ISSN: 1449-1907International Journal of Medical Sciences
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Int J Med Sci 2024; 21(1):95-106. doi:10.7150/ijms.88146 This issue Cite
Research Paper
What happens to the osteoporotic bone mesenchymal stem cells? Evidence from RNA sequencing
1. Senior Department of Orthopedics, the Fourth Medical Center of PLA General Hospital, Beijing, China.
2. Senior Department of Obstetrics & Gynecology, the Seventh Medical Center of PLA General Hospital, Beijing, China.
3. Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, China.
4. Beijing Engineering Research Center of Orthopedics Implants, Beijing, China.
* Joint first author Mingyang Li and Rong Cong contributed equally to the work.
# Joint corresponding author Qin Fu and Li Li contributed equally to the work.
Citation:
Li M, Cong R, Wang H, Ma C, Lv Y, Zheng Y, Zhao Y, Fu Q, Li L. What happens to the osteoporotic bone mesenchymal stem cells? Evidence from RNA sequencing. Int J Med Sci 2024; 21(1):95-106. doi:10.7150/ijms.88146. https://www.medsci.org/v21p0095.htm
Other stylesAbstract
Evidence presented that osteoporosis is closely related to the dysfunction of bone mesenchymal stem cells (BMSCs). But most studies are insufficient to reveal what actually happens to the osteoporotic BMSCs. In this study, BMSCs were harvested from ovariectomized and sham-operated rats. After checking the characteristics of rat models and stem cells, the BMSCs were carried out for RNA sequencing. Part of the findings were verified that seven mRNAs (Abi3bp, Aifm3, Ccl11, Cdkn1c, Chst10, Id2, Vcam1) were significantly up-regulated in osteoporotic BMSCs while seven mRNAs (Cep63, Fgfr3, Myc, Omd, Pou2f1, Smarcal1, Timm10b) were down-regulated. In addition, potential miRNA-mRNA and lncRNA-mRNA regulatory networks were illustrated. The changes in osteoporotic BMSCs covered a large set of biological processes, including cell viability, differentiation, immunoreaction, bone repairment and estrogen defect. This study enriched the pathophysiological mechanisms of BMSCs and osteporosis, as well as provided dozens of attractive RNA targets for further treatment.
Keywords: bone mesenchymal stem cell, osteoporosis, RNA sequencing, mRNA, miRNA, lncRNA
Citation styles
APA
Li, M., Cong, R., Wang, H., Ma, C., Lv, Y., Zheng, Y., Zhao, Y., Fu, Q., Li, L. (2024). What happens to the osteoporotic bone mesenchymal stem cells? Evidence from RNA sequencing. International Journal of Medical Sciences, 21(1), 95-106. https://doi.org/10.7150/ijms.88146.
ACS
Li, M.; Cong, R.; Wang, H.; Ma, C.; Lv, Y.; Zheng, Y.; Zhao, Y.; Fu, Q.; Li, L. What happens to the osteoporotic bone mesenchymal stem cells? Evidence from RNA sequencing. Int. J. Med. Sci. 2024, 21 (1), 95-106. DOI: 10.7150/ijms.88146.
NLM
Li M, Cong R, Wang H, Ma C, Lv Y, Zheng Y, Zhao Y, Fu Q, Li L. What happens to the osteoporotic bone mesenchymal stem cells? Evidence from RNA sequencing. Int J Med Sci 2024; 21(1):95-106. doi:10.7150/ijms.88146. https://www.medsci.org/v21p0095.htm
CSE
Li M, Cong R, Wang H, Ma C, Lv Y, Zheng Y, Zhao Y, Fu Q, Li L. 2024. What happens to the osteoporotic bone mesenchymal stem cells? Evidence from RNA sequencing. Int J Med Sci. 21(1):95-106.
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