25 May 2019
Global reach, higher impact
Int J Med Sci 2018; 15(14):1723-1730. doi:10.7150/ijms.27860
Significance of PD-L1 Expression in Tongue Cancer Development
1. Department of Pathology, Saitama Medical University International Medical Center, Saitama, Japan
Aims: Immunohistochemistry of PD-L1 has been recently established as a surrogate method to predict if immunotherapy targeting PD-L1/PD-1 has a significant effect on suppression of cancers such as lung non-small cell carcinoma, melanoma, and renal cell carcinoma. Here we performed immunohistochemistry for PD-L1 expression in squamous cell carcinoma (SCC) of the tongue to investigate the potential correlation between PD-L1 expression and clinicopathological factors and whether PD-L1 expression would be associated with prognosis.
Methods: Tissue microarray cores of paraffin-embedded blocks from 135 cases with surgically resected tongue SCC were immunohistochemically analysed for PD-L1 expression.
Results: We observed a positive correlation between PD-L1 expression and tongue SCC pT1 and pT2 tumours, but a negative correlation with pT2, pT3 and pT4 tumours. We also observed a positive correlation with lymph node metastasis. However, no positive correlation was demonstrated between PD-L1 expression and overall survival.
Conclusions: PD-L1 tends to be overexpressed at the early stage of tongue SCC, showing a close correlation with initial development of tongue. However, PD-L1 expression may not affect prognosis.
Keywords: PD-L1, immunohistochemistry, oral pathology, squamous cell carcinoma
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How to cite this article:
Yoshida S, Nagatsuka H, Nakano K, Kogashiwa Y, Ebihara Y, Yano M, Yasuda M. Significance of PD-L1 Expression in Tongue Cancer Development. Int J Med Sci 2018; 15(14):1723-1730. doi:10.7150/ijms.27860. Available from http://www.medsci.org/v15p1723.htm