International Journal of Medical Sciences
Official Impact Factor

29 August 2016

ISSN 1449-1907 News feeds of published articles

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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Research Paper
Impact of Diabetes Mellitus on Radial and Ulnar Arterial Vasoreactivity after Radial Artery Cannulation: A Randomized Controlled trial
Eun Jung Kim, Sarah Soh, So Yeon Kim, Hae Keum Kil, Jae Hoon Lee, Jeong Min Kim, Tae Whan Kim, Bon-Nyeo Koo
Int. J. Med. Sci. 2016; 13(9): 701-707. doi:10.7150/ijms.16007
[Abstract] [Full text] [PDF]

Research Paper
Prognostic Value of Prostaglandin-endoperoxide Synthase 2 Polymorphisms in Prostate Cancer Recurrence after Radical Prostatectomy
Cheng-Hsueh Lee, Jiunn-Bey Pao, Te-Ling Lu, Hong-Zin Lee, Yung-Chin Lee, Chia-Chu Liu, Chao-Yuan Huang, Victor C. Lin, Chia-Cheng Yu, Hsin-Ling Yin, Shu-Pin Huang, Bo-Ying Bao
Int. J. Med. Sci. 2016; 13(9): 696-700. doi:10.7150/ijms.16259
[Abstract] [Full text] [PDF]

Research Paper
Overhydration Negatively Affects Quality of Life in Peritoneal Dialysis Patients: Evidence from a Prospective Observational Study
Hye Eun Yoon, Young Joo Kwon, Ho Cheol Song, Jin Kuk Kim, Young Rim Song, Seok Joon Shin, Hyung Wook Kim, Chang Hwa Lee, Tae Won Lee, Young Ok Kim, Byung Soo Kim, Kyoung Hyoub Moon, Yoon Kyung Chang, Seong Suk Kim, Kitae Bang, Jong Tae Cho, Sung Ro Yun, Ki Ryang Na, Yang Wook Kim, Byoung Geun Han, Jong Hoon Chung, Kwang Young Lee, Jong Hyeok Jeong, Eun Ah Hwang, Yong-Soo Kim, the Quality of Life of Dialysis Patients (QOLD) Study Group
Int. J. Med. Sci. 2016; 13(9): 686-695. doi:10.7150/ijms.16372
[Abstract] [Full text] [PDF]

Research Paper
Suppression of Myostatin Stimulates Regenerative Potential of Injured Antigravitational Soleus Muscle in Mice under Unloading Condition
Yoshitaka Ohno, Yusuke Matsuba, Naohiro Hashimoto, Takao Sugiura, Yoshinobu Ohira, Toshitada Yoshioka, Katsumasa Goto
Int. J. Med. Sci. 2016; 13(9): 680-685. doi:10.7150/ijms.16267
[Abstract] [Full text] [PDF]

Research Paper
Utility of Plasma Osteopontin Levels in Management of Community-Acquired Pneumonia
Jer-Hwa Chang, Wen-Yueh Hung, Kuan-Jen Bai, Shun-Fa Yang, Ming-Hsien Chien
Int. J. Med. Sci. 2016; 13(9): 673-679. doi:10.7150/ijms.16175
[Abstract] [Full text] [PDF]

Research Paper
Impact of Cryoballoon Ablation in Hypertrophic Cardiomyopathy-related Heart Failure due to Paroxysmal Atrial Fibrillation. A Comparative Case Series
Petra Maagh, Gunnar Plehn, Arnd Christoph, Ahmet Oernek, Axel Meissner
Int. J. Med. Sci. 2016; 13(9): 664-672. doi:10.7150/ijms.16181
[Abstract] [Full text] [PDF]

Research Paper
Preventative Effects of Sodium Alginate on Indomethacin-induced Small-intestinal Injury in Mice
Sayo Horibe, Toshihito Tanahashi, Shoji Kawauchi, Shigeto Mizuno, Yoshiyuki Rikitake
Int. J. Med. Sci. 2016; 13(9): 653-663. doi:10.7150/ijms.16232
[Abstract] [Full text] [PDF]

Research Paper
NOX2 Antisense Attenuates Hypoxia-Induced Oxidative Stress and Apoptosis in Cardiomyocyte
Bo Yu, Fanbo Meng, Yushuang Yang, Dongna Liu, Kaiyao Shi
Int. J. Med. Sci. 2016; 13(8): 646-652. doi:10.7150/ijms.15177
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Elevated Plasma Matrix Metalloproteinase-9 and Its Correlations with Severity of Disease in Patients with Ventilator-Associated Pneumonia
Yia-Ting Li, Yao-Chen Wang, Hsiang-Lin Lee, Min-Chi Lu, Shun-Fa Yang
Int. J. Med. Sci. 2016; 13(8): 638-645. doi:10.7150/ijms.16187
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Role of the ERK1/2 Signaling Pathway in Osteogenesis of Rat Tendon-Derived Stem Cells in Normoxic and Hypoxic Cultures
Pei Li, Yuan Xu, Yibo Gan, Lei Song, Chengmin Zhang, Liyuan Wang, Qiang Zhou
Int. J. Med. Sci. 2016; 13(8): 629-637. doi:10.7150/ijms.16045
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Predictive Value of Echocardiographic Abnormalities and the Impact of Diastolic Dysfunction on In-hospital Major Cardiovascular Complications after Living Donor Kidney Transplantation
Eun Jung Kim, Suyon Chang, So Yeon Kim, Kyu Ha Huh, Soojeong Kang, Yong Seon Choi
Int. J. Med. Sci. 2016; 13(8): 620-628. doi:10.7150/ijms.15745
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
NLS-RARα Inhibits the Effects of All-trans Retinoic Acid on NB4 Cells by Interacting with P38α MAPK
Chunlan Xiao, Liang Zhong, Zhiling Shan, Ting Xu, Liugen Gan, Hao Song, Rong Yang, Liu Li, Beizhong Liu
Int. J. Med. Sci. 2016; 13(8): 611-619. doi:10.7150/ijms.15374
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Wnt5a Suppresses β-catenin Signaling during Hair Follicle Regeneration
Yizhan Xing, Xiaogen Ma, Haiying Guo, Fang Deng, Jin Yang, Yuhong Li
Int. J. Med. Sci. 2016; 13(8): 603-610. doi:10.7150/ijms.15571
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
The Neutrophil to Lymphocyte Ratio on Admission and Short-Term Outcomes in Orthogeriatric Patients
Alexander Fisher, Wichat Srikusalanukul, Leon Fisher, Paul Smith
Int. J. Med. Sci. 2016; 13(8): 588-602. doi:10.7150/ijms.15445
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Progress on Complications of Direct Bypass for Moyamoya Disease
Jinlu Yu, Lei Shi, Yunbao Guo, Baofeng Xu, Kan Xu
Int. J. Med. Sci. 2016; 13(8): 578-587. doi:10.7150/ijms.15390
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Heat-killed Lactobacillus Reuteri GMNL-263 Prevents Epididymal Fat Accumulation and Cardiac Injury in High-Calorie Diet-Fed Rats
Po-Hsiang Liao, Wei-Wen Kuo, Dennis Jine-Yuan Hsieh, Yu-Lan Yeh, Cecilia-Hsuan Day, Ya-Hui Chen, Sheng-Huang Chang, V. Vijaya Padma, Yi-Hsing Chen, Chih-Yang Huang
Int. J. Med. Sci. 2016; 13(8): 569-577. doi:10.7150/ijms.15597
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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