International Journal of Medical Sciences
Official Impact Factor

9 December 2016

ISSN 1449-1907 News feeds of published articles

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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Research Paper
Decreased Tumor Suppressor Candidate 3 Predicts Poor Prognosis of Patients with Esophageal Squamous Cell Carcinoma
Xinshuang Yu, Jiandong Zhang, Hua Zhong, Fengjun Liu, Ning Liang, Yao Wang, Xiangjiao Meng, Juan Du
Int. J. Med. Sci. 2016; 13(12): 963-969. doi:10.7150/ijms.16381
[Abstract] [Full text] [PDF]

Research Paper
Blockade of Central GLP-1 Receptors Deteriorates the Improvement of Diabetes after Ileal Transposition
Weijie Chen, Qianqian Xu, Yiding Xiao, Jiaolin Zhou, Weimin Zhang, Guole Lin, Fengying Gong
Int. J. Med. Sci. 2016; 13(12): 955-962. doi:10.7150/ijms.17290
[Abstract] [Full text] [PDF]

Research Paper
Resveratrol alleviate hypoxic pulmonary hypertension via anti-inflammation and anti-oxidant pathways in rats
Dunquan Xu, Yan Li, Bo Zhang, Yanxia Wang, Yi Liu, Ying Luo, Wen Niu, Mingqing Dong, Manling Liu, Haiying Dong, Pengtao Zhao, Zhichao Li
Int. J. Med. Sci. 2016; 13(12): 942-954. doi:10.7150/ijms.16810
[Abstract] [Full text] [PDF]

Research Paper
Adhesion Prevention Efficacy of Composite Meshes Parietex®, Proceed® and 4DryField® PH Covered Polypropylene Meshes in an IPOM Rat Model
Markus Winny, Lavinia Maegel, Leonie Grethe, Torsten Lippmann, Danny Jonigk, Harald Schrem, Alexander Kaltenborn, Juergen Klempnauer, Daniel Poehnert
Int. J. Med. Sci. 2016; 13(12): 936-941. doi:10.7150/ijms.16215
[Abstract] [Full text] [PDF]

Research Paper
Association between survivin genetic polymorphisms and epidermal growth factor receptor mutation in non-small-cell lung cancer
Tu-Chen Liu, Ming-Ju Hsieh, Wen-Jun Wu, Ying-Erh Chou, Whei-Ling Chiang, Shun-Fa Yang, Shih-Chi Su, Thomas Chang-Yao Tsao
Int. J. Med. Sci. 2016; 13(12): 929-935. doi:10.7150/ijms.16875
[Abstract] [Full text] [PDF]

Research Paper
Menthol inhibiting parasympathetic function of tracheal smooth muscle
Hsing-Won Wang, Shao-Cheng Liu, Pin-Zhir Chao, Fei-Peng Lee
Int. J. Med. Sci. 2016; 13(12): 923-928. doi:10.7150/ijms.17042
[Abstract] [Full text] [PDF]

Research Paper
Overexpression of lncRNA H19/miR-675 promotes tumorigenesis in head and neck squamous cell carcinoma
Guo-fang Guan, De-jun Zhang, Lian-ji Wen, Ding Xin, Yan Liu, Duo-jiao Yu, Kai Su, Lin Zhu, Ying-yuan Guo, Ke Wang
Int. J. Med. Sci. 2016; 13(12): 914-922. doi:10.7150/ijms.16571
[Abstract] [Full text] [PDF]

Review
Circulating Tumor Cells and Circulating Tumor DNA Provide New Insights into Pancreatic Cancer
Yang Gao, Yayun Zhu, Zhou Yuan
Int. J. Med. Sci. 2016; 13(12): 902-913. doi:10.7150/ijms.16734
[Abstract] [Full text] [PDF]

Research Paper
Association of physical performance and biochemical profile of mice with intrinsic endurance swimming
Wen-Ching Huang, Yi-Ju Hsu, Li Wei, Ying-Ju Chen, Chi-Chang Huang
Int. J. Med. Sci. 2016; 13(12): 892-901. doi:10.7150/ijms.16421
[Abstract] [Full text] [PDF]

Research Paper
Established Population of Blacklegged Ticks with High Infection Prevalence for the Lyme Disease Bacterium, Borrelia burgdorferi Sensu Lato, on Corkscrew Island, Kenora District, Ontario
John D. Scott, Janet E. Foley, Kerry L. Clark, John F. Anderson, Lance A. Durden, Jodi M. Manord, Morgan L. Smith
Int. J. Med. Sci. 2016; 13(11): 881-891. doi:10.7150/ijms.16922
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Expression of the receptor activator of nuclear factor-kB ligand in peripheral blood mononuclear cells in patients with acute Charcot neuroarthropathy
Alberto Bergamini, Francesca Bolacchi, Caterina Delfina Pesce, Giada Veneziano, Luigi Uccioli, Valentina Girardi, Laura De Corato, Maria Teresa Mondillo, Ettore Squillaci
Int. J. Med. Sci. 2016; 13(11): 875-880. doi:10.7150/ijms.14579
[Abstract] [Full text] [PDF]

Research Paper
Amplification and overexpression of CTTN and CCND1 at chromosome 11q13 in Esophagus squamous cell carcinoma (ESCC) of North Eastern Chinese Population
Xiaoxia Hu, Ji Wook Moon, Shibo Li, Weihong Xu, Xianfu Wang, Yuanyuan Liu, Ji-Yun Lee
Int. J. Med. Sci. 2016; 13(11): 868-874. doi:10.7150/ijms.16845
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Activation of the CXCL16/CXCR6 Pathway by Inflammation Contributes to Atherosclerosis in Patients with End-stage Renal Disease
Ze Bo Hu, Yan Chen, Yu Xiang Gong, Min Gao, Yang Zhang, Gui Hua Wang, Ri Ning Tang, Hong Liu, Bi Cheng Liu, Kun Ling Ma
Int. J. Med. Sci. 2016; 13(11): 858-867. doi:10.7150/ijms.16724
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Amelioration of estrogen deficiency-induced obesity by collagen hydrolysate
Tsay-I Chiang, I-Chang Chang, Hsueh-Hui Lee, Kuang hui Hsieh, Yung-Wei Chiu, Te-Jen Lai, Jer-Yuh Liu, Li-Sung Hsu, Shao-Hsuan Kao
Int. J. Med. Sci. 2016; 13(11): 853-857. doi:10.7150/ijms.16706
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Cardiomyogenic Differentiation of Human Dental Follicle-derived Stem Cells by Suberoylanilide Hydroxamic Acid and Their In Vivo Homing Property
Iel-Yong Sung, Han-Na Son, Imran Ullah, Dinesh Bharti, Ju-Mi Park, Yeong-Cheol Cho, June-Ho Byun, Young-Hoon Kang, Su-Jin Sung, Jong-Woo Kim, Gyu-Jin Rho, Bong-Wook Park
Int. J. Med. Sci. 2016; 13(11): 841-852. doi:10.7150/ijms.16573
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
The Limbal Epithelial Progenitors in the Limbal Niche Environment
Yuan Zhang, Hong Sun, Yongsong Liu, Shuangling Chen, Subo Cai, Yingting Zhu, Ping Guo
Int. J. Med. Sci. 2016; 13(11): 835-840. doi:10.7150/ijms.16563
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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