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Int J Med Sci 2015; 12(6):524-529. doi:10.7150/ijms.11352 This issue Cite

Research Paper

Artesunate Induces SKM-1 Cells Apoptosis by Inhibiting Hyperactive β-catenin Signaling Pathway

Na Xu1, #, Xuan Zhou1, #, Shuang Wang2, Lu-lu Xu1, Hong-sheng Zhou1, Xiao-li Liu1,✉

1. Department of Hematology, Nan fang Hospital, Southern Medical University, Guangzhou, China
2. Department of Ultrasound, Xiangtan Central Hospital, Xiangtan, Hunan, China.
# Na Xu and Xuan Zhou contributed equally to this study

✉ Corresponding author: Xiao-li Liu, M.D, Department of Hematology Nan fang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, P.R. China. Email: lxlnfcom; Tel/fax: +86 020 61641616

Citation:
Xu N, Zhou X, Wang S, Xu Ll, Zhou Hs, Liu Xl. Artesunate Induces SKM-1 Cells Apoptosis by Inhibiting Hyperactive β-catenin Signaling Pathway. Int J Med Sci 2015; 12(6):524-529. doi:10.7150/ijms.11352. https://www.medsci.org/v12p0524.htm
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Abstract

Introduction: Artesunate (ART), a wildly used agent to treat severe malarial around the world, also has the power to inhibit growth of different types of tumor. However, the exact molecular mechanisms keep unknown. Method: In this study, we used myelodysplastic syndrome (MDS) cells (SKM-1 cells) with differential ART concentrations treatment at multiple time points to observe the subsequence cell function alteration and the possible involved pathway genes. Results: We found that ART demonstrated the ability to inhibit proliferation and induce apoptosis in SKM-1 in a dose and time-dependent manner. Demethylase recovered CDH1 gene expression may be involved in the apoptosis process. The β-catenin protein translocated from the nucleus and cytoplasm to the membrane result in inactivation of β-catenin signaling pathway. Conclusion: Our findings provide a rational basis to develop ART as a useful therapeutic agent for the treatment of myelodysplastic syndromes.

Keywords: Artesunate (ART), β-catenin pathway, E-cadherin, myelodysplastic syndrome

Citation styles

APA
Xu, N., Zhou, X., Wang, S., Xu, L.l., Zhou, H.s., Liu, X.l. (2015). Artesunate Induces SKM-1 Cells Apoptosis by Inhibiting Hyperactive β-catenin Signaling Pathway. International Journal of Medical Sciences, 12(6), 524-529. https://doi.org/10.7150/ijms.11352.

ACS
Xu, N.; Zhou, X.; Wang, S.; Xu, L.l.; Zhou, H.s.; Liu, X.l. Artesunate Induces SKM-1 Cells Apoptosis by Inhibiting Hyperactive β-catenin Signaling Pathway. Int. J. Med. Sci. 2015, 12 (6), 524-529. DOI: 10.7150/ijms.11352.

NLM
Xu N, Zhou X, Wang S, Xu Ll, Zhou Hs, Liu Xl. Artesunate Induces SKM-1 Cells Apoptosis by Inhibiting Hyperactive β-catenin Signaling Pathway. Int J Med Sci 2015; 12(6):524-529. doi:10.7150/ijms.11352. https://www.medsci.org/v12p0524.htm

CSE
Xu N, Zhou X, Wang S, Xu Ll, Zhou Hs, Liu Xl. 2015. Artesunate Induces SKM-1 Cells Apoptosis by Inhibiting Hyperactive β-catenin Signaling Pathway. Int J Med Sci. 12(6):524-529.

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