International Journal of Medical Sciences

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24 November 2017

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Int J Med Sci 2017; 14(7):680-689. doi:10.7150/ijms.19479

Research Paper

Acute Alcohol Intoxication Exacerbates Rhabdomyolysis-Induced Acute Renal Failure in Rats

Jen-Pi Tsai1, 2, Chung-Jen Lee3, Yi-Maun Subeq4, Ru-Ping Lee5, Bang-Gee Hsu2, 6✉

1. Division of Nephrology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan;
2. School of Medicine, Tzu Chi University, Hualien, Taiwan;
3. Department of Nursing, Tzu Chi University of Science and Technology, Hualien, Taiwan;
4. Department of Nursing, Tzu Chi University, Hualien, Taiwan;
5. Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan;
6. Department of Nephrology, Tzu Chi General Hospital, Hualien, Taiwan.

Abstract

Traumatic and nontraumatic rhabdomyolysis can lead to acute renal failure (ARF), and acute alcohol intoxication can lead to multiple abnormalities of the renal tubules. We examined the effect of acute alcohol intoxication in a rat model of rhabdomyolysis and ARF. Intravenous injections of 5 g/kg ethanol were given to rats over 3 h, followed by glycerol-induced rhabdomyolysis. Biochemical parameters, including blood urea nitrogen (BUN), creatinine (Cre), glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and creatine phosphokinase (CPK), were measured before and after induction of rhabdomyolysis. Renal tissue injury score, renal tubular cell expression of E-cadherin, nuclear factor-κB (NF-κB), and inducible nitric oxide synthase (iNOS) were determined. Relative to rats in the vehicle group, rats in the glycerol-induced rhabdomyolysis group had significantly increased serum levels of BUN, Cre, GOT, GPT, and CPK, elevated renal tissue injury scores, increased expression of NF-κB and iNOS, and decreased expression of E-cadherin. Ethanol exacerbated all of these pathological responses. Our results suggest that acute alcohol intoxication exacerbates rhabdomyolysis-induced ARF through its pro-oxidant and inflammatory effects.

Keywords: Acute renal failure, Acute ethanol intoxication, Rhabdomyolysis.

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How to cite this article:
Tsai JP, Lee CJ, Subeq YM, Lee RP, Hsu BG. Acute Alcohol Intoxication Exacerbates Rhabdomyolysis-Induced Acute Renal Failure in Rats. Int J Med Sci 2017; 14(7):680-689. doi:10.7150/ijms.19479. Available from http://www.medsci.org/v14p0680.htm