Prognostic significance of histological grade in low-risk endometrial cancer

Bak, Seong Eun; Yoo, Ji Geun; Lee, Sung Jong; Yoon, Joo Hee; Park, Dong Choon; Kim, Sang Il

doi:10.7150/ijms.77152

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Int J Med Sci 2022; 19(13):1875-1878. doi:10.7150/ijms.77152 This issue Cite

Research Paper

Prognostic significance of histological grade in low-risk endometrial cancer

Seong Eun Bak¹, Ji Geun Yoo², Sung Jong Lee¹, Joo Hee Yoon³, Dong Choon Park³, Sang Il Kim^3✉

1. Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
2. Department of Obstetrics and Gynecology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
3. Department of Obstetrics and Gynecology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Citation:

Bak SE, Yoo JG, Lee SJ, Yoon JH, Park DC, Kim SI. Prognostic significance of histological grade in low-risk endometrial cancer. Int J Med Sci 2022; 19(13):1875-1878. doi:10.7150/ijms.77152. https://www.medsci.org/v19p1875.htm

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Abstract

Objective: Investigate the risk factors for recurrence in patients with low-risk endometrial cancer.

Method: A retrospective review was performed to identify patients who underwent primary surgical treatment for endometrial cancer from December 2009 to December 2020. Patients who met the following criteria were included in the study: (a) International Federation of Gynecology and Obstetrics stage IA, (b) endometrioid-type histology, (c) histological grade 1 or 2.

Univariate and multivariate analyses using Cox proportional hazards model to evaluate effects of prognostic factors. Disease-free survival and overall survival were calculated using the Kaplan-Meier method.

Results: A total of 171 patients with low-risk endometrial cancer were included in the study. Recurrence was detected in 9 patients. Histological grade was found to be independent risk factors for recurrence in women with low-risk endometrial cancer (OR 8.255, 95% confidence interval (CI) 1.585 - 42.981; p = 0.012).

Conclusion: The results of this study suggest that grade 2 disease should be considered a significant prognostic factor for the recurrence of low-risk endometrial cancer.

Keywords: endometrial cancer, uterine cancer, low risk, risk factors, histological grade

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APA

Bak, S.E., Yoo, J.G., Lee, S.J., Yoon, J.H., Park, D.C., Kim, S.I. (2022). Prognostic significance of histological grade in low-risk endometrial cancer. International Journal of Medical Sciences, 19(13), 1875-1878. https://doi.org/10.7150/ijms.77152.

ACS

Bak, S.E.; Yoo, J.G.; Lee, S.J.; Yoon, J.H.; Park, D.C.; Kim, S.I. Prognostic significance of histological grade in low-risk endometrial cancer. Int. J. Med. Sci. 2022, 19 (13), 1875-1878. DOI: 10.7150/ijms.77152.

NLM

CSE

Bak SE, Yoo JG, Lee SJ, Yoon JH, Park DC, Kim SI. 2022. Prognostic significance of histological grade in low-risk endometrial cancer. Int J Med Sci. 19(13):1875-1878.

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