23 October 2017
Int J Med Sci 2015; 12(3):243-247. doi:10.7150/ijms.10953
Genetic Interaction Analysis of TCF7L2 for Biochemical Recurrence after Radical Prostatectomy in Localized Prostate Cancer
1. Department of Pharmacy, China Medical University, Taichung, Taiwan
Backgroud: Accumulated evidence has demonstrated a significant role of the Wnt pathway in human prostate cancer. We hypothesize that genetic variants in the Wnt pathway effector, Transcription factor 7-like 2 (TCF7L2), may influence clinical outcomes in prostate cancer.
Methods: We comprehensively selected 12 tagged single-nucleotide polymorphisms (SNPs) to capture majority of common variants across TCF7L2, and genotyped in 458 localized prostate cancer patients treated with radical prostatectomy (RP). Kaplan-Meier analysis, Cox proportional hazard model, and survival tree analyses were performed to identify significant SNPs that correlated with biochemical recurrence (BCR) after surgery.
Results: A higher-order SNP-SNP interaction profile consisting of TCF7L2 rs7094463, rs10749127, and rs11196224 was significantly associated with BCR (Ptrend = 0.001). After adjusting for possible confounders, the genetic profile remained significant (Ptrend = 0.007). None of the studied SNPs were individually associated with BCR.
Conclusions: Our results support a genetic interaction in the TCF7L2 SNPs as a predictor of disease recurrence after curative RP in localized prostate cancer patients.
Keywords: biochemical recurrence, prostate cancer, radical prostatectomy, single-nucleotide polymorphism, TCF7L2, Wnt pathway
This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Chen CS, Huang CY, Huang SP, Lin VC, Yu CC, Chang TY, Bao BY. Genetic Interaction Analysis of TCF7L2 for Biochemical Recurrence after Radical Prostatectomy in Localized Prostate Cancer. Int J Med Sci 2015; 12(3):243-247. doi:10.7150/ijms.10953. Available from http://www.medsci.org/v12p0243.htm