International Journal of Medical Sciences
Official Impact Factor

25 September 2016

ISSN 1449-1907 News feeds of published articles

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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Research Paper
Immunohistochemical study of hair follicle stem cells in regenerated hair follicles induced by Wnt10b
Yiming Zhang, Yizhan Xing, Haiying Guo, Xiaogen Ma, Yuhong Li
Int. J. Med. Sci. 2016; 13(10): 765-771. doi:10.7150/ijms.16118
[Abstract] [Full text] [PDF]

Research Paper
Tissue factor: A potent stimulator of Von Willebrand factor synthesis by human umbilical vein endothelial cells
Muriel Meiring, W. Allers, E. Le Roux
Int. J. Med. Sci. 2016; 13(10): 759-764. doi:10.7150/ijms.15688
[Abstract] [Full text] [PDF]

Research Paper
Role of CAPE on cardiomyocyte protection via connexin 43 regulation under hypoxia
Chien-Cheng Chen, Chan-Yen Kuo, Rong-Fu Chen
Int. J. Med. Sci. 2016; 13(10): 754-758. doi:10.7150/ijms.15847
[Abstract] [Full text] [PDF]

Research Paper
Lower Body Mass Index is a Risk Factor for In-Hospital Mortality of Elderly Japanese Patients Treated with Ampicillin/sulbactam
Makoto Miura, Akiko Kuwahara, Akinori Tomozawa, Naoki Omae, Motohiro Yamamori, Kaori Kadoyama, Toshiyuki Sakaeda
Int. J. Med. Sci. 2016; 13(10): 749-753. doi:10.7150/ijms.16090
[Abstract] [Full text] [PDF]

Research Paper
Flooded Lung Generates a Suitable Acoustic Pathway for Transthoracic Application of High Intensity Focused Ultrasound in Liver
Thomas Günther Lesser, Carsten Boltze, Harald Schubert, Frank Wolfram
Int. J. Med. Sci. 2016; 13(10): 741-748. doi:10.7150/ijms.16411
[Abstract] [Full text] [PDF]

Research Paper
Dehydroepiandrosterone Supplementation Combined with Whole-Body Vibration Training Affects Testosterone Level and Body Composition in Mice
Wen-Chyuan Chen, Yi-Ming Chen, Chi-Chang Huang, Yen-Dun Tzeng
Int. J. Med. Sci. 2016; 13(10): 730-740. doi:10.7150/ijms.16132
[Abstract] [Full text] [PDF]

Research Paper
Adding Biotin to Parenteral Nutrition Solutions Without Lipid Accelerates the Growth of Candida albicans
Takashi Kuwahara, Shinya Kaneda, Kazuyuki Shimono
Int. J. Med. Sci. 2016; 13(9): 724-729. doi:10.7150/ijms.15951
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Regulatory SNPs Alter the Gene Expression of Diabetic Retinopathy Associated Secretary Factors
Chian-Feng Chen, Shiow-Wen Liou, Hsin-Han Wu, Chin-Hui Lin, Li-Shan Huang, Lin-Chung Woung, Ching-Yao Tsai
Int. J. Med. Sci. 2016; 13(9): 717-723. doi:10.7150/ijms.16345
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Effects for Sequential Treatment of siAkt and Paclitaxel on Gastric Cancer Cell Lines
Minhee Ku, Myounghwa Kang, Jin-Suck Suh, Jaemoon Yang
Int. J. Med. Sci. 2016; 13(9): 708-716. doi:10.7150/ijms.15501
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Impact of Diabetes Mellitus on Radial and Ulnar Arterial Vasoreactivity after Radial Artery Cannulation: A Randomized Controlled trial
Eun Jung Kim, Sarah Soh, So Yeon Kim, Hae Keum Kil, Jae Hoon Lee, Jeong Min Kim, Tae Whan Kim, Bon-Nyeo Koo
Int. J. Med. Sci. 2016; 13(9): 701-707. doi:10.7150/ijms.16007
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Prognostic Value of Prostaglandin-endoperoxide Synthase 2 Polymorphisms in Prostate Cancer Recurrence after Radical Prostatectomy
Cheng-Hsueh Lee, Jiunn-Bey Pao, Te-Ling Lu, Hong-Zin Lee, Yung-Chin Lee, Chia-Chu Liu, Chao-Yuan Huang, Victor C. Lin, Chia-Cheng Yu, Hsin-Ling Yin, Shu-Pin Huang, Bo-Ying Bao
Int. J. Med. Sci. 2016; 13(9): 696-700. doi:10.7150/ijms.16259
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Overhydration Negatively Affects Quality of Life in Peritoneal Dialysis Patients: Evidence from a Prospective Observational Study
Hye Eun Yoon, Young Joo Kwon, Ho Cheol Song, Jin Kuk Kim, Young Rim Song, Seok Joon Shin, Hyung Wook Kim, Chang Hwa Lee, Tae Won Lee, Young Ok Kim, Byung Soo Kim, Kyoung Hyoub Moon, Yoon Kyung Chang, Seong Suk Kim, Kitae Bang, Jong Tae Cho, Sung Ro Yun, Ki Ryang Na, Yang Wook Kim, Byoung Geun Han, Jong Hoon Chung, Kwang Young Lee, Jong Hyeok Jeong, Eun Ah Hwang, Yong-Soo Kim, the Quality of Life of Dialysis Patients (QOLD) Study Group
Int. J. Med. Sci. 2016; 13(9): 686-695. doi:10.7150/ijms.16372
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Suppression of Myostatin Stimulates Regenerative Potential of Injured Antigravitational Soleus Muscle in Mice under Unloading Condition
Yoshitaka Ohno, Yusuke Matsuba, Naohiro Hashimoto, Takao Sugiura, Yoshinobu Ohira, Toshitada Yoshioka, Katsumasa Goto
Int. J. Med. Sci. 2016; 13(9): 680-685. doi:10.7150/ijms.16267
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Utility of Plasma Osteopontin Levels in Management of Community-Acquired Pneumonia
Jer-Hwa Chang, Wen-Yueh Hung, Kuan-Jen Bai, Shun-Fa Yang, Ming-Hsien Chien
Int. J. Med. Sci. 2016; 13(9): 673-679. doi:10.7150/ijms.16175
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Impact of Cryoballoon Ablation in Hypertrophic Cardiomyopathy-related Heart Failure due to Paroxysmal Atrial Fibrillation. A Comparative Case Series
Petra Maagh, Gunnar Plehn, Arnd Christoph, Ahmet Oernek, Axel Meissner
Int. J. Med. Sci. 2016; 13(9): 664-672. doi:10.7150/ijms.16181
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Preventative Effects of Sodium Alginate on Indomethacin-induced Small-intestinal Injury in Mice
Sayo Horibe, Toshihito Tanahashi, Shoji Kawauchi, Shigeto Mizuno, Yoshiyuki Rikitake
Int. J. Med. Sci. 2016; 13(9): 653-663. doi:10.7150/ijms.16232
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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