International Journal of Medical Sciences

Impact factor
2.284

20 September 2018

ISSN 1449-1907

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Global reach, higher impact

Theranostics

Journal of Cancer

International Journal of Biological Sciences

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

Oncomedicine

Journal of Biomedicine

Nanotheranostics

Indexed in MEDLINE, PubMed, EMBASE, CAS/Chemical Abstracts, CAB Abstracts, Scopus, Science Citation Index (SCI) Expanded ....
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This Journal is ranked very well according to SCImago in the area of Medicine ...details

Impact factor is 2.284 according to 2018 release of Journal Citation Reports®.

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Top cited papers:

Laxmaiah Manchikanti et al. Evaluation of Lumbar Facet Joint Nerve Blocks in Managing Chronic Low Back Pain: A Randomized, Double-Blind, Controlled Trial with a 2-Year Follow-Up. Cited by 95
DS O'Mahony et al. Differential Constitutive and Cytokine-Modulated Expression of Human Toll-like Receptors in Primary Neutrophils, Monocytes, and Macrophages. Cited by 79
Naomi Brooks et al. Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes. Cited by 146
Chikako Kiyohara1 & Kouichi Yoshimasu. Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis. Cited by 137
SL Chen & TR Morgan. The Natural History of Hepatitis C Virus (HCV) Infection. Cited by 283

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details

Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details

A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details

Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details

Research Paper
Mechanical Properties and Porosity of Acrylic Cement Bone Loaded with Alendronate Powder
Guo-Xin Qu, Zhi-Min Ying, Chen-Chen Zhao, Shi-Gui Yan, Xun-Zi Cai
Int. J. Med. Sci. 2018; 15(13): 1458-1465. doi:10.7150/ijms.27759
[Abstract] [Full text] [PDF]

Research Paper
Plasmodium falciparum Treated with Artemisinin-based Combined Therapy Exhibits Enhanced Mutation, Heightened Cortisol and TNF-α Induction
Abel Olusola Idowu, Sanjib Bhattacharyya, Steve Gradus, Wellington Oyibo, Zenas George, Carolyn Black, Joseph Igietseme, Anthony Ajayi Azenabor
Int. J. Med. Sci. 2018; 15(13): 1449-1457. doi:10.7150/ijms.27350
[Abstract] [Full text] [PDF]

Review
Biology of MiR-17-92 Cluster and Its Progress in Lung Cancer
Xinju Zhang, Yanli Li, Pengfei Qi, Zhongliang Ma
Int. J. Med. Sci. 2018; 15(13): 1443-1448. doi:10.7150/ijms.27341
[Abstract] [Full text] [PDF]

Research Paper
Role of Sirolimus in renal tubular apoptosis in response to unilateral ureteral obstruction
Mei Yang, Yang-yang Zhuang, Wei-wei Wang, Hai-ping Zhu, Yan-jie Zhang, Sao-ling Zheng, Yi-Rrong Yang, Bi-Cheng Chen, Peng Xia, Yan Zhang
Int. J. Med. Sci. 2018; 15(13): 1433-1442. doi:10.7150/ijms.26954
[Abstract] [Full text] [PDF]

Research Paper
Administration of CoCl₂ Improves Functional Recovery in a Rat Model of Sciatic Nerve Transection Injury
Shuai An, Meng Zhou, Zheng Li, Mingli Feng, Guanglei Cao, Shibao Lu, Limin Liu
Int. J. Med. Sci. 2018; 15(13): 1423-1432. doi:10.7150/ijms.27867
[Abstract] [Full text] [PDF]

Review
Role of TCF/LEF Transcription Factors in Bone Development and Osteogenesis
Zhengqiang Li, Zhimin Xu, Congcong Duan, Weiwei Liu, Jingchun Sun, Bing Han
Int. J. Med. Sci. 2018; 15(12): 1415-1422. doi:10.7150/ijms.26741
[Abstract] [Full text] [PDF]

Research Paper
Characterization and potential roles of bone marrow-derived stromal cells in cancer development and metastasis
Hotaka Kawai, Hidetsugu Tsujigiwa, Chong Huat Siar, Keisuke Nakano, Kiyofumi Takabatake, Masae Fujii, Mei Hamada, Ryo Tamamura, Hitoshi Nagatsuka
Int. J. Med. Sci. 2018; 15(12): 1406-1414. doi:10.7150/ijms.24370
[Abstract] [Full text] [PDF]

Review
The Emperor's New Clothes: a Critical Appraisal of Evidence-based Medicine
Giovanni D. Tebala
Int. J. Med. Sci. 2018; 15(12): 1397-1405. doi:10.7150/ijms.25869
[Abstract] [Full text] [PDF]

Research Paper
B355252, A Novel Small Molecule, Confers Neuroprotection Against Cobalt Chloride Toxicity In Mouse Hippocampal Cells Through Altering Mitochondrial Dynamics And Limiting Autophagy Induction
Uchechukwu Chimeh, Mary Ann Zimmerman, Nailya Gilyazova, P. Andy Li
Int. J. Med. Sci. 2018; 15(12): 1384-1396. doi:10.7150/ijms.24702
[Abstract] [Full text] [PDF]

Review
The Relationship between Follicle-stimulating Hormone and Bone Health: Alternative Explanation for Bone Loss beyond Oestrogen?
Kok-Yong Chin
Int. J. Med. Sci. 2018; 15(12): 1373-1383. doi:10.7150/ijms.26571
[Abstract] [Full text] [PDF]

Research Paper
Acid-electrolyzed functional water induces extracellular matrix metalloproteinase inducer, a possible novel alarmin, secretion from oral squamous cell carcinoma cell lines
Masafumi Kusunoki, Eri Sata, Kensuke Nishio, Takayoshi Tanaka, Tetsuya Nishida, Naoyuki Sugano, Shuichi Sato, Masatake Asano
Int. J. Med. Sci. 2018; 15(12): 1365-1372. doi:10.7150/ijms.26186
[Abstract] [Full text] [PDF]

Research Paper
AGK2, A SIRT2 Inhibitor, Inhibits Hepatitis B Virus Replication In Vitro And In Vivo
Hai-Bo Yu, Hui Jiang, Sheng-Tao Cheng, Zhong-Wen Hu, Ji-Hua Ren, Juan Chen
Int. J. Med. Sci. 2018; 15(12): 1356-1364. doi:10.7150/ijms.26125
[Abstract] [Full text] [PDF]

Erratum
Association of Genes Variants in RANKL/RANK/OPG Signaling Pathway with the Development of Osteonecrosis of the Femoral Head in Chinese Population: Erratum
Yang Song, Zhen-wu Du, Qi-wei Yang, Ming Ren, Qing-yu Wang, Ao Wang, Gao-yang Chen, Hai-yue Zhao, Tao Yu, Gui-zhen Zhang
Int. J. Med. Sci. 2018; 15(12): 1355. doi:10.7150/ijms.29056
[Abstract] [Full text] [PDF]

Research Paper
GABAergic Alterations in the Rat Testis after Methamphetamine Exposure
Paweena Kaewman, Sutisa Nudmamud-Thanoi, Samur Thanoi
Int. J. Med. Sci. 2018; 15(12): 1349-1354. doi:10.7150/ijms.27609
[Abstract] [Full text] [PDF]

Research Paper
Thrombopoietin could protect cerebral tissue against ischemia-reperfusion injury by suppressing NF-κB and MMP-9 expression in rats
Wenjuan Wu, Wei Zhong, Bing Lang, Zhiping Hu, Jialin He, Xiangqi Tang
Int. J. Med. Sci. 2018; 15(12): 1341-1348. doi:10.7150/ijms.27543
[Abstract] [Full text] [PDF]

Research Paper
Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics
Jr-Shiang Shiu, Ming-Ju Hsieh, Hui-Ling Chiou, Hsiang-Ling Wang, Chao-Bin Yeh, Shun-Fa Yang, Ying-Erh Chou
Int. J. Med. Sci. 2018; 15(12): 1334-1340. doi:10.7150/ijms.27059
[Abstract] [Full text] [PDF]

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