International Journal of Medical Sciences

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23 March 2019

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Int J Med Sci 2018; 15(13):1517-1521. doi:10.7150/ijms.28337

Research Paper

Ethanol Extract from Brucea Javanica Seed Inhibits Angiogenesis Mediated by Platelet Derived Growth Factor Receptor-beta

Xiaotong Wang1,4#, Yunyun Li2#, Yan Mou1,3, Zhen Yue1, Haiying Zhang1, Ronggui Li1✉, Hongxia Sun2✉

1. Key Laboratory of Pathobiology, Ministry of Education, Norman Bethune College of Medicine, Jilin University, Changchun, China
2. People's Hospital of Jilin Province and Changchun University of Chinese Medicine, Changchun, P.R. China
3. Second Hospital of Jilin University, Changchun, China
4. Current address: Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, Tianjin, China
#These authors contributed equally to this work.

Abstract

The present study aimed to investigate the effects of ethanol extract from Brucea javanicaseed (EEBJS) on the angiogenesis of human umbilical vein endothelial cells (HUVECs) and the possible molecular signal involved. Firstly, a Matrigel-based in vitro angiogenesis assay demonstrated that EEBJS inhibited the angiogenesis of HUVECs in a dose-dependent manner. Then by using porcine aortic endothelial cells which stably express human PDGFR-beta, we found that the inhibition of angiogenesis was mediated by PDGFR-beta. Taken together, we conclude that EEBJS inhibited the angiogenesis function of the vascular endothelial cells mediated by PDGFR-beta, and postulate that it might contribute to the therapeutic effects of EEBJS on malignant tumors.

Keywords: Ethanol Extract from Brucea javanica Seed, Angiogenesis, Human Umbilical Vein Endothelial Cells, Platelet Derived Growth Factor Receptor, Malignant Tumors

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How to cite this article:
Wang X, Li Y, Mou Y, Yue Z, Zhang H, Li R, Sun H. Ethanol Extract from Brucea Javanica Seed Inhibits Angiogenesis Mediated by Platelet Derived Growth Factor Receptor-beta. Int J Med Sci 2018; 15(13):1517-1521. doi:10.7150/ijms.28337. Available from http://www.medsci.org/v15p1517.htm