International Journal of Medical Sciences

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20 March 2019

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Int J Med Sci 2018; 15(13):1458-1465. doi:10.7150/ijms.27759

Research Paper

Mechanical Properties and Porosity of Acrylic Cement Bone Loaded with Alendronate Powder

Guo-Xin Qu, Zhi-Min Ying, Chen-Chen Zhao, Shi-Gui Yan, Xun-Zi Cai

Department of Orthopaedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Jiang-Hong Road 1511, Hangzhou, China.


Aseptic loosening is the most common complication of joint replacement. Previous studies showed that acrylic bone cement loaded with a commercially-available alendronate powder (APAC) had good promise against wear debris-mediated osteolysis for prevention of aseptic loosening. The purpose of the present study was to investigate the effect of adding alendronate powder to an acrylic bone cement on quasi-static mechanical properties (namely, compressive strength, compressive modulus, tensile strength, and flexural strength), fatigue life, porosity, and microstructure of the cement. The results showed that adding up to 1 wt./wt.% alendronate powder exerted no detrimental effect on any of the quasi-static mechanical properties. However, the fatigue life of APAC decreased by between ~17% and ~27 % and its porosity increased by between ~ 5-7 times compared with corresponding values for the control cement (no alendronate powder added). Fatigue life was negatively and significantly correlated with porosity. Considering that fatigue life of the cement plays a significant role in joint replacement survival, clinical use of APAC cannot be recommended.

Keywords: Acrylic bone cement, Alendronate, Mechanical properties, Fatigue life, Porosity

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license ( See for full terms and conditions.
How to cite this article:
Qu GX, Ying ZM, Zhao CC, Yan SG, Cai XZ. Mechanical Properties and Porosity of Acrylic Cement Bone Loaded with Alendronate Powder. Int J Med Sci 2018; 15(13):1458-1465. doi:10.7150/ijms.27759. Available from