ISSN: 1449-1907International Journal of Medical Sciences
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Int J Med Sci 2024; 21(7):1227-1240. doi:10.7150/ijms.93464 This issue Cite
Review
Potential Markers to Differentiate Uterine Leiomyosarcomas from Leiomyomas
1. Department of Obstetrics and Gynecology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, 310003 Hangzhou, Zhejiang Province, China.
2. Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, 350014 Fuzhou, Fujian Province, China.
Abstract
Uterine leiomyomas (ULM) are the most common benign tumors of the female genitalia, while uterine leiomyosarcomas (ULMS) are rare. The sarcoma is diffuse growth, prone to hematogenous metastasis, and has a poor prognosis. Due to their similar clinical symptoms and morphological features, it is sometimes difficult to distinguish them, and the final diagnosis depends on histological diagnosis. Misdiagnosis of ULM as ULMS will lead to more invasive and extensive surgery when it is not needed, while misdiagnosis of ULMS as ULM may lead to delayed treatment and poor prognosis. This review searched and studied the published articles on ULM and ULMS, and summarized the potential markers for the differential diagnosis of ULMS. These markers will facilitate differential diagnosis and personalized treatment, providing timely diagnosis and potentially better prognosis for patients.
Keywords: uterine leiomyoma, leiomyosarcoma, sarcoma, marker, diagnosis
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