ISSN: 1449-1907International Journal of Medical Sciences
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Int J Med Sci 2014; 11(5):453-460. doi:10.7150/ijms.8172 This issue Cite
Research Paper
Increased Levels of Circulating Advanced Glycation End-Products in Menopausal Women with Osteoporosis
1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan;
2. Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Taichung Armed-Forces General Hospital, Taichung, Taiwan;
3. Department of Orthopedic Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan;
4. Department of Nursing, College of Medicine & Nursing, Hung Kuang University, Taichung, Taiwan;
5. School of Medicine, Chung Shan Medical University, Taichung, Taiwan;
6. School of Public Health, National Defense Medical Center, Taipei, Taiwan;
7. Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung Taiwan;
8. Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Abstract
Background: Advanced glycation end-products (AGEs) can accumulate in organs and tissues during ageing and diabetes. Increased levels of AGEs are found in the bone tissue of patients with osteoporosis. The purpose of this study was to evaluate circulating AGEs in patients with osteoporosis.
Methods: We evaluated plasma AGEs, osteoporosis-related biomarkers, and bone mass in 82 menopausal women with osteoporosis or osteopenia, 16 young women with osteopenia, and 43 healthy women without osteoporosis or osteopenia.
Results: Higher levels of serum AGEs were found in the osteoporosis or osteopenia group compared to healthy women (P < 0.0001). A negative correlation was observed between serum AGEs and lumbar spine bone density (BMD of lumbar spine, r = -0.249, P = 0.028; T-score of lumbar spine, r = -0.261, P = 0.021). Women with a increased level of serum AGEs (> 8.12 U/mL) had a 5.34-fold risk of osteopenia regarding lumbar spine T-score and a 3.31-fold risk of osteopenia regarding the hip T-score.
Conclusion: Serum AGEs could be used to monitor the severity and progression of osteoporosis. An increased serum level of AGEs was associated with impaired bone formation and was a risk factor for the development of osteoporosis. Targeting AGEs may represent a novel therapeutic approach for primary or secondary osteoporosis.
Keywords: Advanced glycation end-products, Osteopenia, Osteoporosis, Biomarker, Osteopontin.
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