Int J Med Sci 2018; 15(13):1443-1448. doi:10.7150/ijms.27341 This issue Cite

Review

Biology of MiR-17-92 Cluster and Its Progress in Lung Cancer

Xinju Zhang, Yanli Li, Pengfei Qi, Zhongliang Ma

Lab for Noncoding RNA & Cancer, School of Life Sciences Shanghai University, Shanghai 200444

Citation:
Zhang X, Li Y, Qi P, Ma Z. Biology of MiR-17-92 Cluster and Its Progress in Lung Cancer. Int J Med Sci 2018; 15(13):1443-1448. doi:10.7150/ijms.27341. https://www.medsci.org/v15p1443.htm
Other styles

File import instruction

Abstract

MicroRNAs, a class of short endogenous RNAs, acting as post-transcriptional regulators of gene expression, mostly silence gene expression via binding imperfectly matched sequences in the 3'UTR of target mRNA. MiR-17-92, a highly conserved gene cluster, has 6 members including miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92a. The miR-17-92 cluster, regarded as oncogene, is overexpressed in human cancers. Lung cancer is the leading cause of death all over the world. The molecular mechanism of lung cancer has been partly known at the levels of genes and proteins in last decade. However, new prognosis biomarkers and more target drugs should be developed in future. Therefore, noncoding RNAs, especially miRNAs, make them as new potentially clinical biomarkers for diagnosis and prognosis. In this review, we focus the current progress of miR-17-92 cluster in lung cancer.

Keywords: microRNAs, miR-17-92 cluster, oncogene, lung cancer, tumorigenesis


Citation styles

APA
Zhang, X., Li, Y., Qi, P., Ma, Z. (2018). Biology of MiR-17-92 Cluster and Its Progress in Lung Cancer. International Journal of Medical Sciences, 15(13), 1443-1448. https://doi.org/10.7150/ijms.27341.

ACS
Zhang, X.; Li, Y.; Qi, P.; Ma, Z. Biology of MiR-17-92 Cluster and Its Progress in Lung Cancer. Int. J. Med. Sci. 2018, 15 (13), 1443-1448. DOI: 10.7150/ijms.27341.

NLM
Zhang X, Li Y, Qi P, Ma Z. Biology of MiR-17-92 Cluster and Its Progress in Lung Cancer. Int J Med Sci 2018; 15(13):1443-1448. doi:10.7150/ijms.27341. https://www.medsci.org/v15p1443.htm

CSE
Zhang X, Li Y, Qi P, Ma Z. 2018. Biology of MiR-17-92 Cluster and Its Progress in Lung Cancer. Int J Med Sci. 15(13):1443-1448.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Popup Image