International Journal of Medical Sciences

1 November 2014

ISSN 1449-1907 News feeds of published articles

Manuscript Status/Login | Contact

International Journal of Biological Sciences

Journal of Cancer

Theranostics

Journal of Genomics

PubMed Central

Journal of Genomics now in PubMed/PubMed Central. Submit manuscript...

Indexed in Journal Impact Factor

Int J Med Sci 2007; 4(2):59-71. doi:10.7150/ijms.4.59

Review

Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis

Chikako Kiyohara1, Kouichi Yoshimasu2

1. Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
2. Department of Hygiene, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan

Abstract

Various DNA alterations can be caused by exposure to environmental and endogenous carcinogens. Most of these alterations, if not repaired, can result in genetic instability, mutagenesis and cell death. DNA repair mechanisms are important for maintaining DNA integrity and preventing carcinogenesis. Recent lung cancer studies have focused on identifying the effects of single nucleotide polymorphisms (SNPs) in candidate genes, among which DNA repair genes are increasingly being studied. Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and are suggested to be related to lung cancer risk. We identified a sufficient number of epidemiologic studies on lung cancer to conduct a meta-analysis for genetic polymorphisms in nucleotide excision repair pathway genes, focusing on xeroderma pigmentosum group A (XPA), excision repair cross complementing group 1 (ERCC1), ERCC2/XPD, ERCC4/XPF and ERCC5/XPG. We found an increased risk of lung cancer among subjects carrying the ERCC2 751Gln/Gln genotype (odds ratio (OR) = 1.30, 95% confidence interval (CI) = 1.14 - 1.49). We found a protective effect of the XPA 23G/G genotype (OR = 0.75, 95% CI = 0.59 - 0.95). Considering the data available, it can be conjectured that if there is any risk association between a single SNP and lung cancer, the risk fluctuation will probably be minimal. Advances in the identification of new polymorphisms and in high-throughput genotyping techniques will facilitate the analysis of multiple genes in multiple DNA repair pathways. Therefore, it is likely that the defining feature of future epidemiologic studies will be the simultaneous analysis of large samples.

Keywords: Lung cancer, nucleotide excision repair, meta-analysis, genetic polymorphism

How to cite this article:
Kiyohara C, Yoshimasu K. Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis. Int J Med Sci 2007; 4(2):59-71. doi:10.7150/ijms.4.59. Available from http://www.medsci.org/v04p0059.htm