Int J Med Sci 2021; 18(5):1153-1158. doi:10.7150/ijms.52293

Research Paper

Minimally invasive surgery for patients with advanced stage endometrial cancer

Sang Il Kim, MD1, Dong Choon Park, PhD1, Sung Jong Lee, PhD2, Ji Geun Yoo, MD3, Min Jong Song, PhD4, Chan Joo Kim, PhD5, Hae Nam Lee, PhD6, Joo Hee Yoon, PhD1✉

1. Department of Obstetrics and Gynecology, St. Vincent's hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
2. Department of Obstetrics and Gynecology, Seoul St. Mary's hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
3. Department of Obstetrics and Gynecology, Daejeon St. Mary's hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
4. Department of Obstetrics and Gynecology, Yeouido St. Mary's hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
5. Department of Obstetrics and Gynecology, Uijeongbu St. Mary's hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
6. Department of Obstetrics and Gynecology, Buchen St. Mary's hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

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Citation:
Kim SI, Park DC, Lee SJ, Yoo JG, Song MJ, Kim CJ, Lee HN, Yoon JH. Minimally invasive surgery for patients with advanced stage endometrial cancer. Int J Med Sci 2021; 18(5):1153-1158. doi:10.7150/ijms.52293. Available from https://www.medsci.org/v18p1153.htm

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Abstract

Objective: Compare the oncologic outcomes of patients with advanced stage endometrial cancer who were staged by minimally invasive surgery with the outcomes of patients who underwent open surgery.

Methods: Data from 138 patients with advanced stage endometrial cancer who were treated between January 2009 and January 2019 were reviewed. The patients' data were retrieved from five institutions. The patients were divided into two groups: those who underwent open surgery and those who underwent minimally invasive surgery. Tumor characteristics, recurrence rate, disease-free survival, and overall survival were compared according to surgical approach.

Results: Among the 138 patients included in this study, 72 underwent open surgery (52.2%) and 66 underwent MIS (47.8%). In patients with advanced-stage endometrial cancer, the recurrence rate was significantly higher among those who underwent open surgery (43.1% vs. 25.8%, p = 0.033). Patients with advanced-stage endometrial cancer who underwent open surgery had a significantly lower disease-free survival (p = 0.029) than those who underwent minimally invasive surgery, however, the overall survival (p = 0.051) was similar between the two groups.

Conclusion: Minimally invasive surgery showed better survival outcomes when compared to open surgery in advanced-stage EC patients irrespective of the histologic type.

Keywords: endometrial cancer, advanced stage, minimally invasive surgery, adjuvant treatment, PORTEC-3