International Journal of Medical Sciences

Impact factor
2.399

13 December 2017

ISSN 1449-1907 News feeds of published articles

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Impact factor is 2.399 according to 2017 release of Journal Citation Reports®.

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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Research Paper
Variations in the AURKA Gene: Biomarkers for the Development and Progression of Hepatocellular Carcinoma
Bin Wang, Chin-Jung Hsu, Chia-Hsuan Chou, Hsiang-Lin Lee, Whei-Ling Chiang, Chen-Ming Su, Hsiao-Chi Tsai, Shun-Fa Yang, Chih-Hsin Tang
Int. J. Med. Sci. 2018; 15(2): 170-175. doi:10.7150/ijms.22513
[Abstract] [Full text] [PDF]

Research Paper
Assessment of the Temporomandibular Joint Function in Young Adults without Complaints from the Masticatory System
Wojciech Kondrat, Teresa Sierpińska, John Radke
Int. J. Med. Sci. 2018; 15(2): 161-169. doi:10.7150/ijms.21665
[Abstract] [Full text] [PDF]

Research Paper
Pulsed Radiofrequency Applied to the Sciatic Nerve Improves Neuropathic Pain by Down-regulating The Expression of Calcitonin Gene-related Peptide in the Dorsal Root Ganglion
Hao Ren, Hailong Jin, Zipu Jia, Nan Ji, Fang Luo
Int. J. Med. Sci. 2018; 15(2): 153-160. doi:10.7150/ijms.20501
[Abstract] [Full text] [PDF]

Research Paper
MiR-22-3p Regulates Cell Proliferation and Inhibits Cell Apoptosis through Targeting the eIF4EBP3 Gene in Human Cervical Squamous Carcinoma Cells
Kang-tai Lv, Zhu Liu, Jie Feng, Wei Zhao, Tao Hao, Wen-yan Ding, Jing-ping Chu, Ling-juan Gao
Int. J. Med. Sci. 2018; 15(2): 142-152. doi:10.7150/ijms.21645
[Abstract] [Full text] [PDF]

Research Paper
Preliminary Study of MR and Fluorescence Dual-mode Imaging: Combined Macrophage-Targeted and Superparamagnetic Polymeric Micelles
Wen-Juan Li, Yong Wang, Yulin Liu, Teng Wu, Wen-Li Cai, Xin-Tao Shuai, Guo-Bin Hong
Int. J. Med. Sci. 2018; 15(2): 129-141. doi:10.7150/ijms.21610
[Abstract] [Full text] [PDF]

Research Paper
Analysis of MED12 Mutation in Multiple Uterine Leiomyomas in South Korean patients
Minkyoung Lee, Keunyoung Cheon, Boah Chae, Hyesung Hwang, Hyun-Kyung Kim, Youn-Jee Chung, Jae-Yen Song, Hyun-Hee Cho, Jang-Heub Kim, Mee-Ran Kim
Int. J. Med. Sci. 2018; 15(2): 124-128. doi:10.7150/ijms.21856
[Abstract] [Full text] [PDF]

Research Paper
Cinnamomum Cassia Extracts Suppress Human Lung Cancer Cells Invasion by Reducing u-PA/MMP Expression through the FAK to ERK Pathways
Hsing-Chen Wu, Chi-Ting Horng, You-Li Lee, Pei-Ni Chen, Chin-Yin Lin, Chen-Yu Liao, Yih-Shou Hsieh, Shu-Chen Chu
Int. J. Med. Sci. 2018; 15(2): 115-123. doi:10.7150/ijms.22293
[Abstract] [Full text] [PDF]

Research Paper
Left ventricular diastolic and systolic dyssynchrony and dysfunction in heart failure with preserved ejection fraction and a narrow QRS complex
Shuang Liu, Zhengyu Guan, Xuanyi Jin, Pingping Meng, Yonghuai Wang, Xianfeng Zheng, Dalin Jia, Chunyan Ma, Jun Yang
Int. J. Med. Sci. 2018; 15(2): 108-114. doi:10.7150/ijms.21956
[Abstract] [Full text] [PDF]

Research Paper
Bactericidal effects of deep ultraviolet light-emitting diode for solutions during intravenous infusion
Sachiko Omotani, Katsuji Tani, Mai Aoe, Seiji Esaki, Katsuhito Nagai, Yasutoshi Hatsuda, Junji Mukai, Hitomi Teramachi, Michiaki Myotoku
Int. J. Med. Sci. 2018; 15(2): 101-107. doi:10.7150/ijms.22206
[Abstract] [Full text] [PDF]

Research Paper
Role of APOBEC3H in the Viral Control of HIV Elite Controller Patients
José M. Benito, Julia Hillung, Clara Restrepo, José M. Cuevas, Agathe León, Ezequiel Ruiz-Mateos, Rosario Palacios-Muñoz, Miguel Górgolas, Rafael Sanjuán, Norma Rallón
Int. J. Med. Sci. 2018; 15(2): 95-100. doi:10.7150/ijms.22317
[Abstract] [Full text] [PDF]

Research Paper
In vitro and in vivo effects of miRNA-19b/20a/92a on gastric cancer stem cells and the related mechanism
Qianwen Shao, Jing Xu, Xin Guan, Bing Zhou, Wei Wei, Rong Deng, Dongzhen Li, Xinyu Xu, Haitao Zhu
Int. J. Med. Sci. 2018; 15(1): 86-94. doi:10.7150/ijms.21164
[Abstract] [Full text] [PDF]

Research Paper
Gene and Protein Expression Profiles in a Mouse Model of Collagen-Induced Arthritis
Sun-Yeong Gwon, Ki-Jong Rhee, Ho Joong Sung
Int. J. Med. Sci. 2018; 15(1): 77-85. doi:10.7150/ijms.22345
[Abstract] [Full text] [PDF]

Research Paper
Lentivirus-mediated shRNA Targeting CNN2 Inhibits Hepatocarcinoma in Vitro and in Vivo
Xueqing Kang, Feng Wang, Xiuwan Lan, Xiaolong Li, Shunxin Zheng, Zhilue Lv, Yuan Zhuang, Yongxiang Zhao, Sufang Zhou
Int. J. Med. Sci. 2018; 15(1): 69-76. doi:10.7150/ijms.21113
[Abstract] [Full text] [PDF]

Research Paper
Bone Regeneration using Silk Hydroxyapatite Hybrid Composite in a Rat Alveolar Defect Model
Kyung S. Koh, Jong Woo Choi, Eun Jeong Park, Tae Suk Oh
Int. J. Med. Sci. 2018; 15(1): 59-68. doi:10.7150/ijms.21787
[Abstract] [Full text] [PDF]

Research Paper
Antioxydation And Cell Migration Genes Are Identified as Potential Therapeutic Targets in Basal-Like and BRCA1 Mutated Breast Cancer Cell Lines
Maud Privat, Justine Rudewicz, Nicolas Sonnier, Christelle Tamisier, Flora Ponelle-Chachuat, Yves-Jean Bignon
Int. J. Med. Sci. 2018; 15(1): 46-58. doi:10.7150/ijms.20508
[Abstract] [Full text] [PDF]

Review
Ethical and Safety Issues of Stem Cell-Based Therapy
Vladislav Volarevic, Bojana Simovic Markovic, Marina Gazdic, Ana Volarevic, Nemanja Jovicic, Nebojsa Arsenijevic, Lyle Armstrong, Valentin Djonov, Majlinda Lako, Miodrag Stojkovic
Int. J. Med. Sci. 2018; 15(1): 36-45. doi:10.7150/ijms.21666
[Abstract] [Full text] [PDF]

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