International Journal of Medical Sciences
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5 July 2015

ISSN 1449-1907 News feeds of published articles

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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Research Paper
Serum UCH-L1 as a Novel Biomarker to Predict Neuronal Apoptosis Following Deep Hypothermic Circulatory Arrest
Ya-Ping Zhang, Yao-Bin Zhu, Dayue Darrel Duan, Xiang-Ming Fan, Yan He, Jun-Wu Su, Ying-Long Liu
Int. J. Med. Sci. 2015; 12(7): 576-582. doi:10.7150/ijms.12111
[Abstract] [Full text] [PDF]

Review
Research Progress of Moyamoya Disease in Children
Jianmin Piao, Wei Wu, Zhongxi Yang, Jinlu Yu
Int. J. Med. Sci. 2015; 12(7): 566-575. doi:10.7150/ijms.11719
[Abstract] [Full text] [PDF]

Research Paper
Etomidate Anesthesia during ERCP Caused More Stable Haemodynamic Responses Compared with Propofol: A Randomized Clinical Trial
Jin-Chao Song, Zhi-Jie Lu, Ying-Fu Jiao, Bin Yang, Hao Gao, Jinmin Zhang, Wei-Feng Yu
Int. J. Med. Sci. 2015; 12(7): 559-565. doi:10.7150/ijms.11521
[Abstract] [Full text] [PDF]

Research Paper
Depressed Systemic Arterial Compliance is Associated with the Severity of Heart Failure Symptoms in Moderate-to-Severe Aortic Stenosis: a Cross-Sectional Retrospective Study
Olga Kruszelnicka, Mark Chmiela, Beata Bobrowska, Jolanta Świerszcz, Seetha Bhagavatula, Jacek Bednarek, Andrzej Surdacki, Jadwiga Nessler, Tomasz Hryniewiecki
Int. J. Med. Sci. 2015; 12(7): 552-558. doi:10.7150/ijms.12262
[Abstract] [Full text] [PDF]

Research Paper
Cytological Kinetics of Periodontal Ligament in an Experimental Occlusal Trauma Model
Tatsuo Takaya, Hiroaki Mimura, Saeka Matsuda, Keisuke Nakano, Hidetsugu Tsujigiwa, Mihoko Tomida, Norimasa Okafuji, Takeo Fujii, Toshiyuki Kawakami
Int. J. Med. Sci. 2015; 12(7): 544-551. doi:10.7150/ijms.12217
[Abstract] [Full text] [PDF]

Research Paper
Investigation of Somatic NKX2-5 Mutations in Chinese Children with Congenital Heart Disease
Jiayi Zheng, Fen Li, Jinfen Liu, Zhiwei Xu, Haibo Zhang, Qihua Fu, Jian Wang, Kun Sun
Int. J. Med. Sci. 2015; 12(7): 538-543. doi:10.7150/ijms.11700
[Abstract] [Full text] [PDF]

Research Paper
Compliance Index, a Marker of Peripheral Arterial Stiffness, may Predict Renal Function Decline in Patients with Chronic Kidney Disease
Te-Hui Kuo, Deng-Chi Yang, Wei-Hung Lin, Chin-Chung Tseng, Ju-Yi Chen, Chin-Shan Ho, Meng-Fu Cheng, Wei-Chuan Tsai, Ming-Cheng Wang
Int. J. Med. Sci. 2015; 12(7): 530-537. doi:10.7150/ijms.12164
[Abstract] [Full text] [PDF]

Research Paper
Artesunate Induces SKM-1 Cells Apoptosis by Inhibiting Hyperactive β-catenin Signaling Pathway
Na Xu, Xuan Zhou, Shuang Wang, Lu-lu Xu, Hong-sheng Zhou, Xiao-li Liu
Int. J. Med. Sci. 2015; 12(6): 524-529. doi:10.7150/ijms.11352
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Comparison of Drug Concentrations in Human Aqueous Humor after the Administration of 0.3% Gatifloxacin Ophthalmic Gel, 0.3% Gatifloxacin and 0.5% Levofloxacin Ophthalmic Solutions
Wenting Ding, Weiling Ni, Huilian Chen, Jingqun Yuan, Xiaodan Huang, Zheng Zhang, Yao Wang, Yibo Yu, Ke Yao
Int. J. Med. Sci. 2015; 12(6): 517-523. doi:10.7150/ijms.11376
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Impact of Intercellular Adhesion Molecule-1 Genetic Polymorphisms on Coronary Artery Disease Susceptibility in Taiwanese Subjects
Chi-Hung Chou, Kwo-Chang Ueng, Yu-Fan Liu, Chih-Hsien Wu, Shun-Fa Yang, Po-Hui Wang
Int. J. Med. Sci. 2015; 12(6): 510-516. doi:10.7150/ijms.12097
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Chewing Maintains Hippocampus-Dependent Cognitive Function
Huayue Chen, Mitsuo Iinuma, Minoru Onozuka, Kin-Ya Kubo
Int. J. Med. Sci. 2015; 12(6): 502-509. doi:10.7150/ijms.11911
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Changes in Bone Biomarkers, BMC, and Insulin Resistance Following a 10-Week Whole Body Vibration Exercise Program in Overweight Latino Boys
David N. Erceg, Lindsey J. Anderson, Chun M. Nickles, Christianne J. Lane, Marc J. Weigensberg, E. Todd Schroeder
Int. J. Med. Sci. 2015; 12(6): 494-501. doi:10.7150/ijms.11364
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Pim-2 Modulates Aerobic Glycolysis and Energy Production during the Development of Colorectal Tumors
Xue-hui Zhang, Hong-liang Yu, Fu-jing Wang, Yong-long Han, Wei-liang Yang
Int. J. Med. Sci. 2015; 12(6): 487-493. doi:10.7150/ijms.10982
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Effects of Red Wine Tannat on Oxidative Stress Induced by Glucose and Fructose in Erythrocytes in Vitro
Camila Eliza Fernandes Pazzini, Ana Ceolin Colpo, Márcia Rósula Poetini, Cauê Ferreira Pires, Vanessa Brum de Camargo, Andreas Sebastian Loureiro Mendez, Miriane Lucas Azevedo, Júlio César Mendes Soares, Vanderlei Folmer
Int. J. Med. Sci. 2015; 12(6): 478-486. doi:10.7150/ijms.10529
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Enhanced Expression of Sodium Hydrogen Exchanger (NHE)-1, 2 and 4 in the Cervix of Ovariectomised Rats by Phytoestrogen Genistein
Nurain Ismail, Nelli Giribabu, Sekaran Muniandy, Naguib Salleh
Int. J. Med. Sci. 2015; 12(6): 468-477. doi:10.7150/ijms.11210
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Altered Activity and Expression of Cytosolic Peptidases in Colorectal Cancer
Itxaro Perez, Lorena Blanco, Begoña Sanz, Peio Errarte, Usue Ariz, Maider Beitia, Ainhoa Fernández, Alberto Loizate, M Luz Candenas, Francisco M Pinto, Javier Gil, José I. López, Gorka Larrinaga
Int. J. Med. Sci. 2015; 12(6): 458-467. doi:10.7150/ijms.11808
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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