International Journal of Medical Sciences

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17 October 2017

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Int J Med Sci 2015; 12(7):559-565. doi:10.7150/ijms.11521

Research Paper

Etomidate Anesthesia during ERCP Caused More Stable Haemodynamic Responses Compared with Propofol: A Randomized Clinical Trial

Jin-Chao Song1, Zhi-Jie Lu1,*, Ying-Fu Jiao1, Bin Yang2, Hao Gao1, Jinmin Zhang1, Wei-Feng Yu1,✉

1. Department of Anesthesiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
2. Department of Anesthesiology, Shanghai first people's hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
*Contributed equally to this work

Abstract

Background: Propofol may result in hypotension and respiratory depression, while etomidate is considered to be a safe induction agent for haemodynamically unstable patients because of its low risk of hypotension. We hypothesized that etomidate anesthesia during ERCP caused more stable haemodynamic responses compared with propofol. The primary endpoint was to compare the haemodynamic effects of etomidate vs. propofol in ERCP cases. The secondary endpoint was overall survival.

Methods: A total of 80 patients undergoing ERCP were randomly assigned to an etomidate or propofol group. Patients in the etomidate group received etomidate induction and maintenance during ERCP, and patients in the propofol group received propofol induction and maintenance. Cardiovascular parameters and procedure-related time were measured and recorded during ERCP.

Results: The average percent change to baseline in MBP was -8.4±7.8 and -14.4±9.4 with P = 0.002, and in HR was 1.8±16.6 and 2.4±16.3 with P = 0.874 in the etomidate group and the propofol group, respectively. MBP values in the etomidate group decreased significantly less than those in the propofol group (P<0.05). The ERCP duration and recovery time in both groups was similar. There was no significant difference in the survival rates between groups ( p = 0.942).

Conclusions: Etomidate anesthesia during ERCP caused more stable haemodynamic responses compared with propofol.

Keywords: Etomidate anesthesia, propofol

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Song JC, Lu ZJ, Jiao YF, Yang B, Gao H, Zhang J, Yu WF. Etomidate Anesthesia during ERCP Caused More Stable Haemodynamic Responses Compared with Propofol: A Randomized Clinical Trial. Int J Med Sci 2015; 12(7):559-565. doi:10.7150/ijms.11521. Available from http://www.medsci.org/v12p0559.htm