23 March 2018
Int J Med Sci 2018; 15(6):557-563. doi:10.7150/ijms.23700
Vascular calcification and left ventricular hypertrophy in hemodialysis patients: interrelationship and clinical impacts
1. Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea
Background: We examined the relationship and combined effect of vascular calcification (VC) and left ventricular hypertrophy (LVH) on deaths and cardiovascular events (CVEs) in hemodialysis (HD) patients.
Methods: Maintenance HD patients (n=341) were included. Echocardiography data and plain chest radiographs were used to assess LVH and aortic arch VC.
Results: VC was found in 100 patients (29.3%). LVH was more prevalent in patients with VC compared with those without VC (70% vs. 50.2%, P=0.001). VC was independently associated with a 2.42-fold increased risk of LVH (95% CI, 1.26-4.65). In multivariate analysis, compared with patients with neither VC nor LVH, the coexistence of VC and LVH was independently associated with CVE (HR, 2.01; 95% CI, 1.09-3.72), whereas VC or LVH alone was not. Patients with both VC and LVH had the highest risk for a composite event of deaths or CVE (HR, 1.88; 95% CI, 1.15-3.06). Significant synergistic interaction was observed between VC and LVH (P for interaction=0.039).
Conclusions: VC was independently associated with LVH. The coexistence of VC and LVH was associated with higher risk of deaths and CVEs than either factor alone. VC and LVH showed a synergistic interaction for the risk of deaths and CVEs.
Keywords: hemodialysis, cardiovascular event, death, left ventricular hypertrophy, vascular calcification
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How to cite this article:
Hwang HS, Cho JS, Hong YA, Chang YK, Kim SY, Shin SJ, Yoon HE. Vascular calcification and left ventricular hypertrophy in hemodialysis patients: interrelationship and clinical impacts. Int J Med Sci 2018; 15(6):557-563. doi:10.7150/ijms.23700. Available from http://www.medsci.org/v15p0557.htm