toh Leong Tan, Evelyn Yi Wen Chau, Aireen Zamhot, Amirudin Sanip, Amir Muharram Int. J. Med. Sci. 2026; 23(7): 2423-2447. doi:10.7150/ijms.126520 Full text PDF

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Research Paper Zingiber officinale Leaf Subcritical Water Extract Suppresses Adipogenesis and Lipogenesis in 3T3-L1 Adipocytes via the AMPK-SREBP-1c Signaling Pathway Eun-Min Jun, Jong-Yeon Kim, Jeong-Sook Choe, Eun-Jung Park, Hae-Jeung Lee Int. J. Med. Sci. 2026; 23(7): 2408-2422. doi:10.7150/ijms.121198 Full text PDF

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Review Lactate and Lactylation in Pulmonary Hypertension: Comprehensive Landscape and Future Perspectives Qing Dai, Yichao Cai, Xinyu Wang, Xia Li, Runxiu Zheng, Xianya Cao, Chao Zhang, Jun Xu, Jian Yi, Lan Song, Aiguo Dai Int. J. Med. Sci. 2026; 23(7): 2392-2407. doi:10.7150/ijms.125397 Full text PDF

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Issue 6; 2026

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Indexed in MEDLINE, PubMed, EMBASE, CAS/Chemical Abstracts, CAB Abstracts, Scopus, Science Citation Index (SCI) Expanded ....

Full texts of articles appear in PubMed Central and Europe PMC.

Lutein Attenuates Synovial Hyperplasia, Cartilage Loss, and Bone Erosion by Suppressing Inflammatory Pathways in Rheumatoid Arthritis

Lutein is a bioactive carotenoid best known for its role in retinal protection, but emerging evidence suggests that it may also exert anti-inflammatory activity in chronic inflammatory disorders. In this study, we investigated the anti-inflammatory and joint-protective effects of lutein in rheumatoid arthritis (RA)-related experimental models. Transcriptomic profiling was performed in MH7A fibroblast-like synovial cells treated with lutein, followed ...

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