International Journal of Medical Sciences

27 April 2015

ISSN 1449-1907 News feeds of published articles

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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Research Paper
Temporomandibular Disorders in Psoriasis Patients with and without Psoriatic Arthritis: An Observational Study
Vito Crincoli, Mariasevera Di Comite, Maria Beatrice Di Bisceglie, Laura Fatone, Gianfranco Favia
Int. J. Med. Sci. 2015; 12(4): 341-348. doi:10.7150/ijms.11288
[Abstract] [Full text] [PDF]

Short Research Communication
Muscle Extracellular Matrix Scaffold Is a Multipotent Environment
Paola Aulino, Alessandra Costa, Ernesto Chiaravalloti, Barbara Perniconi, Sergio Adamo, Dario Coletti, Massimo Marrelli, Marco Tatullo, Laura Teodori
Int. J. Med. Sci. 2015; 12(4): 336-340. doi:10.7150/ijms.10761
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Can Saliva Proteins Be Used to Predict the Onset of Acute Myocardial Infarction among High-Risk Patients?
Mohd Aizat Abdul Rahim, Zubaidah Haji Abdul Rahim, Wan Azman Wan Ahmad, Onn Haji Hashim
Int. J. Med. Sci. 2015; 12(4): 329-335. doi:10.7150/ijms.11280
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
The Efficacy, Safety and Cost-Effectiveness of Intra-Operative Cell Salvage in High-Bleeding-Risk Cardiac Surgery with Cardiopulmonary Bypass: A Prospective Randomized and Controlled Trial
Yihong Xie, Sheliang Shen, Jun Zhang, Wenyuan Wang, Jiayin Zheng
Int. J. Med. Sci. 2015; 12(4): 322-328. doi:10.7150/ijms.11227
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Evaluation of Dabigatran- and Warfarin-Associated Hemorrhagic Events Using the FDA-Adverse Event Reporting System Database Stratified by Age
Junko ABE, Ryogo UMETSU, Yamato KATO, Natsumi UEDA, Yoko NAKAYAMA, Yukiya SUZUKI, Toshiyuki SUZUKI, Hideko NAGASAWA, Yasutomi KINOSADA, Mitsuhiro NAKAMURA
Int. J. Med. Sci. 2015; 12(4): 312-321. doi:10.7150/ijms.10703
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Using Vascular Closure Devices Following Out-Of-Hospital Cardiac Arrest?
Martin Christ, Katharina Isabel von Auenmueller, Jeanette Liebeton, Martin Grett, Wolfgang Dierschke, Jan Peter Noelke, Irini Maria Breker, Hans-Joachim Trappe
Int. J. Med. Sci. 2015; 12(4): 306-311. doi:10.7150/ijms.11343
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Fetal/Placental Weight Ratio in Term Japanese Pregnancy: Its Difference Among Gender, Parity, and Infant Growth
Yoshio Matsuda, Masaki Ogawa, Akihito Nakai, Masako Hayashi, Shoji Satoh, Shigeki Matsubara
Int. J. Med. Sci. 2015; 12(4): 301-305. doi:10.7150/ijms.11644
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
The Effects of Antenatal Corticosteroids on Short- and Long-Term Outcomes in Small-for-Gestational-Age Infants
Hiroshi Ishikawa, Ken Miyazaki, Tomoaki Ikeda, Nao Murabayashi, Kazutoshi Hayashi, Akihiko Kai, Kaoru Ishikawa, Yoshihiro Miyamoto, Kunihiro Nishimura, Yumi Kono, Satoshi Kusuda, Masanori Fujimura, Neonatal Research Network of Japan
Int. J. Med. Sci. 2015; 12(4): 295-300. doi:10.7150/ijms.11523
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
FDG-PET and NeuN-GFAP Immunohistochemistry of Hippocampus at Different Phases of the Pilocarpine Model of Temporal Lobe Epilepsy
Liang Zhang, Yi Guo, Haitao Hu, Jing Wang, Zhirong Liu, Feng Gao
Int. J. Med. Sci. 2015; 12(3): 288-294. doi:10.7150/ijms.10527
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
No Significant Detectable Anti-infection Effects of Aspirin and Statins in Chronic Obstructive Pulmonary Disease
Josef Yayan
Int. J. Med. Sci. 2015; 12(3): 280-287. doi:10.7150/ijms.11054
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Paradoxical Response to Mechanical Unloading in Bone Loss, Microarchitecture, and Bone Turnover Markers
Xiaodi Sun, Kaiyun Yang, Chune Wang, Sensen Cao, Mackenzie Merritt, Yingwei Hu, Xin Xu
Int. J. Med. Sci. 2015; 12(3): 270-279. doi:10.7150/ijms.11078
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Industrial Noise and Tooth Wear - Experimental Study
Maria Alzira Cavacas, Vitor Tavares, Gonçalo Borrecho, Maria João Oliveira, Pedro Oliveira, José Brito, Artur Águas, José Martins dos Santos
Int. J. Med. Sci. 2015; 12(3): 264-269. doi:10.7150/ijms.11309
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Upregulation of Heat Shock Proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in Tumour Tissues Is Associated with Poor Outcomes from HBV-Related Early-Stage Hepatocellular Carcinoma
Zongguo Yang, Liping Zhuang, Peter Szatmary, Li Wen, Hua Sun, Yunfei Lu, Qingnian Xu, Xiaorong Chen
Int. J. Med. Sci. 2015; 12(3): 256-263. doi:10.7150/ijms.10735
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Establishment and Characterization of an Immortalized Human Hepatic Stellate Cell Line for Applications in Co-Culturing with Immortalized Human Hepatocytes
XiaoPing Pan, Yini Wang, XiaoPeng Yu, JianZhou Li, Ning Zhou, WeiBo Du, YanHong Zhang, HongCui Cao, DanHua Zhu, Yu Chen, LanJuan Li
Int. J. Med. Sci. 2015; 12(3): 248-255. doi:10.7150/ijms.11002
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Genetic Interaction Analysis of TCF7L2 for Biochemical Recurrence after Radical Prostatectomy in Localized Prostate Cancer
Chien-Shu Chen, Chao-Yuan Huang, Shu-Pin Huang, Victor C. Lin, Chia-Cheng Yu, Ta-Yuan Chang, Bo-Ying Bao
Int. J. Med. Sci. 2015; 12(3): 243-247. doi:10.7150/ijms.10953
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Treatment Strategies for Aneurysms Associated with Moyamoya Disease
Lei Zhang, Kan Xu, Yandong Zhang, Xin Wang, Jinlu Yu
Int. J. Med. Sci. 2015; 12(3): 234-242. doi:10.7150/ijms.10837
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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