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Volume 18 (12); 2021

Research Papers

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Immune checkpoint molecules are regulated by transforming growth factor (TGF)-β1-induced epithelial-to-mesenchymal transition in hepatocellular carcinoma
Ritu Shrestha, Kim R. Bridle, Darrell H. G. Crawford, Aparna Jayachandran
Int. J. Med. Sci. 2021; 18(12): 2466-2479. doi:10.7150/ijms.54239
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Inhibition of Lipopolysaccharide-Induced Inflammatory and Oxidative Responses by Trans-cinnamaldehyde in C2C12 Myoblasts
Cheol Park, Hyesook Lee, Suhyun Hong, Ilandarage Menu Neelaka Molagoda, Jin-Woo Jeong, Cheng-Yun Jin, Gi-Young Kim, Sung Hyun Choi, Sang Hoon Hong, Yung Hyun Choi
Int. J. Med. Sci. 2021; 18(12): 2480-2492. doi:10.7150/ijms.59169
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Imaging and anatomical parameters of the lacrimal punctum and vertical canaliculus using optical coherence tomography
Jun Hu, Nan Xiang, Gui gang Li, Ban Luo, Yuan Zhang, Yingting Zhu, Rong Liu
Int. J. Med. Sci. 2021; 18(12): 2493-2499. doi:10.7150/ijms.58291
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Combined B-type Natriuretic Peptide as strong predictor of short-term mortality in patients after Liver Transplantation
Hyun Sik Chung, AMi Woo, Min Suk Chae, Sang Hyun Hong, Chul Soo Park, Jong Ho Choi, Yun Sung Jo
Int. J. Med. Sci. 2021; 18(12): 2500-2509. doi:10.7150/ijms.54202
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Promoter Methylation-mediated Silencing of the MiR-192-5p Promotes Endometrial Cancer Progression by Targeting ALX1
Jianjiao Ni, Wenjuan Tian, Shanhui Liang, Huaying Wang, Yulan Ren
Int. J. Med. Sci. 2021; 18(12): 2510-2520. doi:10.7150/ijms.58954
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Identified the novel resistant biomarkers for taxane-based therapy for triple-negative breast cancer
Ching-Wen Chou, Yu-Min Huang, Yu-Jia Chang, Chien-Yu Huang, Chin-Sheng Hung
Int. J. Med. Sci. 2021; 18(12): 2521-2531. doi:10.7150/ijms.59177
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Somatic Mutation Profiling of Papillary Thyroid Carcinomas by Whole-exome Sequencing and Its Relationship with Clinical Characteristics
Tingyue Qi, Xin Rong, Qingling Feng, Hongguang Sun, Haiyan Cao, Yan Yang, Hao Feng, Linhai Zhu, Lei Wang, Qiu Du
Int. J. Med. Sci. 2021; 18(12): 2532-2544. doi:10.7150/ijms.50916
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Repositive RT-PCR test in discharged COVID-19 patients during medical isolation observation
Kun Huang, Wen Liu, Jinxia Zhou, Yao Wang, Yuxiang Zhang, Xinle Tang, Jing Liang, Fang-Fang Bi
Int. J. Med. Sci. 2021; 18(12): 2545-2550. doi:10.7150/ijms.58766
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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γ-secretase inhibitors, DAPT and RO4929097, promote the migration of Human Glioma Cells via Smad5-downregulated E-cadherin Expression
Shun-Fu Chang, Wei-Hsun Yang, Chun-Yu Cheng, Sheng-Jie Luo, Ting-Chung Wang
Int. J. Med. Sci. 2021; 18(12): 2551-2560. doi:10.7150/ijms.50484
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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SARS-CoV-2 infection activates a subset of intrinsic pathways to inhibit type I interferons in vitro and in vivo
Weisheng Luo, Lianzhou Huang, Xiaohui Wang, Yuying Ma, Ji Xiao, Xiaowei Song, Ping Liu, Yifei Wang, Yiliang Wang, Zhe Ren
Int. J. Med. Sci. 2021; 18(12): 2561-2569. doi:10.7150/ijms.56630
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Feature and impact of guideline-directed medication prescriptions for heart failure with reduced ejection fraction accompanied by chronic kidney disease
Yung-Lung Chen, Chi-Ling Hang, Chien-Hao Su, Po-Jui Wu, Huang-Chung Chen, Hsiu-Yu Fang, Yen-Nan Fang, Cheng-I Cheng, Morgan Fu, Shyh-Ming Chen
Int. J. Med. Sci. 2021; 18(12): 2570-2580. doi:10.7150/ijms.55119
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A clinical study on plasma biomarkers for deciding the use of adjuvant corticosteroid therapy in bronchopulmonary dysplasia of premature infants
Haiyan Zhu, Yian Tian, Huaiping Cheng, Yafei Zheng, Wei Wang, Tianping Bao, Rong Wu, Zhaofang Tian
Int. J. Med. Sci. 2021; 18(12): 2581-2588. doi:10.7150/ijms.58650
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The influence of positive end-expiratory pressure (PEEP) in predicting fluid responsiveness in patients undergoing one-lung ventilation
In-Jung Jun, Mi Hwa Chung, Jung Eun Kim, Hye Sun Lee, Jung Mo Son, Eun Mi Choi
Int. J. Med. Sci. 2021; 18(12): 2589-2598. doi:10.7150/ijms.59653
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Urate-lowering Therapy and Chronic Kidney Disease Development in Patients with Gout
Fu-Shun Yen, James Cheng-Chung Wei, Chia-Ling Chang, Chen-Chang Yang, Chih-Cheng Hsu, Chii-Min Hwu
Int. J. Med. Sci. 2021; 18(12): 2599-2606. doi:10.7150/ijms.59698
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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L-3-n-butylphthalide promotes restoration after an experimental animal model of intracerebral hemorrhage
Zhendong Pi, Jianyang Liu, Han Xiao, Zhiping Hu
Int. J. Med. Sci. 2021; 18(12): 2607-2614. doi:10.7150/ijms.60342
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The feasibility of emergency medical technicians performing intermittent high-quality cardiopulmonary resuscitation
Chun-Hao Chang, Yi-Ju Hsu, Fang Li, Yuan-Shuo Chan, Ching-Ping Lo, Guan-Jian Peng, Chin-Shan Ho, Chi-Chang Huang
Int. J. Med. Sci. 2021; 18(12): 2615-2623. doi:10.7150/ijms.59757
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Analysis of multiple organ damage and clinical immunological characteristics in systemic lupus erythematosus patients with hematologic involvement
Liming Tan, Yonglei Zhao
Int. J. Med. Sci. 2021; 18(12): 2624-2629. doi:10.7150/ijms.48997
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Association between Coronary Artery Spasm and the risk of incident Diabetes: A Nationwide population-based Cohort Study
Ming-Jui Hung, Nen-Chung Chang, Patrick Hu, Tien-Hsing Chen, Chun-Tai Mao, Chi-Tai Yeh, Ming-Yow Hung
Int. J. Med. Sci. 2021; 18(12): 2630-2640. doi:10.7150/ijms.57987
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Evaluation of the Efficacy of Supplementation with Planox® Lemon Verbena Extract in Improving Oxidative Stress and Muscle Damage: A Double-Blind Controlled Trial
Mon-Chien Lee, Yi-Ju Hsu, Chin-Shan Ho, Chun-Hao Chang, Ching-Wen Liu, Chi-Chang Huang, Wen-Dee Chiang
Int. J. Med. Sci. 2021; 18(12): 2641-2652. doi:10.7150/ijms.60726
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Predictability of Macrosomic Birth based on Maternal Factors and Fetal Aneuploidy Screening Biochemical Markers in Hyperglycemic Mothers
Junguk Hur, Jinho Yoo, Dayeon Shin, Kwang-Hyun Baek, Sunwha Park, Kyung Ju Lee
Int. J. Med. Sci. 2021; 18(12): 2653-2660. doi:10.7150/ijms.49857
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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β3-integrin Leu33Pro gain of function variant does not modulate inflammatory activity in human derived macrophages in diabetes
Philipp Helmer, Ellen Damm, Stephan Schiekofer, Kirsten Roomp, Jochen G. Schneider
Int. J. Med. Sci. 2021; 18(12): 2661-2665. doi:10.7150/ijms.55648
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Effect of exopolysaccharides from cariogenic bacteria on human gingival fibroblasts
Anna K. Szkaradkiewicz-Karpińska, Andrzej Szkaradkiewicz
Int. J. Med. Sci. 2021; 18(12): 2666-2672. doi:10.7150/ijms.57221
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Elevated plasma level of neutrophil gelatinase-associated lipocalin (NGAL) in patients with breast cancer
Ching-Ting Wei, I-Ting Tsai, Cheng-Ching Wu, Wei-Chin Hung, Chin-Feng Hsuan, Teng-Hung Yu, Chia-Chang Hsu, Jer-Yiing Houng, Fu-Mei Chung, Yau-Jiunn Lee, Yung-Chuan Lu
Int. J. Med. Sci. 2021; 18(12): 2689-2696. doi:10.7150/ijms.58789
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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The early surgical period in robotic radical hysterectomy is related to the recurrence after surgery in stage IB cervical cancer
Jiheum Paek, Peter C. Lim
Int. J. Med. Sci. 2021; 18(12): 2697-2704. doi:10.7150/ijms.59267
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Dihydroartemisinin inhibits activation of the AIM2 inflammasome pathway and NF-κB/HIF-1α/VEGF pathway by inducing autophagy in A431 human cutaneous squamous cell carcinoma cells
Yajie Wang, Zhijia Li, Muzhou Teng, Junlin Liu
Int. J. Med. Sci. 2021; 18(12): 2705-2715. doi:10.7150/ijms.57167
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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A novel Danshensu/tetramethylpyrazine protects against Myocardial Ischemia Reperfusion Injury in rats
Jinghao Wang, Kai Fan, Cong He, Qingyang Wang, Qianhui Zhang, Wei Huang
Int. J. Med. Sci. 2021; 18(12): 2716-2724. doi:10.7150/ijms.59411
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Patient external dose rate after 177Lu-DOTATATE therapy: factors affecting its decrease and predictive value
Jules Zhang-Yin, Nadine Guilabert, Thierry Kiffel, Françoise Montravers, Phillip Calais, Jean Lumbroso, Jean-Noël Talbot
Int. J. Med. Sci. 2021; 18(12): 2725-2735. doi:10.7150/ijms.58680
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Adjuvant administration of hypertonic saline in lumbar epidural intervention may be associated with successful response in patients with probable neuropathic radicular pain Screened by Douleur Neuropathique 4
Yongsoo Lee, Sunmin Kim, Jin-Woo Shin, Jeong-Gil Leem, Seong-Soo Choi
Int. J. Med. Sci. 2021; 18(12): 2736-2742. doi:10.7150/ijms.59695
[Abstract] [Full text] [PDF] [PubMed] [PMC]


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Cytokine TGF-β1, TNF-α, IFN-γ and IL‐6 Gene Polymorphisms and Localization of Premalignant Gastric Lesions in Immunohistochemically H. pylori-negative Patients
Anca Negovan, Mihaela Iancu, Florin Tripon, Andrei Crauciuc, Simona Mocan, Claudia Bănescu
Int. J. Med. Sci. 2021; 18(12): 2743-2751. doi:10.7150/ijms.60517
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review

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Repurposing New Use for Old Drug Chloroquine against Metabolic Syndrome: A Review on Animal and Human Evidence
Sok Kuan Wong
Int. J. Med. Sci. 2021; 18(12): 2673-2688. doi:10.7150/ijms.58147
[Abstract] [Full text] [PDF] [PubMed] [PMC]