Int J Med Sci 2021; 18(15):3565-3573. doi:10.7150/ijms.63246

Research Paper

Risk of Pneumonia is associated with Antipsychotic Drug Use among older patients with Parkinson's Disease: A Case-control Study

Kuang-Hua Huang1*, Wei-Yin Kuo1*, Yu-Hsiang Kuan2,3, Yu-Chia Chang4,5, Tung-Han Tsai1, Chien-Ying Lee2,3✉

1. Department of Health Services Administration, China Medical University, Taichung, Taiwan.
2. Department of Pharmacology, Chung Shan Medical University, Taichung, Taiwan.
3. Department of Pharmacy, Chung Shan Medical University Hospital, Taichung, Taiwan.
4. Department of Healthcare Administration, Asia University, Taichung, Taiwan.
5. Department of Long Term Care, National Quemoy University, Kinmen, Taiwan.
* These authors contributed equally to this work.

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Citation:
Huang KH, Kuo WY, Kuan YH, Chang YC, Tsai TH, Lee CY. Risk of Pneumonia is associated with Antipsychotic Drug Use among older patients with Parkinson's Disease: A Case-control Study. Int J Med Sci 2021; 18(15):3565-3573. doi:10.7150/ijms.63246. Available from https://www.medsci.org/v18p3565.htm

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Abstract

Graphic abstract

Objective: To investigate the risk of pneumonia associated with the use of antipsychotic drugs in older-adult patients with Parkinson's disease (PD) in Taiwan.

Methods: This case-control study was based on data from the longitudinal health insurance database in Taiwan. We analyzed the data of 51,158 older patients with PD for the period between 2001 and 2016. To reduce the potential confounding caused by unbalanced covariates in nonexperimental settings, we used propensity score matching to include older patients without pneumonia to serve as the control group.

Results: Compared with patients who had never taken antipsychotics, current (adjusted odds ratios [aOR] =1.63, 95% confidence interval [CI] = 1.51-1.75), recent (aOR = 1.63, 95% CI = 1.52-1.74), and past (aOR = 1.89, 95% CI = 1.80-2.00) users of antipsychotics had a higher risk of incident pneumonia. Among typical and atypical antipsychotics, haloperidol and clozapine were associated with higher risks of incident pneumonia, respectively. By contrast, aripiprazole was not associated with a higher risk of pneumonia.

Conclusion: Older patients with PD receiving typical antipsychotics or atypical antipsychotics had a higher risk of pneumonia. Among these antipsychotics, clozapine had the highest risk of pneumonia. Clinicians should pay attention to the risk of pneumonia in older patients with PD who receive typical antipsychotics and atypical antipsychotics.

Keywords: pneumonia, antipsychotics, Parkinson's disease, pharmacoepidemiology