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Volume 18 (8); 2021

Research Papers

Hemolysis in patients with Extracorporeal Membrane Oxygenation therapy for severe Acute Respiratory Distress Syndrome - a systematic review of the literature
Lorenz A. Materne, Oliver Hunsicker, Mario Menk, Jan A. Graw
Int. J. Med. Sci. 2021; 18(8): 1730-1738. doi:10.7150/ijms.50217
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Machining learning predicts the need for escalated care and mortality in COVID-19 patients from clinical variables
Wei Hou, Zirun Zhao, Anne Chen, Haifang Li, Tim Q. Duong
Int. J. Med. Sci. 2021; 18(8): 1739-1745. doi:10.7150/ijms.51235
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Acid-electrolyzed functional water-induces Interleukin-1α release from Intracellular Storage Sites in Oral Squamous Cell Carcinoma
Tomoko Takemoto, Ryo Kaetsu, Machiko Hanayama, Yuuichi Ishiyama, Masayuki Sadamura, Kensuke Nishio, Mariko Tsunoda, Masatake Asano, Mitsuru Motoyoshi
Int. J. Med. Sci. 2021; 18(8): 1746-1752. doi:10.7150/ijms.53999
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Carboxypeptidase A4 negatively correlates with p53 expression and regulates the stemness of breast cancer cells
Yipeng Wang, Yibin Xie, Yanan Niu, Peng Song, Ye Liu, Joseph Burnett, Zhihua Yang, Duxin Sun, Yuliang Ran, Yang Li, Lichao Sun
Int. J. Med. Sci. 2021; 18(8): 1753-1759. doi:10.7150/ijms.54954
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Concentrations of HMGB1 and Hsp70 of healthy subjects in upper and lower airway: Literature Review and Meta-analysis
Hyun Jin Min, Kyung Soo Kim, Geun Joo Choi, Hyun Kang, Fletcher A. White
Int. J. Med. Sci. 2021; 18(8): 1760-1767. doi:10.7150/ijms.53500
[Abstract] [Full text] [PDF] [PubMed] [PMC]

The Association between Obesity and Severity in Patients with Coronavirus Disease 2019: a Retrospective, Single-center Study, Wuhan
Jishou Zhang, Yao Xu, Bo Shen, Hua He, Mingxiao Liu, Mengmeng Zhao, Jianfang Liu, Shuwan Xu, Wei Pan, Jing Ye, Zhen Wang, Di Ye, Menglin Liu, Dan Li, Zhen Luo, Yongqi Feng, Menglong Wang, Jun Wan
Int. J. Med. Sci. 2021; 18(8): 1768-1777. doi:10.7150/ijms.54655
[Abstract] [Full text] [PDF] [PubMed] [PMC]

In vitro effects of velvet antler water extracts from Formosan Sambar deer and red deer on barrier integrity in Caco-2 cell
Ying-Kai Hung, Shang-Tse Ho, Ching-Yun Kuo, Ming-Ju Chen
Int. J. Med. Sci. 2021; 18(8): 1778-1785. doi:10.7150/ijms.53599
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Efficacy and Safety of CAR-T Therapy for Relapse or Refractory Multiple Myeloma: A systematic review and meta-analysis
Qin Yang, Xin Li, Fangrong Zhang, Qiaohui Yang, Wen Zhou, Jing Liu
Int. J. Med. Sci. 2021; 18(8): 1786-1797. doi:10.7150/ijms.46811
[Abstract] [Full text] [PDF] [PubMed] [PMC]

MicroRNA-362 negatively and positively regulates SMAD4 expression in TGF-β/SMAD signaling to suppress cell migration and invasion
Han Ping Cheng, Chiu-Jung Huang, Ming-Long Tsai, Hooi Tin Ong, Soon Keng Cheong, Kong Bung Choo, Shih-Hwa Chiou
Int. J. Med. Sci. 2021; 18(8): 1798-1809. doi:10.7150/ijms.50871
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Hirsutella sinensis mycelium regulates autophagy of alveolar macrophages via TLR4/NF-κB signaling pathway
Juanhua Fu, Li Lu, Haining Wang, Yayi Hou, Huan Dou
Int. J. Med. Sci. 2021; 18(8): 1810-1823. doi:10.7150/ijms.51654
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Potential role of myeloid-derived suppressor cells in transition from reaction to repair phase of bone healing process
Hotaka Kawai, May Wathone Oo, Hidetsugu Tsujigiwa, Keisuke Nakano, Kiyofumi Takabatake, Shintaro Sukegawa, Hitoshi Nagatsuka
Int. J. Med. Sci. 2021; 18(8): 1824-1830. doi:10.7150/ijms.51946
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Artificial intelligence supported anemia control system (AISACS) to prevent anemia in maintenance hemodialysis patients
Toshiaki Ohara, Hiroshi Ikeda, Yoshiki Sugitani, Hiroshi Suito, Viet Quang Huy Huynh, Masaru Kinomura, Soichiro Haraguchi, Kazufumi Sakurama
Int. J. Med. Sci. 2021; 18(8): 1831-1839. doi:10.7150/ijms.53298
[Abstract] [Full text] [PDF] [PubMed] [PMC]

HTRA1 Variants and the Interaction with Smoking Confer the Genetic Susceptibility to Ischemic Stroke
Yuanrui Tian, Wuzhuang Tang, Song Yang, Yanping Zhao, Yanchun Chen, Xianghai Zhao, Chunlan Liu, Xiaotian Chen, Chong Shen
Int. J. Med. Sci. 2021; 18(8): 1840-1847. doi:10.7150/ijms.45856
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Bitter Melon Extract Yields Multiple Effects on Intestinal Epithelial Cells and Likely Contributes to Anti-diabetic Functions
Chi-I Chang, Shi-Yie Cheng, Annisa Oktafianti Nurlatifah, Wei-Wen Sung, Jing-Hong Tu, Lin-Lee Lee, Hsueh-Ling Cheng
Int. J. Med. Sci. 2021; 18(8): 1848-1856. doi:10.7150/ijms.55866
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Value of pretreatment 18F-FDG PET/CT in prognosis and the reflection of tumor burden: a study in pediatric patients with newly diagnosed neuroblastoma
Shuai Man, Jie Yan, Jie Li, Yanna Cao, Jiajian Hu, Wenchao Ma, Jianjing Liu, Qiang Zhao
Int. J. Med. Sci. 2021; 18(8): 1857-1865. doi:10.7150/ijms.58263
[Abstract] [Full text] [PDF] [PubMed] [PMC]

A network pharmacology based approach for predicting active ingredients and potential mechanism of Lianhuaqingwen capsule in treating COVID-19
Xiaobo Zhang, Rui Gao, Zubing Zhou, Xuehua Tang, Jingjing Lin, Long Wang, Xin Zhou, Tao Shen
Int. J. Med. Sci. 2021; 18(8): 1866-1876. doi:10.7150/ijms.53685
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Hydroxyurea regulates the development and survival of B16 Melanoma Cells by upregulating MiR-7013-3p
Yi-Jie Huang, Yan Gao, Chang-Jiang Wang, Dong-Xu Han, Yi Zheng, Wen-Hua Wang, Hao Jiang, Bao Yuan, Jia-Bao Zhang
Int. J. Med. Sci. 2021; 18(8): 1877-1885. doi:10.7150/ijms.52177
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Ammonium Ferric Citrate induced Ferroptosis in Non-Small-Cell Lung Carcinoma through the inhibition of GPX4-GSS/GSR-GGT axis activity
Wei Wu, Zixiang Geng, Haoran Bai, Te Liu, Bimeng Zhang
Int. J. Med. Sci. 2021; 18(8): 1899-1909. doi:10.7150/ijms.54860
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review

Perspectives on long pentraxin 3 and rheumatoid arthritis: several potential breakthrough points relying on study foundation of the past
Cheng Qiu, Yichao Han, Hanwen Zhang, Tianyi Liu, Haodong Hou, Dan Luo, Mingzhi Yu, Kai Bian, Yunpeng Zhao, Xing Xiao
Int. J. Med. Sci. 2021; 18(8): 1886-1898. doi:10.7150/ijms.54787
[Abstract] [Full text] [PDF] [PubMed] [PMC]

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