International Journal of Medical Sciences

Impact factor
2.399

17 October 2017

ISSN 1449-1907 News feeds of published articles

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new Impact factor is 2.399 according to 2017 release of Journal Citation Reports®. Congratulations!

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Top cited papers:

Vector delivery is still a bottleneck for gene therapy. To overcome some disadvantages of adenoviral and retroviral vectors, we developed a hybrid vector. This hybrid vector, AdLTR-luc, was created by adding two elements from Moloney murine leukemia virus (MoMLV) flanking the luciferase cDNA into an E1/E3-deleted, replication deficient serotype 5 adenovirus vector (Zheng et al., Nature Biotechnol, 2000), and demonstrated that the MoMLV element upstream of the luciferase cDNA was broken during the integration event. The purpose of the current study was to determine if the MoMLV element downstream of the luciferase cDNA was also broken when integration occurred. We used the same A5 cell clones (#10 and 11) from the earlier the paper along with restriction endonuclease digestions, plus Southern hybridization, and PCR. Southern hybridization indicated that the luciferase cDNA was intact in the cloned cells. Results from Xho I and Sal I digestions showed that integration occurred in cloned cells. ...details
Vascular endothelial growth factor (VEGF) is essential for normal vascular growth and development during wound repair. VEGF is estrogen responsive and capable of regulating its own receptor, vascular endothelial growth factor receptor-2 (VEGFR-2). Several agricultural pesticides (e.g., methoxychlor) have estrogenic potential that can initiate inappropriate physiological responses in estrogenic-sensitive tissues following exposure in vivo. Thus, the current study was designed to determine whether the VEGFR-2-Luciferase (Luc) reporter transgenic mouse is a useful model for evaluating estrogenic tendencies of methoxychlor by monitoring wound healing via VEGFR-2-mediated gene expression using bioluminescence and real-time imaging technology. ...details
A Human Head Surrogate has been developed for use in behind helmet blunt trauma experiments. This human head surrogate fills the void between Post-Mortem Human Subject testing (with biofidelity but handling restrictions) and commercial ballistic head forms (with no biofidelity but ease of use). This unique human head surrogate is based on refreshed human craniums and surrogate materials representing human head soft tissues such as the skin, dura, and brain. A methodology for refreshing the craniums is developed and verified through material testing. ...details
Study Design: A randomized, double-blind, active-controlled trial. Objective: To assess the effectiveness of cervical interlaminar epidural injections of local anesthetic with or without steroids for the management of axial or discogenic pain in patients without disc herniation, radiculitis, or facet joint pain. Summary of Background Data: Cervical discogenic pain without disc herniation is a common cause of suffering and disability in the adult population. Once conservative management has failed and facet joint pain has been excluded, cervical epidural injections may be considered as a management tool. Despite a paucity of evidence, cervical epidural injections are one of the most commonly performed nonsurgical interventions in the management of chronic axial or disc-related neck pain....details
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Research Paper
Cancer Stem Cell Gene Variants Predict Disease Recurrence in Patients Treated with Radical Prostatectomy for Prostate Cancer
Victor C. Lin, Shu-Pin Huang, Chao-Yuan Huang, Chia-Cheng Yu, Hsin-Ling Yin, Tsung-Yi Huang, Cheng-Hsueh Lee, Te-Ling Lu, Bo-Ying Bao
Int. J. Med. Sci. 2017; 14(12): 1301-1306. doi:10.7150/ijms.21428
[Abstract] [Full text] [PDF]

Research Paper
IER5 is involved in DNA Double-Strand Breaks Repair in Association with PAPR1 in Hela Cells
Xin-Ping Yu, Yu-Mei Wu, Yang Liu, Ming Tian, Jian-Dong Wang, Ku-Ke Ding, Teng Ma, Ping-Kun Zhou
Int. J. Med. Sci. 2017; 14(12): 1292-1300. doi:10.7150/ijms.21510
[Abstract] [Full text] [PDF]

Research Paper
Tanshinone IIA Inhibits β-Catenin Nuclear Translocation and IGF-2R Activation via Estrogen Receptors to Suppress Angiotensin II-Induced H9c2 Cardiomyoblast Cell Apoptosis
Ya-Fang Chen, Cecilia Hsuan Day, Nien-Hung Lee, Yu-Feng Chen, Jaw-Ji Yang, Chih-Hsueh Lin, Ray-Jade Chen, Peramaiyan Rajendran, Vijaya Padma Viswanadha, Chih-Yang Huang
Int. J. Med. Sci. 2017; 14(12): 1284-1291. doi:10.7150/ijms.20396
[Abstract] [Full text] [PDF]

Research Paper
Cell Recognition Molecule L1 Regulates Cell Surface Glycosylation to Modulate Cell Survival and Migration
Gang Shi, Yue Du, Yali Li, Yue An, Zhenwei He, Yingwei Lin, Rui Zhang, Xiaofei Yan, Jianfeng Zhao, Shihua Yang, Pang Nghee Kheem Brendan, Fang Liu
Int. J. Med. Sci. 2017; 14(12): 1276-1283. doi:10.7150/ijms.20479
[Abstract] [Full text] [PDF]

Research Paper
Chlorpheniramine attenuates histamine-mediated aquaporin 5 downregulation in human nasal epithelial cells via suppression of NF-κB activation
Yung-Lung Chang, Chun-Shu Lin, Hsing-Won Wang, Kai Ren Jian, Shao-Cheng Liu
Int. J. Med. Sci. 2017; 14(12): 1268-1275. doi:10.7150/ijms.21573
[Abstract] [Full text] [PDF]

Research Paper
Overexpression of Endothelial Cell-Specific Molecule 1 Correlates with Gleason Score and Expression of Androgen Receptor in Prostate Carcinoma
Chung-Yu Lai, Chien-Min Chen, Wen-Hung Hsu, Yi-Hsien Hsieh, Chung-Jung Liu
Int. J. Med. Sci. 2017; 14(12): 1263-1267. doi:10.7150/ijms.21023
[Abstract] [Full text] [PDF]

Short Research Communication
Human Cartilage Engineering in an In Vitro Repair Model Using Collagen Scaffolds and Mesenchymal Stromal Cells
Clara Sanjurjo-Rodríguez, Rocío Castro-Viñuelas, Tamara Hermida-Gómez, Isaac Manuel Fuentes-Boquete, Francisco Javier de Toro, Francisco Javier Blanco, Silvia María Díaz-Prado
Int. J. Med. Sci. 2017; 14(12): 1257-1262. doi:10.7150/ijms.19835
[Abstract] [Full text] [PDF]

Research Paper
An Application of NGS for WDR36 Gene in Taiwanese Patients with Juvenile-Onset Open-Angle Glaucoma
Hsuan-An Su, Shuan-Yow Li, Jiann-Jou Yang, Yung-Chang Yen
Int. J. Med. Sci. 2017; 14(12): 1251-1256. doi:10.7150/ijms.20729
[Abstract] [Full text] [PDF]

Research Paper
Heart Failure and Mortality of Adult Survivors from Acute Myocarditis Requiring Intensive Care Treatment - A Nationwide Cohort Study
Jung-Jung Chang, Ming-Shyan Lin, Tien-Hsing Chen, Dong-Yi Chen, Shao-Wei Chen, Jen-Te Hsu, Po-Chang Wang, Yu-Sheng Lin
Int. J. Med. Sci. 2017; 14(12): 1241-1250. doi:10.7150/ijms.20618
[Abstract] [Full text] [PDF]

Research Paper
Knockdown of Yes-Associated Protein Induces the Apoptosis While Inhibits the Proliferation of Human Periodontal Ligament Stem Cells through Crosstalk between Erk and Bcl-2 Signaling Pathways
Yong Wen, Yawen Ji, Yunpeng Zhang, Baoqi Jiang, Cuizhu Tang, Qi Wang, Xiyan Chen, Linglu Jia, Weiting Gu, Xin Xu
Int. J. Med. Sci. 2017; 14(12): 1231-1240. doi:10.7150/ijms.20504
[Abstract] [Full text] [PDF]

Research Paper
Extracorporeal Shockwave Therapy Enhances Expression of Pdia-3 Which Is a Key Factor of the 1α,25-Dihydroxyvitamin D 3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis of the Knee
Shan-Ling Hsu, Jai-Hong Cheng, Ching-Jen Wang, Jih-Yang Ko, Chih-Hsiang Hsu
Int. J. Med. Sci. 2017; 14(12): 1220-1230. doi:10.7150/ijms.20303
[Abstract] [Full text] [PDF]

Research Paper
Water Soluble Vitamins Enhance the Growth of Microorganisms in Peripheral Parenteral Nutrition Solutions
Sachiko Omotani, Katsuji Tani, Katsuhito Nagai, Yasutoshi Hatsuda, Junji Mukai, Michiaki Myotoku
Int. J. Med. Sci. 2017; 14(12): 1213-1219. doi:10.7150/ijms.21424
[Abstract] [Full text] [PDF]

Research Paper
GLP-1 Treatment Improves Diabetic Retinopathy by Alleviating Autophagy through GLP-1R-ERK1/2-HDAC6 Signaling Pathway
Xiangsheng Cai, Jingjing Li, Mingzhu Wang, Miaoqin She, Yongming Tang, Jinlong Li, Hongwei Li, Hongxiang Hui
Int. J. Med. Sci. 2017; 14(12): 1203-1212. doi:10.7150/ijms.20962
[Abstract] [Full text] [PDF]

Research Paper
Association of HMGB1 Gene Polymorphisms with Lung Cancer Susceptibility and Clinical Aspects
Weiwei Hu, Po-Yi Liu, Yi-Chen Yang, Po-Chun Chen, Chen-Ming Su, Chia-Chia Chao, Chih-Hsin Tang
Int. J. Med. Sci. 2017; 14(12): 1197-1202. doi:10.7150/ijms.20933
[Abstract] [Full text] [PDF]

Research Paper
Association of Surfactant Protein with Expression of Hoxa5 and Hoxb5 in Rabbit Fetal Lung
Sung-Hoon Chung, Chong-Woo Bae
Int. J. Med. Sci. 2017; 14(12): 1189-1196. doi:10.7150/ijms.20721
[Abstract] [Full text] [PDF]

Research Paper
The inhibition of indoleamine 2, 3-dioxygenase 1 by connexin 43
Han-Chen Lin, Chih-Jen Yang, Yu-Diao Kuan, Wei-Kuang Wang, Wen-Wei Chang, Che-Hsin Lee
Int. J. Med. Sci. 2017; 14(12): 1181-1188. doi:10.7150/ijms.20661
[Abstract] [Full text] [PDF]

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