International Journal of Medical Sciences

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21 February 2018

ISSN 1449-1907 News feeds of published articles

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Impact factor is 2.399 according to 2017 release of Journal Citation Reports®.

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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DJ-1 in Ocular Diseases: A Review
Cong Liu, Xiufen Liu, Jing Qi, Om Prakash Pant, Cheng-wei Lu, Jilong Hao
Int. J. Med. Sci. 2018; 15(5): 430-435. doi:10.7150/ijms.23428
[Abstract] [Full text] [PDF]

Research Paper
Vascular Hyperpermeability Response in Animals Systemically Exposed to Arsenic
Shih-Chieh Chen, Chao-Yuah Chang, Ming-Lu Lin
Int. J. Med. Sci. 2018; 15(5): 425-429. doi:10.7150/ijms.23480
[Abstract] [Full text] [PDF]

Research Paper
Nutrients restriction upregulates adiponectin in epicardial or subcutaneous adipose tissue: impact in de novo heart failure patients
Rosa M Agra, Ángel Fernández-Trasancos, Esther Díaz-Rodríguez, Alberto Cordero, Alfonso Varela-Román, Inés Gómez-Otero, J Nicolás López- Canoa, Ángel Luis Fernández, José Manuel Martínez-Cereijo, José Ramón González-Juanatey, Sonia Eiras
Int. J. Med. Sci. 2018; 15(5): 417-424. doi:10.7150/ijms.22854
[Abstract] [Full text] [PDF]

Research Paper
Differences in C-type lectin receptors and their adaptor molecules in the peritoneal fluid of patients with endometriosis and gynecologic cancers
Seung Geun Yeo, Yong Sung Won, Sang Hoon Kim, Dong Choon Park
Int. J. Med. Sci. 2018; 15(4): 411-416. doi:10.7150/ijms.23360
[Abstract] [Full text] [PDF]

Cardiovascular Adaptations Induced by Resistance Training in Animal Models
S.F.S. Melo, N.D. Silva Júnior, V.G. Baraúna, E.M. Oliveira
Int. J. Med. Sci. 2018; 15(4): 403-410. doi:10.7150/ijms.23150
[Abstract] [Full text] [PDF]

Research Paper
Distribution of Cytotoxic T Lymphocyte-Associated Antigen-4 Promoter Polymorphisms in Taiwanese Patients with Type 2 Diabetes Mellitus
Yung-Luen Shih, Hsu-Feng Lu, Chiao-Wan Hsiao, Kuo-Ting Ho, Pei-Chi Chen, Chien-Ning Huang, Yuanmay Chang, Shang-Jyh Kao, Ming-Yuh Shiau, Yih-Hsin Chang
Int. J. Med. Sci. 2018; 15(4): 395-402. doi:10.7150/ijms.23097
[Abstract] [Full text] [PDF]

Research Paper
Transgenic Expression of A Venous Malformation Related Mutation, TIE2-R849W, Significantly Induces Multiple Malformations of Zebrafish
Zhong Du, Hai-Long Ma, Zhi-Yuan Zhang, Jia-Wei Zheng, Yan-An Wang
Int. J. Med. Sci. 2018; 15(4): 385-394. doi:10.7150/ijms.23054
[Abstract] [Full text] [PDF]

Research Paper
SERPINB5 Expression: Association with CCRT Response and Prognostic Value in Rectal Cancer
I-Wei Chang, Kai-Wen Liu, Marlon Ragunanan, Hong-Lin He, Yow-Ling Shiue, Shou-Chun Yu
Int. J. Med. Sci. 2018; 15(4): 376-384. doi:10.7150/ijms.22823
[Abstract] [Full text] [PDF]

Clinical importance of the anterior choroidal artery: a review of the literature
Jing Yu, Ning Xu, Ying Zhao, Jinlu Yu
Int. J. Med. Sci. 2018; 15(4): 368-375. doi:10.7150/ijms.22631
[Abstract] [Full text] [PDF]

Research Paper
Bisphosphonate Modulation of the Gene Expression of Different Markers Involved in Osteoblast Physiology: Possible Implications in Bisphosphonate-Related Osteonecrosis of the Jaw
Francisco Javier Manzano-Moreno, Javier Ramos-Torrecillas, Lucia Melguizo-Rodríguez, Rebeca Illescas-Montes, Concepción Ruiz, Olga García-Martínez
Int. J. Med. Sci. 2018; 15(4): 359-367. doi:10.7150/ijms.22627
[Abstract] [Full text] [PDF]

Research Paper
Receptor for activated C kinase 1 in rats with ischemia-reperfusion injury: intravenous versus inhalation anaesthetic agents
Eun-Hye Seo, Ga-Yun Song, Ji Hyeon Namgung, Chung-Sik Oh, Seung Hyun Lee, Seong-Hyop Kim
Int. J. Med. Sci. 2018; 15(4): 352-358. doi:10.7150/ijms.22591
[Abstract] [Full text] [PDF]

Research Paper
Claudin-3 Inhibits Lung Squamous Cell Carcinoma Cell Epithelial-mesenchymal Transition and Invasion via Suppression of the Wnt/β-catenin Signaling Pathway
Juanjuan Che, Dongsheng Yue, Bin Zhang, Hua Zhang, Yansong Huo, Liuwei Gao, Hongchao Zhen, Yan Yang, Bangwei Cao
Int. J. Med. Sci. 2018; 15(4): 339-351. doi:10.7150/ijms.22927
[Abstract] [Full text] [PDF]

Research Paper
Bone Turnover Status: Classification Model and Clinical Implications
Alexander Fisher, Leon Fisher, Wichat Srikusalanukul, Paul N Smith
Int. J. Med. Sci. 2018; 15(4): 323-338. doi:10.7150/ijms.22747
[Abstract] [Full text] [PDF]

While it is not deliberate, much of today's biomedical research contains logical and technical flaws, showing a need for corrective action
Yan He, Chengfu Yuan, Lichan Chen, Yanjie Liu, Haiyan Zhou, Ningzhi Xu, Dezhong Joshua Liao
Int. J. Med. Sci. 2018; 15(4): 309-322. doi:10.7150/ijms.23215
[Abstract] [Full text] [PDF]

Research Paper
Establishing an Animal Model of Secondary Osteoporosis by Using a Gonadotropin-releasing Hormone Agonist
Nur-Vaizura Mohamad, Muhammad Afiq Amani Che Zulkepli, Krystine May Theseira, Norain Zulkifli, Nur Quraisha Shahrom, Nurul Amni Mohamad Ridzuan, Nor Aini Jamil, Ima-Nirwana Soelaiman, Kok-Yong Chin
Int. J. Med. Sci. 2018; 15(4): 300-308. doi:10.7150/ijms.22732
[Abstract] [Full text] [PDF]

Research Paper
SCAPs Regulate Differentiation of DFSCs During Tooth Root Development in Swine
Xiaoshan Wu, Lei Hu, Yan Li, Yang Li, Fu Wang, Ping Ma, Jinsong Wang, Chunmei Zhang, Canhua Jiang, Songlin Wang
Int. J. Med. Sci. 2018; 15(4): 291-299. doi:10.7150/ijms.22495
[Abstract] [Full text] [PDF]

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