International Journal of Medical Sciences
ISSN: 1449-1907
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ISSN: 1449-1907
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Int J Med Sci 2021; 18(10):2109-2116. doi:10.7150/ijms.56003 This issue Cite
Review
The role of tumor-associated macrophages in primary hepatocellular carcinoma and its related targeting therapy
Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
* Lu Deng and Kang He contributed equally to this article.
Citation:
Deng L, He K, Pan Y, Wang H, Luo Y, Xia Q. The role of tumor-associated macrophages in primary hepatocellular carcinoma and its related targeting therapy. Int J Med Sci 2021; 18(10):2109-2116. doi:10.7150/ijms.56003. https://www.medsci.org/v18p2109.htm
Other stylesAbstract
Liver macrophages consist of ontogenically distinct populations termed Kupffer cells and monocyte-derived macrophages. Tumor-associated macrophages (TAMs) inhepatocellularcarcinoma (HCC) play a prominent role in tumormicroenvironment by presenting M1(induced by IFN γ along with LPS) and M2(induced by IL-4 and IL13) polarization. Although TAMs are involved in tumor immune surveillance during the course of HCC, they contribute to tumour progression at different levels by inhibiting the anti-tumor immune response, promoting the generation of blood vessels and lymphatic vessels, and supporting the proliferation and survival of tumor cells. In this paper, the multiple functions of TAMs in HCC were reviewed to provide assistance for future researches about therapeutic approaches.
Keywords: Tumor-associated macrophages, hepatocellular carcinoma, therapy
Citation styles
APA
Deng, L., He, K., Pan, Y., Wang, H., Luo, Y., Xia, Q. (2021). The role of tumor-associated macrophages in primary hepatocellular carcinoma and its related targeting therapy. International Journal of Medical Sciences, 18(10), 2109-2116. https://doi.org/10.7150/ijms.56003.
ACS
Deng, L.; He, K.; Pan, Y.; Wang, H.; Luo, Y.; Xia, Q. The role of tumor-associated macrophages in primary hepatocellular carcinoma and its related targeting therapy. Int. J. Med. Sci. 2021, 18 (10), 2109-2116. DOI: 10.7150/ijms.56003.
NLM
Deng L, He K, Pan Y, Wang H, Luo Y, Xia Q. The role of tumor-associated macrophages in primary hepatocellular carcinoma and its related targeting therapy. Int J Med Sci 2021; 18(10):2109-2116. doi:10.7150/ijms.56003. https://www.medsci.org/v18p2109.htm
CSE
Deng L, He K, Pan Y, Wang H, Luo Y, Xia Q. 2021. The role of tumor-associated macrophages in primary hepatocellular carcinoma and its related targeting therapy. Int J Med Sci. 18(10):2109-2116.
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