International Journal of Medical Sciences

Impact factor
2.399

19 November 2017

ISSN 1449-1907 News feeds of published articles

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Impact factor is 2.399 according to 2017 release of Journal Citation Reports®.

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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Research Paper
ZW800-1 for Assessment of Blood-Brain Barrier Disruption in a Photothrombotic Stroke Model
Sungsu Lee, Wonbong Lim, Hye-Won Ryu, Danbi Jo, Jung-Joon Min, Hyung-Seok Kim, Hoon Hyun
Int. J. Med. Sci. 2017; 14(13): 1430-1435. doi:10.7150/ijms.22294
[Abstract] [Full text] [PDF]

Research Paper
Stem Cells from Cryopreserved Human Dental Pulp Tissues Sequentially Differentiate into Definitive Endoderm and Hepatocyte-Like Cells in vitro
Young-Jin Han, Young-Hoon Kang, Sarath Belame Shivakumar, Dinesh Bharti, Young-Bum Son, Yong-Ho Choi, Won-Uk Park, June-Ho Byun, Gyu-Jin Rho, Bong-Wook Park
Int. J. Med. Sci. 2017; 14(13): 1418-1429. doi:10.7150/ijms.22152
[Abstract] [Full text] [PDF]

Research Paper
Evaluating the Prognostic Value of ERCC1 and Thymidylate Synthase Expression and the Epidermal Growth Factor Receptor Mutation Status in Adenocarcinoma Non-Small-Cell Lung Cancer
Chang-Sheng Lin, Tu-Chen Liu, Ji-Ching Lai, Shun-Fa Yang, Thomas Chang-Yao Tsao
Int. J. Med. Sci. 2017; 14(13): 1410-1417. doi:10.7150/ijms.21938
[Abstract] [Full text] [PDF]

Research Paper
Reprogramming Factors Remodel Melanoma Cell Phenotype by Changing Stat3 Expression
Yang Wang, Yan Mou, Haiying Zhang, Xiaomei Wang, Ronggui Li, Zhiqiang Cheng, Xinrui Liu
Int. J. Med. Sci. 2017; 14(13): 1402-1409. doi:10.7150/ijms.21952
[Abstract] [Full text] [PDF]

Research Paper
Effects of Osteogenic-Conditioned Medium from Human Periosteum-Derived Cells on Osteoclast Differentiation
Hyun-Chang Park, Young-Bum Son, Sung-Lim Lee, Gyu-Jin Rho, Young-Hoon Kang, Bong-Wook Park, Sung-Hoon Byun, Sun-Chul Hwang, In-Ae Cho, Yeong-Cheol Cho, Iel-Yong Sung, Dong Kyun Woo, June-Ho Byun
Int. J. Med. Sci. 2017; 14(13): 1389-1401. doi:10.7150/ijms.21894
[Abstract] [Full text] [PDF]

Research Paper
Prognostic significance of high-mobility group box protein 1 genetic polymorphisms in rheumatoid arthritis disease outcome
Li-Hong Wang, Min-Huan Wu, Po-Chun Chen, Chen-Ming Su, Guohong Xu, Chien-Chung Huang, Chun-Hao Tsai, Yuan-Li Huang, Chih-Hsin Tang
Int. J. Med. Sci. 2017; 14(13): 1382-1388. doi:10.7150/ijms.21773
[Abstract] [Full text] [PDF]

Research Paper
The Clinical Usefulness of Measurement of Visceral Fat Area Using Multi-Frequency Bioimpedance: The Association with Cardiac and Renal Function In General Population with Relatively Normal Renal Function
Hye Eun Yoon, Sang Su Choi, Yaeni Kim, Seok Joon Shin
Int. J. Med. Sci. 2017; 14(13): 1375-1381. doi:10.7150/ijms.21393
[Abstract] [Full text] [PDF]

Research Paper
Isolation and determination of four potential antimicrobial components from Pseudomonas aeruginosa extracts
Ling-Qing Xu, Jian-Wen Zeng, Chong-He Jiang, Huan Wang, Yu-Zhen Li, Wei-Hong Wen, Jie-Hua Li, Feng Wang, Wei-Jen Ting, Zi-Yong Sun, Chih-Yang Huang
Int. J. Med. Sci. 2017; 14(13): 1368-1374. doi:10.7150/ijms.18896
[Abstract] [Full text] [PDF]

Research Paper
Over-expression of Activated Signal Transducer and Activator of Transcription 3 Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma
Wei-Ming Li, Chun-Nung Huang, Yi-Chen Lee, Szu-Han Chen, Hui-Hui Lin, Wen-Jeng Wu, Ching-Chia Li, Hsin-Chih Yeh, Lin-Li Chang, Wei-Chi Hsu, Hung-Lung Ke
Int. J. Med. Sci. 2017; 14(13): 1360-1367. doi:10.7150/ijms.17367
[Abstract] [Full text] [PDF]

Review
Peptides as Therapeutic Agents for Dengue Virus
Miaw-Fang Chew, Keat-Seong Poh, Chit-Laa Poh
Int. J. Med. Sci. 2017; 14(13): 1342-1359. doi:10.7150/ijms.21875
[Abstract] [Full text] [PDF]

Research Paper
HSPB8 Promotes the Fusion of Autophagosome and Lysosome during Autophagy in Diabetic Neurons
Xiao-Cheng Li, Qi-Kuan Hu, Ling Chen, Si-yang Liu, Shi Su, Hong Tao, Lin-Na Zhang, Tao Sun, Lan-Jie He
Int. J. Med. Sci. 2017; 14(13): 1335-1341. doi:10.7150/ijms.20653
[Abstract] [Full text] [PDF]

Research Paper
Combined Hemorrhagic Shock and Unilateral Common Carotid Occlusion Induces Neurological Injury in Adult Male Rats
Chung-Ching Chio, Chien-Chin Hsu, Yu-Feng Tian, Chung-Han Wang, Mao-Tsun Lin, Ching-Ping Chang, Hung-Jung Lin
Int. J. Med. Sci. 2017; 14(13): 1327-1334. doi:10.7150/ijms.21022
[Abstract] [Full text] [PDF]

Research Paper
Ulcer Prevention Effect Of 3,4,5-Tihydroxy-N0-[(2-Methyl-1H-Indol-3yl)Methylidene]Benzohydrazide In HCl/Ethanol-Induced Gastric Mucosal Damage In Rats
Faezeh Tayeby, Abbas Abdul Ameer Salman, Sareh Kamran, Si Lay Khaing, Nur'ain Binti Salehen, Gokula Mohan A/L Duchiyanda Mohan
Int. J. Med. Sci. 2017; 14(13): 1317-1326. doi:10.7150/ijms.20984
[Abstract] [Full text] [PDF]

Research Paper
Cost Utility Analysis of Cervical Therapeutic Medial Branch Blocks in Managing Chronic Neck Pain
Laxmaiah Manchikanti, Vidyasagar Pampati, Alan D. Kaye, Joshua A. Hirsch
Int. J. Med. Sci. 2017; 14(13): 1307-1316. doi:10.7150/ijms.20755
[Abstract] [Full text] [PDF]

Research Paper
Cancer Stem Cell Gene Variants Predict Disease Recurrence in Patients Treated with Radical Prostatectomy for Prostate Cancer
Victor C. Lin, Shu-Pin Huang, Chao-Yuan Huang, Chia-Cheng Yu, Hsin-Ling Yin, Tsung-Yi Huang, Cheng-Hsueh Lee, Te-Ling Lu, Bo-Ying Bao
Int. J. Med. Sci. 2017; 14(12): 1301-1306. doi:10.7150/ijms.21428
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
IER5 is involved in DNA Double-Strand Breaks Repair in Association with PAPR1 in Hela Cells
Xin-Ping Yu, Yu-Mei Wu, Yang Liu, Ming Tian, Jian-Dong Wang, Ku-Ke Ding, Teng Ma, Ping-Kun Zhou
Int. J. Med. Sci. 2017; 14(12): 1292-1300. doi:10.7150/ijms.21510
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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