International Journal of Medical Sciences
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3 August 2015

ISSN 1449-1907 News feeds of published articles

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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Research Paper
Increased Expressions of Integrin Subunit β1, β2 and β3 in Patients with Acute Infection
Yanli Song, Lemin Wang, Fan Yang, Xianzheng Wu, Qianglin Duan, Zhu Gong
Int. J. Med. Sci. 2015; 12(8): 639-643. doi:10.7150/ijms.11857
[Abstract] [Full text] [PDF]

Research Paper
Risk Factors of Myopic Shift among Primary School Children in Beijing, China: A Prospective Study
Li-Juan Wu, You-Xin Wang, Qi-Sheng You, Jia-Li Duan, Yan-Xia Luo, Li-Juan Liu, Xia Li, Qi Gao, Hui-Ping Zhu, Yan He, Liang Xu, Man-Shu Song, Jost B Jonas, Xiu-Hua Guo, Wei Wang
Int. J. Med. Sci. 2015; 12(8): 633-638. doi:10.7150/ijms.12133
[Abstract] [Full text] [PDF]

Short Research Communication
Preventing and Treating Hypoxia: Using a Physiology Simulator to Demonstrate the Value of Pre-Oxygenation and the Futility of Hyperventilation
Anna A. Lerant, Robert L. Hester, Thomas G. Coleman, William J. Phillips, Jeffrey D. Orledge, W. Bosseau Murray
Int. J. Med. Sci. 2015; 12(8): 625-632. doi:10.7150/ijms.12077
[Abstract] [Full text] [PDF]

Research Paper
Anemia as an Independent Predictor of Adverse Cardiac Outcomes in Patients with Atrial Fibrillation
Wen-Hsien Lee, Po-Chao Hsu, Chun-Yuan Chu, Hung-Hao Lee, Meng-Kuang Lee, Chee-Siong Lee, Hsueh-Wei Yen, Tsung-Hsien Lin, Wen-Chol Voon, Wen-Ter Lai, Sheng-Hsiung Sheu, Ho-Ming Su
Int. J. Med. Sci. 2015; 12(8): 618-624. doi:10.7150/ijms.11924
[Abstract] [Full text] [PDF]

Research Paper
Relationship between the hs-CRP as non-specific biomarker and Alzheimer's disease according to aging process
In-Uk Song, Sung-Woo Chung, Young-Do Kim, Lee-So Maeng
Int. J. Med. Sci. 2015; 12(8): 613-617. doi:10.7150/ijms.12742
[Abstract] [Full text] [PDF]

Research Paper
Lifestyle and Risk of Hypertension: Follow-Up of a Young Pre-Hypertensive Cohort
Yao Lu, Minggen Lu, Haijiang Dai, Pinting Yang, Julie Smith-Gagen, Rujia Miao, Hua Zhong, Ruifang Chen, Xing Liu, Zhijun Huang, Hong Yuan
Int. J. Med. Sci. 2015; 12(7): 605-612. doi:10.7150/ijms.12446
[Abstract] [Full text] [PDF]

Research Paper
Incidence and Risk Factors of Acute Kidney Injury after Radical Cystectomy: Importance of Preoperative Serum Uric Acid Level
Kyoung-Woon Joung, Seong-Soo Choi, Yu-Gyeong Kong, Jihion Yu, Jinwook Lim, Jai-Hyun Hwang, Young-Kug Kim
Int. J. Med. Sci. 2015; 12(7): 599-604. doi:10.7150/ijms.12106
[Abstract] [Full text] [PDF]

Research Paper
Dysregulated Serum MicroRNA Expression Profile and Potential Biomarkers in Hepatitis C Virus-infected Patients
Shaobo Zhang, Xiaoxi Ouyang, Xin Jiang, Dayong Gu, Yulong Lin, S.K. Kong, Weidong Xie
Int. J. Med. Sci. 2015; 12(7): 590-598. doi:10.7150/ijms.11525
[Abstract] [Full text] [PDF]

Research Paper
Effects of Remifentanil Preconditioning on Osteoblasts under Hypoxia-Reoxygenation Condition
Seung-Wan Baik, Bong-Soo Park, Yong-Ho Kim, Yong-Deok Kim, Cheul-Hong Kim, Ji-Young Yoon, Ji-Uk Yoon
Int. J. Med. Sci. 2015; 12(7): 583-589. doi:10.7150/ijms.11839
[Abstract] [Full text] [PDF]

Research Paper
Serum UCH-L1 as a Novel Biomarker to Predict Neuronal Apoptosis Following Deep Hypothermic Circulatory Arrest
Ya-Ping Zhang, Yao-Bin Zhu, Dayue Darrel Duan, Xiang-Ming Fan, Yan He, Jun-Wu Su, Ying-Long Liu
Int. J. Med. Sci. 2015; 12(7): 576-582. doi:10.7150/ijms.12111
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Research Progress of Moyamoya Disease in Children
Jianmin Piao, Wei Wu, Zhongxi Yang, Jinlu Yu
Int. J. Med. Sci. 2015; 12(7): 566-575. doi:10.7150/ijms.11719
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Etomidate Anesthesia during ERCP Caused More Stable Haemodynamic Responses Compared with Propofol: A Randomized Clinical Trial
Jin-Chao Song, Zhi-Jie Lu, Ying-Fu Jiao, Bin Yang, Hao Gao, Jinmin Zhang, Wei-Feng Yu
Int. J. Med. Sci. 2015; 12(7): 559-565. doi:10.7150/ijms.11521
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Depressed Systemic Arterial Compliance is Associated with the Severity of Heart Failure Symptoms in Moderate-to-Severe Aortic Stenosis: a Cross-Sectional Retrospective Study
Olga Kruszelnicka, Mark Chmiela, Beata Bobrowska, Jolanta Świerszcz, Seetha Bhagavatula, Jacek Bednarek, Andrzej Surdacki, Jadwiga Nessler, Tomasz Hryniewiecki
Int. J. Med. Sci. 2015; 12(7): 552-558. doi:10.7150/ijms.12262
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Cytological Kinetics of Periodontal Ligament in an Experimental Occlusal Trauma Model
Tatsuo Takaya, Hiroaki Mimura, Saeka Matsuda, Keisuke Nakano, Hidetsugu Tsujigiwa, Mihoko Tomida, Norimasa Okafuji, Takeo Fujii, Toshiyuki Kawakami
Int. J. Med. Sci. 2015; 12(7): 544-551. doi:10.7150/ijms.12217
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Investigation of Somatic NKX2-5 Mutations in Chinese Children with Congenital Heart Disease
Jiayi Zheng, Fen Li, Jinfen Liu, Zhiwei Xu, Haibo Zhang, Qihua Fu, Jian Wang, Kun Sun
Int. J. Med. Sci. 2015; 12(7): 538-543. doi:10.7150/ijms.11700
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Compliance Index, a Marker of Peripheral Arterial Stiffness, may Predict Renal Function Decline in Patients with Chronic Kidney Disease
Te-Hui Kuo, Deng-Chi Yang, Wei-Hung Lin, Chin-Chung Tseng, Ju-Yi Chen, Chin-Shan Ho, Meng-Fu Cheng, Wei-Chuan Tsai, Ming-Cheng Wang
Int. J. Med. Sci. 2015; 12(7): 530-537. doi:10.7150/ijms.12164
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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