International Journal of Medical Sciences

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14 December 2017

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Int J Med Sci 2013; 10(1):43-49. doi:10.7150/ijms.5358

Research Paper

Peginterferon Alfa-2a plus Ribavirin in Japanese Patients Infected with Hepatitis C Virus Genotype 2 Who Failed Previous Interferon Therapy

Tatsuo Kanda1✉, Shingo Nakamoto1, Takayoshi Nishino2, Nobuo Takada3, Akihito Tsubota4, Keizo Kato5, Tatsuo Miyamura1, Daisuke Maruoka1, Shuang Wu1, Takeshi Tanaka1, Makoto Arai1, Shigeru Mikami6, Keiichi Fujiwara1, Fumio Imazeki1, Osamu Yokosuka1

1. Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8677, Japan.
2. Department of Gastroenterology, Tokyo Women's Medical University Yachiyo Medical Center, Yachiyo 276-8524, Japan.
3. Department of Gastroenterology, Toho University Sakura Medical Center, Sakura 285-8741, Japan.
4. Institute of Clinical Medicine and Research, Jikei University School of Medicine, Kashiwa 277-8567, Japan.
5. Department of Gastroenterology, Narita Red Cross Hospital, Narita 286-8523, Japan.
6. Department of Medicine, Kikkoman Hospital, Noda 270-0116, Japan.

Abstract

Some patients infected with hepatitis C virus (HCV) genotype 2 could be cured with treatment shorter than 24 weeks using peginterferon plus ribavirin, but there are still treatment-refractory patients. Direct-acting antivirals (DAAs) are not currently available for HCV genotype 2 patients, different from genotype 1 patients, in clinical practice. We investigated 29 HCV genotype 2-infected Japanese patients who had been previously treated and failed to clear HCV. We retreated them with peginterferon alfa-2a plus ribavirin and measured HCV RNA level to assess the efficacy and safety of this treatment in patients who had failed previous therapy. We found that retreatment of HCV genotype 2-infected Japanese patients with peginterferon alfa-2a plus ribavirin for 24-48 weeks led to 60 to 66.6% sustained virological response (SVR) in patients previously treated with (peg-)interferon monotherapy and to 69.9% SVR in relapsers previously treated with peginterferon plus ribavirin. Attention should be paid to certain patients with unique features. Selection of patients according to their previous treatment could lead to optimal therapy in HCV genotype 2 treatment-experienced patients.

Keywords: Retreatment, HCV G2, Japanese

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How to cite this article:
Kanda T, Nakamoto S, Nishino T, Takada N, Tsubota A, Kato K, Miyamura T, Maruoka D, Wu S, Tanaka T, Arai M, Mikami S, Fujiwara K, Imazeki F, Yokosuka O. Peginterferon Alfa-2a plus Ribavirin in Japanese Patients Infected with Hepatitis C Virus Genotype 2 Who Failed Previous Interferon Therapy. Int J Med Sci 2013; 10(1):43-49. doi:10.7150/ijms.5358. Available from http://www.medsci.org/v10p0043.htm