Int J Med Sci 2020; 17(13):1946-1955. doi:10.7150/ijms.44952

Research Paper

The prognostic value of HGF-c-MET signaling pathway in Gastric Cancer: a study based on TCGA and GEO databases

Chao Wang1#, Wenqi Xi1#, Jun Ji2, Qu Cai1, Qianfu Zhao1, Jinling Jiang1, Chenfei Zhou1, Min Shi1, Huan Zhang3, Zhenggang Zhu1,2, Jun Zhang1✉

1. Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin er Road, Shanghai, 200025, China.
2. Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin er Road, Shanghai, 200025, China.
3. Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197 Ruijin er Road, Shanghai, 200025, China.
#These authors contributed equally to this manuscript and should be considered co-first authors.

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Citation:
Wang C, Xi W, Ji J, Cai Q, Zhao Q, Jiang J, Zhou C, Shi M, Zhang H, Zhu Z, Zhang J. The prognostic value of HGF-c-MET signaling pathway in Gastric Cancer: a study based on TCGA and GEO databases. Int J Med Sci 2020; 17(13):1946-1955. doi:10.7150/ijms.44952. Available from http://www.medsci.org/v17p1946.htm

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Abstract

Gastric cancer is a heterogeneous tumor that underlying molecular mechanisms are largely unclear. This study aimed to elucidate the expression level of HGF-c-MET in gastric cancer patients and to investigate the prognostic and diagnostic value of HGF-c-MET. In silico analysis of the TCGA and GEO database found that HGF and c-MET mRNA expression are significantly higher in gastric cancer tissues than those in peritumor tissues. Both higher mRNA expression of HGF and c-MET were associated with a poorer prognosis. c-MET expression was modulated by methylation in the promoter regions. HGF was positively correlated with CD8+ T cell, CD4+ T cell, macrophage, neutrophil and dendritic cell. Furthermore, functional enrichment analysis and protein-protein interaction networks further shown that HGF-c-MET and related proteins mainly participated in growth factor receptor binding, protein tyrosine kinase activity and signaling receptor binding. Finally, outcome of GSEA analysis showed 13 shared KEGG pathways enriched in high expressed group of HGF and c-MET.

Keywords: HGF, c-MET, gastric cancer, TCGA, prognosis, GEO