International Journal of Medical Sciences
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7 February 2016

ISSN 1449-1907 News feeds of published articles

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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Research Paper
Role of Serum Biomarkers in Early Detection of Diabetic Cardiomyopathy in the West Virginian Population
Adam Shaver, Alexandra Nichols, Ellen Thompson, Amrita Mallick, Kristen Payne, Chris Jones, Nandini D. P. K. Manne, Shanmuga Sundaram, Joseph I. Shapiro, Komal Sodhi
Int. J. Med. Sci. 2016; 13(3): 161-168. doi:10.7150/ijms.14141
[Abstract] [Full text] [PDF]

Research Paper
Functional Role of FcγRIIB in the Regulation of Mesenchymal Stem Cell Function
Tianyi Zhu, Ruohua Chen, Zeng Li, Jun Tian, Changwen Deng, Xingxing Zhang, Koudong Zhang, Linrong Tong, Yizhi Yu, Chong Bai
Int. J. Med. Sci. 2016; 13(2): 154-160. doi:10.7150/ijms.13649
[Abstract] [Full text] [PDF]

Research Paper
Vitamin D3 Reduces Tissue Damage and Oxidative Stress Caused by Exhaustive Exercise
Chun-Yen Ke, Fwu-Lin Yang, Wen-Tien Wu, Chen-Han Chung, Ru-Ping Lee, Wan-Ting Yang, Yi-Maun Subeq, Kuang-Wen Liao
Int. J. Med. Sci. 2016; 13(2): 147-153. doi:10.7150/ijms.13746
[Abstract] [Full text] [PDF]

Research Paper
Melissa Officinalis L. Extracts Protect Human Retinal Pigment Epithelial Cells against Oxidative Stress-Induced Apoptosis
In Cheul Jeung, Donghyun Jee, Chang-Rae Rho, Seungbum Kang
Int. J. Med. Sci. 2016; 13(2): 139-146. doi:10.7150/ijms.13861
[Abstract] [Full text] [PDF]

Research Paper
The Association between GWAS-identified BARD1 Gene SNPs and Neuroblastoma Susceptibility in a Southern Chinese Population
Ruizhong Zhang, Yan Zou, Jinhong Zhu, Xinhao Zeng, Tianyou Yang, Fenghua Wang, Jing He, Huimin Xia
Int. J. Med. Sci. 2016; 13(2): 133-138. doi:10.7150/ijms.13426
[Abstract] [Full text] [PDF]

Research Paper
Ageing/Menopausal Status in Healthy Women and Ageing in Healthy Men Differently Affect Cardiometabolic Parameters
Ilaria Campesi, Stefano Occhioni, Giancarlo Tonolo, Sara Cherchi, Stefania Basili, Ciriaco Carru, Angelo Zinellu, Flavia Franconi
Int. J. Med. Sci. 2016; 13(2): 124-132. doi:10.7150/ijms.14163
[Abstract] [Full text] [PDF]

Research Paper
Relationship of Genetic Polymorphisms of Aldosterone Synthase Gene Cytochrome P450 11B2 and Mineralocorticoid Receptors with Coronary Artery Disease in Taiwan
Chi-Hung Chou, Kwo-Chang Ueng, Shun-Fa Yang, Chih-Hsien Wu, Po-Hui Wang
Int. J. Med. Sci. 2016; 13(2): 117-123. doi:10.7150/ijms.13862
[Abstract] [Full text] [PDF]

Review
Exosomes Mediate the Intercellular Communication after Myocardial Infarction
Ming-Jie Yuan, Taneen Maghsoudi, Tao Wang
Int. J. Med. Sci. 2016; 13(2): 113-116. doi:10.7150/ijms.14112
[Abstract] [Full text] [PDF]

Research Paper
Impairment of the Peritoneal Surface as a Decisive Factor for Intestinal Adhesions in Intraperitoneal Onlay Mesh Surgery - Introducing a New Rat Model
M Winny, L Grethe, L Maegel, D Jonigk, T Lippmann, J Klempnauer, D Poehnert
Int. J. Med. Sci. 2016; 13(2): 108-112. doi:10.7150/ijms.14056
[Abstract] [Full text] [PDF]

Research Paper
Comorbidity Analysis According to Sex and Age in Hypertension Patients in China
Jiaqi Liu, James Ma, Jiaojiao Wang, Daniel Dajun Zeng, Hongbin Song, Ligui Wang, Zhidong Cao
Int. J. Med. Sci. 2016; 13(2): 99-107. doi:10.7150/ijms.13456
[Abstract] [Full text] [PDF]

Research Paper
Gelsolin and Progression of Aortic Arch Calcification in Chronic Hemodialysis Patients
Terry Ting-Yu Chiou, Shang-Chih Liao, Yu-Yin Kao, Wen-Chin Lee, Yueh-Ting Lee, Hwee-Yeong Ng, Po-Shun Lee, Chien-Te Lee
Int. J. Med. Sci. 2016; 13(2): 92-98. doi:10.7150/ijms.13785
[Abstract] [Full text] [PDF]

Research Paper
Impact of JAK2V617F Mutation Burden on Disease Phenotype in Chinese Patients with JAK2V617F-positive Polycythemia Vera (PV) and Essential thrombocythemia (ET)
Shixiang Zhao, Xiang Zhang, Yang Xu, Yufeng Feng, Wenhong Sheng, Jiannong Cen, Depei Wu, Yue Han
Int. J. Med. Sci. 2016; 13(1): 85-91. doi:10.7150/ijms.10539
[Abstract] [Full text] [PDF]

Research Paper
Identification of microRNAs in Throat Swab as the Biomarkers for Diagnosis of Influenza
Fang Peng, Jianan He, Jacky Fong Chuen Loo, Jingyu Yao, Lei Shi, Chunxiao Liu, Chunzhong Zhao, Weidong Xie, Yonghong Shao, Siu Kai Kong, Dayong Gu
Int. J. Med. Sci. 2016; 13(1): 77-84. doi:10.7150/ijms.13301
[Abstract] [Full text] [PDF]

Research Paper
Effects of Acidification and Alkalinization on the Lipid Emulsion-Mediated Reversal of Toxic Dose Levobupivacaine-Induced Vasodilation in the Isolated Rat Aorta
Seong-Ho Ok, Won Ho Kim, Jongsun Yu, Youngju Lee, Mun-Jeoung Choi, Dong Hoon Lim, Yeran Hwang, Yeon A Kim, Ju-Tae Sohn
Int. J. Med. Sci. 2016; 13(1): 68-76. doi:10.7150/ijms.13016
[Abstract] [Full text] [PDF]

Research Paper
Prevalence and Spectrum of TBX5 Mutation in Patients with Lone Atrial Fibrillation
Zhan-Cheng Wang, Wen-Hui Ji, Chang-Wu Ruan, Xing-Yuan Liu, Xing-Biao Qiu, Fang Yuan, Ruo-Gu Li, Ying-Jia Xu, Xu Liu, Ru-Tai Huang, Song Xue, Yi-Qing Yang
Int. J. Med. Sci. 2016; 13(1): 60-67. doi:10.7150/ijms.13264
[Abstract] [Full text] [PDF]

Research Paper
Inverse Association between Sodium Channel-Blocking Antiepileptic Drug Use and Cancer: Data Mining of Spontaneous Reporting and Claims Databases
Mitsutaka Takada, Mai Fujimoto, Haruka Motomura, Kouichi Hosomi
Int. J. Med. Sci. 2016; 13(1): 48-59. doi:10.7150/ijms.13834
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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