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Int J Med Sci 2007; 4(1):19-27. doi:10.7150/ijms.4.19 This issue Cite

Research Paper

Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes

Naomi Brooks¹, Jennifer E. Layne¹, Patricia L. Gordon^{1 3}, Ronenn Roubenoff^{1 2}, Miriam E. Nelson^{1 2 4}, Carmen Castaneda-Sceppa^{1 2}

1. Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston MA, USA.
2. The Friedman School of Nutrition Science and Policy, Tufts University, Boston MA, USA.
3. Department of Physiological Nursing, University of California, San Francisco, CA, USA.
4. John Hancock Center for Physical Activity and Nutrition, Tufts University, Boston, MA, USA

Abstract

Hispanics are at increased risk of morbidity and mortality due to their high prevalence of diabetes and poor glycemic control. Strength training is the most effective lifestyle intervention to increase muscle mass but limited data is available in older adults with diabetes. We determined the influence of strength training on muscle quality (strength per unit of muscle mass), skeletal muscle fiber hypertrophy, and metabolic control including insulin resistance (Homeostasis Model Assessment –HOMA-IR), C-Reactive Protein (CRP), adiponectin and Free Fatty Acid (FFA) levels in Hispanic older adults. Sixty-two community-dwelling Hispanics (>55 y) with type 2 diabetes were randomized to 16 weeks of strength training plus standard care (ST group) or standard care alone (CON group). Skeletal muscle biopsies and biochemical measures were taken at baseline and 16 weeks. The ST group show improved muscle quality (mean±SE: 28±3) vs CON (-4±2, p<0.001) and increased type I (860±252µm²) and type II fiber cross-sectional area (720±285µm²) compared to CON (type I: -164±290µm², p=0.04; and type II: -130±336µm², p=0.04). This was accompanied by reduced insulin resistance [ST: median (interquartile range) -0.7(3.6) vs CON: 0.8(3.8), p=0.05]; FFA (ST: -84±30µmol/L vs CON: 149±48µmol/L, p=0.02); and CRP [ST: -1.3(2.9)mg/L vs CON: 0.4(2.3)mg/L, p=0.05]. Serum adiponectin increased with ST [1.0(1.8)µg/mL] compared to CON [-1.2(2.2)µg/mL, p<0.001]. Strength training improved muscle quality and whole-body insulin sensitivity. Decreased inflammation and increased adiponectin levels were related with improved metabolic control. Further studies are needed to understand the mechanisms associated with these findings. However, these data show that strength training is an exercise modality to consider as an adjunct of standard of care in high risk populations with type 2 diabetes.

Keywords: diabetes, strength training, Hispanic, skeletal muscle, insulin sensitivity

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