International Journal of Medical Sciences

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16 November 2018

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Int J Med Sci 2018; 15(10):1005-1013. doi:10.7150/ijms.25553

Research Paper

Relationship of genetic variant distributions of WW domain-containing oxidoreductase gene with uterine cervical cancer

Yu-Hsiang Lin1,#, Yi-Hsuan Hsiao2,3,#, Wen-Jun Wu1,4, Shun-Fa Yang1,4, Chun-Fang Hsu1, Yu-Ting Kang1, Po-Hui Wang1,2,5,✉

1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
2. School of Medicine, Chung Shan Medical University, Taichung, Taiwan
3. Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan
4. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan
5. Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan
#These authors contributed equally to the work.

Abstract

To our knowledge, no study investigates the association of genetic variant distributions of WW domain-containing oxidoreductase (WWOX) gene with development of invasive cancer, clinicopathologic variables and patient survival in uterine cervical cancer for Taiwanese women. We therefore conducted this study to explore the clinical involvements of WWOX single nucleotide polymorphisms (SNPs) in cervical cancer. One hundred and thirty-one patients with cervical invasive cancer and 93 patients with precancerous lesions as well as 316 control women were consecutively enrolled. The genotypic frequencies of WWOX genetic variants rs73569323, rs383362, rs11545028, rs3764340 and rs12918952 were determined by real-time polymerase chain reaction. The results revealed that only WWOX SNP rs3764340 was associated between patients with cervical invasive cancer and normal controls among 5 WWOX genetic variants. Cervical cancer patients with genotypes GA/AA in WWOX SNP rs12918952 were associated with parametrium invasion and pelvic lymph node metastasis. Univariate analysis found that WWOX SNPs rs73569323 and rs11545028 were associated with patient survival, whereas multivariate analysis revealed CT/TT in rs11545028 was the only genetic variant, which could predict better overall survival, among 5 WWOX SNPs in Taiwan. In conclusion, Taiwanese women with CG/GG in WWOX SNP rs3764340 are susceptible to cervical invasive cancer. Cervical cancer patients with GA/AA in rs12918952 tend to have more risk to develop parametrium invasion and pelvic lymph node metastasis. Among 5 WWOX SNPs, rs11545028 is the only genetic variant associated with patient survival, in which CT/TT could predict better overall survival in Taiwanese women.

Keywords: WW domain-containing oxidoreductase, genetic variants, invasive cancer of uterine cervix, clinicopathologic variables, overall survival

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How to cite this article:
Lin YH, Hsiao YH, Wu WJ, Yang SF, Hsu CF, Kang YT, Wang PH. Relationship of genetic variant distributions of WW domain-containing oxidoreductase gene with uterine cervical cancer. Int J Med Sci 2018; 15(10):1005-1013. doi:10.7150/ijms.25553. Available from http://www.medsci.org/v15p1005.htm