International Journal of Medical Sciences

8 February 2010

ISSN 1449-1907

International Journal of Biological Sciences

Editor-in-Chief: Dennis D. Taub, Chief of Clinical Immunology Section, Laboratory of Immunology, NIA, NIH
Editor-in-Chief's Profile

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Previous studies have shown that undenatured type II collagen (UC-II) is effective in the treatment of rheumatoid arthritis, and preliminary human and animal trials have shown it to be effective in treating osteoarthritis (OA). The present clinical trial evaluated the safety and efficacy of UC-II as compared to a combination of glucosamine and chondroitin (G+C) in the treatment of OA of the knee. The results indicate that UC-II treatment was more efficacious resulting in a significant reduction in all assessments from the baseline at 90 days; whereas, this effect was not observed in G+C treatment group. Specifically, although both treatments reduced the Western Ontario McMaster Osteoarthritis Index (WOMAC) score, treatment with UC-II reduced the WOMAC score by 33% as compared to 14% in G+C treated group after 90 days. More ...

Objective: The effects of replacing cisplatin (CDDP) with cis-diammineglycolatoplatinum (nedaplatin, NDP), a second-generation platinum complex, on the pharmacokinetics of 5-fluorouracil (5-FU) were investigated in Japanese patients with esophageal squamous cell carcinoma, who were treated with a definitive 5-FU/CDDP-based chemoradiotherapy. Methods: Fifty-six patients were enrolled, 49 treated with CDDP and 7 treated with NDP. A course consisted of continuous infusion of 5-FU at 400 mg/m²/day for days 1-5 and 8-12, infusion of CDDP or NDP at 40 mg/m²/day on days 1 and 8, and radiation at 2 Gy/day on days 1 to 5, 8 to 12, and 15 to 19, with a second course repeated after a 2-week interval. More ...

Infections still remain one of the most devastating complications in hip joint surgery. Classification of these infections help the orthopaedic surgeon to identify the acuteness or chronicity of the infection, predict the complexity of the treatment procedure and ensure that all necessary device are available at the time of the revision surgery. The present article reviews the actual literature and provides an overview of clinical, arthroscopic, microbiological and radiological staging systems. More ...

Systemic sclerosis (SSc) is an often fatal disease characterized by autoimmunity and inflammation, leading to widespread vasculopathy and fibrosis. Lysophosphatidic acid (LPA), a bioactive phospholipid in serum, is generated from lysophospholipids secreted from activated platelets in part by the action of lysophospholipase D (lysoPLD). Sphingosine 1-phosphate (S1P), a member of the bioactive lysophospholipid family, is also released from activated platelets. Because activated platelets are a hallmark of SSc, we wanted to determine whether subjects with SSc have altered serum lysophospholipid levels or lysoPLD activity. Lysophospholipid levels were measured using mass spectrometric analysis. More ...

Background: To investigate the improvement in quality of life (QoL) of alcohol-dependent patients during a 3-week inpatient withdrawal programme, and to identify the sociodemographic, clinical and alcohol-related variables associated with baseline QoL on admission and with improvement of QoL during residential treatment. Methods: This prospective, observational study included 414 alcohol-dependent patients, hospitalised for a period of 3 weeks. QoL was measured on admission and at discharge using the French version of the Medical Outcome Study SF-36. The mean scores for each dimension and for the Physical and Mental Component Summary scores were calculated. More ...

Understanding of molecular mechanisms governing the enucleating phenomena of human erythrocytes is of major importance in both fundamental and applied studies. Total RNA (n=7) from human RBCs (purity of erythrocyte preparation >99,99%) was tested using 2100 Bioanalyzer (Agilent, USA), and transcribed to cDNA. Microarray analysis was performed with the Human Genome Focus GeneChip (Affymetrix, USA), containing 8500 transcripts corresponding to 8400 human genes. Here we report that human RBCs contain typical eukaryotic RNA with 28S- and18S-rRNA standard bands. More ...

International Journal of Medical Sciences Cover Page

Effect of dose-escalation of 5-fluorouracil on circadian variability of its pharmacokinetics in Japanese patients with Stage III/IVa esophageal squamous cell carcinoma
Akiko Kuwahara, Motohiro Yamamori, Kohshi Nishiguchi, Tatsuya Okuno, Naoko Chayahara, Ikuya Miki, Takao Tamura, Kaori Kadoyama, Tsubasa Inokuma, Yoshiji Takemoto, Tsutomu Nakamura, Kazusaburo Kataoka, Toshiyuki Sakaeda
Int. J. Med. Sci. 2010, 7: 48-54
[Abstract] [Full text] [PDF]

Growth of Microorganisms in Total Parenteral Nutrition Solutions Without Lipid
Takashi Kuwahara, Shinya Kaneda, Kazuyuki Shimono, Yoshifumi Inoue
Int. J. Med. Sci. 2010, 7: 43-47
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Weight loss, leukopenia and thrombocytopenia associated with sustained virologic response to Hepatitis C treatment
Nuntra Suwantarat, Alan D. Tice, Thana Khawcharoenporn, Dominic C. Chow
Int. J. Med. Sci. 2010, 7: 36-42
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Fat-Storing Multilocular Cells Expressing CCR5 Increase in the Thymus with Advancing Age: Potential Role for CCR5 Ligands on the Differentiation and Migration of Preadipocytes
Valeria de Mello Coelho, Allyson Bunbury, Leticia B. Rangel, Banabihari Giri, Ashani Weeraratna, Patrice J. Morin, Michel Bernier, Dennis D. Taub
Int. J. Med. Sci. 2010, 7: 1-14
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Comparison between single antiplatelet therapy and combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke patients with antiphospholipid syndrome
Hirohisa Okuma, Yasuhisa Kitagawa, Takashi Yasuda, Kentaro Tokuoka, Shigeharu Takagi
Int. J. Med. Sci. 2010, 7: 15-18
[Abstract] [Full text] [PDF] [PubMed] [PMC]

The Diels-Alder-Reaction with inverse-Electron-Demand, a very efficient versatile Click-Reaction Concept for proper Ligation of variable molecular Partners
Manfred Wiessler, Waldemar Waldeck, Christian Kliem, Ruediger Pipkorn, Klaus Braun
Int. J. Med. Sci. 2010, 7: 19-28
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action
Bok Y. Lee, Noori AL-Waili, Dean Stubbs, Keith Wendell, Glenn Butler, Thia AL-Waili, Ali AL-Waili
Int. J. Med. Sci. 2010, 7: 29-35
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Campylobacter cholecystitis
Deepak Udayakumar, Mohammed Sanaullah
Int. J. Med. Sci. 2009, 6: 374-375
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Autofluorescent Proteins as Photosensitizer in Eukaryontes
Waldemar Waldeck, Gabriele Mueller, Manfred Wiessler, Manuela Brom, Katalin Tóth, Klaus Braun
Int. J. Med. Sci. 2009, 6: 365-373
[Abstract] [Full text] [PDF] [PubMed] [PMC]

980 nm diode lasers in oral and facial practice: current state of the science and art
Apollonia DESIATE, Stefania CANTORE, Domenica TULLO, Giovanni PROFETA, Felice Roberto GRASSI, Andrea BALLINI
Int. J. Med. Sci. 2009, 6: 358-364
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Why are some children with early onset of asthma getting better over the years? - Diagnostic failure or salutogenetic factors
Eduardo Roel, Olle Zetterström, Erik Trell, Tomas Faresjö
Int. J. Med. Sci. 2009, 6: 348-357
[Abstract] [Full text] [PDF] [PubMed] [PMC]

High-Resolution Flow Cytometry: a Suitable Tool for Monitoring Aneuploid Prostate Cancer Cells after TMZ and TMZ-BioShuttle Treatment
Klaus Braun, Volker Ehemann, Manfred Wiessler, Ruediger Pipkorn, Bernd Didinger, Gabriele Mueller, Waldemar Waldeck
Int. J. Med. Sci. 2009, 6: 338-347
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Comparative study of control selection in a national population -based case-control study: Estimating risk of smoking on cancer deaths in Chinese men
Jingmei Jiang, Boqi Liu, Philip C. Nasca, Wei Han, Xiaonong Zou, Xianjia Zeng, Xiaobing Tian, Yanping Wu, Ping Zhao, Junyao Li
Int. J. Med. Sci. 2009, 6: 329-337
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Foreign body aspirations in Infancy: a 20-year experience
Nader Saki, Soheila Nikakhlagh, Fakher Rahim, Hassan Abshirini
Int. J. Med. Sci. 2009, 6: 322-328
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial
David C. Crowley, Francis C. Lau, Prachi Sharma, Malkanthi Evans, Najla Guthrie, Manashi Bagchi, Debasis Bagchi, Dipak K. Dey, Siba P. Raychaudhuri
Int. J. Med. Sci. 2009, 6: 312-321
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma
Akiko Kuwahara, Motohiro Yamamori, Kohshi Nishiguchi, Tatsuya Okuno, Naoko Chayahara, Ikuya Miki, Takao Tamura, Tsubasa Inokuma, Yoshiji Takemoto, Tsutomu Nakamura, Kazusaburo Kataoka, Toshiyuki Sakaeda
Int. J. Med. Sci. 2009, 6: 305-311
[Abstract] [Full text] [PDF] [PubMed] [PMC]

A k₂A-positive Klebsiella pneumoniae causes liver and brain abscess in a Saint Kitt's man
Melissa S. Doud, Reni Grimes-Zeppegno, Enrique Molina, Nancimae Miller, Danajeyan Balachandar, Lisa Schneper, Robert Poppiti, Kalai Mathee
Int. J. Med. Sci. 2009, 6: 301-304
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Differentiation of convulsive syncope from epilepsy with an implantable loop recorder
Khalil Kanjwal, Beverly Karabin, Yousuf Kanjwal, Blair P Grubb
Int. J. Med. Sci. 2009, 6: 296-300
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Revision of late periprosthetic infections of total hip endoprostheses: pros and cons of different concepts
Bernd Fink
Int. J. Med. Sci. 2009, 6: 287-295
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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