International Journal of Medical Sciences

24 May 2015

ISSN 1449-1907 News feeds of published articles

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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Research Paper
Delayed Reduction of Hepatitis B Viral Load and Dynamics of Adefovir-Resistant Variants during Adefovir plus Entecavir Combination Rescue Therapy
Yang Wang, Shuang Liu, Yu Chen, Sujun Zheng, Li Zhou, Fengmin Lu, Zhongping Duan
Int. J. Med. Sci. 2015; 12(5): 416-422. doi:10.7150/ijms.11687
[Abstract] [Full text] [PDF]

Research Paper
Lentiviral Vectors Mediate Long-Term and High Efficiency Transgene Expression in HEK 293T cells
Yingying Mao, Renhe Yan, Andrew Li, Yanling Zhang, Jinlong Li, Hongyan Du, Baihong Chen, Wenjin Wei, Yi Zhang, Colin Sumners, Haifa Zheng, Hongwei Li
Int. J. Med. Sci. 2015; 12(5): 407-415. doi:10.7150/ijms.11270
[Abstract] [Full text] [PDF]

Research Paper
Efficient Inhibition of Ovarian Cancer by Gelonin Toxin Gene Delivered by Biodegradable Cationic Heparin-polyethyleneimine Nanogels
Yu Bai, Maling Gou, Tao Yi, Li Yang, Lili Liu, Xiaojuan Lin, Dan Su, Yuquan Wei, Xia Zhao
Int. J. Med. Sci. 2015; 12(5): 397-406. doi:10.7150/ijms.10929
[Abstract] [Full text] [PDF]

Review
Major Pathophysiological Correlations of Rosacea: A Complete Clinical Appraisal
Ravi Chandra Vemuri, Rohit Gundamaraju, Shamala Devi Sekaran, Rishya Manikam
Int. J. Med. Sci. 2015; 12(5): 387-396. doi:10.7150/ijms.10608
[Abstract] [Full text] [PDF]

Research Paper
Reduction of QTD - A Novel Marker of Successful Reperfusion in NSTEMI. Pathophysiologic Insights by CMR
Christoph J. Jensen, Sarah Lusebrink, Alexander Wolf, Thomas Schlosser, Kai Nassenstein, Christoph K. Naber, Georg V. Sabin, Oliver Bruder
Int. J. Med. Sci. 2015; 12(5): 378-386. doi:10.7150/ijms.11224
[Abstract] [Full text] [PDF]

Research Paper
The Association between Glomerular Hyperfiltration and Left Ventricular Structure and Function in Patients with Primary Aldosteronism
Min-Tsun Liao, Xue-Ming Wu, Chin-Chen Chang, Che-Wei Liao, Ying-Hsien Chen, Ching-Chu Lu, Yen-Ting Lin, Yi-Yao Chang, Chi-Sheng Hung, Lung-Chun Lin, Chao-Lun Lai, Lian-Yu Lin, Vin-Cent Wu, Yi-Lwun Ho, Kwan-Dun Wu, Yen-Hung Lin, the TAIPAI Study Group
Int. J. Med. Sci. 2015; 12(5): 369-377. doi:10.7150/ijms.10975
[Abstract] [Full text] [PDF]

Research Paper
Association of Vitamin D Levels with Type 2 Diabetes in Older Working Adults
Daniel Mauss, Marc N. Jarczok, Kristina Hoffmann, G. Neil Thomas, Joachim E. Fischer
Int. J. Med. Sci. 2015; 12(5): 362-368. doi:10.7150/ijms.10540
[Abstract] [Full text] [PDF]

Research Paper
Predicting One-Year Mortality in Peritoneal Dialysis Patients: An Analysis of the China Peritoneal Dialysis Registry
Xue-Ying Cao, Jian-Hui Zhou, Guang-Yan Cai, Ni-Na Tan, Jing Huang, Xiang-Cheng Xie, Li Tang, Xiang-Mei Chen
Int. J. Med. Sci. 2015; 12(4): 354-361. doi:10.7150/ijms.11694
[Abstract] [Full text] [PDF]

Research Paper
PIK3CA Amplification Is Common in Left Side-Tubular Adenomas but Uncommon Sessile Serrated Adenomas Exclusively with KRAS Mutation
Hyunsu Lee, Jae-Ho Lee, Dae-Kwang Kim, In-Jang Choi, Ilseon Hwang, Yu-Na Kang, Shin Kim
Int. J. Med. Sci. 2015; 12(4): 349-353. doi:10.7150/ijms.11281
[Abstract] [Full text] [PDF]

Research Paper
Temporomandibular Disorders in Psoriasis Patients with and without Psoriatic Arthritis: An Observational Study
Vito Crincoli, Mariasevera Di Comite, Maria Beatrice Di Bisceglie, Laura Fatone, Gianfranco Favia
Int. J. Med. Sci. 2015; 12(4): 341-348. doi:10.7150/ijms.11288
[Abstract] [Full text] [PDF]

Short Research Communication
Muscle Extracellular Matrix Scaffold Is a Multipotent Environment
Paola Aulino, Alessandra Costa, Ernesto Chiaravalloti, Barbara Perniconi, Sergio Adamo, Dario Coletti, Massimo Marrelli, Marco Tatullo, Laura Teodori
Int. J. Med. Sci. 2015; 12(4): 336-340. doi:10.7150/ijms.10761
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Can Saliva Proteins Be Used to Predict the Onset of Acute Myocardial Infarction among High-Risk Patients?
Mohd Aizat Abdul Rahim, Zubaidah Haji Abdul Rahim, Wan Azman Wan Ahmad, Onn Haji Hashim
Int. J. Med. Sci. 2015; 12(4): 329-335. doi:10.7150/ijms.11280
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
The Efficacy, Safety and Cost-Effectiveness of Intra-Operative Cell Salvage in High-Bleeding-Risk Cardiac Surgery with Cardiopulmonary Bypass: A Prospective Randomized and Controlled Trial
Yihong Xie, Sheliang Shen, Jun Zhang, Wenyuan Wang, Jiayin Zheng
Int. J. Med. Sci. 2015; 12(4): 322-328. doi:10.7150/ijms.11227
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Evaluation of Dabigatran- and Warfarin-Associated Hemorrhagic Events Using the FDA-Adverse Event Reporting System Database Stratified by Age
Junko ABE, Ryogo UMETSU, Yamato KATO, Natsumi UEDA, Yoko NAKAYAMA, Yukiya SUZUKI, Toshiyuki SUZUKI, Hideko NAGASAWA, Yasutomi KINOSADA, Mitsuhiro NAKAMURA
Int. J. Med. Sci. 2015; 12(4): 312-321. doi:10.7150/ijms.10703
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Using Vascular Closure Devices Following Out-Of-Hospital Cardiac Arrest?
Martin Christ, Katharina Isabel von Auenmueller, Jeanette Liebeton, Martin Grett, Wolfgang Dierschke, Jan Peter Noelke, Irini Maria Breker, Hans-Joachim Trappe
Int. J. Med. Sci. 2015; 12(4): 306-311. doi:10.7150/ijms.11343
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Fetal/Placental Weight Ratio in Term Japanese Pregnancy: Its Difference Among Gender, Parity, and Infant Growth
Yoshio Matsuda, Masaki Ogawa, Akihito Nakai, Masako Hayashi, Shoji Satoh, Shigeki Matsubara
Int. J. Med. Sci. 2015; 12(4): 301-305. doi:10.7150/ijms.11644
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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