International Journal of Medical Sciences

22 July 2014

ISSN 1449-1907

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International Journal of Biological Sciences

Journal of Cancer

Theranostics

Journal of Genomics

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Editor-in-Chief: Dennis D. Taub, Ph.D.
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Official impact factor is 2.065 (in 2013) and 2.244 (in 2012) according to the Journal Citation Report from Thomson Reuters.
Indexed in MEDLINE, PubMed, EMBASE, CAS/Chemical Abstracts, CAB Abstracts, Scopus, Science Citation Index (SCI) Expanded ....
Full texts of articles appear in PubMed Central, Europe PMC, and PMC Canada.
High visibility of articles over the Internet.
(For NIH-funded researchers) Save time by submitting your paper to us - this journal is in full compliance with NIH Public Access Requirement.
This Journal is ranked very well according to SCImago in the area of Medicine ...details

Top cited papers:

Laxmaiah Manchikanti et al. Evaluation of Lumbar Facet Joint Nerve Blocks in Managing Chronic Low Back Pain: A Randomized, Double-Blind, Controlled Trial with a 2-Year Follow-Up. Cited by 95
DS O'Mahony et al. Differential Constitutive and Cytokine-Modulated Expression of Human Toll-like Receptors in Primary Neutrophils, Monocytes, and Macrophages. Cited by 79
Naomi Brooks et al. Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes. Cited by 146
Chikako Kiyohara1 & Kouichi Yoshimasu. Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis. Cited by 137
SL Chen & TR Morgan. The Natural History of Hepatitis C Virus (HCV) Infection. Cited by 283

Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details

A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details

The promoter is a major element in the expression cassette of gene therapy vectors. Optimal promoter selection can enhance target specificity and gene expression. Recently, we evaluated three different human elongation factor 1 alpha (EF1α) promoters. The three promoters were put into the same expression vector, pAC-luc, driving expression of the luciferase cDNA. The activity from one EF1α promoter (termed EF1α -3), obtained in a commercial vector, was markedly lower when tested in vitro (from 50 - 500 x) in four cell lines and in vivo in rat submandibular glands (~250 x). Sequence differences in the EF1α -3 promoter likely account for the activity differences seen. Investigators need to recognize that all promoters of the same name may not be equivalent in driving transgene expression. ...details

Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details

International Journal of Medical Sciences Cover Page

Research Paper
Thickness of Palatal Masticatory Mucosa and Its Relationship with Different Parameters in Turkish Subjects
Duygu Yaman, Seden Aksu, Rian Dişçi, Korkud Demirel
Int. J. Med. Sci. 2014; 11(10): 1009-1014. doi:10.7150/ijms.9112
[Abstract] [Full text] [PDF]

Research Paper
The Effects of ABCG2 on the Viability, Proliferation and Paracrine Actions of Kidney Side Population Cells under Oxygen-Glucose Deprivation
Hong-Bao Liu, Qiu-Hong Meng, De-Wei Du, Ji-Feng Sun, Jian-Bo Wang, Hua Han
Int. J. Med. Sci. 2014; 11(10): 1001-1008. doi:10.7150/ijms.8705
[Abstract] [Full text] [PDF]

Research Paper
Expression of Histone Deacetylases in Diffuse Large B-cell Lymphoma and Its Clinical Significance
Sung Hak Lee, Changyoung Yoo, Soyoung Im, Ji-Han Jung, Hyun Joo Choi, Jinyoung Yoo
Int. J. Med. Sci. 2014; 11(10): 994-1000. doi:10.7150/ijms.8522
[Abstract] [Full text] [PDF]

Research Paper
Identification of de novo Mutations of Duchénnè/Becker Muscular Dystrophies in Southern Spain
Susana Garcia, Tomás de Haro, Mercedes Zafra-Ceres, Antonio Poyatos, Jose A. Gomez-Capilla, Carolina Gomez-Llorente
Int. J. Med. Sci. 2014; 11(10): 988-993. doi:10.7150/ijms.8391
[Abstract] [Full text] [PDF]

Research Paper
Cell Therapy with Human MSCs Isolated from the Umbilical Cord Wharton Jelly Associated to a PVA Membrane in the Treatment of Chronic Skin Wounds
Jorge Ribeiro, Tiago Pereira, Irina Amorim, Ana Rita Caseiro, Maria A Lopes, Joana Lima, Andrea Gartner, José Domingos Santos, Paulo J Bártolo, Jorge Manuel Rodrigues, Ana Colette Mauricio, Ana Lúcia Luís
Int. J. Med. Sci. 2014; 11(10): 979-987. doi:10.7150/ijms.9139
[Abstract] [Full text] [PDF]

Research Paper
Wnt Signaling as a Possible Promoting Factor of Cell Differentiation in Pleomorphic Adenomas
Yukiko Okuda, Keisuke Nakano, Koji Suzuki, Yoshihiko Sugita, Katsutoshi Kubo, Hatsuhiko Maeda, Norimasa Okafuji, Hiromasa Hasegawa, Toshiyuki Kawakami
Int. J. Med. Sci. 2014; 11(9): 971-978. doi:10.7150/ijms.9453
[Abstract] [Full text] [PDF]

Research Paper
DHRSX, A Novel Non-Classical Secretory Protein Associated With Starvation Induced Autophagy
Guoying Zhang, Yang Luo, Ge Li, Lanlan Wang, Daxiang Na, Xiaotong Wu, Yingmei Zhang, Xiaoning Mo, Lu Wang
Int. J. Med. Sci. 2014; 11(9): 962-970. doi:10.7150/ijms.9529
[Abstract] [Full text] [PDF]

Research Paper
Cyclic Phosphatidic Acid Inhibits Alkyl-Glycerophosphate-Induced Downregulation of Histone Deacetylase 2 Expression and Suppresses the Inflammatory Response in Human Coronary Artery Endothelial Cells
Tamotsu Tsukahara, Hisao Haniu, Yoshikazu Matsuda
Int. J. Med. Sci. 2014; 11(9): 955-961. doi:10.7150/ijms.9316
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Short Research Communication
Lycopene Treatment of Prostate Cancer Cell Lines Inhibits Adhesion and Migration Properties of the Cells
Simone Elgass, Alan Cooper, Mridula Chopra
Int. J. Med. Sci. 2014; 11(9): 948-954. doi:10.7150/ijms.9137
[Abstract] [Full text] [PDF]

Research Paper
Potential Dual Immunomodulatory Role of VEGF in Ulcerative Colitis and Colorectal Carcinoma
Natasa D Zdravkovic, Ivan P Jovanovic, Gordana D Radosavljevic, Aleksandar N Arsenijevic, Nebojsa D Zdravkovic, Slobodanka Lj Mitrovic, Nebojsa N Arsenijevic
Int. J. Med. Sci. 2014; 11(9): 936-947. doi:10.7150/ijms.8277
[Abstract] [Full text] [PDF]

Review
Alanine Aminotransferase-Old Biomarker and New Concept: A Review
Zhengtao Liu, Shuping Que, Jing Xu, Tao Peng
Int. J. Med. Sci. 2014; 11(9): 925-935. doi:10.7150/ijms.8951
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Renal Transplantation: Relationship between Hospital/Surgeon Volume and Postoperative Severe Sepsis/Graft-Failure. A Nationwide Population-Based Study
Shih-Feng Weng, Chin-Chen Chu, Chih-Chiang Chien, Jhi-Joung Wang, Yi-Chen Chen, Shang-Jyh Chiou
Int. J. Med. Sci. 2014; 11(9): 918-924. doi:10.7150/ijms.8850
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
The Basic Social Medical Insurance Is Associated with Clinical Outcomes in the Patients with ST-elevation Myocardial Infarction: A Retrospective Study from Shanghai, China
Baoxin Liu, Han Yan, Rong Guo, Xueyuan Liu, Xiankai Li, Yawei Xu
Int. J. Med. Sci. 2014; 11(9): 905-917. doi:10.7150/ijms.8877
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Comparison of the Antialbuminuric Effects of Benidipine and Hydrochlorothiazide in Renin-Angiotensin System (RAS) Inhibitor-Treated Hypertensive Patients with Albuminuria: the COSMO-CKD (COmbination Strategy on Renal Function of Benidipine or Diuretics TreatMent with RAS inhibitOrs in a Chronic Kidney Disease Hypertensive Population) Study
Katsuyuki Ando, Kosaku Nitta, Hiromi Rakugi, Yoshiki Nishizawa, Hitoshi Yokoyama, Takeshi Nakanishi, Naoki Kashihara, Kimio Tomita, Masaomi Nangaku, Katsutoshi Takahashi, Masashi Isshiki, Tatsuo Shimosawa, Toshiro Fujita
Int. J. Med. Sci. 2014; 11(9): 897-904. doi:10.7150/ijms.9026
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Comparison of Iodine-125 Seed Implantation and Pancreaticoduodenectomy in the Treatment of Pancreatic Cancer
Kai Liu, Bai Ji, Wei Zhang, Songyang Liu, Yingchao Wang, Yahui Liu
Int. J. Med. Sci. 2014; 11(9): 893-896. doi:10.7150/ijms.8948
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Gestational Hypoxia Up-regulates Protein Kinase C and Inhibits Calcium-Activated Potassium Channels in Ovine Uterine Arteries
Daliao Xiao, Ronghui Zhu, Lubo Zhang
Int. J. Med. Sci. 2014; 11(9): 886-892. doi:10.7150/ijms.9338
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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