Int J Med Sci 2018; 15(13):1443-1448. doi:10.7150/ijms.27341
Biology of MiR-17-92 Cluster and Its Progress in Lung Cancer
Lab for Noncoding RNA & Cancer, School of Life Sciences Shanghai University, Shanghai 200444
Zhang X, Li Y, Qi P, Ma Z. Biology of MiR-17-92 Cluster and Its Progress in Lung Cancer. Int J Med Sci 2018; 15(13):1443-1448. doi:10.7150/ijms.27341. Available from http://www.medsci.org/v15p1443.htm
MicroRNAs, a class of short endogenous RNAs, acting as post-transcriptional regulators of gene expression, mostly silence gene expression via binding imperfectly matched sequences in the 3'UTR of target mRNA. MiR-17-92, a highly conserved gene cluster, has 6 members including miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92a. The miR-17-92 cluster, regarded as oncogene, is overexpressed in human cancers. Lung cancer is the leading cause of death all over the world. The molecular mechanism of lung cancer has been partly known at the levels of genes and proteins in last decade. However, new prognosis biomarkers and more target drugs should be developed in future. Therefore, noncoding RNAs, especially miRNAs, make them as new potentially clinical biomarkers for diagnosis and prognosis. In this review, we focus the current progress of miR-17-92 cluster in lung cancer.
Keywords: microRNAs, miR-17-92 cluster, oncogene, lung cancer, tumorigenesis