International Journal of Medical Sciences

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16 November 2018

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Int J Med Sci 2018; 15(14):1640-1647. doi:10.7150/ijms.27834

Research Paper

The effect of the primary tumor location on the survival of colorectal cancer patients after radical surgery

Xiaona Cai1*, Dianna Gu1*, Mengfeng Chen2, Linger Liu1, Didi Chen1, Lihuai Lu1, Mengdan Gao1, Xuxue Ye1, Xiance Jin1✉, Congying Xie1✉

1. Department of Radiation and Medical Oncology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China, 325000.
2. Department of Oncology Medicine, Yueqing Third People's Hospital, Wenzhou, China, 325000
*These authors contributed equally

Abstract

Background and Objectives: Colorectal cancer is one of the most common cancers and the leading cause of cancer-related death worldwide. The impact of the primary tumor location on the prognosis of patients with colorectal cancer has long been a concern, but studies have led to conflicting conclusions.

Methods: In total, 465 colorectal cancer patients who received radical surgery were reviewed in this study. Enrolled patients were divided into two groups according to the tumor location. Disease-free survival (DFS) and overall survival (OS) were analyzed via the Kaplan-Meier method. A Cox regression model was employed to evaluate the independent prognostic factors for DFS and OS.

Results: The right colorectal cancer (RCC) and left colorectal cancer (LCC) groups comprised 202 and 140 patients, respectively. Univariate and multivariate analyses revealed that the tumor location and TNM stage were independent predictors of DFS and OS. Subgroup analyses by stage demonstrated that there were significant differences in DFS and OS between patients with stage II and III RCC and LCC, but not for those with stage I colorectal cancer.

Conclusions: Patients with stage II and III LCC had better survival than those with RCC. However, this improvement in DFS and OS was not observed in patients with stage I colorectal cancer.

Keywords: Colorectal cancer, Tumor location, Surgery, Overall survival, Disease-free survival

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Cai X, Gu D, Chen M, Liu L, Chen D, Lu L, Gao M, Ye X, Jin X, Xie C. The effect of the primary tumor location on the survival of colorectal cancer patients after radical surgery. Int J Med Sci 2018; 15(14):1640-1647. doi:10.7150/ijms.27834. Available from http://www.medsci.org/v15p1640.htm