International Journal of Medical Sciences

Research Paper
Protein chip and bioinformatic analyses of differentially expressed proteins involved in the effect of hydrogen-rich water on myocardial ischemia-reperfusion injury
Liangtong Li, Tongtong Liu, Xiangzi Li, Xuanchen Liu, Li Liu, Shaochun Li, Zhilin Li, Yujuan Zhou, Fulin Liu
Int. J. Med. Sci. 2019; 16(9): 1254-1259. doi:10.7150/ijms.35984
[Abstract] [Full text] [PDF]

Research Paper
Increased resting-state functional connectivity in suprasellar tumor patients with postoperative visual improvement
Jianyou Ying, Chuzhong Li, Taoyang Yuan, Lu Jin, Rui Wang, Zhentao Zuo, Yazhuo Zhang
Int. J. Med. Sci. 2019; 16(9): 1245-1253. doi:10.7150/ijms.35660
[Abstract] [Full text] [PDF]

Research Paper
Exosomes Released by Bone Marrow Mesenchymal Stem Cells Attenuate Lung Injury Induced by Intestinal Ischemia Reperfusion via the TLR4/NF-κB Pathway
Janpei Liu, Tufeng Chen, Purun Lei, Xiao Tang, Pinjie Huang
Int. J. Med. Sci. 2019; 16(9): 1238-1244. doi:10.7150/ijms.35369
[Abstract] [Full text] [PDF]

Research Paper
Loss of Circulating Exosomal miR-92b is a Novel Biomarker of Colorectal Cancer at Early Stage
Li Min, Lei Chen, Si Liu, Yang Yu, Qingdong Guo, Peng Li, Shengtao Zhu
Int. J. Med. Sci. 2019; 16(9): 1231-1237. doi:10.7150/ijms.34540
[Abstract] [Full text] [PDF]

Research Paper
Circulating and Pulmonary T-cell Populations Driving the Immune Response in Non-HIV Immunocompromised Patients with Pneumocystis jirovecii Pneumonia
Nan-Nan Zhang, Xu Huang, Hui-Ying Feng, Lin-Na Huang, Jin-Gen Xia, Yan Wang, Yi Zhang, Xiao-Jing Wu, Min Li, Wei Cui, Qing-Yuan Zhan
Int. J. Med. Sci. 2019; 16(9): 1221-1230. doi:10.7150/ijms.34512
[Abstract] [Full text] [PDF]

Research Paper
Living Donor Liver Transplantation in Biliary Atresia Children with Pulmonary Hypertension
Xiao-Yan Meng, Mi-Yuan Chen, Zhi-Ying Pan, Ye-Feng Lu, Wei Wei, Yu-Gang Lu
Int. J. Med. Sci. 2019; 16(9): 1215-1220. doi:10.7150/ijms.34073
[Abstract] [Full text] [PDF]

Research Paper
Parvalbumin Promoter Methylation Altered in Major Depressive Disorder
Benjamard Thaweethee-Sukjai, Sirijit Suttajit, Samur Thanoi, Caroline F. Dalton, Gavin P. Reynolds, Sutisa Nudmamud-Thanoi
Int. J. Med. Sci. 2019; 16(9): 1207-1214. doi:10.7150/ijms.36131
[Abstract] [Full text] [PDF]

Research Paper
The impact of PRDX4 and the EGFR mutation status on cellular proliferation in lung adenocarcinoma
Kenichi Mizutani, Xin Guo, Akihiro Shioya, Jing Zhang, Jianbo Zheng, Nozomu Kurose, Hiroaki Ishibashi, Nozomu Motono, Hidetaka Uramoto, Sohsuke Yamada
Int. J. Med. Sci. 2019; 16(9): 1199-1206. doi:10.7150/ijms.36071
[Abstract] [Full text] [PDF]

Research Paper
Evaluation of a novel monoclonal antibody against tumor-associated MUC1 for diagnosis and prognosis of breast cancer
Natascha Stergiou, Johannes Nagel, Stefanie Pektor, Anne-Sophie Heimes, Jörg Jäkel, Walburgis Brenner, Marcus Schmidt, Matthias Miederer, Horst Kunz, Frank Roesch, Edgar Schmitt
Int. J. Med. Sci. 2019; 16(9): 1188-1198. doi:10.7150/ijms.35452
[Abstract] [Full text] [PDF]

Research Paper
Greater Protective Potent of s-Methyl Cysteine and Syringic Acid Combination for NGF-differentiated PC12 Cells against Kainic acid-induced Injury
I-ching Chou, Mei-chin Mong, Chih-lung Lin, Mei-chin Yin
Int. J. Med. Sci. 2019; 16(8): 1180-1187. doi:10.7150/ijms.35083
[Abstract] [Full text] [PDF]

Research Paper
Elevated plasma S100A1 level is a risk factor for ST-segment elevation myocardial infarction and associated with post-infarction cardiac function
Linlin Fan, Baoxin Liu, Rong Guo, Jiachen Luo, Hongqiang Li, Zhiqiang Li, Weigang Xu
Int. J. Med. Sci. 2019; 16(8): 1171-1179. doi:10.7150/ijms.35037
[Abstract] [Full text] [PDF]

Research Paper
MRC-5 Cancer-associated Fibroblasts Influence Production of Cancer Stem Cell Markers and Inflammation-associated Cell Surface Molecules, in Liver Cancer Cell Lines
Song-Ming Ding, Jian-Fang Lu, Muhammad Ibrahim Alhadi Edoo, Lin Zhou, Hai-Yang Xie, Shu-Sen Zheng, Qi-Yong Li
Int. J. Med. Sci. 2019; 16(8): 1157-1170. doi:10.7150/ijms.34758
[Abstract] [Full text] [PDF]

Research Paper
The phenotype of vascular smooth muscle cells co-cultured with endothelial cells is modulated by PDGFR-β/IQGAP1 signaling in LPS-induced intravascular injury
Xia Zheng, Xiaotong Hu, Wang Zhang
Int. J. Med. Sci. 2019; 16(8): 1149-1156. doi:10.7150/ijms.34749
[Abstract] [Full text] [PDF]

Research Paper
Expression pattern of CDK12 protein in gastric cancer and its positive correlation with CD8⁺ cell density and CCL12 expression
Jun Ji, Chenfei Zhou, Junwei Wu, Qu Cai, Min Shi, Huan Zhang, Yingyan Yu, Zhenggang Zhu, Jun Zhang
Int. J. Med. Sci. 2019; 16(8): 1142-1148. doi:10.7150/ijms.34541
[Abstract] [Full text] [PDF]

Research Paper
Ribosomal Protein L15 is involved in Colon Carcinogenesis
Zhixiong Dong, Hongyu Jiang, Shuangshuang Liang, Yajie Wang, Wei Jiang, Changjun Zhu
Int. J. Med. Sci. 2019; 16(8): 1132-1141. doi:10.7150/ijms.34386
[Abstract] [Full text] [PDF]

Research Paper
High mobility group box 1 protein (HMGB1) as biomarker in hypoxia-induced persistent pulmonary hypertension of the newborn: a clinical and in vivo pilot study
Zhen Tang, Min Jiang, Zhicui Ou-yang, Hailan Wu, Shixiao Dong, Mingyan Hei
Int. J. Med. Sci. 2019; 16(8): 1123-1131. doi:10.7150/ijms.34344
[Abstract] [Full text] [PDF]

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Plasma viral load was positively correlated with VWF adhesive activity, which was elevated in acute relative to chronic treated HIV-1 infection. ADAMTS13 antigen and activity were both positively correlated with plasma viral load, and ADAMTS13 activity was significantly higher in men with acute HIV infection than in uninfected controls, and in both acute and chronic untreated HIV infection relative to chronic treated infection.

Conclusion: These findings suggest that even in the setting of increased ADAMTS13 protease activity, VWF in HIV-1 infection is hyperadhesive, which may favor development of microvascular and arterial thromboses and thereby contribute to increased cardiovascular risk in HIV-1-infected individuals.

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Colorectal cancer (CRC) is one of leading causes of mortality in western countries and novel treatment strategies are required. The medicinal application of mushrooms has been used in traditional medicine in many oriental countries. Polysaccharide-rich extracts obtained from certain medicinal mushroom species have shown antitumor effects in different experimental models. In the present study, we have developed polysaccharide-rich extracts from Trametes versicolor (TV) and Grifola frondosa (GF) fruit bodies. We aim to evaluate the anticancer effects of these polysaccharide-rich extracts in LoVo and HT-29 human colon cancer cells. The in vitro effects were determined by cytotoxicity assay, proliferation assay, wound healing assay and invasion assay. Moreover, the effect on anchorage independent-cell growth was also determined. Our results showed that TV and GF extracts did inhibit human colon cell proliferation and induce cytotoxicity.. ...details