Int J Med Sci 2021; 18(5):1216-1224. doi:10.7150/ijms.49241

Review

Src-family Protein Tyrosine Kinases: A promising target for treating Cardiovascular Diseases

Yuhong Zhai1,2,3*, Jun Yang1,2✉*, Jing Zhang2,3, Jian Yang1, Qi Li1,2,3, Tao Zheng1,2,3✉

1. Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang 443000, China.
2. Institute of Cardiovascular Diseases, China Three Gorges University, Yichang 443000, China.
3. Central Laboratory, Yichang Central People's Hospital, Yichang 443000, China.
*These authors contributed equally to this manuscript.

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Citation:
Zhai Y, Yang J, Zhang J, Yang J, Li Q, Zheng T. Src-family Protein Tyrosine Kinases: A promising target for treating Cardiovascular Diseases. Int J Med Sci 2021; 18(5):1216-1224. doi:10.7150/ijms.49241. Available from https://www.medsci.org/v18p1216.htm

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Abstract

The Src-family protein tyrosine kinases (SFKs), a subfamily of non-receptor tyrosine kinases, are ubiquitously expressed in various cell types. Numerous studies have suggested that SFKs are related to signal transduction in major cardiac physiological and pathological processes, it is the activity of SFKs that is connected with the maintenance of cardiovascular homeostasis. Upon stimulation of various injury factors or stress, the phosphorylation state of SFKs is changed, which has been found to modulate different cardiac pathological conditions, such as hypertension, coronary heart disease, ischemic heart disease, myocardial ischemia-reperfusion injury, arrhythmia and cardiomyopathy via regulating cell growth, differentiation, movement and function, electrophysiologic signals. This review summarizes the basic information about SFKs, updates its role in the different processes underlying the development of multiple cardiovascular diseases (CVDs), and highlights their potential role as disease biomarkers and therapeutic targets, which would help understand the pathophysiology of CVDs and promote the further potential clinical adhibition.

Keywords: Src-family protein tyrosine kinases, hypertension, coronary heart disease, ischemic heart disease, myocardial ischemia reperfusion injury