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Volume 22 (6); 2025

Research Papers

Comparison of Temperature Changes during Implant Osteotomy: Conventional, Single, and Osseodensification Drilling Zeynep Afra Akbiyik Az, Gulsum Ak Int. J. Med. Sci. 2025; 22(6): 1237-1245. doi:10.7150/ijms.105544 Full text PDF PubMed PMC

The Impact of Weekend Catch-up Sleep on Hepatic Steatosis among Adults in the United States Si-Jie Hong, Li-Wei Hong, Xiao-Qin He, Xiao-Hong Zhong, Xue-Qin Zhang Int. J. Med. Sci. 2025; 22(6): 1246-1253. doi:10.7150/ijms.107214 Full text PDF PubMed PMC

Platelet-rich fibrin promotes mesothelial cell proliferation and peritoneal repair by up-regulating calretinin to prevent postoperative intestinal adhesion Xinming Li, Yifan Guo, Zhuoyin Wang, Xu Guo, Jia Wang, Jianlu Zhang, Tao Zhang, Jing Wang, Tianxiong Li, Jian Zhou, Nengwei Zhang, Buhe Amin, Bin Zhu Int. J. Med. Sci. 2025; 22(6): 1254-1268. doi:10.7150/ijms.105523 Full text PDF PubMed PMC

Genetic variants of IGF2BP2 as potential predictors for perineural invasion of prostate cancer in a Taiwanese population Wei-Chun Weng, Yung-Wei Lin, Chung-Howe Lai, Chia-Yen Lin, Yu-Ching Wen, Lun-Ching Chang, Shun-Fa Yang, Ming-Hsien Chien Int. J. Med. Sci. 2025; 22(6): 1269-1277. doi:10.7150/ijms.109770 Full text PDF PubMed PMC

Discovery and confirmation of crucial genes associated with radiation-induced heart disease Chuanbin Liu, Jingqi Shi, Lei Xing, Binwei Yao, Jing Liu, Yiru Wang, Jiao Fan Int. J. Med. Sci. 2025; 22(6): 1278-1291. doi:10.7150/ijms.107667 Full text PDF PubMed PMC

Analysis risk factors of long-term adverse outcomes and a prediction nomogram for coronary artery disease patients underwent fractional flow reserve Fanqi Li, Jiayi Zhu, Jiabao Zhou, Gaoming Zeng, Yong Zhou, Qiuzhen Lin, Zixi Zhang, Siyuan Tan, Qiming Liu Int. J. Med. Sci. 2025; 22(6): 1292-1300. doi:10.7150/ijms.106807 Full text PDF PubMed PMC

NADPH oxidase activator 1 (NOXA1) suppresses ferroptosis and radiosensitization in colorectal cancer Qingyu Jiang, Qianping Chen, Quanquan Sun, Dong Liu, Ji Zhu, Wei Mao Int. J. Med. Sci. 2025; 22(6): 1301-1312. doi:10.7150/ijms.107038 Full text PDF PubMed PMC

Comprehensive Multi-Omics Analysis Identifies FUT1 as a Prognostic and Therapeutic Biomarker Across Pan-Cancer Yunqing Liu, Guanjun Chen, Xiaotian Yuan, Yaxin Chen, YuJie Cui, Ke Cao Int. J. Med. Sci. 2025; 22(6): 1313-1328. doi:10.7150/ijms.108072 Full text PDF PubMed PMC

Molecular network analysis of CPEB4 translational control and targeting CPEB4/β-catenin to modulate invasion and migration of nasopharyngeal carcinoma cells Li Fen, Wei Yuanyuan, Chen Tian, Wang Yingying, Wang Yongping, Zhu Mingwan, Chen Fuhai, Zeng Manli, Tao Zezhang Int. J. Med. Sci. 2025; 22(6): 1329-1343. doi:10.7150/ijms.103024 Full text PDF PubMed PMC

A study on the genetic comorbidity between autoimmune diseases and pulmonary hypertension: an observational study and POST-GWAS analysis Biao Hu, Haoyu Zhong, Raymond Shi, Zeru Chen, Aofeng Liu, Xiang Li, Dansha Zhou, Jiaxuan Lai, Chenting Zhang, Yuqin Chen, Jian Wang Int. J. Med. Sci. 2025; 22(6): 1344-1362. doi:10.7150/ijms.107884 Full text PDF PubMed PMC

LncRNA FTX accelerates the progression of hepatocellular carcinoma by FTX/miR-374a-3p/HMGB1 pathway Min Zhang, Songman Yu, Shang Gao, Haiyan Bu, Lihua Duan, Yan Huang Int. J. Med. Sci. 2025; 22(6): 1363-1374. doi:10.7150/ijms.106867 Full text PDF PubMed PMC

Multi-omics and single-cell analysis reveals machine learning-based pyrimidine metabolism-related signature in the prognosis of patients with lung adenocarcinoma Tong Hu, Run Shi, Yangyue Xu, Tingting Xu, Yuan Fang, Yunru Gu, Zhaokai Zhou, Yongqian Shu Int. J. Med. Sci. 2025; 22(6): 1375-1392. doi:10.7150/ijms.107694 Full text PDF PubMed PMC

A Pilot Study on Predicting Ocular Hypertension in Chinese Patients Undergoing Femtosecond Laser-Assisted Penetrating Keratoplasty Xueqian Cao, Jin Huang, Yang Liu, Yuting Gong, Duoduo Wang, Meihuan Wang, Zhongguo Li, Junxin Ma, Linnong Wang Int. J. Med. Sci. 2025; 22(6): 1393-1403. doi:10.7150/ijms.106586 Full text PDF PubMed PMC

Low-dose Spironolactone Combined with ACEIs/ARBs May Reduce Cardiovascular Events in Patients with CKD Stages 3b-5: A Nationwide Population-Based Cohort Study in Taiwan Li-Nien Chien, Po-Jen Hsiao, Chih-Chien Chiu, Wan-Ting Chen, Chih-Jen Cheng, Leon Li-Ming Tsou, Yung-Hsi Kao, Chu-Lin Chou, Te-Chao Fang Int. J. Med. Sci. 2025; 22(6): 1404-1414. doi:10.7150/ijms.103390 Full text PDF PubMed PMC

Transarterial chemoembolization versus hepatic arterial infusion chemotherapy as first treatment for hepatocellular carcinoma with macrovascular invasion Benyi He, Min Deng, Shaohua Li, Jie Mei, Lianghe Lu, Zhijun Zuo, Rongping Guo, Wei Wei Int. J. Med. Sci. 2025; 22(6): 1415-1424. doi:10.7150/ijms.108144 Full text PDF PubMed PMC

The Value of Texture Analysis of Multi-parameter MRI Images in Distinguishing Benign and Malignant Lesions of O-RADS MRI 4 Lesions Yan Lei, Hanzhou Tang, Lianlian Liu, Tingting Zheng, Yuan Zhang, Tong Chen, Junkang Shen, Bin Song Int. J. Med. Sci. 2025; 22(6): 1425-1436. doi:10.7150/ijms.107452 Full text PDF PubMed PMC

Preoperative integrated oxidative stress score as a prognostic factor for predicting clinical outcomes in breast cancer patients received neoadjuvant chemotherapy: a real-world retrospective study Li Chen, Caixia Dai, Shu Peng, Hao Dong, Xiangyu Wang, Yanfei Liu, Jing Wang Int. J. Med. Sci. 2025; 22(6): 1437-1449. doi:10.7150/ijms.109915 Full text PDF PubMed PMC

Specific immune landscape of heatstroke distinguished from sepsis and aseptic inflammation Juan Wu, Zhenzhen Cheng, Sha Yang, Qinjuan Wu, Ping Yang, Xinyi Liao, Tao Cheng, Wenxia Huang, Yuan Zhu, Zongcheng Tang, Min Yan, Rong Yao, Lei Du Int. J. Med. Sci. 2025; 22(6): 1450-1464. doi:10.7150/ijms.108212 Full text PDF PubMed PMC

Radiofrequency electromagnetic field ınhibits HIF-1 alpha and activates eNOS signaling to prevent intestinal damage in a model of mesenteric artery ischemia in rats Eyyup Sabri Ozden, Mustafa Soner Ozcan, Ilter Ilhan, Muhammet Yusuf Tepebasi, Rumeysa Taner, Dincer Uysal, Halil Asci, Selcuk Comlekci, Ozlem Ozmen Int. J. Med. Sci. 2025; 22(6): 1465-1476. doi:10.7150/ijms.105479 Full text PDF PubMed PMC

Review

VIM model: a novel model to depict the spatial heterogeneity of the radiation microenvironment Yinan Sun, Ying Bi, Xiaohui Wang, Shunfang Liu, Lu Wang Int. J. Med. Sci. 2025; 22(6): 1477-1484. doi:10.7150/ijms.104046 Full text PDF PubMed PMC

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