Expression and regulation of HIF-1a in hypoxic pulmonary hypertension: Focus on pathological mechanism and Pharmacological Treatment

Wan, Jia-Jing; Yi, Jian; Wang, Fei-Ying; Zhang, Chao; Dai, Ai-Guo

doi:10.7150/ijms.88216

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Int J Med Sci 2024; 21(1):45-60. doi:10.7150/ijms.88216 This issue Cite

Review

Expression and regulation of HIF-1a in hypoxic pulmonary hypertension: Focus on pathological mechanism and Pharmacological Treatment

Jia-Jing Wan^1,2,3, Jian Yi⁵, Fei-Ying Wang^2,3, Chao Zhang^2,3, Ai-Guo Dai^2,3,4,✉

1. School of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, Hunan, People's Republic of China.
2. Department of Respiratory Diseases, Medical School, Hunan University of Chinese Medicine, Changsha 410208, Hunan, People's Republic of China.
3. Hunan Provincial Key Laboratory of Vascular Biology and Translational Medicine, Changsha 410208, Hunan, People's Republic of China.
4. Department of Respiratory Medicine, First Affiliated Hospital, Hunan University of Chinese Medicine, Changsha 410021, Hunan, People's Republic of China.
5. The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410021, Hunan, People's Republic of China.

Citation:

Wan JJ, Yi J, Wang FY, Zhang C, Dai AG. Expression and regulation of HIF-1a in hypoxic pulmonary hypertension: Focus on pathological mechanism and Pharmacological Treatment. Int J Med Sci 2024; 21(1):45-60. doi:10.7150/ijms.88216. https://www.medsci.org/v21p0045.htm

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Abstract

Hypoxia inducible factor-1(HIF-1), a heterodimeric transcription factor, is composed of two subunits (HIF-1α and HIF-1β). It is considered as an important transcription factor for regulating oxygen changes in hypoxic environment, which can regulate the expression of various hypoxia-related target genes and play a role in acute and chronic hypoxia pulmonary vascular reactions. In this paper, the function and mechanism of HIF-1a expression and regulation in hypoxic pulmonary hypertension (HPH) were reviewed, and current candidate schemes for treating pulmonary hypertension by using HIF-1a as the target were introduced, so as to provide reference for studying the pathogenesis of HPH and screening effective treatment methods.

Keywords: Hypoxia-inducible factor-1a, Hypoxia induced pulmonary hypertension, Pulmonary vascular remodeling, Right ventricular remodeling

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APA

Wan, J.J., Yi, J., Wang, F.Y., Zhang, C., Dai, A.G. (2024). Expression and regulation of HIF-1a in hypoxic pulmonary hypertension: Focus on pathological mechanism and Pharmacological Treatment. International Journal of Medical Sciences, 21(1), 45-60. https://doi.org/10.7150/ijms.88216.

ACS

Wan, J.J.; Yi, J.; Wang, F.Y.; Zhang, C.; Dai, A.G. Expression and regulation of HIF-1a in hypoxic pulmonary hypertension: Focus on pathological mechanism and Pharmacological Treatment. Int. J. Med. Sci. 2024, 21 (1), 45-60. DOI: 10.7150/ijms.88216.

NLM

CSE

Wan JJ, Yi J, Wang FY, Zhang C, Dai AG. 2024. Expression and regulation of HIF-1a in hypoxic pulmonary hypertension: Focus on pathological mechanism and Pharmacological Treatment. Int J Med Sci. 21(1):45-60.

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