International Journal of Medical Sciences

Impact factor

22 April 2018

ISSN 1449-1907 News feeds of published articles

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  • This Journal is ranked very well according to SCImago in the area of Medicine ...details

Impact factor is 2.399 according to 2017 release of Journal Citation ReportsĀ®.

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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Research Paper
Inhibition of CRL-NEDD8 pathway as a new approach to enhance ATRA-induced differentiation of acute promyelocytic leukemia cells
Shuyuan Liu, Jinhua Wan, Yunyuan Kong, Yonglu Zhang, Lagen Wan, Zhanglin Zhang
Int. J. Med. Sci. 2018; 15(7): 674-681. doi:10.7150/ijms.23782
[Abstract] [Full text] [PDF]

Research Paper
ICOS signal facilitates Foxp3 transcription to favor suppressive function of regulatory T cells
Qianmei Chen, Lijun Mo, Xiangsheng Cai, Lili Wei, Zhengneng Xie, Hongwei Li, Jinlong Li, Zhiming Hu
Int. J. Med. Sci. 2018; 15(7): 666-673. doi:10.7150/ijms.23940
[Abstract] [Full text] [PDF]

New Trends in the Therapeutic Approach to Metastatic Colorectal Cancer
Julia Sánchez-Gundín, Ana María Fernández-Carballido, Lidia Martínez-Valdivieso, Dolores Barreda-Hernández, Ana Isabel Torres-Suárez
Int. J. Med. Sci. 2018; 15(7): 659-665. doi:10.7150/ijms.24453
[Abstract] [Full text] [PDF]

Research Paper
Impact of matrix metalloproteinase-11 gene polymorphisms upon the development and progression of hepatocellular carcinoma
Bin Wang, Chin-Jung Hsu, Hsiang-Lin Lee, Chia-Hsuan Chou, Chen-Ming Su, Shun-Fa Yang, Chih-Hsin Tang
Int. J. Med. Sci. 2018; 15(6): 653-658. doi:10.7150/ijms.23733
[Abstract] [Full text] [PDF]

Research Paper
Verteporfin inhibits YAP-induced bladder cancer cell growth and invasion via Hippo signaling pathway
Liang Dong, Fan Lin, Wanjun Wu, Yuchen Liu, Weiren Huang
Int. J. Med. Sci. 2018; 15(6): 645-652. doi:10.7150/ijms.23460
[Abstract] [Full text] [PDF]

Research Paper
AMACR overexpression acts as a negative prognostic factor in oral squamous cell carcinoma
Hong-Lin He, Ying-En Lee, Min-Te Chang, Yow-Ling Shiue, Shih-Lun Chang, Tzu-Ju Chen, Chang-Ta Chiu
Int. J. Med. Sci. 2018; 15(6): 638-644. doi:10.7150/ijms.23291
[Abstract] [Full text] [PDF]

Research Paper
Resveratrol attenuates denervation-induced muscle atrophy due to the blockade of atrogin-1 and p62 accumulation
Yuka Asami, Miki Aizawa, Masakazu Kinoshita, Junji Ishikawa, Kunihiro Sakuma
Int. J. Med. Sci. 2018; 15(6): 628-637. doi:10.7150/ijms.22723
[Abstract] [Full text] [PDF]

Research Paper
Anti-biofilm and Anti-Virulence Efficacy of Celastrol Against Stenotrophomonas maltophilia
Hye-Rim Kim, Dongsup Lee, Yong-Bin Eom
Int. J. Med. Sci. 2018; 15(6): 617-627. doi:10.7150/ijms.23924
[Abstract] [Full text] [PDF]

Research Paper
Potential miRNA-target interactions for the screening of gastric carcinoma development in gastric adenoma/dysplasia
Yu Jin Kim, Ki-Chul Hwang, Sang Woo Kim, Yong Chan Lee
Int. J. Med. Sci. 2018; 15(6): 610-616. doi:10.7150/ijms.24061
[Abstract] [Full text] [PDF]

Research Paper
Glucagon-Like Peptide-1 Receptor Agonist and Glucagon Increase Glucose-Stimulated Insulin Secretion in Beta Cells via Distinct Adenylyl Cyclases
Young-Sun Lee, Hee-Sook Jun
Int. J. Med. Sci. 2018; 15(6): 603-609. doi:10.7150/ijms.24492
[Abstract] [Full text] [PDF]

Research Paper
Lipopolysaccharide Mediates the Destruction of Intercellular Tight Junction among Renal Tubular Epithelial Cells via RhoT1/SMAD-4/JAM-3 Pathway
Shixiang Zheng, Zhuoyong Lin, Zhongwei Liu, Yipeng Liu, Wenwei Wu
Int. J. Med. Sci. 2018; 15(6): 595-602. doi:10.7150/ijms.23786
[Abstract] [Full text] [PDF]

Research Paper
Single nucleotide polymorphisms and haplotypes of carbonic anhydrase 9 can predict invasive squamous cell carcinoma of uterine cervix
Huang-Pin Shen, Yi-Hsuan Hsiao, Shun-Fa Yang, Yu-Fan Liu, Jiunn-Liang Ko, Po-Hui Wang
Int. J. Med. Sci. 2018; 15(6): 587-594. doi:10.7150/ijms.23359
[Abstract] [Full text] [PDF]

Research Paper
HMGB1 genetic polymorphisms are biomarkers for the development and progression of breast cancer
Bi-Fei Huang, Huey-En Tzeng, Po-Chun Chen, Chao-Qun Wang, Chen-Ming Su, Yan Wang, Gui-Nv Hu, Yong-Ming Zhao, Qian Wang, Chih-Hsin Tang
Int. J. Med. Sci. 2018; 15(6): 580-586. doi:10.7150/ijms.23462
[Abstract] [Full text] [PDF]

Research Paper
Salmonella Overcomes Drug Resistance in Tumor through P-glycoprotein Downregulation
Chih-Jen Yang, Wen-Wei Chang, Song-Tao Lin, Man-Chin Chen, Che-Hsin Lee
Int. J. Med. Sci. 2018; 15(6): 574-579. doi:10.7150/ijms.23285
[Abstract] [Full text] [PDF]

Research Paper
Dehydroepiandrosterone supplementation combined with Weight-Loading Whole-Body Vibration Training (WWBV) affects exercise performance and muscle glycogen storage in middle-aged C57BL/6 mice
Yi-Ming Chen, Hao-Chieh Lee, Mu-Tsung Chen, Chi-Chang Huang, Wen-Chyuan Chen
Int. J. Med. Sci. 2018; 15(6): 564-573. doi:10.7150/ijms.23352
[Abstract] [Full text] [PDF]

Research Paper
Vascular calcification and left ventricular hypertrophy in hemodialysis patients: interrelationship and clinical impacts
Hyeon Seok Hwang, Jung Sun Cho, Yu Ah Hong, Yoon Kyung Chang, Suk Young Kim, Seok Joon Shin, Hye Eun Yoon
Int. J. Med. Sci. 2018; 15(6): 557-563. doi:10.7150/ijms.23700
[Abstract] [Full text] [PDF]

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