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Volume 22 (5); 2025

Research Papers

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Information Extraction from Clinical Texts with Generative Pre-trained Transformer Models Min-Soo Kim, Philip Chung, Nima Aghaeepour, Namo Kim Int. J. Med. Sci. 2025; 22(5): 1015-1028. doi:10.7150/ijms.103332 Full text PDF PubMed PMC

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Prognostic Value of Circulating Lymphocyte Subsets in Cervical Cancer Following Postoperative Radiotherapy Shanshan Wang, Mengli Zhao, Zhongrong Gao, Xiaojing Yang, Yuan Lu, Jie Fu Int. J. Med. Sci. 2025; 22(5): 1029-1038. doi:10.7150/ijms.107392 Full text PDF PubMed PMC

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Lung commensal bacteria promote lung cancer progression through NK cell-mediated immunosuppressive microenvironment Haiyang Wang, Jiayi Hu, Yirou Ma, Yilimunuer Abulimiti, Yongxin Zhou Int. J. Med. Sci. 2025; 22(5): 1039-1051. doi:10.7150/ijms.107026 Full text PDF PubMed PMC

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Downregulation of lncRNA MNX1-AS1 promotes the ferroptosis and apoptosis of non-small cell lung cancer Xinming Chi, Lingya Feng, Longzhu Wang, Shijie Yu, Minna Wei, Qianran Zhang, Xuefeng Liu, Shujuan Shao Int. J. Med. Sci. 2025; 22(5): 1052-1063. doi:10.7150/ijms.97790 Full text PDF PubMed PMC

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Routine Clinic Surveillance on Arteriovenous Graft Patency in Hemodialysis Patients with Previous Access Complications Cheng-Chieh Yen, Hung-Pin Tu, Tzu-Chen Lin, Kuan-Ying Li, Szu-Chia Chen Int. J. Med. Sci. 2025; 22(5): 1064-1071. doi:10.7150/ijms.106651 Full text PDF PubMed PMC

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Serum legumain is a potential biomarker for community-acquired pneumonia: a prospective cohort study Xian-Ling Meng, Kai-Shu Ma, Kai-Xin Qu, Zhen-Yu Cheng, Lin Fu, Yi-Qing Qu Int. J. Med. Sci. 2025; 22(5): 1072-1080. doi:10.7150/ijms.106118 Full text PDF PubMed PMC

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A synthetic molecule targeting STAT3 against human oral squamous cell carcinoma cells Li-Yuan Bai, Eman M. E. Dokla, Po-Chen Chu, Chia-Hsien Feng, Jing-Lan Hu, Liang-Jun Wang, Jing-Ru Weng Int. J. Med. Sci. 2025; 22(5): 1081-1091. doi:10.7150/ijms.105200 Full text PDF PubMed PMC

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Exploring the Plasma Proteome: Identifying Hub Proteins linking Aging, Homeostasis, and Organ Function Juan Jiao, Fei Gao, Hongye Zhao, Mingjun Jiang, Yan Zhou, Dizhi Liu, Sihang Fang, Danni Gao, Zhaoping Wang, Ze Yang, Huiping Yuan Int. J. Med. Sci. 2025; 22(5): 1109-1123. doi:10.7150/ijms.107750 Full text PDF PubMed PMC

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Ceramide Complex Ameliorates Metabolically Driven Neutrophil Senescence by Regulating Apoptosis via the cGAS-STING Pathway Xi Gao, Cheng Lu, Kaixuan Wang, Chunfang Zheng, Linbin Li, Xin Zhang, Bingwei Sun Int. J. Med. Sci. 2025; 22(5): 1124-1137. doi:10.7150/ijms.104801 Full text PDF PubMed PMC

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Galactose-Induced Cataracts in Rats: A Machine Learning Analysis Ahmed Jasim Mahmood Al-Mashhadani, Qi Gong, Franko Shehaj, Lianhong Zhou Int. J. Med. Sci. 2025; 22(5): 1138-1149. doi:10.7150/ijms.103892 Full text PDF PubMed PMC

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Therapeutic Drug Monitoring for Lacosamide in Chinese Pediatric Patients with Epilepsy: Focus on Clinical Effectiveness, Tolerability and Drug Interactions Fengqian Mao, Shunan Chen, Yani Hu, Suhong Wang, Meng Chen, Junjun Xu, Mingdong Yang, Jie Chen, Xiuping Zhu, Wei Hu, Feng Li, Lingyan Yu, Haibin Dai Int. J. Med. Sci. 2025; 22(5): 1150-1157. doi:10.7150/ijms.107660 Full text PDF PubMed PMC

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Novel Insights into PGM2L1 as a Prognostic Biomarker in Cholangiocarcinoma: Implications for Metabolic Reprogramming and Tumor Microenvironment Modulation Guo-Wei Wu, Yi-Hsien Hsieh, Yi-Chung Chien, Li-Yuan Bai, Yung-Luen Yu Int. J. Med. Sci. 2025; 22(5): 1158-1166. doi:10.7150/ijms.106566 Full text PDF PubMed PMC

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Comparative Efficacy of Silicone Sheets and Hyperbaric Oxygen Therapy in Post-Surgical Scar Prevention: A Prospective Observational Study Po-Chung Chen, Tzung-Cheng Liao, Chang-Yi Chou, Chi-Ming Chu, Po-Jen Hsiao, Hsieh-Chih Tsai Int. J. Med. Sci. 2025; 22(5): 1167-1175. doi:10.7150/ijms.108397 Full text PDF PubMed PMC

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The association between aortic stenosis and the risk of consecutive eyelid inflammatory diseases Shu-Ling Peng, Tung-Lin Tsui, Ke-Hsin Ting, Yasser Nassef, Chia-Yi Lee, Jing-Yang Huang, Chao-Bin Yeh, Chia-Jui Weng, Shun-Fa Yang Int. J. Med. Sci. 2025; 22(5): 1176-1183. doi:10.7150/ijms.108261 Full text PDF PubMed PMC

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Association between composite dietary antioxidant index and rheumatoid arthritis: results from NHANES 2003-2018 Qi Meng, Shankun Dong, Jianxun Ge, Chuanhong Qin, Guojiang Zhang, Chuanyun Fu, Shui Sun Int. J. Med. Sci. 2025; 22(5): 1184-1193. doi:10.7150/ijms.107332 Full text PDF PubMed PMC

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Nutraceutical Evaluation of Trigonelline's Therapeutic Potential by Targeting Bladder Cancer Stem Cells and Cancer-Associated Fibroblasts via Downregulation of TGFβ3/GLI2/YAP1 Signaling Hub Chien-Chang Kao, Jing-Wen Shih, Huong Thi Luu Kim Huynh, Ching-Hsin Chang, Bashir Lawal, Sitthichai Iamsaard, Nur Azizah, Ritmaleni Ritmaleni, Justin Kung-Yi Lin, Po-Yang Huang, Alexander T.H. Wu, Ming-Che Liu Int. J. Med. Sci. 2025; 22(5): 1194-1207. doi:10.7150/ijms.107228 Full text PDF PubMed PMC

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Genetic associations of Neat1 polymorphisms with clinicopathologic characteristics of tongue cancer Kwei-Jing Chen, Chun-Yi Chuang, Ming-Yu Lien, Chun-Wen Su, Michael Yuan-Chien Chen, Hsiao-Chi Tsai, Shun-Fa Yang, Chih-Hsin Tang Int. J. Med. Sci. 2025; 22(5): 1208-1214. doi:10.7150/ijms.103842 Full text PDF PubMed PMC

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Exosomes derived from TNF-α preconditioned bone marrow mesenchymal stem cells alleviate cisplatin-induced ototoxicity in mice Wei Li, Tao Yang, Zhiwen Zhang, Anquan Peng, Qin Wang Int. J. Med. Sci. 2025; 22(5): 1215-1222. doi:10.7150/ijms.104121 Full text PDF PubMed PMC

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CD36 knockdown attenuates pressure overload-induced cardiac injury by preventing lipotoxicity and improving myocardial energy metabolism Jing Geng, Xiaoliang Zhang, Ying Wang, Dong Guo, Panpan Liu, Siying Pu, Xue Yang, Qi Liang, Pan Chang, Tao Li, Lang Hu, Yanjie Guo Int. J. Med. Sci. 2025; 22(5): 1223-1236. doi:10.7150/ijms.107224 Full text PDF PubMed PMC

Review

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Research Progress on Contrast-Enhanced Ultrasound (CEUS) Assisted Diagnosis and Treatment in Liver-Related Diseases Xiaoqing Ying, Shangxin Dong, Yuanyuan Zhao, Zhishui Chen, Jipin Jiang, Huibo Shi Int. J. Med. Sci. 2025; 22(5): 1092-1108. doi:10.7150/ijms.101789 Full text PDF PubMed PMC

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