International Journal of Medical Sciences

Impact factor
2.399

22 June 2018

ISSN 1449-1907 News feeds of published articles

Manuscript login | Account

Theranostics

Journal of Cancer

International Journal of Biological Sciences

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

Oncomedicine

Journal of Biomedicine

Nanotheranostics

PubMed Central Indexed in Journal Impact Factor

Int J Med Sci 2018; 15(6):557-563. doi:10.7150/ijms.23700

Research Paper

Vascular calcification and left ventricular hypertrophy in hemodialysis patients: interrelationship and clinical impacts

Hyeon Seok Hwang1, Jung Sun Cho2, Yu Ah Hong1, Yoon Kyung Chang1, Suk Young Kim1, Seok Joon Shin1, Hye Eun Yoon1✉

1. Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea
2. Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea

Abstract

Background: We examined the relationship and combined effect of vascular calcification (VC) and left ventricular hypertrophy (LVH) on deaths and cardiovascular events (CVEs) in hemodialysis (HD) patients.

Methods: Maintenance HD patients (n=341) were included. Echocardiography data and plain chest radiographs were used to assess LVH and aortic arch VC.

Results: VC was found in 100 patients (29.3%). LVH was more prevalent in patients with VC compared with those without VC (70% vs. 50.2%, P=0.001). VC was independently associated with a 2.42-fold increased risk of LVH (95% CI, 1.26-4.65). In multivariate analysis, compared with patients with neither VC nor LVH, the coexistence of VC and LVH was independently associated with CVE (HR, 2.01; 95% CI, 1.09-3.72), whereas VC or LVH alone was not. Patients with both VC and LVH had the highest risk for a composite event of deaths or CVE (HR, 1.88; 95% CI, 1.15-3.06). Significant synergistic interaction was observed between VC and LVH (P for interaction=0.039).

Conclusions: VC was independently associated with LVH. The coexistence of VC and LVH was associated with higher risk of deaths and CVEs than either factor alone. VC and LVH showed a synergistic interaction for the risk of deaths and CVEs.

Keywords: hemodialysis, cardiovascular event, death, left ventricular hypertrophy, vascular calcification

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Hwang HS, Cho JS, Hong YA, Chang YK, Kim SY, Shin SJ, Yoon HE. Vascular calcification and left ventricular hypertrophy in hemodialysis patients: interrelationship and clinical impacts. Int J Med Sci 2018; 15(6):557-563. doi:10.7150/ijms.23700. Available from http://www.medsci.org/v15p0557.htm