International Journal of Medical Sciences

30 January 2015

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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Research Paper
Association between Statin Use and Cancer: Data Mining of a Spontaneous Reporting Database and a Claims Database
Mai Fujimoto, Tomoya Higuchi, Kouichi Hosomi, Mitsutaka Takada
Int. J. Med. Sci. 2015; 12(3): 223-233. doi:10.7150/ijms.10656
[Abstract] [Full text] [PDF]

Research Paper
Analysis of Efficacy Differences between Caudal and Lumbar Interlaminar Epidural Injections in Chronic Lumbar Axial Discogenic Pain: Local Anesthetic Alone vs. Local Combined with Steroids
Laxmaiah Manchikanti, Vidyasagar Pampati, Ramsin M. Benyamin, Mark V. Boswell
Int. J. Med. Sci. 2015; 12(3): 214-222. doi:10.7150/ijms.10870
[Abstract] [Full text] [PDF]

Review
New Developments in the Pathogenesis and Therapeutic Targeting of the IDH1 Mutation in Glioma
Lilia Dimitrov, Christopher S. Hong, Chunzhang Yang, Zhengping Zhuang, John D. Heiss
Int. J. Med. Sci. 2015; 12(3): 201-213. doi:10.7150/ijms.11047
[Abstract] [Full text] [PDF]

Review
Nanoparticle-Based Targeted Therapeutics in Head-And-Neck Cancer
Ting-Ting Wu, Shui-Hong Zhou
Int. J. Med. Sci. 2015; 12(2): 187-200. doi:10.7150/ijms.10083
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
High Producing Tumor Necrosis Factor Alpha Gene Alleles in Protection against Severe Manifestations of Dengue
Sing-Sin Sam, Boon-Teong Teoh, Karuthan Chinna, Sazaly AbuBakar
Int. J. Med. Sci. 2015; 12(2): 177-186. doi:10.7150/ijms.8988
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Identification of Novel Compounds against an R294K Substitution of Influenza A (H7N9) Virus Using Ensemble Based Drug Virtual Screening
Nhut Tran, Thanh Van, Hieu Nguyen, Ly Le
Int. J. Med. Sci. 2015; 12(2): 163-176. doi:10.7150/ijms.10826
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
New Adipose Tissue Formation by Human Adipose-Derived Stem Cells with Hyaluronic Acid Gel in Immunodeficient Mice
Shu-Hung Huang, Yun-Nan Lin, Su-Shin Lee, Chee-Yin Chai, Hsueh-Wei Chang, Tsai-Ming Lin, Chung-Sheng Lai, Sin-Daw Lin
Int. J. Med. Sci. 2015; 12(2): 154-162. doi:10.7150/ijms.9964
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Utility of Kynurenic Acid for Non-Invasive Detection of Metastatic Spread to Lymph Nodes in Non-Small Cell Lung Cancer
Dariusz Sagan, Tomasz Kocki, Samir Patel, Janusz Kocki
Int. J. Med. Sci. 2015; 12(2): 146-153. doi:10.7150/ijms.7541
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Malignant Lymphomas in the Head and Neck Region - a Retrospective, Single-Center Study over 41 Years
Christian Walter, Thomas Ziebart, Keyvan Sagheb, Roman Kia Rahimi-Nedjat, Asina Manz, Georg Hess
Int. J. Med. Sci. 2015; 12(2): 141-145. doi:10.7150/ijms.10483
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Antipsychotics-Associated Serious Adverse Events in Children: An Analysis of the FAERS Database
Goji Kimura, Kaori Kadoyama, J.B. Brown, Tsutomu Nakamura, Ikuya Miki, Kohshi Nisiguchi, Toshiyuki Sakaeda, Yasushi Okuno
Int. J. Med. Sci. 2015; 12(2): 135-140. doi:10.7150/ijms.10453
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Single Nucleotide Polymorphism in Ag85 Genes of Mycobacterium Tuberculosis Complex: Analysis of 178 Clinical Isolates from China and 13 BCG strains
Yi Jiang, Haican Liu, Machao Li, Guilian Li, Hui Pang, Xiangfeng Dou, Xiuqin Zhao, Kanglin Wan
Int. J. Med. Sci. 2015; 12(2): 126-134. doi:10.7150/ijms.9951
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Effect of the Hand Antiseptic Agents Benzalkonium Chloride, Povidone-Iodine, Ethanol, and Chlorhexidine Gluconate on Atopic Dermatitis in NC/Nga Mice
Kaori Sadakane, Takamichi Ichinose
Int. J. Med. Sci. 2015; 12(2): 116-125. doi:10.7150/ijms.10322
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Liver Function Parameters in Hip Fracture Patients: Relations to Age, Adipokines, Comorbidities and Outcomes
Leon Fisher, Wichat Srikusalanukul, Alexander Fisher, Paul Smith
Int. J. Med. Sci. 2015; 12(2): 100-115. doi:10.7150/ijms.10696
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Syndecan-1 Expression Is Associated with Tumor Size and EGFR Expression in Colorectal Carcinoma: A Clinicopathological Study of 230 Cases
Su Young Kim, Eun Ji Choi, Jeong A Yun, Eun Sun Jung, Seung Taek Oh, Jun Gi Kim, Won Kyung Kang, Sung Hak Lee
Int. J. Med. Sci. 2015; 12(2): 92-99. doi:10.7150/ijms.10497
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Nerve Growth Factor Protects the Ischemic Heart via Attenuation of the Endoplasmic Reticulum Stress Induced Apoptosis by Activation of Phosphatidylinositol 3-Kinase
Ke Wei, Li Liu, Fei Xie, Xuechao Hao, Jie Luo, Su Min
Int. J. Med. Sci. 2015; 12(1): 83-91. doi:10.7150/ijms.10101
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Combination Analysis in Genetic Polymorphisms of Drug-Metabolizing Enzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A5 in the Japanese Population
Tomoko Ota, Yuka Kamada, Mariko Hayashida, Kyoko Iwao-Koizumi, Shigenori Murata, Kenji Kinoshita
Int. J. Med. Sci. 2015; 12(1): 78-82. doi:10.7150/ijms.10263
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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