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Volume 22 (7); 2025

Research Papers

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Data Mining of the FDA Adverse Event Reporting System and Animal Experiments for Assessment of Rhabdomyolysis Risk Associated with Lipid-lowering Drugs Shinji Kobuchi, Daisuke Sugiyama, Anna Iima, Ami Obuchi, Ayumi Osaka, Ayana Doi, Hikaru Ueta, Satoshi Yokoyama, Kouichi Hosomi, Mitsutaka Takada, Toshiyuki Sakaeda Int. J. Med. Sci. 2025; 22(7): 1485-1492. doi:10.7150/ijms.109034 Full text PDF PubMed PMC


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Impact of Chronic Kidney Disease on Aortic Dissection in Patients with Polycystic Kidney Disease: A Fifteen-year Nationwide Population-based Cohort Study in Taiwan Chia-Ning Fan, Chi-Hsiang Chung, Wu-Chien Chien, Chang-Huei Tsao, Tzu-Hsuan Weng, Kun-Lin Wu, Wen-Fang Chiang, Chih-Chien Yen, Jenq-Shyong Chan, Po-Jen Hsiao Int. J. Med. Sci. 2025; 22(7): 1493-1503. doi:10.7150/ijms.106518 Full text PDF PubMed PMC


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Interleukin 26 attenuates osteoblast differentiation in osteoarthritis patients by activating COX2 and NF-κB pathways Yi-Hsuan Lin, Yi-Hsun Wang, Yi-Jen Peng, Feng-Cheng Liu, Huey-Kang Sytwu, Chia-Pi Cheng Int. J. Med. Sci. 2025; 22(7): 1504-1515. doi:10.7150/ijms.102967 Full text PDF PubMed PMC


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Dextrose Prolotherapy's Impact on the Urinary Microbiome in Interstitial Cystitis/Bladder Pain Syndrome Liang-Kun Chen, Shu-Jen Chang, Chin-Li Chen, Jing-Heng Yan, Juin-Hong Cherng, Gang-Yi Fan, En Meng, Yi-Chiung Hsu Int. J. Med. Sci. 2025; 22(7): 1516-1527. doi:10.7150/ijms.104028 Full text PDF PubMed PMC


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Association between Triglyceride-Glucose Index and Prognosis in Critically Ill Patients with Acute Coronary Syndrome: Evidence from the MIMIC Database Manqing Chen, Yuhui Yang, Weiwei Hu, Lingmin Gong, Zhenli Liao, Yifan Fu, Xingyan Li, Hongman Feng, Fangyao Chen Int. J. Med. Sci. 2025; 22(7): 1528-1541. doi:10.7150/ijms.107976 Full text PDF PubMed PMC


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Targeted inhibition of integrin αVβ3 induces cytotoxicity and suppresses migration ability in ovarian cancer cells and tumor spheroids I-Lun Hsin, Ling-Yen Chiu, Jiunn-Liang Ko, Po-Hui Wang, Pei-Ju Wu Int. J. Med. Sci. 2025; 22(7): 1544-1554. doi:10.7150/ijms.103141 Full text PDF PubMed PMC


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Metabolic syndrome is associated with gastroesophageal reflux disease in a large Taiwanese population study Wen-Hung Hsu, Jiun-Hung Geng, Pei-Yu Wu, Jiun-Chi Huang, Chao-Hung Kuo, Szu-Chia Chen Int. J. Med. Sci. 2025; 22(7): 1555-1561. doi:10.7150/ijms.109616 Full text PDF PubMed PMC


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Non-epithelial Circulating Tumor Cells Enhance Disease Progression in High-risk Prostate Cancer through EMT and COL1A1 Expression Yiyuan Li, Ruji Wu, Hua Wang, Meinong Zhong, Yunhao Qing, Shuo Lu, Zixiao Zhang, Tan Ma, Jieheng Luo, Hengjun Xiao, Jianguang Qiu, Ke Li Int. J. Med. Sci. 2025; 22(7): 1562-1573. doi:10.7150/ijms.107703 Full text PDF PubMed PMC


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Quantification of Fascin-1-Positive Extracellular Vesicles by Nanoflow Cytometry for Early Detection of Hepatocellular Carcinoma in Liquid Biopsy Bodeng Wu, Zhenxun Wang, Guanbo Wang, Quan Zhong, Qiaoting Wu, Jiawei Li, Bo Ma, Xinyi Tan, Jiaming Chen, Yu Wang, Xin Zhang Int. J. Med. Sci. 2025; 22(7): 1574-1584. doi:10.7150/ijms.102438 Full text PDF PubMed PMC


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Knowledge Landscape and Hotspots of Research in Transthyretin Amyloid Cardiomyopathy: A Bibliometric Analysis Yanzhi Liu, Xinqing Li, Anran Xin, Yuhui Zhang, Jian Zhang Int. J. Med. Sci. 2025; 22(7): 1585-1601. doi:10.7150/ijms.101888 Full text PDF PubMed PMC


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Escin Rescues Blood-brain Barrier and Inhibits NLRP3 Inflammasome-mediated Pyroptosis in Rats with Superior Sagital Sinus Thrombosis Min Li, Xinjian Liu, Xinyu Zhou, Ran Meng, Xunming Ji Int. J. Med. Sci. 2025; 22(7): 1602-1611. doi:10.7150/ijms.102624 Full text PDF PubMed PMC


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Association of nutrient intake and dietary patterns with serum folate and anemia-related biomarkers in Taiwanese pregnant women with pre-pregnancy overweightness or obesity Nhi Thi Hong Nguyen, Chyi-Huey Bai, Jung-Su Chang, Yi-Chun Chen, Ya-Li Huang, Fan-Fen Wang, Chien-Yeh Hsu, Arpita Das, Jane C.-J. Chao Int. J. Med. Sci. 2025; 22(7): 1630-1639. doi:10.7150/ijms.108760 Full text PDF PubMed PMC


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SIRT6 mitigates doxorubicin-induced cardiomyopathy via amelioration of mitochondrial dysfunction: A mechanistic study implicating the activation of the Nrf-2/FUNDC1 signaling axis Qi Wang, Hongshuo Shi, Haowen Zhuang, Guangtong Dong, Kuo Gao, Leilei Liu, Hao Zhou, Yifeng Nie, Junyan Wang, Li Liu Int. J. Med. Sci. 2025; 22(7): 1640-1657. doi:10.7150/ijms.101520 Full text PDF PubMed PMC


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Large-scale genomic-wide CRISPR screening revealed PRC1 as a tumor essential candidate in clear cell renal cell carcinoma Baochao Li, Yongsheng Pan, Jiajin Wu, Chenkui Miao, Zengjun Wang Int. J. Med. Sci. 2025; 22(7): 1658-1671. doi:10.7150/ijms.107691 Full text PDF PubMed PMC


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Association of lung immune prognostic index with overall survival in pancreatic ductal adenocarcinoma patients treated using chemotherapy Nan Zhang, Guochao Deng, Ru Jia, Quanli Han, Guanghai Dai Int. J. Med. Sci. 2025; 22(7): 1672-1679. doi:10.7150/ijms.102404 Full text PDF PubMed PMC


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Exploring the Shared Diagnostic Genes in IBD and Psoriasis through Bioinformatics and Experimental Assays Lichun Han, Guangfu Lin, Xiaodan Lv, Bing Han, Xiaofang Xu, Yu Li, Shiquan Li, Deyi Chen, Zhixi Huang, Guangli Gu, Xiaoping Lv Int. J. Med. Sci. 2025; 22(7): 1680-1697. doi:10.7150/ijms.107018 Full text PDF PubMed PMC


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Effect of Premature Acute Coronary Syndrome on Ocular Hemodynamics Jia-lin Wang, Lan-ting Wu, Yan-ling Wang Int. J. Med. Sci. 2025; 22(7): 1698-1707. doi:10.7150/ijms.107842 Full text PDF PubMed PMC


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Inhibition of autophagy promotes ultrasound‑targeted microbubble destruction-induced apoptosis of pancreatic cancer cells Nan Chen, Xiaoyu Zhang, Ping Yang, Xuemei He Int. J. Med. Sci. 2025; 22(7): 1708-1719. doi:10.7150/ijms.106509 Full text PDF PubMed PMC


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The Role of Mesenchymal Stem Cells in Treating Diabetic Kidney Disease: Immunomodulatory Effects and Kidney Regeneration Po-Jen Hsiao, Wen-Yi Kao, Li-Chin Sung, Chia-Yi Lin, Liam Li-An Tsou, Yung-Hsi Kao, Chu-Lin Chou, Kung-Ta Lee Int. J. Med. Sci. 2025; 22(7): 1720-1735. doi:10.7150/ijms.103806 Full text PDF PubMed PMC

Review

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Circular RNA in Pancreatic Cancer: Biogenesis, Mechanism, Function and Clinical Application Hang Chen, Xianxing Wang, Shan Liu, Ziwei Tang, Fuming Xie, Jingyang Yin, Pijiang Sun, Huaizhi Wang Int. J. Med. Sci. 2025; 22(7): 1612-1629. doi:10.7150/ijms.107773 Full text PDF PubMed PMC

Erratum

Interaction of RAS Activation and Lipid Disorders Accelerates the Progression of Glomerulosclerosis: Erratum Kun-Ling Ma, Jie Ni, Chang-Xian Wang, Jing Liu, Yang Zhang, Yu Wu, Lin-Li Lv, Xiong-Zhong Ruan, Bi-Cheng Liu Int. J. Med. Sci. 2025; 22(7): 1542-1543. doi:10.7150/ijms.108559 Full text PDF PubMed PMC

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