Int J Med Sci 2020; 17(9):1187-1195. doi:10.7150/ijms.44583

Research Paper

The relationships of genetic polymorphisms of the long noncoding RNA growth arrest-specific transcript 5 with uterine cervical cancer

Shun-Long Weng1,2,3, Soo-Cheen Ng4,5,6, Yueh‐Chun Lee4,6,7, Yi-Hsuan Hsiao6,8, Chun-Fang Hsu4,5, Shun-Fa Yang4,9, Po-Hui Wang4,5,6,9,✉

1. Department of Obstetrics and Gynaecology, Hsinchu Mackay Memorial Hospital, Hsinchu City, Taiwan
2. Department of Medicine, Mackay Medical College, New Taipei City, Taiwan
3. Mackay Junior College of Medicine, Nursing and Management College, Taipei, Taiwan
4. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
5. Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan
6. School of Medicine, Chung Shan Medical University, Taichung, Taiwan
7. Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung, Taiwan
8. Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan
9. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan
10. Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan

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Citation:
Weng SL, Ng SC, Lee Y, Hsiao YH, Hsu CF, Yang SF, Wang PH. The relationships of genetic polymorphisms of the long noncoding RNA growth arrest-specific transcript 5 with uterine cervical cancer. Int J Med Sci 2020; 17(9):1187-1195. doi:10.7150/ijms.44583. Available from http://www.medsci.org/v17p1187.htm

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Abstract

The purposes of the investigation were to examine the implications of long noncoding RNA growth arrest-specific transcript 5 (GAS5) in progression and clinicopathological factors of uterine cervical cancer, and patient survival in Taiwan. Genotypic distributions of two GAS5 genetic variants rs145204276 and rs55829688 were detected in 208 patients including 111 patients with invasive cancer, 97 with precancerous lesions as well as 307 control women using real-time polymerase chain reaction. It explored that patients with cervical precancerous lesion had lower rate of AGGCA deletion (Del) in both alleles (Del/Del) of GAS5 rs145204276 as compared with control women. Patients with invasive cancer did not exhibit higher rate of Del/Del. Meanwhile, there were no different genotypic distributions in rs55829688 among patients with cervical invasive cancer and those with precancerous lesions as well as control women. Moreover, cervical cancer patients with Ins (insertion, AGGCA)/Del and Del/Del (-/-) in GAS5 rs55829688 tended to have poorer hazard ratio (HR) of 5 years survival. In addition, lymph node metastasis status exerted the most significantly predictive of 5 years survival rate. Conclusively, GAS5 polymorphism rs145204276 is probably applicable to predict 5 years survival HR of cervical cancer patients. However, the mechanism elucidating the methylation status and transcription function of rs145204276 in uterine cervical cancer needs to be delineated for its unique implication in uterine cervical cancer.

Keywords: long noncoding RNA growth arrest-specific transcript 5, genetic variants, uterine cervical cancer, precancerous lesions, 5 years survival rate