International Journal of Medical Sciences
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30 November 2015

ISSN 1449-1907 News feeds of published articles

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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Short Research Communication
Chronic Alcohol Consumption Leads to a Tissue Specific Expression of Uncoupling Protein-2
Jan A. Graw, Clarissa von Haefen, Deniz Poyraz, Nadine Möbius, Marco Sifringer, Claudia D. Spies
Int. J. Med. Sci. 2015; 12(12): 995-999. doi:10.7150/ijms.13193
[Abstract] [Full text] [PDF]

Research Paper
Extract of Ginkgo Biloba Ameliorates Streptozotocin-Induced Type 1 Diabetes Mellitus and High-Fat Diet-Induced Type 2 Diabetes Mellitus in Mice
Ki-Jong Rhee, Chang Gun Lee, Sung Woo Kim, Dong-Hyeon Gim, Hyun-Cheol Kim, Bae Dong Jung
Int. J. Med. Sci. 2015; 12(12): 987-994. doi:10.7150/ijms.13339
[Abstract] [Full text] [PDF]

Research Paper
No Resistance to Penicillin, Cefuroxime, Cefotaxime, or Vancomycin in Pneumococcal Pneumonia
Josef Yayan, Beniam Ghebremedhin, Kurt Rasche
Int. J. Med. Sci. 2015; 12(12): 980-986. doi:10.7150/ijms.13203
[Abstract] [Full text] [PDF]

Research Paper
The Influence of C3435T Polymorphism of the ABCB1 Gene on Genetic Susceptibility to Depression and Treatment Response in Polish Population - Preliminary Report
Agnieszka Maria Jeleń, Aleksandra Sałagacka, Marta Karolina Żebrowska, Marek Mirowski, Monika Talarowska, Piotr Gałecki, Ewa Izabela Balcerczak
Int. J. Med. Sci. 2015; 12(12): 974-979. doi:10.7150/ijms.13119
[Abstract] [Full text] [PDF]

Research Paper
QT interval Independently Predicts Mortality and Heart Failure in Patients with ST-Elevation Myocardial Infarction
Jeng-Feng Lin, Shun-Yi Hsu, Semon Wu, Ming-Sheng Teng, Hsin-Hua Chou, Shih-Tsung Cheng, Tien-Yu Wu, Yu-Lin Ko
Int. J. Med. Sci. 2015; 12(12): 968-973. doi:10.7150/ijms.13121
[Abstract] [Full text] [PDF]

Research Paper
Lipid Emulsion Inhibits Vasodilation Induced by a Toxic Dose of Bupivacaine via Attenuated Dephosphorylation of Myosin Phosphatase Target Subunit 1 in Isolated Rat Aorta
Seong-Ho Ok, Hyo-Jin Byon, Seong-Chun Kwon, Jungchul Park, Youngju Lee, Yeran Hwang, Jiseok Baik, Mun-Jeoung Choi, Ju-Tae Sohn
Int. J. Med. Sci. 2015; 12(12): 958-967. doi:10.7150/ijms.13299
[Abstract] [Full text] [PDF]

Research Paper
Effects of Active Mastication on Chronic Stress-Induced Bone Loss in Mice
Kagaku Azuma, Manabu Furuzawa, Shu Fujiwara, Kumiko Yamada, Kin-ya Kubo
Int. J. Med. Sci. 2015; 12(12): 952-957. doi:10.7150/ijms.13298
[Abstract] [Full text] [PDF]

Research Paper
Visceral Fat Area Determined Using Bioimpedance Analysis Is Associated with Hearing Loss
Seok Hui Kang, Da Jung Jung, Eun Woo Choi, Jong Won Park, Kyu Hyang Cho, Kyu Yup Lee, Jun Young Do
Int. J. Med. Sci. 2015; 12(12): 946-951. doi:10.7150/ijms.13184
[Abstract] [Full text] [PDF]

Research Paper
Collagen Triple Helix Repeat Containing-1 (CTHRC1) Expression in Oral Squamous Cell Carcinoma (OSCC): Prognostic Value and Clinico-Pathological Implications
Chia Ee Lee, Vui King Vincent-Chong, Anand Ramanathan, Thomas George Kallarakkal, Lee Peng Karen-Ng, Wan Maria Nabillah Ghani, Zainal Ariff Abdul Rahman, Siti Mazlipah Ismail, Mannil Thomas Abraham, Keng Kiong Tay, Wan Mahadzir Wan Mustafa, Sok Ching Cheong, Rosnah Binti Zain
Int. J. Med. Sci. 2015; 12(12): 937-945. doi:10.7150/ijms.11605
[Abstract] [Full text] [PDF]

Neurological Effects of Bisphenol A and its Analogues
Hidekuni Inadera
Int. J. Med. Sci. 2015; 12(12): 926-936. doi:10.7150/ijms.13267
[Abstract] [Full text] [PDF]

Research Paper
Bisphenol A, Dichlorodiphenyltrichloroethane (DDT) and Vinclozolin Affect ex-vivo Uterine Contraction in Rats via Uterotonin (Prostaglandin F2α, Acetylcholine and Oxytocin) Related Pathways
Naguib Salleh, Nelli Giribabu, Angeline Oh Mei Feng, Kyaimon Myint
Int. J. Med. Sci. 2015; 12(11): 914-925. doi:10.7150/ijms.11957
[Abstract] [Full text] [PDF]

Research Paper
Tension Force Downregulates Matrix Metalloproteinase Expression and Upregulates the Expression of Their Inhibitors through MAPK Signaling Pathways in MC3T3-E1 cells
Yoko Karasawa, Hideki Tanaka, Kumiko Nakai, Natsuko Tanabe, Takayuki Kawato, Masao Maeno, Noriyoshi Shimizu
Int. J. Med. Sci. 2015; 12(11): 905-913. doi:10.7150/ijms.13263
[Abstract] [Full text] [PDF]

Research Paper
Fimasartan, a Novel Angiotensin-Receptor Blocker, Protects against Renal Inflammation and Fibrosis in Mice with Unilateral Ureteral Obstruction: the Possible Role of Nrf2
Soojeong Kim, Sung Jun Kim, Hye Eun Yoon, Sungjin Chung, Bum Soon Choi, Cheol Whee Park, Seok Joon Shin
Int. J. Med. Sci. 2015; 12(11): 891-904. doi:10.7150/ijms.13187
[Abstract] [Full text] [PDF]

Research Paper
FOXO1 Is Involved in the Effects of Cigarette Smoke Extract on Osteoblastic Differentiation of Cultured Human Periosteum-derived Cells
Iel-Yong Sung, Bong-Chan Park, Young-Sool Hah, Hee-Young Cho, Jeong-Won Yun, Bong-Wook Park, Young-Hoon Kang, Ho-Cheol Kim, Sun-Chul Hwang, Gyu-Jin Rho, Uk-Kyu Kim, Dong Kyun Woo, Se-Heang Oh, June-Ho Byun
Int. J. Med. Sci. 2015; 12(11): 881-890. doi:10.7150/ijms.13172
[Abstract] [Full text] [PDF]

Research Paper
Association study of polymorphisms in miRNAs with T2DM in Chinese population
Yiping Li, Yu Zhang, Xianli Li, Li Shi, Wenyu Tao, Lei Shi, Man Yang, Xiaoling Wang, Ying Yang, Yufeng Yao
Int. J. Med. Sci. 2015; 12(11): 875-880. doi:10.7150/ijms.12954
[Abstract] [Full text] [PDF]

Research Paper
Effects of Notch2 and Notch3 on Cell Proliferation and Apoptosis of Trophoblast Cell Lines
Wei-Xiu Zhao, Xu Zhuang, Tao-Tao Huang, Ran Feng, Jian-Hua Lin
Int. J. Med. Sci. 2015; 12(11): 867-874. doi:10.7150/ijms.12935
[Abstract] [Full text] [PDF]

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