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Int J Med Sci 2021; 18(13):2997-3003. doi:10.7150/ijms.56614 This issue Cite

Research Paper

TRIM21 Polymorphisms are associated with Susceptibility and Clinical Status of Oral Squamous Cell Carcinoma patients

Chun-Yi Chuang^1,2#, Yi-Chung Chien^3,4,5,6,7#, Chiao-Wen Lin^8,9, Chia-Hsuan Chou^10,11, Shuo-Chueh Chen¹², Chun-Lin Liu¹³, Li-Yuan Bai¹⁴, Shun-Fa Yang^10,11✉, Yung-Luen Yu^{3,4,5,6,7,15✉}

1. School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
2. Department of Otolaryngology, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
3. Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
4. Ph.D. Program for Translational Medicine, China Medical University, Taichung 40402, Taiwan.
5. Institute of New Drug Development, China Medical University, Taichung, 404, Taiwan.
6. Drug Development Center, Research Center for Cancer Biology, China Medical University, Taichung, 404, Taiwan.
7. Center for Molecular Medicine, China Medical University Hospital, Taichung 40402, Taiwan.
8. Institute of Oral Sciences, Chung Shan Medical University, Taichung 40201, Taiwan.
9. Department of Dentistry, Chung Shan Medical University Hospital 40201, Taichung, Taiwan.
10. Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
11. Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
12. Division of Chest Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung 40402, Taiwan.
13. Department of Neurosurgery, China Medical University Hospital, Taichung 40402, Taiwan.
14. Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung 40402, Taiwan.
15. Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung 41354, Taiwan.
#Equal contributions to this work.

✉ Corresponding authors: ysfedu.tw (S.F.Y.); ylyucmu.edu.tw (Y.L.Y.).

Abstract

Squamous cell cancer of head and neck (HNSCC) is the sixth most common malignancy worldwide. One of the most common HNSCC types is oral squamous cell carcinoma (OSCC), which is the fifth leading cause of cancer death in Taiwan. Tripartite motif 21 (TRIM21) has been reported to play an important role in different cancer types. We found a correlation between TRIM21 and survival of HNSCC patients, but little information exists about how altered TRIM21 expression contributes to tumorigenesis. Thus, we investigated the combined effect of TRIM21 polymorphisms and exposure to environmental carcinogens on the susceptibility and clinicopathological characteristics of OSCC. Two single-nucleotide polymorphisms (SNPs) of TRIM21 (rs4144331, rs915956) from 1194 healthy controls and 1192 OSCC patients were analyzed by real-time PCR. Among 1632 smokers, TRIM21 polymorphism carriers with the betel-nut chewing habit had a ~4.8-fold greater risk of OSCC than TRIM21 wild-type carriers without the betel-nut chewing habit. After adjusting for other covariants, OSCC patients with G/T at TRIM21 rs4144331 had a high risk for distant metastasis compared with G/G homozygotes. This study is the first to examine the risk factors associated with TRIM21 SNPs in OSCC progression and development. Thus, our findings suggest that this study is the first to examine the risk factors associated with TRIM21 SNPs in OSCC progression and development and suggest that interactions between mutant genes may alter the susceptibility to OSCC.

Keywords: tripartite motif 21 (TRIM21), oral squamous cell carcinoma (OSCC), single-nucleotide polymorphism (SNP)

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