Association of renal systolic time intervals with brachial-ankle pulse wave velocity

Lee, Wen-Hsien; Hsu, Po-Chao; Chu, Chun-Yuan; Chen, Szu-Chia; Lee, Hung-Hao; Chen, Ying-Chih; Lee, Meng-Kuang; Lee, Chee-Siong; Yen, Hsueh-Wei; Lin, Tsung-Hsien; Voon, Wen-Chol; Lai, Wen-Ter; Sheu, Sheng-Hsiung; Kuo, Po-Lin; Su, Ho-Ming

doi:10.7150/ijms.24451

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Int J Med Sci 2018; 15(11):1235-1240. doi:10.7150/ijms.24451 This issue Cite

Research Paper

Association of renal systolic time intervals with brachial-ankle pulse wave velocity

Wen-Hsien Lee^1,2,3,4, Po-Chao Hsu^2,4, Chun-Yuan Chu^2,4, Szu-Chia Chen^1,3,4, Hung-Hao Lee², Ying-Chih Chen^2,3, Meng-Kuang Lee^2,3, Chee-Siong Lee^2,4, Hsueh-Wei Yen^2,4, Tsung-Hsien Lin^2,4, Wen-Chol Voon^2,4, Wen-Ter Lai^2,4, Sheng-Hsiung Sheu^2,4, Po-Lin Kuo¹, Ho-Ming Su^2,3,4✉

1. Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
2. Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
3. Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
4. Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

Citation:

Lee WH, Hsu PC, Chu CY, Chen SC, Lee HH, Chen YC, Lee MK, Lee CS, Yen HW, Lin TH, Voon WC, Lai WT, Sheu SH, Kuo PL, Su HM. Association of renal systolic time intervals with brachial-ankle pulse wave velocity. Int J Med Sci 2018; 15(11):1235-1240. doi:10.7150/ijms.24451. https://www.medsci.org/v15p1235.htm

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Abstract

Aims: The renal systolic time intervals (STIs), including renal pre-ejection period (PEP), renal ejection time (ET), and renal PEP/renal ET measured by renal Doppler ultrasound, were associated with poor cardiac function and adverse cardiac outcomes. However, the relationship between renal hemodynamic parameters and arterial stiffness in terms of brachial-ankle pulse wave velocity (baPWV) has never been evaluated. The aim of this study was to assess the relationship between renal STIs and baPWV.

Methods: This cross-sectional study enrolled 230 patients. The renal hemodynamics was measured from Doppler ultrasonography and baPWV was measured from ABI-form device by an oscillometric method.

Results: Patients with baPWV ≧ 1672 cm/s had a higher value of renal resistive index (RI) and lower values of renal PEP and renal PEP/ET (all P< 0.001). In univariable analysis, baPWV was significantly associated with renal RI, renal PEP, and renal PEP/renal ET (all P< 0.001). In multivariable analysis, renal PEP (unstandardized coefficient β = -3.185; 95% confidence interval = -5.169 to -1.201; P = 0.002) and renal PEP/renal ET (unstandardized coefficient β = -5.605; 95% CI = -10.217 to -0.992; P = 0.018), but not renal RI, were still the independent determinants of baPWV.

Conclusion: Our results found that renal PEP and renal PEP/renal ET were independently associated with baPWV. Hence, renal STIs measured from renal echo may have a significant correlation with arterial stiffness.

Keywords: Systolic time intervals, renal Doppler, arterial stiffness, blood pressure, brachial-ankle pulse wave velocity

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APA

Lee, W.H., Hsu, P.C., Chu, C.Y., Chen, S.C., Lee, H.H., Chen, Y.C., Lee, M.K., Lee, C.S., Yen, H.W., Lin, T.H., Voon, W.C., Lai, W.T., Sheu, S.H., Kuo, P.L., Su, H.M. (2018). Association of renal systolic time intervals with brachial-ankle pulse wave velocity. International Journal of Medical Sciences, 15(11), 1235-1240. https://doi.org/10.7150/ijms.24451.

ACS

Lee, W.H.; Hsu, P.C.; Chu, C.Y.; Chen, S.C.; Lee, H.H.; Chen, Y.C.; Lee, M.K.; Lee, C.S.; Yen, H.W.; Lin, T.H.; Voon, W.C.; Lai, W.T.; Sheu, S.H.; Kuo, P.L.; Su, H.M. Association of renal systolic time intervals with brachial-ankle pulse wave velocity. Int. J. Med. Sci. 2018, 15 (11), 1235-1240. DOI: 10.7150/ijms.24451.

NLM

CSE

Lee WH, Hsu PC, Chu CY, Chen SC, Lee HH, Chen YC, Lee MK, Lee CS, Yen HW, Lin TH, Voon WC, Lai WT, Sheu SH, Kuo PL, Su HM. 2018. Association of renal systolic time intervals with brachial-ankle pulse wave velocity. Int J Med Sci. 15(11):1235-1240.

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