Int J Med Sci 2014; 11(7):697-706. doi:10.7150/ijms.8168
A Peptide & Peptide Nucleic Acid Synthesis Technology for Transporter Molecules and Theranostics - The SPPS
1. German Cancer Research Center, Dept. of Translational Immunology, INF 410, D-69120 Heidelberg, Germany
2. German Cancer Research Center, Dept. of Medical Physics in Radiology, INF 280, D-69120 Heidelberg, Germany
3. German Cancer Research Center, Division of Biophysics of Macromolecules, INF 580, D-69120 Heidelberg, Germany.
Pipkorn R, Braun K, Wiessler M, Waldeck W, Schrenk HH, Koch M, Semmler W, Komljenovic D. A Peptide & Peptide Nucleic Acid Synthesis Technology for Transporter Molecules and Theranostics - The SPPS. Int J Med Sci 2014; 11(7):697-706. doi:10.7150/ijms.8168. Available from http://www.medsci.org/v11p0697.htm
Advances in imaging diagnostics using magnetic resonance tomography (MRT), positron emission tomography (PET) and fluorescence imaging including near infrared (NIR) imaging methods are facilitated by constant improvement of the concepts of peptide synthesis. Feasible patient-specific theranostic platforms in the personalized medicine are particularly dependent on efficient and clinically applicable peptide constructs. The role of peptides in the interrelations between the structure and function of proteins is widely investigated, especially by using computer-assisted methods.
Nowadays the solid phase synthesis (SPPS) chemistry emerges as a key technology and is considered as a promising methodology to design peptides for the investigation of molecular pharmacological processes at the transcriptional level. SPPS syntheses could be carried out in core facilities producing peptides for large-scale scientific implementations as presented here.
Keywords: Functional peptides, Ligation chemistry, Linker systems, Solid Phase Peptide Synthesis, Therapy, Diagnostics, Theranostics.