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Volume 22 (4); 2025

Research Papers

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Long sleep duration and good sleep quality reduced incident peptic ulcer disease in a large Taiwanese population follow-up study Yi-Hsiang Huang, Hsin-Yi Huang, Jia-In Lee, Ting-Yi Wu, Shu-Pin Huang, Jiun-Hung Geng, Chao-Hung Kuo, Szu-Chia Chen Int. J. Med. Sci. 2025; 22(4): 754-763. doi:10.7150/ijms.103639 Full text PDF PubMed PMC

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Metabolic dysfunction-associated fatty liver disease as a mediator of urolithiasis risk: evidence from cross-sectional and genetic studies Lin-Tao Miao, Wen-Jie Wang, Jin-Zhou Xu, Ming-Liang Zhong, Yuan Gong, Cong Li, Yang Xun, Shao-Gang Wang Int. J. Med. Sci. 2025; 22(4): 764-774. doi:10.7150/ijms.106824 Full text PDF PubMed PMC

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Intramuscular Injection of rAAV2-retro for Low Motor Neuron Transduction: Evaluating Five Promoters Xueqi Gong, Haitong Gao, Wenyuan Wang, Tonghui Xu Int. J. Med. Sci. 2025; 22(4): 775-789. doi:10.7150/ijms.101807 Full text PDF PubMed PMC

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Potential Biomarkers and Therapeutic Targets in Hepatitis B Virus-related Acute Liver Failure: Interplay of the Ferroptosis, Autophagy and Immune Responses Jing Zuo, Yu-Xin Tian, Qi An, Bai-Yun Wu, Jie-Ru Yang, Yu-Chen Fan Int. J. Med. Sci. 2025; 22(4): 806-818. doi:10.7150/ijms.106360 Full text PDF PubMed PMC

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Predictivity of Hepatic Steatosis Index for Gestational Hypertension and Preeclampsia: a Prospective Cohort Study Lin Zhang, Shen Gao, Yingyi Luan, Shaofei Su, Enjie Zhang, Jianhui Liu, Shuanghua Xie, Yue Zhang, Wentao Yue, Ruixia Liu, Chenghong Yin Int. J. Med. Sci. 2025; 22(4): 834-844. doi:10.7150/ijms.104943 Full text PDF PubMed PMC

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Identifying Water-Salt Homeostasis and Inflammatory Response in Pathological Cardiac Surgery-Associated Acute Kidney Injury: NT-proBNP-related lncRNAs and miRNAs as Novel Diagnostic Biomarkers and Therapeutic Targets Bianfang Li, Jianhui Wang, Yuchen Gao, Xiaojing Wu, Chunrong Wang, Jin Wang, Jia Liu, Yuefu Wang Int. J. Med. Sci. 2025; 22(4): 845-855. doi:10.7150/ijms.107589 Full text PDF PubMed PMC

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Extracts of Portulaca oleracea and Patrinia scabiosaefolia relieve ultraviolet B-induced skin injury in solar dermatitis mice via inhibiting IL-17/CCL2 pathway and oxidative stress Bowei Li, Jingyuan Yang, Zhixing Wang, Mingzhu He, Xujing Chen, Yixuan Chen, Baoying Shen, Junru Chen, Chunqi Yang, Tian Li, Chengcai Lai, Yue Gao, Hong Cai Int. J. Med. Sci. 2025; 22(4): 856-872. doi:10.7150/ijms.106289 Full text PDF PubMed PMC

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Establishment of a nomogram model based on immune-related genes using machine learning for aortic dissection diagnosis and immunomodulation assessment Yanjun Hou, Yangyang Zhao, Zhensu Shi, Yipeng Pan, Kaijia Shi, Chaoyang Zhao, Shengnan Liu, Yongkun Chen, Lini Zhao, Jizhen Wu, Guangquan Ge, Wei Jie Int. J. Med. Sci. 2025; 22(4): 873-886. doi:10.7150/ijms.100572 Full text PDF PubMed PMC

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Accuracy of Sonographic Renal Pelvic Diameter in Assessment of Renal Function among Patients with Ureteropelvic Junction Obstruction using Scintigraphy as a Gold Standard Mahasin G. Hassan, Tasneem S.A. Elmahdi, Moudi Alotaibi, Enas Fallatah, Faten A. Nasser Int. J. Med. Sci. 2025; 22(4): 897-902. doi:10.7150/ijms.100216 Full text PDF PubMed PMC

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Deficiency of Caveolin-1 Aggravates Cardiac Infarction Injury by Disturbing the Endothelial Homeostasis Chunlei Liu, Junwei Zhang, Bing Qi, Zhuqing Li, Qi Li, Li Wang, Chao Li, Ziwei Wang, Zhi Qi, Chengzhi Lu Int. J. Med. Sci. 2025; 22(4): 920-932. doi:10.7150/ijms.101074 Full text PDF PubMed PMC

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Pretreatment FDG PET in prognosis of locoregionally advanced nasopharyngeal carcinoma treated with intensity-modulated radiation therapy Xiaoshuang Niu, Fen Xue, Dan Ou, Yuming Zheng, Chaosu Hu, Chunying Shen, Xiayun He Int. J. Med. Sci. 2025; 22(4): 933-939. doi:10.7150/ijms.105995 Full text PDF PubMed PMC

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NCAPH Promotes the Proliferation of Prostate Cancer Cells Via Modulating the E2F1 Mediated PI3K/AKT/mTOR Axis Qing Shi, Jinpeng Ma, Xiang Pan, Te Liu, Kailai Chen, Meiqi Xu, Zhichong Wu, Bin Sun, Manjie Zhang, Yakun Luo Int. J. Med. Sci. 2025; 22(4): 940-954. doi:10.7150/ijms.103444 Full text PDF PubMed PMC

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S1R mediates NRF2 dependent ferroptosis of renal tubular epithelial cells to promote renal fibrosis in diabetic nephropathy Cheng Yuan, Fengpei Chang, Qiuyuan Zhou, Feng Chen, Xueyun Gao, Ayinigaer Yusufu, Jinhu Chen, Zejin Liao, Xiaoyan Wu, Lihua Ni Int. J. Med. Sci. 2025; 22(4): 955-970. doi:10.7150/ijms.104324 Full text PDF PubMed PMC

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Kidney Injury under Diminished Pulsatile Flow Induced by V-A ECMO in Sheep Weidong Yan, Tianlong Wang, Jiachen Qi, Luyu Bian, Shengqiang Pei, Qiaoni Zhang, Sizhe Gao, Shujie Yan, Gang Liu, Yuan Teng, Jian Wang, Chun Zhou, Qian Wang, Jing Wang, Bingyang Ji Int. J. Med. Sci. 2025; 22(4): 971-981. doi:10.7150/ijms.103349 Full text PDF PubMed PMC

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Effects of 100 IU versus 150 IU hCG supplementation on oocyte and embryo quality in patients aged ≥ 35 years: a propensity score-matched analysis Nguyen Thi Lien Huong, Tran Thu Thuy, Phi Thi Tu Anh, Hoang Bao Long, Le Duc Thang, Vu Thi Ngoc, Le Quang Do, Nguyen Xuan Anh Duy, Bui Thi Hanh, Do Van Loi, Le Hoang Int. J. Med. Sci. 2025; 22(4): 982-989. doi:10.7150/ijms.106965 Full text PDF PubMed PMC

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LRP5 enhances glioma cell proliferation by modulating the MAPK/p53/cdc2 pathway Ying-Yi Feng, Xin Jin, Min-Xuan Pan, Jia-Min Liao, Xian-Zhang Huang, Chun-Min Kang Int. J. Med. Sci. 2025; 22(4): 990-1001. doi:10.7150/ijms.99920 Full text PDF PubMed PMC

Reviews

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The Role of HK2 in Tumorigenesis and Development: Potential for Targeted Therapy with Natural Products Keren He, Fangfang Tao, Yangyuxiao Lu, Mengqi Fang, Hong Huang, Yuan Zhou Int. J. Med. Sci. 2025; 22(4): 790-805. doi:10.7150/ijms.105553 Full text PDF PubMed PMC

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Exploring the Potential of Moringa oleifera in Managing Bone Loss: Insights from Preclinical Studies Haryati Ahmad Hairi, Rusdiah Ruzanna Jusoh, Muhammad Zulfiqah Sadikan, Wan Nuraini Wan Hasan, Ahmad Nazrun Shuid Int. J. Med. Sci. 2025; 22(4): 819-833. doi:10.7150/ijms.103241 Full text PDF PubMed PMC

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Clusterin: structure, function and roles in disease Xing Du, Zhongyao Chen, Wei Shui Int. J. Med. Sci. 2025; 22(4): 887-896. doi:10.7150/ijms.107159 Full text PDF PubMed PMC

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Understanding Genetic Screening: Harnessing Health Information to Prevent Disease Risks Chung-Lin Lee, Chih-Kuang Chuang, Huei-Ching Chiu, Ya-Hui Chang, Yuan-Rong Tu, Yun-Ting Lo, Hsiang-Yu Lin, Shuan-Pei Lin Int. J. Med. Sci. 2025; 22(4): 903-919. doi:10.7150/ijms.101219 Full text PDF PubMed PMC

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Aberrant DNA Methylation in Esophageal Squamous Cell Carcinoma and its Clinical Implications in Systemic Chemotherapy Zhao Li, Xi Chen, Yongkang Li, Yan Xu, Yang Zhou Int. J. Med. Sci. 2025; 22(4): 1002-1014. doi:10.7150/ijms.109161 Full text PDF PubMed PMC

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