International Journal of Medical Sciences

Impact factor
2.399

26 June 2017

ISSN 1449-1907 News feeds of published articles

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new Impact factor is 2.399 according to 2017 release of Journal Citation Reports®. Congratulations!

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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Research Paper
Autophagy was involved in the protective effect of metformin on hyperglycemia-induced cardiomyocyte apoptosis and Connexin43 downregulation in H9c2 cells
Guang-Yu Wang, Ya-Guang Bi, Xiang-Dong Liu, Yu Zhao, Jun-Feng Han, Meng Wei, Qing-Yong Zhang
Int. J. Med. Sci. 2017; 14(7): 698-704. doi:10.7150/ijms.19800
[Abstract] [Full text] [PDF]

Research Paper
Association of Genes Variants in RANKL/RANK/OPG Signaling Pathway with the Development of Osteonecrosis of the Femoral Head in Chinese Population
Yang Song, Zhen-wu Du, Qi-wei Yang, Ming Ren, Qing-yu Wang, Ao Wang, Gao-yang Chen, Hai-yue Zhao, Tao Yu, Gui-zhen Zhang
Int. J. Med. Sci. 2017; 14(7): 690-697. doi:10.7150/ijms.19124
[Abstract] [Full text] [PDF]

Research Paper
Acute Alcohol Intoxication Exacerbates Rhabdomyolysis-Induced Acute Renal Failure in Rats
Jen-Pi Tsai, Chung-Jen Lee, Yi-Maun Subeq, Ru-Ping Lee, Bang-Gee Hsu
Int. J. Med. Sci. 2017; 14(7): 680-689. doi:10.7150/ijms.19479
[Abstract] [Full text] [PDF]

Research Paper
The EMSY Gene Collaborates with CCND1 in Non-Small Cell Lung Carcinogenesis
Onur Baykara, Nejat Dalay, Burak Bakir, Pelin Bulut, Kamil Kaynak, Nur Buyru
Int. J. Med. Sci. 2017; 14(7): 675-679. doi:10.7150/ijms.19355
[Abstract] [Full text] [PDF]

Research Paper
Diagnostic Value of Gadoxetic Acid-Enhanced MR Imaging to Distinguish HCA and Its Subtype from FNH: A Systematic Review
Yongfei Guo, Wenjuan Li, Wenli Cai, Yi Zhang, Yijie Fang, Guobin Hong
Int. J. Med. Sci. 2017; 14(7): 668-674. doi:10.7150/ijms.17865
[Abstract] [Full text] [PDF]

Research Paper
Diagnostic Accuracy of the Neck Tornado Test as a New Screening Test in Cervical Radiculopathy
Juyeon Park, Woo Young Park, Seungbae Hong, Jiwon An, Jae Chul Koh, Youn-Woo Lee, Yong Chan Kim, Jong Bum Choi
Int. J. Med. Sci. 2017; 14(7): 662-667. doi:10.7150/ijms.19110
[Abstract] [Full text] [PDF]

Research Paper
Over-Expression of Alpha-Enolase as a Prognostic Biomarker in Patients with Pancreatic Cancer
Lichao Sun, Chunguang Guo, Jianzhong Cao, Joseph Burnett, Zhihua Yang, Yuliang Ran, Duxin Sun
Int. J. Med. Sci. 2017; 14(7): 655-661. doi:10.7150/ijms.18736
[Abstract] [Full text] [PDF]

Research Paper
Whey Protein Improves Marathon-Induced Injury and Exercise Performance in Elite Track Runners
Wen-Ching Huang, Yung-Cheng Chang, Yi-Ming Chen, Yi-Ju Hsu, Chi-Chang Huang, Nai-Wen Kan, Sheng-Shih Chen
Int. J. Med. Sci. 2017; 14(7): 648-654. doi:10.7150/ijms.19584
[Abstract] [Full text] [PDF]

Review
Characterization of the Asian Phenotype - An Emerging Paradigm with Clinicopathological and Human Research Implications
Melvin Khee-Shing Leow
Int. J. Med. Sci. 2017; 14(7): 639-647. doi:10.7150/ijms.18880
[Abstract] [Full text] [PDF]

Research Paper
Involvement of Ornithine Carbamoyltransferase in the Progression of Chronic Hepatitis C and Liver Cirrhosis
Masahiko Ohnishi, Akihisa Higuchi, Hiroshi Matsumura, Yasuo Arakawa, Hitomi Nakamura, Kazushige Nirei, Toshiki Yamamoto, Hiroaki Yamagami, Masahiro Ogawa, Takuji Gotoda, Shunichi Matsuoka, Noriko Nakajima, Masahiko Sugitani, Mitsuhiko Moriyama, Hiroshi Murayama
Int. J. Med. Sci. 2017; 14(7): 629-638. doi:10.7150/ijms.17641
[Abstract] [Full text] [PDF]

Research Paper
MicroRNA Expression Analysis of Centenarians and Rheumatoid Arthritis Patients Reveals a Common Expression Pattern
Francesca Balzano, Marta Deiana, Silvia Dei Giudici, Annalisa Oggiano, Sara Pasella, Sara Pinna, Andrea Mannu, Nicola Deiana, Baingio Porcu, Antonio G.E. Masala, Piera V. Pileri, Fabrizio Scognamillo, Carlo Pala, Angelo Zinellu, Ciriaco Carru, Luca Deiana
Int. J. Med. Sci. 2017; 14(7): 622-628. doi:10.7150/ijms.18972
[Abstract] [Full text] [PDF]

Research Paper
Systematic Evaluation of Corticosteroid Use in Obese and Non-obese Individuals: A Multi-cohort Study
Mesut Savas, Vincent L. Wester, Sabine M. Staufenbiel, Jan W. Koper, Erica L.T. van den Akker, Jenny A. Visser, Aart J. van der Lely, Brenda W.J.H. Penninx, Elisabeth F.C. van Rossum
Int. J. Med. Sci. 2017; 14(7): 615-621. doi:10.7150/ijms.19213
[Abstract] [Full text] [PDF]

Research Paper
Titanium Dioxide Nanoparticles as Radiosensitisers: An In vitro and Phantom-Based Study
Esho Qasho Youkhana, Bryce Feltis, Anton Blencowe, Moshi Geso
Int. J. Med. Sci. 2017; 14(6): 602-614. doi:10.7150/ijms.19058
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Gastric Juice-Based Real-Time PCR for Tailored Helicobacter Pylori Treatment: A Practical Approach
Xianhui Peng, Zhiqiang Song, Lihua He, Sanren Lin, Yanan Gong, Lu Sun, Fei Zhao, Yixin Gu, Yuanhai You, Liya Zhou, Jianzhong Zhang
Int. J. Med. Sci. 2017; 14(6): 595-601. doi:10.7150/ijms.18996
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
The Application of Dehydroepiandrosterone on Improving Mitochondrial Function and Reducing Apoptosis of Cumulus Cells in Poor Ovarian Responders
Li-Te Lin, Peng-Hui Wang, Zhi-Hong Wen, Chia-Jung Li, San-Nung Chen, Eing-Mei Tsai, Jiin-Tsuey Cheng, Kuan-Hao Tsui
Int. J. Med. Sci. 2017; 14(6): 585-594. doi:10.7150/ijms.18706
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma
Hung-Lung Ke, Wei-Ming Li, Hui-Hui Lin, Wei-Chi Hsu, Ya-Ling Hsu, Lin-Li Chang, Chun-Nung Huang, Ching-Chia Li, Hsin-Ping Chang, Hsin-Chih Yeh, Chien-Feng Li, Wen-Jeng Wu
Int. J. Med. Sci. 2017; 14(6): 578-584. doi:10.7150/ijms.15699
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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