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Volume 22 (16); 2025

Research Papers

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Endothelin-1 Stimulates the Growth of Visceral and Subcutaneous Human Preadipocytes through Similar and Alternative Signaling Pathways via Type A and Type B Endothelin Receptors: Potential Implications for Therapeutic Strategies for Obesity and Metabolic Disorders
An-Ci Siao, Yung-Hsi Kao, Chih-Chun Kuo, Hann-Yeh Shyu, Yow-Chii Kuo, Wen-Fang Chiang, Kuo-An Wu, Li-Jane Shih, Po-Jen Hsiao
Int. J. Med. Sci. 2025; 22(16): 4161-4174. doi:10.7150/ijms.110073
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Stage-dependent EZH2 methylation correlates with immune polarization, metabolic suppression, and unfavorable outcomes in hepatocellular carcinoma
Yi-Chung Chien, Guo-Wei Wu, Jia-Yan Wu, Liang-Chih Liu, Yi-Hsien Hsieh, Yung-Luen Yu
Int. J. Med. Sci. 2025; 22(16): 4201-4213. doi:10.7150/ijms.119496
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Aberrant ALPP Expression Serves as a Prognostic Biomarker and Facilitates Cholangiocarcinoma Progression through Immune Evasion and PI3K-Akt Signaling Activation
Guo-Wei Wu, Yi-Chung Chien, Li-Yuan Bai, Yung-Luen Yu
Int. J. Med. Sci. 2025; 22(16): 4214-4226. doi:10.7150/ijms.116260
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Association Between Cardiopulmonary Fitness and Degenerative Lumbar Spine Disease in Patients with Heart Failure: a Retrospective Study Using CPET
Zong-Han Lin, Sheng-Hui Tuan, Ko-Long Lin, Wen-Hwa Wang, Wan-Yun Huang, Shu-Fen Sun, Ruei-Sian Ding, I-Hsiu Liou
Int. J. Med. Sci. 2025; 22(16): 4227-4235. doi:10.7150/ijms.121138
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Real-Time Ultrasound Diagnosis of Developmental Dysplasia of the Hip Using an Attention-Enhanced YOLOv11 Model
Wen-Shin Hsu, Guang-Tao Lin, Wei-Hsun Wang
Int. J. Med. Sci. 2025; 22(16): 4236-4249. doi:10.7150/ijms.120138
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A Novel Erinacine S Derivative from Hericium erinaceus Overcomes Chemoresistance in Colorectal Cancer Cells by Enhancing TRAIL/TNFR1/DR5 Expression through Histone Acetylation
Shui-Yi Tung, Kam-Fai Lee, Yung-Yu Hsieh, Kung-Chuan Cheng, Ko-Chao Lee, Li-Ya Lee, Wan-Ping Chen, Chin-Chu Chen, Chih-Chuan Teng, Meng-Chiao Hsieh, Cheng-Yi Huang, Hsing-Chun Kuo
Int. J. Med. Sci. 2025; 22(16): 4278-4294. doi:10.7150/ijms.119894
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Molecular mechanisms and biomarkers of total parenteral nutrition-induced hepatotoxicity revealed by iTRAQ proteomics analysis
Yung-Yu Hsieh, Jai-Jen Tsai, Shui-Yi Tung, Ko-Chao Lee, Kung-Chuan Cheng, Kam-Fai Lee, Meng-Chiao Hsieh, Cheng-Yi Huang, Chih-Chuan Teng, Chien-Heng Shen, Hsing-Chun Kuo
Int. J. Med. Sci. 2025; 22(16): 4295-4312. doi:10.7150/ijms.122025
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Impact of Subcutaneous Adipose Tissue Index Change During Neoadjuvant Chemoradiotherapy on Disease-Free Survival and Tumor Response in Patients with Locally Advanced Rectal Cancer
Qing Yang, Siyi Lu, Ruize Qu, Nan Zhang, Maoye Chen, Yi Zhang, Yanpeng Ma, Zhipeng Zhang, Hao Wang, Wei Fu
Int. J. Med. Sci. 2025; 22(16): 4313-4324. doi:10.7150/ijms.114915
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Green tea containing inulin and catechins ameliorates high-fat diet-induced metabolic dysfunction-associated fatty liver disease in mice
Yu-Hao Lee, Chi-Chang Huang, Hung-Lung Lin, Yi-Xuan Chen, Yi-Ju Hsu
Int. J. Med. Sci. 2025; 22(16): 4325-4334. doi:10.7150/ijms.122441
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Decreased plasma level of C-type lectin-like receptor 2 (CLEC-2) in patients with breast cancer
Chia-Chi Chen, Chin-Feng Hsuan, Teng-Hung Yu, Chia-Chang Hsu, Cheng-Ching Wu, Wei-Hua Tang, Wei-Chin Hung, Yung-Chuan Lu, Fu-Mei Chung, Yau-Jiunn Lee, Ching-Ting Wei
Int. J. Med. Sci. 2025; 22(16): 4335-4343. doi:10.7150/ijms.117190
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Tricin inhibits the migration of human retinal pigment epithelium cells by suppressing the RUNX2-CYP1A1 axis and STAT3 pathway
Wei-Yang Lu, I-Chia Liang, Yi-Hsien Hsieh, Kai Wang, Chia-Yi Lee, Nuo-Yi Yu, Shun-Fa Yang, Hsiang-Wen Chien
Int. J. Med. Sci. 2025; 22(16): 4344-4352. doi:10.7150/ijms.122814
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Disrupting CARMA3 Signaling with Triptolide Reverses Sorafenib Resistance in Hepatocellular Carcinoma
Wan-Yu Wang, Tung-Wei Hsu, Yen-Hao Su, Chih-Ming Su, Tzu-Hsuan Wang, Ching-Feng Chiu, Kuei-Yen Tsai, Chih-Yang Huang, Hsin-An Chen, Po-Hsiang Liao
Int. J. Med. Sci. 2025; 22(16): 4353-4364. doi:10.7150/ijms.121880
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Reduced Risk of Sleep Disturbance and Obstructive Sleep Apnea Following Joint Replacement in Osteoarthritis Patients
Ying-Chi Fan, Shih-Wen Kao, Wei-Yang Lu, Chih-Hsin Tang, Jing-Yang Huang, Chia-Yi Lee, Chun-Yi Chuang, Shih-Chi Su, Shun-Fa Yang
Int. J. Med. Sci. 2025; 22(16): 4365-4373. doi:10.7150/ijms.116325
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Synergistic increase in anti-cancer stemness activity and pro-apoptotic effects in human glioblastoma cancer stem-like cells by combination treatment with temozolomide and corosolic acid
Chuan-Yi Kao, Hsiang-Yao Shih, Yi-Hsien Hsieh, Chung-Jung Liu, Ming-Chun Hung, Jeng-Yih Wu, Yi-Chen Lin, Chien-Min Chen
Int. J. Med. Sci. 2025; 22(16): 4374-4383. doi:10.7150/ijms.122961
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Impact of Latent Tuberculosis Infection on Ovarian Reserve and In Vitro Fertilization or Intracytoplasmic Sperm Injection Outcomes: A Retrospective Cohort Study with Propensity Score Matching
Yifan Chu, Jialiang Zhang, Luyao Wang, Jiaxin Xie, Jiayun Chen, Miao Yan, Xinyao Hu, Bo Zhang, Jing Yue
Int. J. Med. Sci. 2025; 22(16): 4384-4395. doi:10.7150/ijms.114851
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Comprehensive Analysis of Aberrant m6A RNA Modifications Identifies Prognostic Biomarkers in Non-Small Cell Lung Cancer
Yifei Li, Peng Jiao, Donghang Li, Yi Tian, Hexin Li, Gaoyuan Sun, Xiaonan Wu, Xin Nie, Xu Li, Siyuan Xu, Xiaokun Tang, Lili Zhang, Li Wan, Lanxin Zhang, Jiahui Cai, Min Tang, Lin Li
Int. J. Med. Sci. 2025; 22(16): 4396-4405. doi:10.7150/ijms.119651
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Clostridium butyricum GKB7 increase Physical Performance and Improve Biochemistry Profile on Mice with Inherently Low Aerobic Capacity
Mon-Chien Lee, Chao-Yuan Chen, Yi-Ju Hsu, Shih-Wei Lin, You-Shan Tsai, Yen-Lien Chen, Chin-Chu Chen, Chi-Chang Huang
Int. J. Med. Sci. 2025; 22(16): 4418-4431. doi:10.7150/ijms.118805
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Risk-based screening and prognostic analysis for second primary malignancies in kidney cancer patients: a retrospective cohort study based on large-scale population and Mendelian randomization analysis
Mingrui Zou, Ruiyi Deng, Haode Liu, Jianhui Qiu, Peidong Tian, Jiaheng Shang, Jingcheng Zhou, Xueying Li, Lin Cai, Yizhou Wang, Kan Gong
Int. J. Med. Sci. 2025; 22(16): 4432-4450. doi:10.7150/ijms.118457
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Age-stratified Associations between Chronic Periodontal Disease and Clinical Outcomes in Hemodialysis Patients: Mortality, Pneumonia, and Fractures
Min-Tser Liao, Chien-Lin Lu, Ren-Yeong Huang, Joshua Wang, Cai-Mei Zheng, Yi-Chou Hou, Chen-Yen Tai, Kuo-Cheng Lu
Int. J. Med. Sci. 2025; 22(16): 4469-4482. doi:10.7150/ijms.116133
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Risk of acute kidney injury and mortality in patients vaccinated against COVID-19
Po-Yu Tsai, Yu-Hsun Wang, Jing-Yang Huang, Shun-Fa Yang, Sheng-Wen Wu
Int. J. Med. Sci. 2025; 22(16): 4483-4492. doi:10.7150/ijms.119217
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Machine Learning-Based WGCNA Approach for Developing an Immunogenic Cell Death-Related Hub Gene Signature and Identification of AJM1 as a Prognostic Biomarker in Pancreatic Adenocarcinoma
Tianyin Ma, Xiangdong Gongye, Cairang Dongzhi, Yibo Chai, Qikun Wang, Ming Tian
Int. J. Med. Sci. 2025; 22(16): 4493-4508. doi:10.7150/ijms.119960
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Theobroma cacao seed extracts attenuate dyslipidemia and oxidative stress in L-NAME induced hypertension in Wistar rats
Eyuwa I. Agwupuye, Abdulhakeem R. Agboola, Yu-Cheng Kuo, Ako H. Itam, Lawrence U. Ezeayinka, Item J. Atangwho, Bolaji M. Ayeyemi, Adeleye A. Edema, Bashir Lawal, Modhi O. Alotaibi, Najlaa Hamed Almohmadi, Gaber El-Saber Batiha, Nasser M. El-Sabbagh, Hsu-Shan Huang
Int. J. Med. Sci. 2025; 22(16): 4509-4522. doi:10.7150/ijms.123888
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Mapping the Somatic Mutation Landscape of Familial NF2-Related Schwannomatosis using Whole-Exome Sequencing
Fushu Luo, Liangqi Jiang, Yimin Pan, Haoyu Li, Jun Tan, Changwu Wu, Qing Liu
Int. J. Med. Sci. 2025; 22(16): 4523-4531. doi:10.7150/ijms.121550
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The impact of evodiamine on human anaplastic thyroid cancer therapy—an in vitro and in vivo study
Yin-Che Lu, Tsung-Hsing Lin, Kai-Liang Tang, Chin-Ho Kuo, Yi-Sheng Zhang, Yi-Ping Chang, Shu-Hsin Chen, Yi-Zhen Li, Pei-Wen Zhao, Jen-Hsien Lin, Ying-Ray Lee
Int. J. Med. Sci. 2025; 22(16): 4532-4546. doi:10.7150/ijms.122604
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Reviews

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Exploring the Role of Tripeptides in Wound Healing and Skin Regeneration: A Comprehensive Review
Siti Balqis Adnan, Manira Maarof, Mh Busra Fauzi, Nur Izzah Md Fadilah
Int. J. Med. Sci. 2025; 22(16): 4175-4200. doi:10.7150/ijms.118118
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Bispecific Antibodies in Glioblastoma: Mechanistic Advances, Delivery Innovations, and Translational Challenges in Overcoming Immune Escape
He-Lu Wang, Nan Chi, Hong-Tao Zhang
Int. J. Med. Sci. 2025; 22(16): 4250-4277. doi:10.7150/ijms.121829
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Advances in Tumor Antigen Vaccines: A New Frontier in Cancer Immunotherapy
Wanqi Feng, Yifan Zhao, Dongran Yu, Wenyu Jia, Hui Cao, Yuling Zhang, Jie Cao, Zequn Li
Int. J. Med. Sci. 2025; 22(16): 4406-4417. doi:10.7150/ijms.120868
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New Exploration of Therapeutic Targets for Radiation Pneumonitis: Comparative Analysis of Molecular Pathways in Radiation-Induced and LPS-Induced Pneumonitis
Siyi Niu, Zhen Li, Nan Wang, Guoliang Xue, Huiwen Xue, Qian Hong, Wei Xu, Zhigang Wei, Xin Ye, Qi Xie
Int. J. Med. Sci. 2025; 22(16): 4451-4468. doi:10.7150/ijms.124332
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Molecular mechanisms and Biological Functions of Autophagy in Endometrial Diseases
Jin Xie, Risheng She, Lu Wang, Muhua Yi, Mingjie Dai, Mingxiu Wu, Xianxiu Qiu, Xiaojun Yang
Int. J. Med. Sci. 2025; 22(16): 4547-4560. doi:10.7150/ijms.122545
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Endoplasmic Reticulum Stress in Cancer Progression: A Comprehensive Review of Its Role and Mechanisms
Xin Yu, Wenge Li, Shengrong Sun, Juanjuan Li
Int. J. Med. Sci. 2025; 22(16): 4561-4585. doi:10.7150/ijms.120874
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