International Journal of Medical Sciences
Official Impact Factor

24 March 2017

ISSN 1449-1907 News feeds of published articles

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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Research Paper
Recombinant AAV8-mediated intrastriatal gene delivery of CDNF protects rats against methamphetamine neurotoxicity
Lizheng Wang, Zixuan Wang, Xiaoyu Xu, Rui Zhu, Jinpeng Bi, Wenmo Liu, Xinyao Feng, Hui Wu, Haihong Zhang, Jiaxin Wu, Wei Kong, Bin Yu, Xianghui Yu
Int. J. Med. Sci. 2017; 14(4): 340-347. doi:10.7150/ijms.18623
[Abstract] [Full text] [PDF]

Research Paper
GSK-3β as a target for protection against transient cerebral ischemia
Wei Wang, Mingchang Li, Yuefei Wang, Zhongyu Wang, Wei Zhang, Fangxia Guan, Qianxue Chen, Jian Wang
Int. J. Med. Sci. 2017; 14(4): 333-339. doi:10.7150/ijms.17514
[Abstract] [Full text] [PDF]

Research Paper
TBX20 loss-of-function mutation responsible for familial tetralogy of Fallot or sporadic persistent truncus arteriosus
Ri-Tai Huang, Juan Wang, Song Xue, Xing-Biao Qiu, Hong-Yu Shi, Ruo-Gu Li, Xin-Kai Qu, Xiao-Xiao Yang, Hua Liu, Ning Li, Yan-Jie Li, Ying-Jia Xu, Yi-Qing Yang
Int. J. Med. Sci. 2017; 14(4): 323-332. doi:10.7150/ijms.17834
[Abstract] [Full text] [PDF]

Short Research Communication
Parkinson's disease might increase the risk of cerebral ischemic lesions
In-Uk Song, Ji-Eun Lee, Do-Young Kwon, Jeong-Ho Park, Hyeo-Il Ma
Int. J. Med. Sci. 2017; 14(4): 319-322. doi:10.7150/ijms.18025
[Abstract] [Full text] [PDF]

Research Paper
Bladder Reconstruction with Human Amniotic Membrane in a Xenograft Rat Model: A Preclinical Study
Dimitri Barski, Holger Gerullis, Thorsten Ecke, Jin Yang, Gabriella Varga, Mihaly Boros, Isabel Pintelon, Jean-Pierre Timmermans, Thomas Otto
Int. J. Med. Sci. 2017; 14(4): 310-318. doi:10.7150/ijms.18127
[Abstract] [Full text] [PDF]

Research Paper
Presentation of a method at the Exploration Stage according to IDEAL: Percutaneous nephrolithotomy (PCNL) under local infiltrative anesthesia is a feasible and effective method - retrospective analysis of 439 patients
Thorsten H. Ecke, Dimitri Barski, Guido Weingart, Carsten Lange, Steffen Hallmann, Jürgen Ruttloff, Friedhelm Wawroschek, Holger Gerullis
Int. J. Med. Sci. 2017; 14(4): 302-309. doi:10.7150/ijms.17963
[Abstract] [Full text] [PDF]

Research Paper
High quality in vitro expansion of human endothelial progenitor cells of human umbilical vein origin
Yan Mou, Zhen Yue, Haiying Zhang, Xu Shi, Mingrui Zhang, Xiaona Chang, Hang Gao, Ronggui Li, Zonggui Wang
Int. J. Med. Sci. 2017; 14(3): 294-301. doi:10.7150/ijms.18137
[Abstract] [Full text] [PDF]

Research Paper
Upregulation of heat shock protein 70 and the differential protein expression induced by tumor necrosis factor-alpha enhances migration and inhibits apoptosis of hepatocellular carcinoma cell HepG2
Bee-Piao Huang, Chun-Shiang Lin, Chau-Jong Wang, Shao-Hsuan Kao
Int. J. Med. Sci. 2017; 14(3): 284-293. doi:10.7150/ijms.17861
[Abstract] [Full text] [PDF]

Research Paper
Regulation of DMT1 on autophagy and apoptosis in osteoblast
Fei Liu, Wei-Lin Zhang, Hong-Zheng Meng, Zheng-Yu Cai, Mao-Wei Yang
Int. J. Med. Sci. 2017; 14(3): 275-283. doi:10.7150/ijms.17860
[Abstract] [Full text] [PDF]

Research Paper
Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study
Luis M. Pérez-Belmonte, Inmaculada Moreno-Santos, Fernando Cabrera-Bueno, Gemma Sánchez-Espín, Daniel Castellano, Miguel Such, María G Crespo-Leiro, Fernando Carrasco-Chinchilla, Luis Alonso-Pulpón, Miguel López-Garrido, Amalio Ruiz-Salas, Víctor M. Becerra-Muñoz, Juan J. Gómez-Doblas, Eduardo de Teresa-Galván, Manuel Jiménez-Navarro
Int. J. Med. Sci. 2017; 14(3): 268-274. doi:10.7150/ijms.17821
[Abstract] [Full text] [PDF]

Research Paper
Characterization of the serum and liver proteomes in gut-microbiota-lacking mice
Yu-Tang Tung, Ying-Ju Chen, Hsiao-Li Chuang, Wen-Ching Huang, Chun-Tsung Lo, Chen-Chung Liao, Chi-Chang Huang
Int. J. Med. Sci. 2017; 14(3): 257-267. doi:10.7150/ijms.17792
[Abstract] [Full text] [PDF]

Research Paper
Functional analysis of a nonsyndromic hearing loss-associated mutation in the transmembrane II domain of the GJC3 gene
Swee-Hee Wong, Wen-Hung Wang, Pin-Hua Chen, Shuan-Yow Li, Jiann-Jou Yang
Int. J. Med. Sci. 2017; 14(3): 246-256. doi:10.7150/ijms.17785
[Abstract] [Full text] [PDF]

Research Paper
Interrelationship between insulin resistance and portal haemodynamic abnormality in cirrhosis
Hitoshi Maruyama, Kazufumi Kobayashi, Soichiro Kiyono, Osamu Yokosuka
Int. J. Med. Sci. 2017; 14(3): 240-245. doi:10.7150/ijms.17738
[Abstract] [Full text] [PDF]

Research Paper
Proteomics Analysis to Identify and Characterize the Biomarkers and Physical Activities of Non-Frail and Frail Older Adults
Ching-Hung Lin, Chen-Chung Liao, Chi-Huang Huang, Yu-Tang Tung, Huan-Cheng Chang, Mei-Chich Hsu, Chi-Chang Huang
Int. J. Med. Sci. 2017; 14(3): 231-239. doi:10.7150/ijms.17627
[Abstract] [Full text] [PDF]

Research Paper
Neuronal Effects of Sugammadex in combination with Rocuronium or Vecuronium
Martin Aldasoro, Adrian Jorda, Constanza Aldasoro, Patricia Marchio, Sol Guerra-Ojeda, Marc Gimeno-Raga, Mª Dolores Mauricio, Antonio Iradi, Elena Obrador, Jose Mª Vila, Soraya L. Valles
Int. J. Med. Sci. 2017; 14(3): 224-230. doi:10.7150/ijms.17545
[Abstract] [Full text] [PDF]

Research Paper
Changes of articular cartilage and subchondral bone after extracorporeal shockwave therapy in osteoarthritis of the knee
Ching-Jen Wang, Jai-Hong Cheng, Wen-Yi Chou, Shan-Ling Hsu, Jen-Hung Chen, Chien-Yiu Huang
Int. J. Med. Sci. 2017; 14(3): 213-223. doi:10.7150/ijms.17469
[Abstract] [Full text] [PDF]

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