23 January 2019
Global reach, higher impact
Int J Med Sci 2018; 15(8):782-787. doi:10.7150/ijms.24755
Hyperbaric Oxygen Therapy in Liver Diseases
1. Department of Rehabilitation Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Hyperbaric oxygen therapy (HBOT) is an efficient therapeutic option to improve progress of lots of diseases especially hypoxia-related injuries, and has been clinically established as a wide-used therapy for patients with carbon monoxide poisoning, decompression sickness, arterial gas embolism, problematic wound, and so on. In the liver, most studies positively evaluated HBOT as a potential therapeutic option for liver transplantation, acute liver injury, nonalcoholic steatohepatitis, fibrosis and cancer, especially for hepatic artery thrombosis. This might mainly attribute to the anti-oxidation and anti-inflammation of HBOT. However, some controversies are existed, possibly due to hyperbaric oxygen toxicity. This review summarizes the current understandings of the role of HBOT in liver diseases and hepatic regeneration. Future understanding of HBOT in clinical trials and its in-depth mechanisms may contribute to the development of this novel adjuvant strategy for clinical therapy of liver diseases.
Keywords: hyperbaric oxygen, liver diseases, toxicity
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How to cite this article:
Sun Y, Wen Y, Shen C, Zhu Y, You W, Meng Y, Chen L, Feng Y, Yang X, Chen ZB. Hyperbaric Oxygen Therapy in Liver Diseases. Int J Med Sci 2018; 15(8):782-787. doi:10.7150/ijms.24755. Available from http://www.medsci.org/v15p0782.htm