Skeletal muscle satellite cell-derived mesenchymal stem cells ameliorate acute alcohol-induced liver injury

Chung, Jae Sik; Hwang, Soonjae; Hong, Ju Eun; Jo, Minjeong; Rhee, Ki-Jong; Kim, Seongyup; Jung, Pil Young; Yoon, Youngdae; Kang, Seong Hee; Ryu, Hoon; Kim, Moon Young; Bae, Keum Seok; Eom, Young Woo

doi:10.7150/ijms.68971

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Int J Med Sci 2022; 19(2):353-363. doi:10.7150/ijms.68971 This issue Cite

Research Paper

Skeletal muscle satellite cell-derived mesenchymal stem cells ameliorate acute alcohol-induced liver injury

Jae Sik Chung^1*, Soonjae Hwang^2,3*, Ju Eun Hong⁴, Minjeong Jo⁴, Ki-Jong Rhee⁴, Seongyup Kim¹, Pil Young Jung¹, Youngdae Yoon^2,5, Seong Hee Kang^2,6, Hoon Ryu¹, Moon Young Kim^2,6,7✉, Keum Seok Bae^1✉, Young Woo Eom^2,7✉

1. Department of Surgery, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Republic of Korea.
2. Regeneration Medicine Research Center, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Republic of Korea.
3. Department of Biochemistry, Lee Gil Ya Cancer and Diabetes Institute, GAIHST, Gachon University College of Medicine, Incheon 21999, Republic of Korea.
4. Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University MIRAE Campus, Wonju, Gangwon-do 26493, Republic of Korea.
5. Mitohormesis Research Center, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Republic of Korea.
6. Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Republic of Korea.
7. Cell Therapy and Tissue Engineering Center, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Republic of Korea.
*These authors contributed equally to this work.

✉ Corresponding authors: Moon Young Kim, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Republic of Korea. E-mail: drkimmyac.kr; Keum Seok Bae, Department of General Surgery, Yonsei Unive More

Citation:

Chung JS, Hwang S, Hong JE, Jo M, Rhee KJ, Kim S, Jung PY, Yoon Y, Kang SH, Ryu H, Kim MY, Bae KS, Eom YW. Skeletal muscle satellite cell-derived mesenchymal stem cells ameliorate acute alcohol-induced liver injury. Int J Med Sci 2022; 19(2):353-363. doi:10.7150/ijms.68971. https://www.medsci.org/v19p0353.htm

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Abstract

Cultured human skeletal-muscle satellite cells have properties of mesenchymal stem cells (skeletal muscle satellite cell-derived mesenchymal stem cells, SkMSCs) and play anti-inflammatory roles by secreting prostaglandin E2 and hepatocyte growth factor (HGF). To evaluate the utility of SkMSCs in treating liver diseases, we determined whether SkMSCs could ameliorate acute liver and gut inflammation induced by binge ethanol administration. Binge drinking of ethanol led to weight loss in the body and spleen, liver inflammation and steatosis, and increased serum ALT and AST levels (markers of liver injury), along with increased IL-1β, TNF-α, and iNOS expression levels in mice. However, levels of these binge-drinking-induced indicators were reduced by a single intraperitoneal treatment of SkMSCs. Furthermore, levels of bacteria-derived lipopolysaccharide decreased in the livers and sera of ethanol-exposed mice after SkMSC administration. SkMSCs decreased the extent of tissue inflammation and reduced villus and crypt lengths in the small intestine after alcohol binge drinking. SkMSCs also reduced the leakage of blood albumin, an indicator of leaky gut, in the stool of ethanol-exposed mice. Alcohol-induced damage to human colonic Caco-2/tc7 cells was also alleviated by HGF. Therefore, a single treatment with SkMSCs can attenuate alcoholic liver damage by reducing inflammatory responses in the liver and gut, suggesting that SkMSCs could be used in cell therapy to treat alcoholic liver diseases.

Keywords: skeletal muscle satellite cells, mesenchymal stem cells, binge ethanol, inflammation, liver, gut

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APA

Chung, J.S., Hwang, S., Hong, J.E., Jo, M., Rhee, K.J., Kim, S., Jung, P.Y., Yoon, Y., Kang, S.H., Ryu, H., Kim, M.Y., Bae, K.S., Eom, Y.W. (2022). Skeletal muscle satellite cell-derived mesenchymal stem cells ameliorate acute alcohol-induced liver injury. International Journal of Medical Sciences, 19(2), 353-363. https://doi.org/10.7150/ijms.68971.

ACS

Chung, J.S.; Hwang, S.; Hong, J.E.; Jo, M.; Rhee, K.J.; Kim, S.; Jung, P.Y.; Yoon, Y.; Kang, S.H.; Ryu, H.; Kim, M.Y.; Bae, K.S.; Eom, Y.W. Skeletal muscle satellite cell-derived mesenchymal stem cells ameliorate acute alcohol-induced liver injury. Int. J. Med. Sci. 2022, 19 (2), 353-363. DOI: 10.7150/ijms.68971.

NLM

CSE

Chung JS, Hwang S, Hong JE, Jo M, Rhee KJ, Kim S, Jung PY, Yoon Y, Kang SH, Ryu H, Kim MY, Bae KS, Eom YW. 2022. Skeletal muscle satellite cell-derived mesenchymal stem cells ameliorate acute alcohol-induced liver injury. Int J Med Sci. 19(2):353-363.

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