International Journal of Medical Sciences
Official Impact Factor

17 January 2017

ISSN 1449-1907 News feeds of published articles

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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Research Paper
Age-related trends in injection site reaction incidence induced by the tumor necrosis factor-α (TNF-α) inhibitors etanercept and adalimumab: the Food and Drug Administration adverse event reporting system, 2004-2015
Toshinobu Matsui, Ryogo Umetsu, Yamato Kato, Yuuki Hane, Sayaka Sasaoka, Yumi Motooka, Haruna Hatahira, Junko Abe, Akiho Fukuda, Misa Naganuma, Yasutomi Kinosada, Mitsuhiro Nakamura
Int. J. Med. Sci. 2017; 14(2): 102-109. doi:10.7150/ijms.17025
[Abstract] [Full text] [PDF]

Research Paper
The Therapeutic Effect of Vitamin C in an Animal Model of Complex Regional Pain Syndrome Produced by Prolonged Hindpaw Ischemia-Reperfusion in Rats
Jae Hun Kim, Yong Chul Kim, Francis Sahngun Nahm, Pyung Bok Lee
Int. J. Med. Sci. 2017; 14(1): 97-101. doi:10.7150/ijms.17681
[Abstract] [Full text] [PDF]

Research Paper
The influence of individual socioeconomic status on the clinical outcomes in ischemic stroke patients with different neighborhood status in Shanghai, China
Han Yan, Baoxin Liu, Guilin Meng, Bo Shang, Qiqiang Jie, Yidong Wei, Xueyuan Liu
Int. J. Med. Sci. 2017; 14(1): 86-96. doi:10.7150/ijms.17241
[Abstract] [Full text] [PDF]

Research Paper
Predictors of Left Ventricle Remodeling: Combined Plasma B-type Natriuretic Peptide Decreasing Ratio and Peak Creatine Kinase-MB
Jen-Te Hsu, Chang-Min Chung, Chi-Ming Chu, Yu-Shen Lin, Kuo-Li Pan, Jung-Jung Chang, Po-Chang Wang, Shih-Tai Chang, Teng-Yao Yang, Shih-Jung Jang, Tsung-Han Yang, Ju-Feng Hsiao
Int. J. Med. Sci. 2017; 14(1): 75-85. doi:10.7150/ijms.17145
[Abstract] [Full text] [PDF]

Research Paper
Specific networks of plasma acute phase reactants are associated with the severity of chronic obstructive pulmonary disease: a case-control study
Elena Arellano-Orden, Carmen Calero-Acuña, Juan Antonio Cordero, María Abad-Arranz, Verónica Sánchez-López, Eduardo Márquez-Martín, Francisco Ortega-Ruiz, José Luis López-Campos
Int. J. Med. Sci. 2017; 14(1): 67-74. doi:10.7150/ijms.16907
[Abstract] [Full text] [PDF]

Research Paper
Efficacy of FurosapTM, a novel Trigonella foenum-graecum seed extract, in Enhancing Testosterone Level and Improving Sperm Profile in Male Volunteers
Anuj Maheshwari, Narsingh Verma, Anand Swaroop, Manashi Bagchi, Harry G. Preuss, Kiran Tiwari, Debasis Bagchi
Int. J. Med. Sci. 2017; 14(1): 58-66. doi:10.7150/ijms.17256
[Abstract] [Full text] [PDF]

Research Paper
Polymorphisms in MicroRNA Binding Sites Predict Colorectal Cancer Survival
Ying-Pi Yang, Wen-Chien Ting, Lu-Min Chen, Te-Ling Lu, Bo-Ying Bao
Int. J. Med. Sci. 2017; 14(1): 53-57. doi:10.7150/ijms.17027
[Abstract] [Full text] [PDF]

Research Paper
Steatosis influences the clinical profiles and long-term outcomes of interferon-treated chronic hepatitis C and liver cirrhosis patients
Kazushige Nirei, Hiroshi Matsumura, Mariko Kumakawa, Naoki Matsumoto, Hitomi Nakamura, Hiroaki Yamagami, Shunichi Matsuoka, Mitsuhiko Moriyama
Int. J. Med. Sci. 2017; 14(1): 45-52. doi:10.7150/ijms.17202
[Abstract] [Full text] [PDF]

Research Paper
Plasma levels of the tissue inhibitor matrix metalloproteinase-3 as a potential biomarker in oral cancer progression
Chun-Wen Su, Bo-Feng Su, Whei-Ling Chiang, Shun-Fa Yang, Mu-Kuan Chen, Chiao-Wen Lin
Int. J. Med. Sci. 2017; 14(1): 37-44. doi:10.7150/ijms.17024
[Abstract] [Full text] [PDF]

Research Paper
Trigeminal nerve block with alcohol for medically intractable classic trigeminal neuralgia: long-term clinical effectiveness on pain
Kyung Ream Han, Yun Jeong Chae, Jung Dong Lee, Chan Kim
Int. J. Med. Sci. 2017; 14(1): 29-36. doi:10.7150/ijms.16964
[Abstract] [Full text] [PDF]

Research Paper
Physical and chemical characteristics of mucin secreted by pseudomyxoma peritonei (PMP)
Krishna Pillai, Javed Akhter, Ahmed Mekkawy, Terence C Chua, David L Morris
Int. J. Med. Sci. 2017; 14(1): 18-28. doi:10.7150/ijms.16422
[Abstract] [Full text] [PDF]

Radiation therapy and cancer control in developing countries: Can we save more lives?
Rajamanickam Baskar, Koji Itahana
Int. J. Med. Sci. 2017; 14(1): 13-17. doi:10.7150/ijms.17288
[Abstract] [Full text] [PDF]

Research Paper
Amino Acid Profiles of Serum and Urine in Search for Prostate Cancer Biomarkers: a Pilot Study
Paweł Dereziński, Agnieszka Klupczynska, Wojciech Sawicki, Jerzy A. Pałka, Zenon J. Kokot
Int. J. Med. Sci. 2017; 14(1): 1-12. doi:10.7150/ijms.15783
[Abstract] [Full text] [PDF]

Research Paper
Pulsed radiofrequency attenuates diabetic neuropathic pain and suppresses formalin-evoked spinal glutamate release in rats
Yu-Hsin Huang, Shao-Yun Hou, Jen-Kun Cheng, Chih-Hsien Wu, Chung-Ren Lin
Int. J. Med. Sci. 2016; 13(12): 984-991. doi:10.7150/ijms.16072
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Genetic Analysis of BDNF, GNB3, MTHFR, ACE and APOE Variants in Major and Recurrent Depressive Disorders in Russia
EA Bondarenko, MI Shadrina, MN Grishkina, TA Druzhkova, RG Akzhigitov, NV Gulyaeva, AB Guekht, PA Slominsky
Int. J. Med. Sci. 2016; 13(12): 977-983. doi:10.7150/ijms.16642
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Association of Far-Infrared Radiation Therapy and Ankle-Brachial Index of Patients on Hemodialysis with Peripheral Artery Occlusive Disease
Szu-Chia Chen, Mei-Yueh Lee, Jiun-Chi Huang, I-Ching Kuo, Hsiu-Chin Mai, Po-Lin Kuo, Jer-Ming Chang, Shang-Jyh Hwang, Hung-Chun Chen
Int. J. Med. Sci. 2016; 13(12): 970-976. doi:10.7150/ijms.17329
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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