Int J Med Sci 2019; 16(9):1283-1286. doi:10.7150/ijms.35471

Short Research Communication

Effects of semi-solidification of enteral nutrients on the pharmacokinetic behavior of orally administered carbamazepine in rats

Katsuhito Nagai1, Sachiko Omotani1, Masahito Shibano1, Akihide Kobayashi1, Akihiko Ito2, Ikumi Nishimura2, Yasutoshi Hatsuda1, Junji Mukai1, Hitomi Teramachi3, Michiaki Myotoku1✉

1. Laboratory of Practical Pharmacy and Pharmaceutical Care, Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nishikiori-kita, Tondabayashi, 584-0066, Japan
2. National Hospital Organization Higashi-Ohmi General Medical Center, 255, Gochi-cho, Higashiomi, 527-8505, Japan
3. Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifushi, 501-1196, Japan

Abstract

The use of semi-solid enteral nutrients plays an extremely important role in accurate nutrition management. In the present study, we compared the pharmacokinetic profile of orally administered carbamazepine (CBZ) in rats treated with liquid RACOL®, semi-solid RACOL®, and HINE E-gel®, which are enteral nutrients marketed in Japan. Since liquid and semi-solid formulations are both marketed in Japan for RACOL®, liquid RACOL® was orally administered to control rats. The serum concentration of CBZ at each sampling point was lower in the semi-solid RACOL®-treated group than in the liquid RACOL®-treated group. No significant differences were observed in the pharmacokinetic behavior of CBZ between the semi-solid RACOL®-treated and HINE E-gel®-treated groups. Regarding pharmacokinetic parameters, the impact of the area under the curve (AUC0→5h) was the liquid RACOL® group > the semi-solid RACOL® group ≈ the HINE E-gel® group. Therefore, we concluded that serum concentrations of CBZ were lower when concurrently treating with semi-solid enteral nutrients than when simultaneously processing liquid enteral nutrients.

Keywords: Nutrition management, semi-solid enteral nutrient, carbamazepine, pharmacokinetics

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How to cite this article:
Nagai K, Omotani S, Shibano M, Kobayashi A, Ito A, Nishimura I, Hatsuda Y, Mukai J, Teramachi H, Myotoku M. Effects of semi-solidification of enteral nutrients on the pharmacokinetic behavior of orally administered carbamazepine in rats. Int J Med Sci 2019; 16(9):1283-1286. doi:10.7150/ijms.35471. Available from http://www.medsci.org/v16p1283.htm