International Journal of Medical Sciences

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26 July 2017

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Int J Med Sci 2017; 14(3):224-230. doi:10.7150/ijms.17545

Research Paper

Neuronal Effects of Sugammadex in combination with Rocuronium or Vecuronium

Martin Aldasoro1, Adrian Jorda1, Constanza Aldasoro2, Patricia Marchio1, Sol Guerra-Ojeda1, Marc Gimeno-Raga1, Mª Dolores Mauricio1, Antonio Iradi1, Elena Obrador1, Jose Mª Vila1, Soraya L. Valles1✉

1. Department of Physiology, School of Medicine, University of Valencia, Valencia, Spain;
2. Hospital General de Castellon, Castellon, Spain.

Abstract

Rocuronium (ROC) and Vecuronium (VEC) are the most currently used steroidal non-depolarizing neuromuscular blocking (MNB) agents. Sugammadex (SUG) rapidly reverses steroidal NMB agents after anaesthesia. The present study was conducted in order to evaluate neuronal effects of SUG alone and in combination with both ROC and VEC. Using MTT, CASP-3 activity and Western-blot we determined the toxicity of SUG, ROC or VEC in neurons in primary culture. SUG induces apoptosis/necrosis in neurons in primary culture and increases cytochrome C (CytC), apoptosis-inducing factor (AIF), Smac/Diablo and Caspase 3 (CASP-3) protein expression. Our results also demonstrated that both ROC and VEC prevent these SUG effects. The protective role of both ROC and VEC could be explained by the fact that SUG encapsulates NMB drugs. In BBB impaired conditions it would be desirable to control SUG doses to prevent the excess of free SUG in plasma that may induce neuronal damage. A balance between SUG, ROC or VEC would be necessary to prevent the risk of cell damage.

Keywords: rocuronium, vecuronium, sugammadex, neuron, apoptosis.

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How to cite this article:
Aldasoro M, Jorda A, Aldasoro C, Marchio P, Guerra-Ojeda S, Gimeno-Raga M, Mauricio MD, Iradi A, Obrador E, Vila JM, Valles SL. Neuronal Effects of Sugammadex in combination with Rocuronium or Vecuronium. Int J Med Sci 2017; 14(3):224-230. doi:10.7150/ijms.17545. Available from http://www.medsci.org/v14p0224.htm