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Research Paper
Anti-Tumor Activity and Pharmacokinetics of AP25-Fc Fusion Protein
Dening Pei, Jialiang Hu, Chunming Rao, Pengcheng Yu, Hanmei Xu, Junzhi Wang
Int. J. Med. Sci. 2019; 16(7): 1032-1041. doi:10.7150/ijms.34365
[Abstract] [Full text] [PDF]

Research Paper
Treatment Strategies and Prognostic Factors of Primary Gastric Diffuse Large B Cell Lymphoma: A Retrospective Multicenter Study of 272 Cases from the China Lymphoma Patient Registry
Haiyan Yang, Meng Wu, Ye Shen, Tao Lei, Lan Mi, Xin Leng, Lingyan Ping, Yan Xie, Yuqin Song, Xinan Cen, Jun Zhu
Int. J. Med. Sci. 2019; 16(7): 1023-1031. doi:10.7150/ijms.34175
[Abstract] [Full text] [PDF]

Research Paper
Torsades de pointes and QT prolongation Associations with Antibiotics: A Pharmacovigilance Study of the FDA Adverse Event Reporting System
Chengwen Teng, Elizabeth A. Walter, Daryl Kevin S. Gaspar, Obiageri O. Obodozie-Ofoegbu, Christopher R. Frei
Int. J. Med. Sci. 2019; 16(7): 1018-1022. doi:10.7150/ijms.34141
[Abstract] [Full text] [PDF]

Research Paper
Synthesis and Evaluation of BMMSC-seeded BMP-6/nHAG/GMS Scaffolds for Bone Regeneration
Xuewen Li, Ran Zhang, Xuexin Tan, Bo Li, Yao Liu, Xukai Wang
Int. J. Med. Sci. 2019; 16(7): 1007-1017. doi:10.7150/ijms.31966
[Abstract] [Full text] [PDF]

Research Paper
MiR-539-5p negatively regulates migration of rMSCs induced by Bushen Huoxue decoction through targeting Wnt5a
Liuchao Hu, Yamei Liu, Bin Wang, Zhifang Wu, Yingxiong Chen, Lijuan Yu, Junlang Zhu, Wei Shen, Chen Chen, Dongfeng Chen, Gang Li, Liangliang Xu, Yiwen Luo
Int. J. Med. Sci. 2019; 16(7): 998-1006. doi:10.7150/ijms.33437
[Abstract] [Full text] [PDF]

Research Paper
Locus 5p13.1 may be associated with the selection of cancer-related HBV core promoter mutations
Qin-Yan Chen, Yan-Ling Hu, Xue-Yan Wang, Tim J. Harrison, Chao Wang, Li-Ping Hu, Qing-Li Yang, Chuang-Chuang Ren, Hui-Hua Jia, and Zhong-Liao Fang
Int. J. Med. Sci. 2019; 16(7): 990-997. doi:10.7150/ijms.34297
[Abstract] [Full text] [PDF]

Review
Molecular heterogeneity in lung cancer: from mechanisms of origin to clinical implications
Federica Zito Marino, Roberto Bianco, Marina Accardo, Andrea Ronchi, Immacolata Cozzolino, Floriana Morgillo, Giulio Rossi, Renato Franco
Int. J. Med. Sci. 2019; 16(7): 981-989. doi:10.7150/ijms.34739
[Abstract] [Full text] [PDF]

Review
Management of Chronic Respiratory Failure in Interstitial Lung Diseases: Overview and Clinical Insights
Paola Faverio, Federica De Giacomi, Giulia Bonaiti, Anna Stainer, Luca Sardella, Giulia Pellegrino, Giuseppe Francesco Sferrazza Papa, Francesco Bini, Bruno Dino Bodini, Mauro Carone, Sara Annoni, Grazia Messinesi, Alberto Pesci
Int. J. Med. Sci. 2019; 16(7): 967-980. doi:10.7150/ijms.32752
[Abstract] [Full text] [PDF]

Research Paper
Metformin Inhibits Epithelial-to-Mesenchymal Transition of Keloid Fibroblasts via the HIF-1α/PKM2 Signaling Pathway
Rui Lei, Shizhen Zhang, Yuming Wang, Siya Dai, Jiaqi Sun, Chaoqun Zhu
Int. J. Med. Sci. 2019; 16(7): 960-966. doi:10.7150/ijms.32157
[Abstract] [Full text] [PDF]

Research Paper
Ensemble Feature Learning to Identify Risk Factors for Predicting Secondary Cancer
Xiucai Ye, Hongmin Li, Tetsuya Sakurai, Pei-Wei Shueng
Int. J. Med. Sci. 2019; 16(7): 949-959. doi:10.7150/ijms.33820
[Abstract] [Full text] [PDF]

Research Paper
Assessment of abdominal aortic calcification by computed tomography for prediction of latent left ventricular stiffness and future cardiovascular risk in pre-dialysis patients with chronic kidney disease: A single center cross-sectional study
Kenji Furusawa, Kyosuke Takeshita, Susumu Suzuki, Yosuke Tatami, Ryota Morimoto, Takahiro Okumura, Yoshinari Yasuda, Toyoaki Murohara
Int. J. Med. Sci. 2019; 16(7): 939-948. doi:10.7150/ijms.32629
[Abstract] [Full text] [PDF]

Research Paper
First-line Screening of OXPHOS Deficiencies Using Microscale Oxygraphy in Human Skin Fibroblasts: A Preliminary Study
Nicolas Germain, Anne-Frédérique Dessein, Jean-Claude Vienne, Dries Dobbelaere, Karine Mention, Marie Joncquel, Salim Dekiouk, William Laine, Jérome Kluza, Philippe Marchetti
Int. J. Med. Sci. 2019; 16(7): 931-938. doi:10.7150/ijms.32413
[Abstract] [Full text] [PDF]

Research Paper
The molecular landscape of histone lysine methyltransferases and demethylases in non-small cell lung cancer
Jiaping Li, Xinlu Tao, Jing Shen, Linling Liu, Qijie Zhao, Yongshun Ma, Zheng Tao, Yan Zhang, Boying Ding, Zhangang Xiao
Int. J. Med. Sci. 2019; 16(7): 922-930. doi:10.7150/ijms.34322
[Abstract] [Full text] [PDF]

Research Paper
Possible association of arrestin domain-containing protein 3 and progression of non-alcoholic fatty liver disease
Masahiro Ogawa, Tatsuo Kanda, Teruhisa Higuchi, Hiroshi Takahashi, Tomohiro Kaneko, Naoki Matsumoto, Kazushige Nirei, Hiroaki Yamagami, Shunichi Matsuoka, Kazumichi Kuroda, Mitsuhiko Moriyama
Int. J. Med. Sci. 2019; 16(7): 909-921. doi:10.7150/ijms.34245
[Abstract] [Full text] [PDF]

Review
NONRATT021972 long-noncoding RNA: A promising lncRNA in diabetes-related diseases
Abhishek Suwal, Ji-long Hao, Xiu-fen Liu, Dan-dan Zhou, Om Prakash Pant, Ying Gao, Peng Hui, Xin-xuan Dai, Cheng-wei Lu
Int. J. Med. Sci. 2019; 16(6): 902-908. doi:10.7150/ijms.34200
[Abstract] [Full text] [PDF]

Research Paper
Differential Response of Non-cancerous and Malignant Breast Cancer Cells to Conditioned Medium of Adipose tissue-derived Stromal Cells (ASCs)
Yi-Chia Wu, Wei-Ting Wang, Li-Ju Huang, Ruo-You Cheng, Yur-Ren Kuo, Ming-Feng Hou, Chung-Sheng Lai, John Yu
Int. J. Med. Sci. 2019; 16(6): 893-901. doi:10.7150/ijms.27125
[Abstract] [Full text] [PDF]

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Top cited papers:

Plasma viral load was positively correlated with VWF adhesive activity, which was elevated in acute relative to chronic treated HIV-1 infection. ADAMTS13 antigen and activity were both positively correlated with plasma viral load, and ADAMTS13 activity was significantly higher in men with acute HIV infection than in uninfected controls, and in both acute and chronic untreated HIV infection relative to chronic treated infection.

Conclusion: These findings suggest that even in the setting of increased ADAMTS13 protease activity, VWF in HIV-1 infection is hyperadhesive, which may favor development of microvascular and arterial thromboses and thereby contribute to increased cardiovascular risk in HIV-1-infected individuals.

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Colorectal cancer (CRC) is one of leading causes of mortality in western countries and novel treatment strategies are required. The medicinal application of mushrooms has been used in traditional medicine in many oriental countries. Polysaccharide-rich extracts obtained from certain medicinal mushroom species have shown antitumor effects in different experimental models. In the present study, we have developed polysaccharide-rich extracts from Trametes versicolor (TV) and Grifola frondosa (GF) fruit bodies. We aim to evaluate the anticancer effects of these polysaccharide-rich extracts in LoVo and HT-29 human colon cancer cells. The in vitro effects were determined by cytotoxicity assay, proliferation assay, wound healing assay and invasion assay. Moreover, the effect on anchorage independent-cell growth was also determined. Our results showed that TV and GF extracts did inhibit human colon cell proliferation and induce cytotoxicity.. ...details