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Volume 22 (12); 2025

Research Papers

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Validation of a Fall Predictive Model for Inpatients in Japanese Long Term Care Hospitals Hitomi Shimada, Risa Hirata, Naoko E. Katsuki, Eiji Nakatani, Kiyoshi Shikino, Maiko Ono, Midori Tokushima, Tomoyo Nishi, Shizuka Yaita, Chihiro Saito, Kaori Amari, Kazuya Kurogi, Yoshimasa Oda, Mariko Yoshimura, Shun Yamashita, Yoshinori Tokushima, Hidetoshi Aihara, Motoshi Fujiwara, Masaki Tago Int. J. Med. Sci. 2025; 22(12): 2877-2883. doi:10.7150/ijms.106600 Full text PDF PubMed PMC


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Long-term Cardiovascular Outcomes in Patients with Omicron COVID-19 and Elevated Cardiac Biomarkers: A Prospective Multicenter Cohort Study in Shanghai, China Shun Yao, Yamei Xu, Zhonglei Xie, Shuai Yuan, Junqing Gao, Qianwei Chen, Kailei Shi, Zongjun Liu, Xiaotong Cui, Yanyan Wang, Yu Song, Xueting Han, Junbo Ge, Zhenju Song, Jingmin Zhou Int. J. Med. Sci. 2025; 22(12): 2884-2895. doi:10.7150/ijms.112282 Full text PDF PubMed PMC


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Repurposing Antidiabetic Drugs for Gangrene: A Mendelian Randomization and Text Mining Study Chenfeng Wang, Huiwei Wang, Ting Feng, Yihe Hu, Feng Liang Int. J. Med. Sci. 2025; 22(12): 2896-2905. doi:10.7150/ijms.111050 Full text PDF PubMed PMC


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CircRNA Sequencing Analysis Reveals the Regulatory Role of circ_CDR1as in Penile Squamous Cell Carcinoma via the ceRNA Network Lin Du, Shanshan Lv, Zhenzhen Jiang, Xiaohong Song, Leping Liu, Rong Huang, Xinmin Nie, Rong Gui, Jian Li, Junhua Zhang, Jie Guo, Jian Cao, Zhizhong Liu, Zhaojian Gong, Yanwei Luo Int. J. Med. Sci. 2025; 22(12): 2919-2931. doi:10.7150/ijms.112109 Full text PDF PubMed PMC


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Association between Vessels Encapsulating Tumor Clusters and Circulating Tumor Cells in Hepatocellular Carcinoma: Clinical Evidence and Risk Model Development Da-feng Xu, Rong-rong Li, Chang Shu, Ya-ni Li, Ran Tao, Yue-yue Chen, Hui-yuan Yang, Xiao-ping Chen, Jing-jing Yu, Wei Xiao Int. J. Med. Sci. 2025; 22(12): 2944-2955. doi:10.7150/ijms.111025 Full text PDF PubMed PMC


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Integration of Multi-Scale Profiling and Machine Learning Reveals the Prognostic Role of Extracellular Matrix-Related Cancer-Associated Fibroblasts in Lung Adenocarcinoma Ziyi Chen, Mengyuan Chen, Changqing Yang, Jiajing Wang, Yuan Gao, Yuanying Feng, Dongqi Yuan, Peng Chen Int. J. Med. Sci. 2025; 22(12): 2956-2972. doi:10.7150/ijms.113580 Full text PDF PubMed PMC


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Exploring the Role of Immune Cells in Glioma: Causal Associations and Clinical Implications Yimin Pan, Xiaoshun Sun, Fushu Luo, Zheng Chen, Chunbo Liu, Yongye Zhu, Jiaxiang Wang, Ruixuan Chen, Qing Liu, Changwu Wu, Jun Tan Int. J. Med. Sci. 2025; 22(12): 2973-2991. doi:10.7150/ijms.116560 Full text PDF PubMed PMC


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Effect of individualized PEEP titrated by EIT on postoperative atelectasis in children undergoing laparoscopy: A randomized controlled trial Sheng-Hua Wang, Ye Wang, Si-Yuan Li, Lai Jiang, Yan-Fei Mao, Qin Xia, Han Gan Int. J. Med. Sci. 2025; 22(12): 3007-3013. doi:10.7150/ijms.112280 Full text PDF PubMed PMC


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Features of Undiagnosed Abdominal Pain and Diagnostic Status of Acute Hepatic Porphyria in Japan: A Retrospective Study Masaki Tago, Yosuke Sasaki, Naoko E. Katsuki, Risa Hirata, Hidetoshi Aihara, Fumiya Komatsu, Kazunobu Une, Taiju Miyagami, Yudai Suzuki, Ren Kawamura, Hiroaki Takeoka, Yuka Yasuoka, Taro Shimizu, Shigeki Nabeshima, Toshio Naito, Susumu Tazuma Int. J. Med. Sci. 2025; 22(12): 3014-3021. doi:10.7150/ijms.107826 Full text PDF PubMed PMC


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NSUN2 rs13181449 variant decreases the risk of oral cancer development Li-Chung Hung, Cheng-Chen Huang, Yen-Ting Lu, Chun-Wen Su, Chiao-Wen Lin, Hsiao-Ju Chu, Shun-Fa Yang, Hsueh-Ju Lu Int. J. Med. Sci. 2025; 22(12): 3022-3031. doi:10.7150/ijms.113676 Full text PDF PubMed PMC


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The correlation between intraocular pressure and choroidal microcirculation in patients with high myopia Dongjie Song, Yutong Han, Zongchan Zhang, Jiayun Ge, Kuangqi Chen, Jianping Tong, Ye Shen Int. J. Med. Sci. 2025; 22(12): 3032-3043. doi:10.7150/ijms.113035 Full text PDF PubMed PMC


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A Potential Predictor of Proximal Flow-Diverter Stent Jailed Artery Stenosis: Distal to Proximal Artery Diameter Ratio Yudi Tang, Peike Chen, Jian Lv, Haining Wei, Xiaoyan Wang, Junqiang Feng, Yuhua Jiang, Peng Liu, Youxiang Li, Yunna Yang Int. J. Med. Sci. 2025; 22(12): 3044-3052. doi:10.7150/ijms.115452 Full text PDF PubMed PMC


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Ginsenoside Rh7 affects β-catenin nuclear translocation by inhibiting SHCBP1 expression, thereby inhibiting epithelial-mesenchymal transition in gastric cancer cells Xiaohong Zhang, Yanqing Mo, Li Feng Int. J. Med. Sci. 2025; 22(12): 3053-3069. doi:10.7150/ijms.112622 Full text PDF PubMed PMC


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IL1A regulates MSU-induced apoptosis and inflammatory response through TLR4/MyD88/NF-κB signaling pathway Fei Pan, Yun Zhang, Min Li, Mei Liu Int. J. Med. Sci. 2025; 22(12): 3070-3083. doi:10.7150/ijms.112102 Full text PDF PubMed PMC


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Association between Magnesium Depletion Score and Advanced Cardiovascular-Kidney-Metabolic Syndrome Stages in US Adults Juan Tian, Xiaoyu Ding, Xiaoying Ren, Guang Wang, Wei Wang, Jia Liu Int. J. Med. Sci. 2025; 22(12): 3101-3111. doi:10.7150/ijms.115217 Full text PDF PubMed PMC


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Problematic Smartphone Use in Adolescents with Attention-Deficit/Hyperactivity Disorder: The Roles of Domestic Violence, Parenting Styles, and Peer Bullying Victimization Po-Chun Lin, Cheng-Fang Yen, Ray C. Hsiao, Peng-Wei Wang Int. J. Med. Sci. 2025; 22(12): 3112-3119. doi:10.7150/ijms.112302 Full text PDF PubMed PMC


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Niclosamide-Modulated Apoptosis and Autophagy in Breast Cancer Cells via Phosphorylated JNK as a Common Regulator Ming-Shan Chen, Tsung-Yi Chen, Shu-Hsin Chen, Shew-Meei Sheu Int. J. Med. Sci. 2025; 22(12): 3120-3131. doi:10.7150/ijms.106429 Full text PDF PubMed PMC


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Novel Genetic Variants in PATL2 Corresponding to Different Clinical Phenotypes of Female Infertility Xiaotao Yang, Xiangrui Shi, Jing Wang, Jingying Guo, Yinhu Huang, Pan Tang, Yu Zhao, Yanxi Li, Wei Liu, Qinghua Zhang Int. J. Med. Sci. 2025; 22(12): 3132-3141. doi:10.7150/ijms.109085 Full text PDF PubMed PMC


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Causal Relationship between Gut Microbiota and Endometrial Cancer: A Two-Sample Mendelian Randomization Study Xinrui Yao, Sitong Dong, Xiao Li, Ouxuan Liu, Yuexin Hu, Yuxuan Wang, Xiangcheng Fan, Bei Lin Int. J. Med. Sci. 2025; 22(12): 3142-3153. doi:10.7150/ijms.112922 Full text PDF PubMed PMC


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Investigation of the Relationship Between University Students' Nomophobia and Psychological Distress: A Cross-sectional Study Rakesh Kumar, Aisha Osman Yousif, Mohammed Ismail Humaida Int. J. Med. Sci. 2025; 22(12): 3154-3161. doi:10.7150/ijms.112738 Full text PDF PubMed PMC

Reviews

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Actin-Like Protein 6A as an Oncogene and Therapeutic Target in Cancer Guo-Bin Song, Lin Xiang, Tian Peng, Ya-Nan Li, Hou-Qun Ying, Xue-Xin Cheng Int. J. Med. Sci. 2025; 22(12): 2906-2918. doi:10.7150/ijms.113736 Full text PDF PubMed PMC


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Cancer-Associated PIK3R1 Genetic Aberrations and Precision Medicine Huan Xie, Yirong Li, Xinran Li Int. J. Med. Sci. 2025; 22(12): 2932-2943. doi:10.7150/ijms.109506 Full text PDF PubMed PMC


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An Overview of the Role of Genetic factors in Idiopathic Pulmonary Fibrosis: Insights from Epidemiology to Prognosis Jiahao Liu, Zihan Yi, Ting Chen, Yinghua Ying, Yue Hu Int. J. Med. Sci. 2025; 22(12): 2992-3006. doi:10.7150/ijms.113226 Full text PDF PubMed PMC


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Research Progress of Epigenetic Modifications in Myopia Yinqiao Zhang, Zhaohui Yang, Miao Zhang, Yuanting Yang, Zhongyu Ma, Mengke Wu, Hongsheng Bi, Dadong Guo Int. J. Med. Sci. 2025; 22(12): 3084-3100. doi:10.7150/ijms.110640 Full text PDF PubMed PMC

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