Int J Med Sci 2018; 15(8):808-815. doi:10.7150/ijms.25140
Iroquois Homeodomain transcription factors in ventricular conduction system and arrhythmia
1. Department of Cardiology, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China
2. Department of Cardiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
3. Department of Cardiology, Jinqiu Hosipital Of Liaoning Province, Shenyang, Liaoning110001, China
4. Department of Neurology, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China
*These two authors contributed equally to this work.
Iroquois homeobox genes, Irx, encode cardiac transcription factors, Irx1-6 in most mammals. These six transcription factors are expressed in different patterns mainly in the ventricular part of the heart. Existing researches show that Irx genes play key roles in the differentiation and development of ventricular conduction system and the establishment and maintenance of gradient expression of potassium channels, Kv4.2. Our main focus of this review is on the recent advances in the discovery of above-mentioned genes and the function of the encoding products, how Irx genes establish ventricular conduction system and regulate ventricular repolarization, how the individual and complementary functions can be verified to complement our cognition and leads to novel therapeutic approaches.
Keywords: Arrhythmia, Ionic channels, Iroquois homeobox, Ventricular conduction system, Ventricular repolarization
Hu W, Xin Y, Zhang L, Hu J, Sun Y, Zhao Y. Iroquois Homeodomain transcription factors in ventricular conduction system and arrhythmia. Int J Med Sci 2018; 15(8):808-815. doi:10.7150/ijms.25140. Available from http://www.medsci.org/v15p0808.htm