International Journal of Medical Sciences

23 November 2014

ISSN 1449-1907 News feeds of published articles

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details

International Journal of Medical Sciences Cover Page

Research Paper
Berberine Inhibits the Metastatic Ability of Prostate Cancer Cells by Suppressing Epithelial-to-Mesenchymal Transition (EMT)-Associated Genes with Predictive and Prognostic Relevance
Chia-Hung Liu, Wan-Chun Tang, Peik Sia, Chi-Chen Huang, Pei-Ming Yang, Ming-Heng Wu, I-Lu Lai, Kuen-Haur Lee
Int. J. Med. Sci. 2015; 12(1): 63-71. doi:10.7150/ijms.9982
[Abstract] [Full text] [PDF]

Research Paper
The Effect of Single Embryo Transfer on Perinatal Outcomes in Japan
Masako Hayashi, Shoji Satoh, Yoshio Matsuda, Akihito Nakai
Int. J. Med. Sci. 2015; 12(1): 57-62. doi:10.7150/ijms.10352
[Abstract] [Full text] [PDF]

Research Paper
Astrocytes Protect Neurons from Aβ1-42 Peptide-Induced Neurotoxicity Increasing TFAM and PGC-1 and Decreasing PPAR-γ and SIRT-1
Diana Aguirre-Rueda, Sol Guerra-Ojeda, Martin Aldasoro, Antonio Iradi, Elena Obrador, Angel Ortega, M. Dolores Mauricio, Jose Mª Vila, Soraya L. Valles
Int. J. Med. Sci. 2015; 12(1): 48-56. doi:10.7150/ijms.10035
[Abstract] [Full text] [PDF]

Research Paper
Effect of Helixor A on Natural Killer Cell Activity in Endometriosis
In-Cheul Jeung, Youn-Jee Chung, Boah Chae, So-Yeon Kang, Jae-Yen Song, Hyun-Hee Jo, Young-Ok Lew, Jang-Heub Kim, Mee-Ran Kim
Int. J. Med. Sci. 2015; 12(1): 42-47. doi:10.7150/ijms.10076
[Abstract] [Full text] [PDF]

Research Paper
A Microsatellite Polymorphism in IGF1 Gene Promoter and Timing of Natural Menopause in Caucasian Women
Maria Kaczmarek, Joanna Pacholska-Bogalska, Wojciech Kwaśniewski, Jan Kotarski, Barbara Halerz-Nowakowska, Anna Goździka-Józefiak
Int. J. Med. Sci. 2015; 12(1): 32-41. doi:10.7150/ijms.9840
[Abstract] [Full text] [PDF]

Research Paper
Genome-based Proteomic Analysis of Lignosus rhinocerotis (Cooke) Ryvarden Sclerotium
Hui-Yeng Yeannie Yap, Shin-Yee Fung, Szu-Ting Ng, Chon-Seng Tan, Nget-Hong Tan
Int. J. Med. Sci. 2015; 12(1): 23-31. doi:10.7150/ijms.10019
[Abstract] [Full text] [PDF]

Research Paper
Quantitative Detection of Circulating Nucleophosmin Mutations DNA in the Plasma of Patients with Acute Myeloid Leukemia
Jing Quan, Yu-jie Gao, Zai-lin Yang, Hui Chen, Jing-rong Xian, Shuai-shuai Zhang, Qin Zou, Ling Zhang
Int. J. Med. Sci. 2015; 12(1): 17-22. doi:10.7150/ijms.10144
[Abstract] [Full text] [PDF]

Research Paper
The Expression Levels of Transcription Factors T-bet, GATA-3, RORγt and FOXP3 in Peripheral Blood Lymphocyte (PBL) of Patients with Liver Cancer and their Significance
Ze-Wei Lin, Li-Xuan Wu, Yong Xie, Xi Ou, Pei-Kai Tian, Xiao-Ping Liu, Jun Min, Jie Wang, Ru-Fu Chen, Ya-Jing Chen, Chao Liu, Hua Ye, Qing-Jia Ou
Int. J. Med. Sci. 2015; 12(1): 7-16. doi:10.7150/ijms.8352
[Abstract] [Full text] [PDF]

Research Paper
High Reproducibility of Adhesion Formation in Rat with Meso-Stitch Approximation of Injured Cecum and Abdominal Wall
Daniel Poehnert, Mahmoud Abbas, Hans-Heinrich Kreipe, Juergen Klempnauer, Markus Winny
Int. J. Med. Sci. 2015; 12(1): 1-6. doi:10.7150/ijms.8870
[Abstract] [Full text] [PDF]

Review
Odontomas and Supernumerary Teeth: Is There a Common Origin?
Roberto Pippi
Int. J. Med. Sci. 2014; 11(12): 1282-1297. doi:10.7150/ijms.10501
[Abstract] [Full text] [PDF]

Review
Application of the Chick Embryo Chorioallantoic Membrane in Neurosurgery Disease
Yong-Jie Yuan, Kan Xu, Wei Wu, Qi Luo, Jin-Lu Yu
Int. J. Med. Sci. 2014; 11(12): 1275-1281. doi:10.7150/ijms.10443
[Abstract] [Full text] [PDF]

Research Paper
A Novel PCR-Based Approach to Discover miRNA Target Genes
Shiwei Duan, Yunliang Wang, Hongwei Wang, Shufei Wang, Lindan Ji, Dongjun Dai, Danjie Jiang, Xiaoxi Zhang, Qiang Wang
Int. J. Med. Sci. 2014; 11(12): 1270-1274. doi:10.7150/ijms.9343
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Silencing SATB1 Inhibits the Malignant Phenotype and Increases Sensitivity of Human Osteosarcoma U2OS Cells to Arsenic Trioxide
Haiying Zhang, Xuejin Su, Li Guo, Lingzhi Zhong, Wenxue Li, Zhen Yue, Xiaotong Wang, Yan Mu, Xinna Li, Ronggui Li, Zonggui Wang
Int. J. Med. Sci. 2014; 11(12): 1262-1269. doi:10.7150/ijms.10038
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Age and Gender Are Important Considerations in Choosing the Sniffing Position for Laryngoscopic View
Sung-Wook Park, Kang-Woo Lee, Myung-Soo Jang, Jun-Young Jung, Bong-Jae Lee, Jong-Man Kang
Int. J. Med. Sci. 2014; 11(12): 1258-1261. doi:10.7150/ijms.8585
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Influence of Exercise on the Metabolic Profile Caused by 28 days of Bed Rest with Energy Deficit and Amino Acid Supplementation in Healthy Men
Naomi E. Brooks, Samuel M. Cadena, Gregory Cloutier, Sonia Vega-López, Ronenn Roubenoff, Carmen Castaneda-Sceppa
Int. J. Med. Sci. 2014; 11(12): 1248-1257. doi:10.7150/ijms.9694
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Immunomodulatory Effects of Newcastle Disease Virus AF2240 Strain on Human Peripheral Blood Mononuclear Cells
Han Yuen Lam, Khatijah Yusoff, Swee Keong Yeap, Tamilselvan Subramani, Suraini Abd-Aziz, Abdul Rahman Omar, Noorjahan Banu Alitheen
Int. J. Med. Sci. 2014; 11(12): 1240-1247. doi:10.7150/ijms.8170
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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