Department of Orthopaedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Jiang-Hong Road 1511, Hangzhou, China.
✉ Corresponding author: Xun-Zi Cai, MD, Department of Orthopaedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Jiang-Hong Road 1511, Hangzhou, China. E-mail: 2506053edu.cn
Citation:
Qu GX, Ying ZM, Zhao CC, Yan SG, Cai XZ. Mechanical Properties and Porosity of Acrylic Cement Bone Loaded with Alendronate Powder. Int J Med Sci 2018; 15(13):1458-1465. doi:10.7150/ijms.27759. https://www.medsci.org/v15p1458.htm
Aseptic loosening is the most common complication of joint replacement. Previous studies showed that acrylic bone cement loaded with a commercially-available alendronate powder (APAC) had good promise against wear debris-mediated osteolysis for prevention of aseptic loosening. The purpose of the present study was to investigate the effect of adding alendronate powder to an acrylic bone cement on quasi-static mechanical properties (namely, compressive strength, compressive modulus, tensile strength, and flexural strength), fatigue life, porosity, and microstructure of the cement. The results showed that adding up to 1 wt./wt.% alendronate powder exerted no detrimental effect on any of the quasi-static mechanical properties. However, the fatigue life of APAC decreased by between ~17% and ~27 % and its porosity increased by between ~ 5-7 times compared with corresponding values for the control cement (no alendronate powder added). Fatigue life was negatively and significantly correlated with porosity. Considering that fatigue life of the cement plays a significant role in joint replacement survival, clinical use of APAC cannot be recommended.
Keywords: Acrylic bone cement, Alendronate, Mechanical properties, Fatigue life, Porosity
Citation styles
APA
Qu, G.X., Ying, Z.M., Zhao, C.C., Yan, S.G., Cai, X.Z. (2018). Mechanical Properties and Porosity of Acrylic Cement Bone Loaded with Alendronate Powder. International Journal of Medical Sciences, 15(13), 1458-1465. https://doi.org/10.7150/ijms.27759.
ACS
Qu, G.X.; Ying, Z.M.; Zhao, C.C.; Yan, S.G.; Cai, X.Z. Mechanical Properties and Porosity of Acrylic Cement Bone Loaded with Alendronate Powder. Int. J. Med. Sci. 2018, 15 (13), 1458-1465. DOI: 10.7150/ijms.27759.
NLM
Qu GX, Ying ZM, Zhao CC, Yan SG, Cai XZ. Mechanical Properties and Porosity of Acrylic Cement Bone Loaded with Alendronate Powder. Int J Med Sci 2018; 15(13):1458-1465. doi:10.7150/ijms.27759. https://www.medsci.org/v15p1458.htm
CSE
Qu GX, Ying ZM, Zhao CC, Yan SG, Cai XZ. 2018. Mechanical Properties and Porosity of Acrylic Cement Bone Loaded with Alendronate Powder. Int J Med Sci. 15(13):1458-1465.
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