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Volume 22 (8); 2025

Research Papers

Indoxyl sulfate is associated with cognitive impairment in ESRD patients by activating the extrinsic apoptosis in the neuronal cells during differentiating process
Chih-Chuan Hsieh, Kuo-Cheng Lu, Chuen-Lin Huang, Jiun-Jie Wang, Ting-Yin Yeh, Shyh-Min Lin, Ya-Ling Chung, Yi-Chou Hou, Yuahn-Sieh Huang
Int. J. Med. Sci. 2025; 22(8): 1736-1749. doi:10.7150/ijms.109245
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Exploring the Relationship Between Gut Microbiota and Aortic Stenosis: Role of Inflammatory Proteins, Blood Metabolites, and Immune Cells
Fanhui Jing, Jiapeng Zhou, Fengwen Zhang, Guangzhi Zhao, Fang Fang, Xiangbin Pan
Int. J. Med. Sci. 2025; 22(8): 1750-1761. doi:10.7150/ijms.110392
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Assessing the Role of Polyamine Metabolites in Blood and the DNA Methylation of Mycobacterium Tuberculosis in Patients with Multidrug-Resistant Tuberculosis
Li Yan, Xinxin Niu, Kuidi Liang, Feifeng Guan, Xiaolin Yu, Ziyu Ye, Mingyuan Huang, Hancheng Liang, Xinguang Zhong, Jincheng Zeng
Int. J. Med. Sci. 2025; 22(8): 1762-1772. doi:10.7150/ijms.102568
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Integrated Phenotypic and Transcriptomic Analyses of Osteoporosis in Type 2 Diabetic Mice
Shu-Juan Xing, Ying-Feng Gao, Lu Liu, Bing-Dong Sui, Ning-Ning Da, Jin-Yu Liu, Hao Wang, Yuan Yuan, Yuan Qin, Pei-Sheng Liu, Si-Qi Ying, Kai Zhang, Jie-Xi Liu, Ji Chen, Yi-Han Liu, Xin Xie, Yan Jin, Sha Zhang, Chen-Xi Zheng
Int. J. Med. Sci. 2025; 22(8): 1773-1790. doi:10.7150/ijms.109537
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Mechanisms of Huhuang decoction in treating diabetic wounds: a network pharmacological and experimental study
Jie Zhang, Yan Shi, Jiaqiang Wang, Min Gao, Shan Zhong, Yunsheng Chen, Jiaqi Hao, Peilang Yang, Shun Xu, Yan Liu
Int. J. Med. Sci. 2025; 22(8): 1811-1824. doi:10.7150/ijms.108187
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Oncogenic and Immunological Roles of FRS2 and its Potential Value in Retroperitoneal Liposarcoma: from Bioinformatics Analysis to Clinicopathological Evidence
Hao Yu, Shuquan Li, Yifan Wu, Zhen Wang, Xiaopeng Wang, Sha Zhang, Xiaoya Guan, Bin Dong, Chunyi Hao, Xiuyun Tian, Ang Lv
Int. J. Med. Sci. 2025; 22(8): 1825-1836. doi:10.7150/ijms.103802
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Bioprospection of Hura crepitans metabolites against oxidative stress and inflammation: An in vitro and in silico exploration
Yu-Cheng Kuo, Bashir Lawal, Halimat Yusuf Lukman, Lung-Ching Chen, Sheng-Liang Huang, Yi-Fong Chen, Adewale O. Fadaka, Femi Olawale, Ayo Olasupo, Olabode T Ajenifujah, Dalia Fouad, Marios Papadakis, Gaber El-Saber Batiha, Saheed Sabiu, Alexander T.H. Wu, Hsu-Shan Huang
Int. J. Med. Sci. 2025; 22(8): 1837-1851. doi:10.7150/ijms.109116
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Mitochondrial Quality Control Systems in Septic AKI: Molecular Mechanisms and Therapeutic Implications
Ying Tan, Yue Ouyang, Zisheng Ma, Jianming Huang, Chuhong Tan, Junxiong Qiu, Feng Wu
Int. J. Med. Sci. 2025; 22(8): 1852-1864. doi:10.7150/ijms.107012
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Danshensu Attenuates Palmitic Acid-Induced Activation of Hepatic Stellate Cells by Regulating Pyroptosis
Han-Fang Tseng, Huan-Nung Chao, Chih-Hung Lin, Chan-Yen Kuo
Int. J. Med. Sci. 2025; 22(8): 1865-1874. doi:10.7150/ijms.107564
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Gene Signature-Based Prognostic Model for Acute Myeloid Leukemia: The Role of BATF, EGR1, PD-1, PD-L1, and TIM-3
Yupei Zhang, Zhixi Chen, Jiamian Zheng, Shaohua Chen, Liye Zhong, Jie Chen, Cunte Chen, Songnan Sui, Yangqiu Li
Int. J. Med. Sci. 2025; 22(8): 1875-1884. doi:10.7150/ijms.108527
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In Silico Identification of ANKRD22 as a Theragnostic Target for Pancreatic Cancer and Fostamatinib's Therapeutic Potential
Huong Thi Luu Kim Huynh, Hendrick Gao-Min Lim, Yuan-Chii Gladys Lee, Thien-Vy Phan, Thanh-Hoa Vo, Chien-Hsin Chen, Alexander T.H. Wu
Int. J. Med. Sci. 2025; 22(8): 1885-1904. doi:10.7150/ijms.105193
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MUC15 acts as a tumor suppressor gene which correlates with prognosis and immune infiltration in esophageal squamous cell carcinoma
Xiang Fei, Ai-li Wang, Hao Wu, Si-wei Xing, Lei Chen, Ying Chen, Xue-jing Lin, Hai-long Liu, Bin Sun
Int. J. Med. Sci. 2025; 22(8): 1905-1915. doi:10.7150/ijms.108926
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Predictors of the Fear of COVID-19 in Individuals with Schizophrenia: a Prospective Study
Cheng-Fang Yen, Ching-Shu Tsai, Chien-Wen Lin, Ray C. Hsiao, Peng-Wei Wang
Int. J. Med. Sci. 2025; 22(8): 1916-1923. doi:10.7150/ijms.106953
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Hematological parameters and major adverse cardiovascular events: a prospective study in a Chinese population involving 2,970 participants
Hongna Mu, Xinyue Wang, Xianghui Zhao, Ruiyue Yang, Wenduo Zhang, Hongxia Li, Siming Wang, Fusui Ji, Wenxiang Chen, Jun Dong, Xue Yu
Int. J. Med. Sci. 2025; 22(8): 1924-1935. doi:10.7150/ijms.104118
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FBXW2 inhibits the progression of gastric cancer via promoting β-catenin ubiquitylation
Yanshen Kuang, Mu Ke, Weizheng Liu, Fengming Xu
Int. J. Med. Sci. 2025; 22(8): 1936-1943. doi:10.7150/ijms.108501
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How telomere maintenance affects endometriosis development: a preliminary study
Xiaoling Zhao, Weimin Kong, Dan Luo, Yunkai Xie, He Zhang
Int. J. Med. Sci. 2025; 22(8): 1944-1957. doi:10.7150/ijms.102646
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Integrating Single-Cell and Bulk RNA Sequencing Data to Explore Sphingolipid Metabolism Molecular Signatures in Ovarian Cancer Prognosis: an Original Study
Xu Huang, Xiaoyu Li, Wulin Shan, Yingyu Dou, Qiongli Yu, Yao Chen, Zengying Wang, Haomin Zhang, Yumeng Wang, Xiaofei Lu, Wenju Peng, Bairong Xia
Int. J. Med. Sci. 2025; 22(8): 1958-1977. doi:10.7150/ijms.107391
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Reviews

The roles of the ubiquitin-proteasome system in renal disease
Danqin Lu, Yingying Zhang, Ping Zhu, Jiao Wu, Cheng Yuan, Lihua Ni
Int. J. Med. Sci. 2025; 22(8): 1791-1810. doi:10.7150/ijms.107284
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RNA-binding proteins as a molecular link between COPD and pulmonary hypertension
Yi Liu, Ran Wang, Tao Jiang
Int. J. Med. Sci. 2025; 22(8): 1979-1991. doi:10.7150/ijms.108587
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Erratum

Overexpression of ATAD2 indicates Poor Prognosis in Oral Squamous Cell Carcinoma: Erratum
Xiao-Long Wang, Shuo Wang, Zhi-Zhong Wu, Qi-Chao Yang, Hao Li, Hong-Gang Xiong, Shu-Cheng Wan, Zhi-Jun Sun
Int. J. Med. Sci. 2025; 22(8): 1978. doi:10.7150/ijms.112159
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