Int J Med Sci 2021; 18(1):1-7. doi:10.7150/ijms.50646 This issue

Research Paper

Circulating hepassocin level in patients with stable angina is associated with fatty liver and renal function

I-Ting Tsai1,5, Wei-Chin Hung2,5, Yung-Chuan Lu3,7, Cheng-Ching Wu2,6,11, Thung-Lip Lee2,7, Chin-Feng Hsuan2,5, Teng-Hung Yu2,6, Ching-Ting Wei4,7,8,9, Fu-Mei Chung2, Yau-Jiunn Lee10, Chao-Ping Wang2,7✉

1. Department of Emergency, E-Da Hospital, Kaohsiung 82445 Taiwan.
2. Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445 Taiwan.
3. Division of Endocrinology and Metabolism, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445 Taiwan.
4. Division of General Surgery, Department of Surgery, E-Da Hospital, Kaohsiung 82445 Taiwan.
5. School of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan.
6. The School of Chinese Medicine for Post Baccalaureate, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan.
7. School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, 82445 Taiwan.
8. Department of Biomedical Engineering, I-Shou University, Kaohsiung, 82445 Taiwan.
9. Department of Electrical Engineering, I-Shou University, Kaohsiung, 82445 Taiwan.
10. Lee's Endocrinologic Clinic, Pingtung 90000 Taiwan.
11. Division of Cardiology, Department of Internal Medicine, E-Da Cancer Hospital, Kaohsiung 82445 Taiwan.

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Citation:
Tsai IT, Hung WC, Lu YC, Wu CC, Lee TL, Hsuan CF, Yu TH, Wei CT, Chung FM, Lee YJ, Wang CP. Circulating hepassocin level in patients with stable angina is associated with fatty liver and renal function. Int J Med Sci 2021; 18(1):1-7. doi:10.7150/ijms.50646. Available from https://www.medsci.org/v18p0001.htm

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Abstract

Background: Chronic kidney disease (CKD) is a major risk factor for coronary artery disease and it is often associated with hepatic steatosis. Hepassocin (also known as hepatocyte-derived fibrinogen related protein or fibrinogen-like 1) is a novel hepatokine that causes hepatic steatosis and induces insulin resistance. However, the role of hepassocin in renal function status remains unclear. Our objective was to investigate the association of plasma hepassocin level with fatty liver and renal function status in patients with stable angina.

Methods: Plasma hepassocin levels were determined by enzyme-linked immunosorbent assays in 395 consecutive patients with stable angina. Renal function was defined as an estimated glomerular filtration rate (eGFR). Fatty liver was defined by ultrasonography and fibrosis-4 (FIB-4) index.

Results: With increasing hepassocin tertiles, patients had higher prevalence of fatty live, an increased waist-to-hip ratio, and neutrophil count, monocyte count, and FIB-4 index, higher levels of uric acid, blood urine nitrogen and higher sensitivity C-reactive protein. They also had incrementally lower eGFR, serum hemoglobin and albumin levels. In multiple linear stepwise regression analysis, only eGFR was significantly independent negatively associated with plasma hepassocin levels.

Conclusion: Our results indicate that circulating hepassocin in patients with stable angina is associated with fatty liver and renal function, which suggests that increased plasma hepassocin may be involved in the pathogenesis of fatty liver and CKD.

Keywords: Hepassocin, fatty liver, renal function, stable angina