International Journal of Medical Sciences
Official Impact Factor

23 April 2017

ISSN 1449-1907 News feeds of published articles

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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Research Paper
Existence of a Strong Correlation of Biomarkers and miRNA in Females with Metabolic Syndrome and Obesity in a Population of West Virginia
Perrine Goguet-Rubio, Rebecca L. Klug, Dana L. Sharma, Krithika Srikanthan, Nitin Puri, Vishal H Lakhani, Alexandra Nichols, Kathleen M. O'Hanlon, Nader G. Abraham, Joseph I. Shapiro, Komal Sodhi
Int. J. Med. Sci. 2017; 14(6): 543-553. doi:10.7150/ijms.18988
[Abstract] [Full text] [PDF]

Research Paper
Clinical insomnia and associated factors in failed back surgery syndrome: a retrospective cross-sectional study
Soon Young Yun, Do Heon Kim, Hae Yoon Do, Shin Hyung Kim
Int. J. Med. Sci. 2017; 14(6): 536-542. doi:10.7150/ijms.18926
[Abstract] [Full text] [PDF]

Research Paper
KLF6 inhibited oral cancer migration and invasion via downregulation of mesenchymal markers and inhibition of MMP-9 activities
Li-Sung Hsu, Ren-Hung Huang, Hung-Wen Lai, Hui-Ting Hsu, Wen-Wei Sung, Ming-Ju Hsieh, Chong-Yu Wu, Yueh-Min Lin, Mu-Kuan Chen, Yu-Sheng Lo, Chih-Jung Chen
Int. J. Med. Sci. 2017; 14(6): 530-535. doi:10.7150/ijms.19024
[Abstract] [Full text] [PDF]

Research Paper
Synergistic Antitumor Effect of Sorafenib in Combination with ATM Inhibitor in Hepatocellular Carcinoma Cells
Jianhua Liu, Yahui Liu, Lingyu Meng, Bai Ji, Daqing Yang
Int. J. Med. Sci. 2017; 14(6): 523-529. doi:10.7150/ijms.19033
[Abstract] [Full text] [PDF]

Research Paper
Nuclear Expression of GS28 Protein: A Novel Biomarker that Predicts Prognosis in Colorectal Cancers
Sung Hak Lee, Hyung Jae Yoo, Do Eun Rim, Yinji Cui, Ahwon Lee, Eun Sun Jung, Seung Taek Oh, Jun Gi Kim, Oh-Joo Kwon, Su Young Kim, Seong-Whan Jeong
Int. J. Med. Sci. 2017; 14(6): 515-522. doi:10.7150/ijms.19368
[Abstract] [Full text] [PDF]

Research Paper
Traditional Chinese Medication Qiliqiangxin Protects Against Cardiac Remodeling and Dysfunction in Spontaneously Hypertensive Rats
Hui Wang, Xiaomin Zhang, Pujiao Yu, Qiulian Zhou, Jialiang Zhang, Haifeng Zhang, Hongsheng Zhu, Chenlin Zhang, Wenming Yao, Lin Che, Jiahong Xu, Yihua Bei, Xinli Li
Int. J. Med. Sci. 2017; 14(5): 506-514. doi:10.7150/ijms.18142
[Abstract] [Full text] [PDF]

Improving on Laboratory Traumatic Brain Injury Models to Achieve Better Results
Mark Nyanzu, Felix Siaw-Debrah, Haoqi Ni, Zhu Xu, Hua Wang, Xiao Lin, Qichuan Zhuge, Lijie Huang
Int. J. Med. Sci. 2017; 14(5): 494-505. doi:10.7150/ijms.18075
[Abstract] [Full text] [PDF]

Research Paper
Effects of C-reactive protein on the expression of matrix metalloproteinases and their inhibitors via Fcγ receptors on 3T3-L1 adipocytes
Kumiko Nakai, Hideki Tanaka, Kazuhiro Yamanaka, Yumi Takahashi, Fumiko Murakami, Rieko Matsuike, Jumpei Sekino, Natsuko Tanabe, Toyoko Morita, Yoji Yamazaki, Takayuki Kawato, Masao Maeno
Int. J. Med. Sci. 2017; 14(5): 484-493. doi:10.7150/ijms.18059
[Abstract] [Full text] [PDF]

Research Paper
Effect of Metoprolol Succinate in Patients with Stable Angina and Elevated Heart Rate Receiving Low-Dose β-Blocker Therapy
Jie Jiang, Hongliang Cong, Yan Zhang, Zhanquan Li, Guizhou Tao, Xiaodong Li, Liang Qing, Ning Tan, Zhichen Zhao, Yugang Dong, Zheng Ji, Yundai Chen, Junbo Ge, Ben He, Yingxian Sun, Kejiang Cao, Yong Huo
Int. J. Med. Sci. 2017; 14(5): 477-483. doi:10.7150/ijms.18054
[Abstract] [Full text] [PDF]

Research Paper
Association between sarcopenia and hearing thresholds in postmenopausal women
Seok Hui Kang, Da Jung Jung, Kyu Hyang Cho, Jong Won Park, Kyu-Yup Lee, Jun Young Do
Int. J. Med. Sci. 2017; 14(5): 470-476. doi:10.7150/ijms.18048
[Abstract] [Full text] [PDF]

Research Paper
Induction of Mitotic Delay in Pharyngeal and Nasopharyngeal Carcinoma Cells Using an Aqueous Extract of Ajuga bracteosa
Yu-Tsai Lin, Chih-Che Lin, Hung-Chen Wang, Yi-Chiang Hsu
Int. J. Med. Sci. 2017; 14(5): 462-469. doi:10.7150/ijms.18154
[Abstract] [Full text] [PDF]

Research Paper
Stabilization of 4E-BP1 by PI3K kinase and its involvement in CHK2 phosphorylation in the cellular response to radiation
Zi-Jian Yu, Hui-Hui Luo, Zeng-Fu Shang, Hua Guan, Bei-Bei Xiao, Xiao-Dan Liu, Yu Wang, Bo Huang, Ping-Kun Zhou
Int. J. Med. Sci. 2017; 14(5): 452-461. doi:10.7150/ijms.18329
[Abstract] [Full text] [PDF]

Research Paper
Bifidobacterium pseudocatenulatum CECT 7765 supplementation restores altered vascular function in an experimental model of obese mice
María D. Mauricio, Eva Serna, María Leonor Fernández-Murga, Jesica Portero, Martín Aldasoro, Soraya L. Valles, Yolanda Sanz, José M. Vila
Int. J. Med. Sci. 2017; 14(5): 444-451. doi:10.7150/ijms.18354
[Abstract] [Full text] [PDF]

Research Paper
Dexamethasone Treatment at the Myoblast Stage Enhanced C2C12 Myocyte Differentiation
Der-Sheng Han, Wei-Shiung Yang, Tung-Wei Kao
Int. J. Med. Sci. 2017; 14(5): 434-443. doi:10.7150/ijms.18427
[Abstract] [Full text] [PDF]

Research Paper
Isoflurane preconditioning inhibits the effects of tissue-type plasminogen activator on brain endothelial cell in an in vitro model of ischemic stroke
So Yeong Cheon, So Yeon Kim, Eun Hee Kam, Jae Hoon Lee, Jeong Min Kim, Eun Jung Kim, Tae Whan Kim, Bon-Nyeo Koo
Int. J. Med. Sci. 2017; 14(5): 425-433. doi:10.7150/ijms.18037
[Abstract] [Full text] [PDF]

Research Paper
High Level of Plasma EGFL6 Is Associated with Clinicopathological Characteristics in Patients with Oral Squamous Cell Carcinoma
Chun-Yi Chuang, Mu-Kuan Chen, Ming-Ju Hsieh, Chia-Ming Yeh, Chiao-Wen Lin, Wei-En Yang, Shun-Fa Yang, Ying-Erh Chou
Int. J. Med. Sci. 2017; 14(5): 419-424. doi:10.7150/ijms.18555
[Abstract] [Full text] [PDF]

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