International Journal of Medical Sciences

23 October 2014

ISSN 1449-1907 News feeds of published articles

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details

International Journal of Medical Sciences Cover Page

Research Paper
A Novel PCR-Based Approach to Discover miRNA Target Genes
Shiwei Duan, Yunliang Wang, Hongwei Wang, Shufei Wang, Lindan Ji, Dongjun Dai, Danjie Jiang, Xiaoxi Zhang, Qiang Wang
Int. J. Med. Sci. 2014; 11(12): 1270-1274. doi:10.7150/ijms.9343
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Silencing SATB1 Inhibits the Malignant Phenotype and Increases Sensitivity of Human Osteosarcoma U2OS Cells to Arsenic Trioxide
Haiying Zhang, Xuejin Su, Li Guo, Lingzhi Zhong, Wenxue Li, Zhen Yue, Xiaotong Wang, Yan Mu, Xinna Li, Ronggui Li, Zonggui Wang
Int. J. Med. Sci. 2014; 11(12): 1262-1269. doi:10.7150/ijms.10038
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Age and Gender Are Important Considerations in Choosing the Sniffing Position for Laryngoscopic View
Sung-Wook Park, Kang-Woo Lee, Myung-Soo Jang, Jun-Young Jung, Bong-Jae Lee, Jong-Man Kang
Int. J. Med. Sci. 2014; 11(12): 1258-1261. doi:10.7150/ijms.8585
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Influence of Exercise on the Metabolic Profile Caused by 28 days of Bed Rest with Energy Deficit and Amino Acid Supplementation in Healthy Men
Naomi E. Brooks, Samuel M. Cadena, Gregory Cloutier, Sonia Vega-López, Ronenn Roubenoff, Carmen Castaneda-Sceppa
Int. J. Med. Sci. 2014; 11(12): 1248-1257. doi:10.7150/ijms.9694
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Immunomodulatory Effects of Newcastle Disease Virus AF2240 Strain on Human Peripheral Blood Mononuclear Cells
Han Yuen Lam, Khatijah Yusoff, Swee Keong Yeap, Tamilselvan Subramani, Suraini Abd-Aziz, Abdul Rahman Omar, Noorjahan Banu Alitheen
Int. J. Med. Sci. 2014; 11(12): 1240-1247. doi:10.7150/ijms.8170
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Female Specific Association between NNMT Gene and Schizophrenia in a Han Chinese population
Guo-xia Wang, Yong Zhang, Zhuang-wei Lv, Mao Sun, Dan Wu, Xin-yu Chen, Yuan-ming Wu
Int. J. Med. Sci. 2014; 11(12): 1234-1239. doi:10.7150/ijms.9426
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Short Research Communication
Detection of Platelet-Monocyte Aggregates by the ADAM® Image Cytometer
Bo Kyeung Jung, Chi Hyun Cho, Kyung Chul Moon, Dae sung Hur, Jeong-Ah Yoon, Soo-Young Yoon
Int. J. Med. Sci. 2014; 11(12): 1228-1233. doi:10.7150/ijms.10008
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Whole-Body Vibration Training Effect on Physical Performance and Obesity in Mice
Chi-Chang Huang, Tzu-Ling Tseng, Wen-Ching Huang, Yi-Hsiu Chung, Hsiao-Li Chuang, Jyh-Horng Wu
Int. J. Med. Sci. 2014; 11(12): 1218-1227. doi:10.7150/ijms.9975
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Intestinal and Hepatic Expression of Cytochrome P450s and mdr1a in Rats with Indomethacin-Induced Small Intestinal Ulcers
Shoji Kawauchi, Tsutomu Nakamura, Hiroyuki Yasui, Chikako Nishikawa, Ikuya Miki, Jun Inoue, Sayo Horibe, Tsuneo Hamaguchi, Toshihito Tanahashi, Shigeto Mizuno
Int. J. Med. Sci. 2014; 11(12): 1208-1217. doi:10.7150/ijms.9866
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Short Research Communication
Oxidative Stress-Induced Premature Senescence in Wharton's Jelly-Derived Mesenchymal Stem Cells
Kong Bung Choo, Lihui Tai, K.Shri Hymavathee, Chee Yin Wong, Phan Nguyen Nhi Nguyen, Chiu-Jung Huang, Soon Keng Cheong, Tunku Kamarul
Int. J. Med. Sci. 2014; 11(11): 1201-1207. doi:10.7150/ijms.8356
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention
Yanling Wu, Yanping Ding, Yoshimasa Tanaka, Wen Zhang
Int. J. Med. Sci. 2014; 11(11): 1185-1200. doi:10.7150/ijms.10001
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Chlorophytum borivilianum Root Extract Maintains near Normal Blood Glucose, Insulin and Lipid Profile Levels and Prevents Oxidative Stress in the Pancreas of Streptozotocin-Induced Adult Male Diabetic Rats
Nelli Giribabu, Kilari Eswar Kumar, Somesula Swapna Rekha, Sekaran Muniandy, Naguib Salleh
Int. J. Med. Sci. 2014; 11(11): 1172-1184. doi:10.7150/ijms.9056
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Coronary Artery Spasm: Review and Update
Ming-Jui Hung, Patrick Hu, Ming-Yow Hung
Int. J. Med. Sci. 2014; 11(11): 1161-1171. doi:10.7150/ijms.9623
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Short Research Communication
Heterogeneity of Osteosarcoma Cell Lines Led to Variable Responses in Reprogramming
Pei Feng Choong, Hui Xin Teh, Hoon Koon Teoh, Han Kiat Ong, Kong Bung Choo, Shigeki Sugii, Soon Keng Cheong, Tunku Kamarul
Int. J. Med. Sci. 2014; 11(11): 1154-1160. doi:10.7150/ijms.8281
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Impact of Single Nucleotide Polymorphism in IL-4, IL-4R Genes and Systemic Concentration of IL-4 on the Incidence of Glioma in Iraqi Patients
Haidar A. Shamran, Subah J. Hamza, Nahi Y. Yaseen, Ahmad A. Al-Juboory, Dennis D Taub, Robert L. Price, Mitzi Nagarkatti, Prakash S. Nagarkatti, Udai P. Singh
Int. J. Med. Sci. 2014; 11(11): 1147-1153. doi:10.7150/ijms.9412
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
P Wave Dispersion and QT Dispersion in Adult Turkish Migrants with Familial Mediterranean Fever Living in Germany
Arnd Giese, Ahmet Örnek, Mustafa Kurucay, Kaffer Kara, Helmut Wittkowski, Faekah Gohar, Bjoern A. Menge, Wolfgang E. Schmidt, Christoph Zeidler
Int. J. Med. Sci. 2014; 11(11): 1140-1146. doi:10.7150/ijms.9444
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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