International Journal of Medical Sciences

Impact factor
2.399

26 July 2017

ISSN 1449-1907 News feeds of published articles

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new Impact factor is 2.399 according to 2017 release of Journal Citation Reports®. Congratulations!

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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Research Paper
Identification and Characteristics of Time-Related Shifts in Suicide-Related Event Frequency During Smoking Cessation Treatment with Varenicline
Hayato Akimoto, Haruna Wakiyama, Shinji Oshima, Akio Negishi, Kousuke Ohara, Sachihiko Numajiri, Mitsuyoshi Okita, Shigeru Ohshima, Naoko Inoue, Daisuke Kobayashi
Int. J. Med. Sci. 2017; 14(10): 920-926. doi:10.7150/ijms.19877
[Abstract] [Full text] [PDF]

Research Paper
Gender-dimorphic effects of adipose-derived stromal vascular fractions on HUVECs exposed to oxidative stress
Soyeon Lim, Il-Kwon Kim, Jung-Won Choi, Hyang-Hee Seo, Kyu Hee Lim, Seahyoung Lee, Hoon-Bum Lee, Sang Woo Kim, Ki-Chul Hwang
Int. J. Med. Sci. 2017; 14(9): 911-919. doi:10.7150/ijms.19998
[Abstract] [Full text] [PDF]

Research Paper
Effect of YAP Inhibition on Human Leukemia HL-60 Cells
Min Chen, Jian Wang, Shi-Fei Yao, Yi Zhao, Lu Liu, Lian-Wen Li, Ting Xu, Liu-Gen Gan, Chun-Lan Xiao, Zhi-Ling Shan, Liang Zhong, Bei-Zhong Liu
Int. J. Med. Sci. 2017; 14(9): 902-910. doi:10.7150/ijms.19965
[Abstract] [Full text] [PDF]

Research Paper
Amelioration of estrogen-deficiency-induced obesity by Ocimum gratissimum
Pei-Yu Chao, Tsay-I Chiang, I-Chang Chang, Fang-Ling Tsai, Hsueh-Hui Lee, Kuanghui Hsieh, Yung-Wei Chiu, Te-Jen Lai, Jer-Yuh Liu, Li-Sung Hsu, Yang-Chia Shih
Int. J. Med. Sci. 2017; 14(9): 896-901. doi:10.7150/ijms.19933
[Abstract] [Full text] [PDF]

Research Paper
Expression of epicardial adipose tissue thermogenic genes in patients with reduced and preserved ejection fraction heart failure
Luis M. Pérez-Belmonte, Inmaculada Moreno-Santos, Juan J. Gómez-Doblas, José M. García-Pinilla, Luis Morcillo-Hidalgo, Lourdes Garrido-Sánchez, Concepción Santiago-Fernández, María G. Crespo-Leiro, Fernando Carrasco-Chinchilla, Pedro L. Sánchez-Fernández, Eduardo de Teresa-Galván, Manuel Jiménez-Navarro
Int. J. Med. Sci. 2017; 14(9): 891-895. doi:10.7150/ijms.19854
[Abstract] [Full text] [PDF]

Research Paper
FUT2 genetic variants as predictors of tumor development with hepatocellular carcinoma
Chih Tien Chen, Wen Ying Liao, Chia Chun Hsu, Kuan Chun Hsueh, Shun Fa Yang, Ying Hock Teng, Yung Luen Yu
Int. J. Med. Sci. 2017; 14(9): 885-890. doi:10.7150/ijms.19734
[Abstract] [Full text] [PDF]

Research Paper
Impacts of CCL4 gene polymorphisms on hepatocellular carcinoma susceptibility and development
Bin Wang, Ying-Erh Chou, Ming-Yu Lien, Chen-Ming Su, Shun-Fa Yang, Chih-Hsin Tang
Int. J. Med. Sci. 2017; 14(9): 880-884. doi:10.7150/ijms.19620
[Abstract] [Full text] [PDF]

Research Paper
Combination of Heel-strike like Mechanical Loading with Deproteinized Cancellous Bone Scaffold Implantation to Repair Segmental Bone Defects in Rabbits
Guofeng Huang, Guojun Liu, Feng Zhang, Jianting Gao, Jiangze Wang, Qi Chen, Benwen Wu, Zhenqi Ding, Taoyi Cai
Int. J. Med. Sci. 2017; 14(9): 871-879. doi:10.7150/ijms.19613
[Abstract] [Full text] [PDF]

Research Paper
Rhododendron oldhamii leaf extract improves fatty liver syndrome by increasing lipid oxidation and decreasing the lipogenesis pathway in mice
Ya-Ling Liu, Lei-Chen Lin, Yu-Tang Tung, Shang-Tse Ho, Yao-Li Chen, Chi-Chen Lin, Jyh-Horng Wu
Int. J. Med. Sci. 2017; 14(9): 862-870. doi:10.7150/ijms.19553
[Abstract] [Full text] [PDF]

Research Paper
β2 Adrenoceptors are underexpressed in peripheral blood mononuclear cells and associated with a better metabolic profile in central obesity
Fernanda Leite, Margarida Lima, Franca Marino, Marco Cosentino, Laura Ribeiro
Int. J. Med. Sci. 2017; 14(9): 853-861. doi:10.7150/ijms.19638
[Abstract] [Full text] [PDF]

Research Paper
The Simultaneous Inhibitory Effect of Niclosamide on RANKL-Induced Osteoclast Formation and Osteoblast Differentiation
Fei-Lan Liu, Chun-Liang Chen, Chia-Chung Lee, Cheng-Chi Wu, Teng-Hsu Hsu, Chang-Youh Tsai, Hsu-Shan Huang, Deh-Ming Chang
Int. J. Med. Sci. 2017; 14(9): 840-852. doi:10.7150/ijms.19268
[Abstract] [Full text] [PDF]

Research Paper
Effect of Platelet-Rich Plasma on Ischemia-Reperfusion Injury in a Skin Flap Mouse Model
Dong Kyun Rah, Hyung Jun Min, Yang Woo Kim, Young Woo Cheon
Int. J. Med. Sci. 2017; 14(9): 829-839. doi:10.7150/ijms.19573
[Abstract] [Full text] [PDF]

Research Paper
Cysteine-rich 61 (Cyr61) upregulated in pulmonary arterial hypertension promotes the proliferation of pulmonary artery smooth muscle cells
Lan Gao, Yong Fan, Yanjie Hao, Ping Yuan, Dong Liu, Zhicheng Jing, Zhuoli Zhang
Int. J. Med. Sci. 2017; 14(9): 820-828. doi:10.7150/ijms.19282
[Abstract] [Full text] [PDF]

Research Paper
Urinary UBC Rapid and NMP22 Test for Bladder Cancer Surveillance in Comparison to Urinary Cytology: Results from a Prospective Single-Center Study
Renate Pichler, Gennadi Tulchiner, Josef Fritz, Georg Schaefer, Wolfgang Horninger, Isabel Heidegger
Int. J. Med. Sci. 2017; 14(9): 811-819. doi:10.7150/ijms.19929
[Abstract] [Full text] [PDF]

Research Paper
Compensating effect of minor portal hypertension on the muscle mass loss-related poor prognosis in cirrhosis
Hitoshi Maruyama, Kazufumi Kobayashi, Soichiro Kiyono, Sadahisa Ogasawara, Eichiro Suzuki, Yoshihiko Ooka, Tetsuhiro Chiba, Tadashi Yamaguchi
Int. J. Med. Sci. 2017; 14(9): 804-810. doi:10.7150/ijms.19847
[Abstract] [Full text] [PDF]

Short Research Communication
High Efficiency Low Cost Fibroblast Nucleofection for GMP Compatible Cell-based Gene Therapy
Ziyang Zhang, Alex Slobodianski, Astrid Arnold, Jessica Nehlsen, Ursula Hopfner, Arndt F. Schilling, Tatjana Perisic, Hans-Günther Machens
Int. J. Med. Sci. 2017; 14(9): 798-803. doi:10.7150/ijms.19241
[Abstract] [Full text] [PDF]

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