International Journal of Medical Sciences

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24 September 2018

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Int J Med Sci 2018; 15(13):1443-1448. doi:10.7150/ijms.27341

Review

Biology of MiR-17-92 Cluster and Its Progress in Lung Cancer

Xinju Zhang, Yanli Li, Pengfei Qi, Zhongliang Ma

Lab for Noncoding RNA & Cancer, School of Life Sciences Shanghai University, Shanghai 200444

Abstract

MicroRNAs, a class of short endogenous RNAs, acting as post-transcriptional regulators of gene expression, mostly silence gene expression via binding imperfectly matched sequences in the 3'UTR of target mRNA. MiR-17-92, a highly conserved gene cluster, has 6 members including miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92a. The miR-17-92 cluster, regarded as oncogene, is overexpressed in human cancers. Lung cancer is the leading cause of death all over the world. The molecular mechanism of lung cancer has been partly known at the levels of genes and proteins in last decade. However, new prognosis biomarkers and more target drugs should be developed in future. Therefore, noncoding RNAs, especially miRNAs, make them as new potentially clinical biomarkers for diagnosis and prognosis. In this review, we focus the current progress of miR-17-92 cluster in lung cancer.

Keywords: microRNAs, miR-17-92 cluster, oncogene, lung cancer, tumorigenesis

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Zhang X, Li Y, Qi P, Ma Z. Biology of MiR-17-92 Cluster and Its Progress in Lung Cancer. Int J Med Sci 2018; 15(13):1443-1448. doi:10.7150/ijms.27341. Available from http://www.medsci.org/v15p1443.htm