International Journal of Medical Sciences

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24 September 2017

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Int J Med Sci 2017; 14(11):1040-1048. doi:10.7150/ijms.20388

Research Paper

Sports and HDL-Quality Reflected By Serum Amyloid A and Surfactant Protein B

Michael Sponder1✉, Chantal Kopecky2, Ioana-Alexandra Campean1, Michael Emich3, Monika Fritzer-Szekeres4, Brigitte Litschauer5, Senta Graf1, Marcus D. Säemann2, Jeanette Strametz-Juranek1

1. Medical University of Vienna, Department of Cardiology, Währinger Gürtel 18-20, 1090 Vienna, Austria;
2. Medical University of Vienna, Department of Nephrology and Dialysis, Währinger Gürtel 18-20, 1090 Vienna, Austria;
3. Austrian Federal Ministry of Defence and Sports, Austrian Armed Forces, Brünnerstraße 238, 1210 Vienna, Austria;
4. Medical University of Vienna, Department of Medical-Chemical Laboratory Analysis, Währinger Gürtel 18-20, 1090 Vienna, Austria;
5. Medical University of Vienna, Department of Pharmacology, Währinger Gürtel 18-20, 1090 Vienna, Austria.

Abstract

Background: The aim of this prospective study was to investigate the influence of long-term physical activity on HDL quality, reflected by serum amyloid A (SAA) and surfactant protein B (SPB).

Methods and results: 109 healthy subjects were recruited, 98 completed the study. Participants perform within the calculated training pulse for 8 months. The performance gain was measured/quantified by bicycle stress tests at the beginning and end of the observation period. SAA and SPB were measured at baseline and after 4 and 8 months by ELISA. In contrary to HDL-quantity, there was no sports-induced change in SAA or SPB observable. However, significant predictors for SPB-levels were smoking status, BMI and weekly alcohol consumption and for SAA weekly alcohol consumption together with sex and hsCRP-levels.

Conclusions: Long-term physical activity increases HDL-quantity but has no impact on HDL-quality reflected by SAA and SPB. Smoking is associated with higher SPB-levels and the weekly alcohol intake is associated with both higher SAA and SPB-levels suggesting a damaging effect of smoking and drinking alcohol on the HDL-quality. We assume that HDL-quality is at least as important as HDL-quantity when investigating the role of HDL in (cardiovascular) disease and should receive attention in further studies dealing with HDL.

Keywords: high-density lipoprotein, serum amyloid A, surfactant protein B, physical activity, HDL-quality.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Sponder M, Kopecky C, Campean IA, Emich M, Fritzer-Szekeres M, Litschauer B, Graf S, Säemann MD, Strametz-Juranek J. Sports and HDL-Quality Reflected By Serum Amyloid A and Surfactant Protein B. Int J Med Sci 2017; 14(11):1040-1048. doi:10.7150/ijms.20388. Available from http://www.medsci.org/v14p1040.htm