Int J Med Sci 2013; 10(6):691-698. doi:10.7150/ijms.6170
Wnt10b Promotes Differentiation of Mouse Hair Follicle Melanocytes
1. Bioengineering College, Chongqing University, Chongqing 400044, PR China;
2. Department of Cell Biology, Third Military Medical University, Chongqing 400038, PR China;
3. Department of Genetics, Institute of Basic Medicine, Medical University of Chongqing, Chongqing 400016, PR China.
Ye J, Yang T, Guo H, Tang Y, Deng F, Li Y, Xing Y, Yang L, Yang K. Wnt10b Promotes Differentiation of Mouse Hair Follicle Melanocytes. Int J Med Sci 2013; 10(6):691-698. doi:10.7150/ijms.6170. Available from http://www.medsci.org/v10p0691.htm
Previous research has revealed that Wnt10b activates canonical Wnt signaling, which is integral to melanocyte differentiation in hair follicles (HFs). However, the function of Wnt10b in HF melanocytes remains poorly understood. We determined using Dct-LacZ transgenic mice that Wnt10b is mainly expressed near and within melanocytes of the hair bulbs during the anagen stage of the hair cycle. We also found that Wnt10b promotes an increase in melanocyte maturation and pigmentation in the hair bulbs of the mouse HF. To further explore the potential functions of Wnt10b in mouse HF melanocytes, we infected iMC23 cells with Ad-Wnt10b to overexpress Wnt10b. We demonstrated that Wnt10b promotes the differentiation of melanocytes by activating canonical Wnt signaling in melanocytes.
Keywords: Wnt10b, Wnt/β-catenin signaling, Hair follicle, Melanocyte, Differentiation.